WERAM Information

Tag Content
WERAM ID WERAM-Mum-0013
Ensembl Protein ID ENSMUSP00000005175.4
Uniprot Accession A2A8L1; CHD5_MOUSE; Q6ZQB2
Genbank Protein ID XP_006538995.1
Protein Name Chromodomain-helicase-DNA-binding protein 5
Genbank Nucleotide ID XM_006538932.1
Gene Name CHD5;Kiaa0444
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000005045.16 ENSMUST00000005175.4 ENSMUSP00000005175.4
ENSMUSG00000005045.16 ENSMUST00000030775.11 ENSMUSP00000030775.5
ENSMUSG00000005045.16 ENSMUST00000164662.7 ENSMUSP00000132600.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader DCD Chromo1 H3K4; H3K27me3 K 23201125
Me_Reader PHD PHD1 H3K4; H3K27me3 K 23201125
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 3.60e-20 73.4 346 463
Me_Reader DCD 6.80e-36 109.1 500 554
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
Domain Profile
  Me_Reader PHD
               PHD.txt   2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
                           ++C vC +++ +   ++ Cd+C++++Hl C++++l+++peg +w Cp+C++
  ENSMUSP00000005175.4 346 DYCEVC-QQGGE---IILCDTCPRAYHLVCLDPELEKAPEG-KWSCPHCEK 391
                           69****.55444...9*************************.*******87 PP
               PHD.txt   2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                           ++C+vC kd+ +   +++Cd C+  +Hl+C+++pl ++p+g +w+Cp+C+
  ENSMUSP00000005175.4 419 EFCRVC-KDGGE---LLCCDACPSSYHLHCLNPPLPEIPNG-EWLCPRCT 463
                           69****.66665...9*************************.*******7 PP
  Me_Reader DCD
          Chromo-1.txt   2 vvekvldgrvekgeveylvKWkGmsyihntWeseeqLelqcrvllrnYqkkndedeep 59 
                           + +++l+g++   e+e++vKW+G+sy+h++W++e+qLel+++v++rnYq+knd+de+p
  ENSMUSP00000005175.4 500 PPPRPLEGIP---EREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPP 554
                           89********...*******************************************98 PP
          Chromo-1.txt   7 ldgrv......ekgeveylvKWkGmsyihntWese 35 
                           + +r+      +kg++ yl+KWk++ y  +tWe +
  ENSMUSP00000005175.4 595 MVHRIlnhsfdKKGDIHYLIKWKDLPYDQCTWEID 629
                           444445555589********************965 PP
          Chromo-1.txt   24 GmsyihntWeseeq 37  
                            G++++h  W+ ee 
  ENSMUSP00000005175.4 1709 GFTELHTLWQNEER 1722
                            8999******9985 PP
Protein Sequence
(Fasta)		MRGPLGTEEE LPRLFAEEME NEEEMSEEED GGLEGFEDFF PAEPVSLPKK KPKKLKESKS 60
SKGKRKKKEG SNDEMSDNEE DLEEKSESEG SDYSPTKKKK KKLKEKKEKK EKKEKRKKRG 120
EDEDDNDDGG LKEPKSSGQL MAEWGLDDVD YLFSEDDYHT LTNYKAFSQF LRPLIAKKNP 180
KIPMSKMMTV LGAKWREFSA NNPFKGSSAA AAAAAVAAAV ETVTIAPPLA ISPQQVPQTL 240
PIRKAKTKEG KGPGVRKKNK GAKDSKKKGR GKRVAGLKFR FGGISKRKKG SSSEEDERED 300
SDLDNASIHS SSVRSECSAA LGKKNKRRRK KKRIDDGDGY ETDHQDYCEV CQQGGEIILC 360
DTCPRAYHLV CLDPELEKAP EGKWSCPHCE KEGIQWEPKD DDEEEEEGGC EEEEDDHMEF 420
CRVCKDGGEL LCCDACPSSY HLHCLNPPLP EIPNGEWLCP RCTCPPLKGK VQRILHWRWT 480
EPPAPFVVGL PGPEVEPGMP PPRPLEGIPE REFFVKWAGL SYWHCSWVKE LQLELYHTVM 540
YRNYQRKNDM DEPPPFDYGS GDEDGKSEKR KNKDPLYAKM EERFYRYGIK PEWMMVHRIL 600
NHSFDKKGDI HYLIKWKDLP YDQCTWEIDE IDIPYYDNLK QAYWGHRELM LGEDARLPKR 660
LVKKGKKLKD DKQEKPPDTP IVDPTVKFDK QPWYIDATGG TLHPYQLEGL NWLRFSWAQG 720
TDTILADEMG LGKTVQTIVF LYSLYKEGHS KGPYLVSAPL STIINWEREF EMWAPDFYVV 780
TYTGDKESRS VIRENEFSFE DNAIRGGKKV FRMKKEVQIK FHVLLTSYEL ITIDQAILGS 840
IEWACLVVDE AHRLKNNQSK FFRVLNSYKI DYKLLLTGTP LQNNLEELFH LLNFLTPERF 900
NNLEGFLEEF ADISKEDQIK KLHDLLGPHM LRRLKADVFK NMPAKTELIV RVELSQMQKK 960
YYKFILTRNF EALNSKGGGN QVSLLNIMMD LKKCCNHPYL FPVAAVEAPV LPNGSYDGSS 1020
LVKSSGKLML LQKMLKKLRD EGHRVLIFSQ MTKMLDLLED FLEYEGYKYE RIDGGITGGL 1080
RQEAIDRFNA PGAQQFCFLL STRAGGLGIN LATADTVIIY DSDWNPHNDI QAFSRAHRIG 1140
QNKKVMIYRF VTRASVEERI TQVAKRKMML THLVVRPGLG SKSGSMTKQE LDDILKFGTE 1200
ELFKDDVEGM MSQGQRPTTP IPDIQSTKGG SLTAGAKKKH GSTPPGDNKD VEDSSVIHYD 1260
DAAISKLLDR NQDATDDTEL QNMNEYLSSF KVAQYVVREE DGVEEVEREV IKQEENVDPD 1320
YWEKLLRHHY EQQQEDLARN LGKGKRIRKQ VNYNDASQED QEWQDELSDN QSEYSIGSED 1380
EDEDFEERPE GQSGRRQSRR QLKSDRDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR 1440
WGMPPQDAFN SHWLVRDLRG KSEKEFRAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ 1500
HVLTRIGVMS LVRKKVQEFE HVNGKYSTPD LVPEGAEGKK PGEVISSDPN TPVPASPAQL 1560
PPAPLGLTDK MEAQLGYTDE KESGMQKPKK SLEIQTLPTA LDRVEGEDKH QSSDSKDRAR 1620
EERTEEVEKA QGSPEQPLKE EVLPDKEPIP DKPELSLGHS GDFRPDDPKT EEKEPGETQQ 1680
NGDREEDEEG KKEDKNGKFK FMFNIADGGF TELHTLWQNE ERAAVSSGKI YEIWHRRHDY 1740
WLLAGIVTHG YARWQDIQND PRYMILNEPF KSEIHKGNYL EMKNKFLARR FKLLEQALVI 1800
EEQLRRAAYL NMTQDPNHPA MALNARLAEV ECLAESHQHL SKESLAGNKP ANAVLHKVLN 1860
QLEELLSDMK ADVTRLPSML SRIPPVAARL QMSERSILSR LTNRAGDPTI QQTSSRRRDF 1920
PLFQRSFPAE PSHLPNPRGR EKLQPF 1946
Nucleotide Sequence
(Fasta)		GTTAAGGCTG GCACCGCGCC CGGCGGGAGG GGGGCGCCCA CCTTCCTTCC CCCCCCGCGC 60
CGGGCATGCG GGGCCCGCTG GGCACCGAGG AGGAGCTGCC GCGGCTGTTC GCGGAGGAGA 120
TGGAGAACGA GGAGGAGATG TCAGAAGAAG AAGACGGTGG CCTTGAAGGC TTTGAGGACT 180
TCTTCCCTGC AGAGCCCGTG AGTCTTCCCA AGAAGAAGCC GAAGAAGCTG AAAGAGAGCA 240
AGTCCTCCAA AGGTAAAAGG AAGAAGAAAG AGGGGAGCAA TGACGAGATG TCAGACAACG 300
AGGAGGACCT GGAAGAGAAG TCAGAGAGCG AAGGTAGCGA CTACTCCCCC ACCAAGAAGA 360
AGAAGAAGAA ACTGAAGGAG AAGAAGGAGA AGAAGGAGAA GAAGGAGAAG CGGAAAAAGA 420
GGGGTGAGGA TGAAGATGAT AACGACGACG GAGGCTTGAA GGAGCCCAAG TCCTCGGGAC 480
AACTCATGGC GGAGTGGGGG CTGGACGACG TGGACTACCT GTTTTCTGAG GATGACTACC 540
ACACACTGAC CAACTACAAA GCCTTCAGCC AGTTCCTCAG GCCCCTTATT GCCAAGAAGA 600
ATCCGAAGAT CCCCATGTCC AAAATGATGA CTGTCCTGGG GGCCAAGTGG CGAGAATTCA 660
GCGCCAACAA CCCGTTTAAG GGTAGCTCGG CAGCAGCAGC TGCGGCGGCC GTGGCCGCGG 720
CCGTGGAGAC AGTGACCATT GCTCCTCCCT TGGCCATCAG TCCCCAGCAA GTGCCCCAGA 780
CTCTGCCCAT ACGAAAGGCC AAGACCAAAG AGGGCAAGGG GCCCGGAGTG AGGAAGAAGA 840
ACAAAGGCGC CAAAGATTCC AAGAAAAAGG GCAGGGGCAA GAGAGTGGCA GGGCTCAAGT 900
TCCGCTTCGG AGGGATCAGC AAGAGGAAGA AGGGTTCCTC GAGCGAGGAG GATGAACGGG 960
AGGACTCAGA CTTGGACAAT GCCAGCATCC ACAGCTCTTC TGTGCGTTCT GAGTGCTCTG 1020
CAGCTCTGGG CAAGAAGAAC AAGAGGAGGC GCAAGAAGAA GAGGATTGAC GATGGTGACG 1080
GCTATGAGAC AGACCACCAG GACTACTGTG AGGTGTGCCA GCAGGGAGGC GAGATCATTC 1140
TCTGTGACAC CTGCCCGAGG GCATATCACC TAGTCTGCCT GGACCCGGAG CTGGAGAAGG 1200
CTCCAGAGGG CAAGTGGAGC TGCCCACACT GTGAGAAGGA GGGGATCCAG TGGGAGCCGA 1260
AGGATGATGA TGAAGAGGAG GAGGAGGGCG GCTGCGAGGA AGAGGAGGAT GACCACATGG 1320
AGTTCTGCCG CGTGTGCAAG GACGGTGGCG AGCTCCTGTG CTGTGATGCC TGTCCCTCCT 1380
CCTACCACTT GCACTGCCTC AACCCGCCGC TGCCGGAGAT ACCGAACGGT GAATGGCTCT 1440
GCCCGCGCTG TACATGTCCC CCGCTGAAGG GCAAAGTTCA GCGGATCCTA CACTGGAGGT 1500
GGACAGAACC CCCGGCTCCC TTTGTGGTGG GGCTGCCAGG ACCAGAGGTG GAGCCAGGCA 1560
TGCCCCCGCC CAGGCCTCTG GAGGGCATTC CTGAGAGAGA GTTCTTTGTC AAGTGGGCTG 1620
GTCTCTCCTA CTGGCACTGC TCCTGGGTGA AGGAGCTACA GTTGGAGCTG TACCACACCG 1680
TGATGTATCG CAACTACCAA AGAAAGAATG ACATGGACGA ACCGCCACCC TTTGATTACG 1740
GCTCTGGCGA TGAGGATGGT AAGAGCGAGA AACGGAAGAA CAAGGACCCT CTCTACGCCA 1800
AGATGGAGGA ACGCTTCTAC CGCTACGGCA TCAAGCCCGA GTGGATGATG GTTCACCGCA 1860
TCCTGAACCA CAGCTTTGAC AAGAAGGGGG ACATACATTA CCTGATCAAG TGGAAGGACC 1920
TGCCCTACGA CCAGTGCACC TGGGAGATTG ATGAGATTGA CATTCCCTAC TACGACAACC 1980
TGAAGCAGGC CTACTGGGGC CACAGGGAGC TGATGCTGGG GGAAGATGCC AGGCTGCCCA 2040
AGCGGCTGGT GAAGAAGGGC AAGAAGCTGA AGGACGATAA ACAAGAGAAG CCACCCGATA 2100
CGCCCATCGT GGACCCCACA GTCAAGTTCG ACAAGCAGCC GTGGTACATC GACGCCACAG 2160
GAGGCACGCT GCACCCTTAC CAGCTGGAGG GCCTTAACTG GTTACGCTTC TCCTGGGCCC 2220
AGGGCACCGA CACTATCCTG GCTGACGAGA TGGGTTTGGG GAAGACAGTA CAGACCATTG 2280
TGTTTCTCTA TTCTCTGTAC AAGGAGGGCC ACTCCAAGGG GCCTTACCTG GTCAGCGCGC 2340
CCCTGTCCAC CATCATCAAC TGGGAACGGG AGTTTGAGAT GTGGGCGCCT GACTTTTACG 2400
TGGTCACCTA CACGGGGGAC AAGGAGAGCC GCTCTGTGAT CCGTGAGAAC GAGTTTTCCT 2460
TTGAGGACAA CGCCATTCGC GGTGGCAAGA AAGTATTCCG CATGAAGAAG GAAGTGCAGA 2520
TCAAATTCCA CGTGCTGCTC ACCTCTTATG AGCTCATCAC CATTGACCAA GCCATCCTGG 2580
GCTCCATCGA GTGGGCCTGC CTCGTGGTGG ACGAGGCCCA CCGGCTCAAG AACAACCAGT 2640
CCAAGTTCTT TAGGGTCTTG AATAGCTACA AGATCGACTA CAAGCTGCTG CTGACAGGGA 2700
CCCCCCTCCA GAACAACCTG GAGGAACTGT TCCATCTCCT CAACTTCCTG ACTCCAGAGA 2760
GGTTCAACAA TCTGGAAGGC TTCTTGGAGG AGTTTGCTGA CATATCCAAG GAAGATCAGA 2820
TCAAAAAGCT GCATGATCTA TTGGGGCCGC ACATGCTTCG GCGGCTCAAG GCCGACGTGT 2880
TCAAGAACAT GCCGGCTAAG ACAGAGCTGA TTGTCCGAGT GGAGCTGAGC CAGATGCAGA 2940
AGAAGTACTA CAAGTTCATC CTGACTCGGA ACTTTGAGGC GCTCAATTCC AAGGGGGGTG 3000
GCAACCAGGT GTCTCTACTC AATATCATGA TGGATCTGAA GAAGTGCTGC AACCATCCGT 3060
ACCTCTTCCC TGTGGCTGCT GTGGAAGCCC CTGTACTGCC CAATGGCTCC TACGATGGCA 3120
GCTCCCTGGT CAAGTCTTCG GGGAAGCTCA TGCTATTGCA GAAGATGCTC AAGAAACTGC 3180
GGGATGAAGG GCACAGAGTG CTGATCTTCT CCCAGATGAC CAAGATGTTG GACCTCTTGG 3240
AGGACTTCCT GGAGTACGAG GGCTACAAGT ATGAGCGGAT CGACGGTGGC ATCACTGGGG 3300
GCCTCCGGCA AGAGGCCATC GACAGATTCA ACGCTCCTGG GGCCCAACAG TTCTGCTTCC 3360
TGCTCTCAAC ACGTGCCGGT GGCCTGGGCA TCAACCTGGC CACAGCAGAC ACGGTCATCA 3420
TCTATGACTC GGACTGGAAC CCTCACAATG ACATCCAGGC CTTCAGCCGT GCTCACCGCA 3480
TCGGGCAGAA CAAGAAGGTC ATGATCTATC GCTTCGTGAC ACGGGCCTCC GTGGAGGAGC 3540
GCATCACTCA GGTGGCCAAG CGTAAGATGA TGCTCACACA CCTGGTGGTG CGGCCTGGCT 3600
TGGGCTCCAA GTCGGGCTCC ATGACCAAGC AGGAACTGGA TGATATCCTT AAGTTCGGGA 3660
CAGAGGAGCT TTTCAAGGAC GACGTGGAAG GCATGATGTC CCAGGGCCAG AGGCCTACCA 3720
CACCCATCCC TGACATACAA TCTACCAAGG GCGGATCTCT GACCGCCGGC GCAAAGAAAA 3780
AGCACGGCAG CACCCCGCCA GGCGATAACA AAGATGTAGA AGACAGCAGT GTGATCCATT 3840
ATGACGACGC AGCCATATCC AAGCTGCTGG ATCGGAACCA GGACGCCACG GATGACACCG 3900
AGCTGCAGAA CATGAACGAG TACCTGAGCT CCTTCAAGGT GGCACAGTAT GTGGTCCGCG 3960
AGGAAGATGG CGTGGAGGAG GTAGAGAGGG AGGTGATCAA GCAGGAGGAG AACGTGGACC 4020
CTGACTACTG GGAGAAGCTG CTGCGCCATC ACTATGAACA GCAGCAGGAG GACTTGGCCC 4080
GCAACCTGGG CAAGGGCAAG CGCATCCGCA AGCAGGTCAA CTACAATGAT GCCTCCCAGG 4140
AGGACCAGGA GTGGCAGGAT GAGCTCTCGG ACAACCAGTC GGAGTATTCC ATCGGTTCTG 4200
AGGATGAGGA CGAGGACTTT GAGGAGCGAC CAGAAGGGCA GAGTGGACGA CGACAATCCA 4260
GGAGGCAGCT TAAGAGTGAC AGGGACAAGC CCCTGCCTCC CCTTCTGGCT CGGGTTGGGG 4320
GCAACATTGA GGTTCTGGGC TTCAATGCCA GACAGAGGAA GGCTTTTTTG AACGCCATCA 4380
TGCGCTGGGG CATGCCGCCT CAGGATGCCT TCAACTCCCA CTGGCTGGTG CGGGACCTTC 4440
GAGGGAAGAG TGAGAAGGAA TTTAGGGCCT ATGTATCACT CTTCATGCGC CACCTGTGTG 4500
AGCCGGGCGC AGACGGCGCG GAGACCTTCG CAGACGGCGT GCCCCGGGAG GGCCTGTCTA 4560
GGCAGCACGT GCTCACGCGT ATTGGGGTCA TGTCGCTGGT TAGGAAGAAG GTGCAGGAGT 4620
TTGAGCATGT CAACGGCAAG TACAGCACCC CAGACCTGGT CCCCGAGGGG GCCGAGGGCA 4680
AGAAGCCGGG CGAGGTCATC TCCTCAGACC CCAACACACC TGTGCCTGCC AGCCCTGCAC 4740
AGCTTCCACC GGCCCCACTG GGCCTGACAG ACAAAATGGA AGCCCAGCTG GGCTACACAG 4800
ATGAGAAGGA GTCAGGCATG CAGAAGCCAA AGAAGTCCCT GGAAATCCAG ACCCTGCCAA 4860
CTGCCCTGGA CAGAGTAGAG GGTGAAGACA AACATCAGAG CTCAGACAGC AAGGACAGGG 4920
CTCGGGAGGA GAGGACAGAA GAGGTGGAGA AGGCCCAGGG GTCTCCAGAG CAGCCACTGA 4980
AAGAGGAAGT GCTGCCGGAC AAGGAGCCGA TCCCAGACAA GCCGGAGCTG AGCTTGGGTC 5040
ACAGCGGGGA TTTCAGGCCA GATGACCCCA AGACTGAGGA GAAGGAGCCC GGGGAGACTC 5100
AGCAAAACGG CGACAGAGAG GAAGATGAGG AAGGCAAGAA AGAAGACAAA AATGGGAAAT 5160
TCAAATTCAT GTTCAACATT GCAGATGGCG GTTTCACAGA GCTGCACACT CTGTGGCAGA 5220
ACGAGGAGCG GGCGGCTGTG TCCTCGGGGA AAATCTACGA AATCTGGCAC CGCCGTCACG 5280
ACTACTGGCT GCTGGCAGGC ATTGTGACGC ATGGCTATGC CCGCTGGCAG GACATTCAGA 5340
ATGACCCGAG ATACATGATC CTAAATGAAC CTTTCAAGTC TGAGATCCAC AAGGGCAACT 5400
ACTTGGAGAT GAAGAACAAG TTTTTGGCCC GTAGGTTCAA GCTGCTGGAG CAGGCGCTGG 5460
TGATTGAGGA GCAGCTCCGG AGGGCAGCGT ACCTCAACAT GACCCAGGAT CCCAACCACC 5520
CAGCCATGGC GCTCAATGCT CGCCTGGCAG AGGTGGAGTG CCTTGCCGAG AGCCACCAGC 5580
ACCTATCCAA GGAGTCCCTC GCCGGAAACA AGCCTGCCAA TGCTGTCCTG CACAAGGTCC 5640
TAAACCAGCT GGAGGAGCTG CTGAGTGACA TGAAAGCAGA TGTGACACGC TTGCCCTCCA 5700
TGTTGTCACG CATCCCCCCG GTGGCCGCCC GTCTGCAGAT GTCTGAACGC AGCATCTTGA 5760
GTCGCCTGAC CAACCGAGCT GGTGACCCCA CCATCCAGCA GACATCTAGC CGTCGTCGTG 5820
ACTTCCCCCT GTTTCAGCGC TCCTTTCCAG CTGAGCCAAG CCACCTGCCC AACCCCCGCG 5880
GGAGAGAAAA GCTACAGCCC TTTTAGGAGT TGGTGCGGTG TTGGGGTACA AAAGGGAAAC 5940
CATGAAATTC TATCACACGG AGGACAGGCC CAGGCTGGCT GCGCAAGAGT CCAGAAGTGC 6000
CACCTCATCG TAGTTGAAGC CTTCTTCCAC ACGGCATCCC ATCTACAGCT ACGCCTGGCA 6060
AGGTCCTGGC GCCTTTTCCA GAGTGACTGA CTTAGAGGAA ATTCCATTTA CCTGTAAATT 6120
TTTTTTTTGG CACTTTCCTA CTGAAGATGC AAACATGTTT GTCTTGATAA AAAGTTGGAT 6180
GACGTGTGGA AGATTCAGAT TCACGACACT CCTGTCTGTC ACCGGCTCCA GACCTCAAGG 6240
GGAAGCTCTT TGGAGGCCCT TGGTGCTGCT GCTCTATGGA TTCAACTGCG GCCGAAGAGA 6300
ATGCAGCATC CAGTGCTCTG GAAACCCTTA GTCTGCCCCC CGCCCCCGTC TGTACCCGTG 6360
TGACTGCTCC AGACCCCTGC CTGCTTGGGA CCCTAGTGCT AGCCTAGCCA GGGAGGGGAT 6420
CAGGTCTGGA GAGTGGCTGC CTACCCTGCT GATGCCCAGC ATGGGAGACG GCCCGGTACA 6480
TCCCACTTCT GGGCAGGAGC GCATATCTCA AGGTCTCTGG CATCTCTCAT TTCCAGTGGA 6540
CACGTGGTGG TGCCAGCAAT GTGTGGCAGG TTGAAGTGAG GGTACCTCGC TCAGAGGGTG 6600
GAGCAGATTT AGACCTTGGA CAAAGCCCCC TGCAGGGGTT TTTGGACATT TTCTGTCTGC 6660
AGGAGTGTGG TATAGATAGG TGTGAGCTGG TGTCCCAGAG AAGGGTGGTG TTTGTTGGGT 6720
GGCCCTGCGA GACTTGTCCC ACTCACCTTG GCAAAGACAA GCATCTTGGA GTGTCCTGGG 6780
CCACACAGAT GCCAGCAGCC CCTCCCAGAG CTGAATTGAT CTCTGTTGTC TTGGTCCTAG 6840
AGAAGCCTTG ACTAGGGTGA CTTCTGCATG AAGTAGGGGC CACAGGGGCC TTTGCTGGAT 6900
CTCCGAGGGT ATGGAGAGAG CTGTGCTTGG AGTGGGGCCT GGAGCTGATG GTGACTTTAG 6960
ATCCTTCCTA CCCGGAGCCT TCAAGGCTTC TGACCTCATT TCCTGCAGGG AAGCCTTAAG 7020
AGTGCCAGGC CCATCTTCCC ATGTCACTGT TGACACGCCA CTTGTCTTGC TCTACCCCAG 7080
CCTGTGGCAC CACGTAACGC TCCATGCTGG GGTGGGGGTG GGTGGAGCCT GCCAGGCTCC 7140
AGGCCTGTGT CTGAACTTCT TACTGGCCCT TGGCTCAACC TGGAGAGATC CTGGGGTTCA 7200
GTTTACCCTG AAGATGAGGA CGGGGCTTGT GGAGAGAAGC CAGTCGGGTC CGAGGGAGCT 7260
TGGTAGGGGT CAGATTGTCC CTGGAAAAGG AGTTGGGGGG TATGCAGCAT CTCTGGGCCT 7320
GCCAAAAATG GGGGCAGGTC TCCATGGCTT GTTTTGAGGA CACTGGGCAG GTGGCTGGCC 7380
TTTACTTAGC CCAGATATGT ACACATCTGT AACATAGTTC CTCCTCTGCT CCTGGAGGGC 7440
TGGACCCCCA CAGCTTCTTA TACTTTGCCA CTCCTATACT TGAGTGTCTA TCCAAGTCTT 7500
AAGGCTAGCA ACTGGCCGCA CACTGTGGGT AGGCGGGGAG GGGGAGGGGA CTCTGGCCAT 7560
AGACAGGACC ACTGAAGGCT TGAGTGCATT ATGGTGGCTG ACCCCGCTCT CCAAGAAGGG 7620
CTGTCCTCTG CACAGGAGTG TCTTCCCTAG TTCGCTCCCC AACCCAGACC TCTGTGCTAA 7680
TCCCAAGATG GGCAAGATGG TCAGCCCTGT TGGCCTCAGT TGCCACACTG ACATCCTAAG 7740
ACTTAGGCCT GCAGGCTCAC GTGGGACAGA ATAGGGTCTG TGTCTCTTGA CTTCAGGGGT 7800
CCATCCCTTC CCTGAAGACT TCCCCCAGGA GTCTTGCTCT GTCCATCCAT CTCTGCTTCT 7860
TCCTGGGCCA TACCCACCCT CTGTGGCCTT CCCCTCTCCA CAGCCACCTT GACCTGAGAC 7920
CCCTGCTGGC CTGGGAGGGC CTTAGCGCCT CAGTTCTCCA GGGTAGACTG CCCAGGCAGC 7980
TGAGGAGAGG ACAAAGTCCT TCAGAGTGTT CGCATCTTGG CCCTTCAGCT GTCGCCTGCT 8040
AGAGAGTGAT AGGATAGAGG TGGCATCTTG AGGTGGCTCT CATTTTGCTG CTGATAGAAC 8100
TGGGTCCTCA TGCCCGAGCT GTCAGAGCTG CAGTGACAGT GATTTCTAGC TGCTTTGGCT 8160
TGCTTAATTC TATAGGATCT CTGTGGAAGG TGTGGGGTGG CTCTCGGTGA CATAGGGGTT 8220
TGGGTCAGAG CTACATCATC TGAGGGCACC CCCTCACCCC TGTTCTGAAT TGCTTACTCC 8280
CCATACCCCA GGGGCCACCT GTGAGCCAGG GTTCCCTCCC CCAGCCTCTG GGTGCTCCCT 8340
AGCCCATGTG GGCTGCTGGC TCAGTGACAC CGGCAACCAG TCTAAGTCTT GAGTCCTGCA 8400
GGGGGCACGT GGAGGGTAGG CTAGGGGGCC AGGGCTCTTT GTAGTCTCAT AGAGTGGGCA 8460
AGTGTTGATG CTTGGAGTGT CTCGTGTGTG CCAAGGAAGG GGGTTGGGGG CCTAGGCTGA 8520
CCCTCCCTCC AACTTCGCTG TCTTGGTCTA CCCACAAGGG CTCCTGCGCA GACCACAGCC 8580
AGGAGGAGGA GGAGGCCAAC CTGCCCAATT TATATACCCG AAAGTTTACA GGTCGTGGCG 8640
CGTCAGCCCA AAGTCTTTGG TGTCCCTGCG TTTATGGATA TTTCCCTCTT AATTTTCAGA 8700
TTTTTTTTTT TAAAAACAAA AGTATTTTTT TAGGTATGAT AAACCCGGAA AGGGCCTGTT 8760
GGGTATGTGT GTATGTCCTG AACTCTCCAC AAAGCCACAC GGACCAGAGC CCAGGTCAGA 8820
GGCAGCTCTT CCACCTGGCC TGGAGGGGAG GGAGGGTCCC CTGCTGCCTA CCAGGGTCAA 8880
GCTAGACTGC AGGGATTCTC TTCCTGCCCA GGCCGGGCTG GCATCTGTCC TACCCTTGCC 8940
CAATCGAGCA CACCCTGATG AAGTCAGAGT AGGTGCTTGG GGTCAGCTGG GAGCACCTCA 9000
GCAGGGGTCC CAAGGGCACA TCAGGAGCCC CTCTGAAGGC TGGGCAGACC AGTGGTATCT 9060
CCACTTGTAT TCTCTGTGTG TATGTTTTGG TTTCTGTGTT TTAATAAACC CTTTGGGAAG 9120
GG 9123
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR028727--CHD5
IPR012957--CHD_C2
IPR012958--CHD_N
IPR000953--Chromo/shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR009462--DUF1086
IPR009463--DUF1087
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50013--CHROMO_2
PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF08074--CHDCT2
PF08073--CHDNT
PF00385--Chromo
PF06461--DUF1086
PF06465--DUF1087
PF00271--Helicase_C
PF00628--PHD
PF00176--SNF2_N
Gene Ontology

GO:0000792--C:heterochromatin
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0005524--F:ATP binding
GO:0008026--F:ATP-dependent helicase activity
GO:0003677--F:DNA binding
GO:0061628--F:H3K27me3 modified histone binding
GO:0042826--F:histone deacetylase binding
GO:0008270--F:zinc ion binding
GO:0021895--P:cerebral cortex neuron differentiation
GO:0098532--P:histone H3-K27 trimethylation
GO:0043967--P:histone H4 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:1901798--P:positive regulation of signal transduction by p53 class mediator
GO:0045595--P:regulation of cell differentiation
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0035093--P:spermatogenesis, exchange of chromosomal proteins
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0069 ENSRNOP00000024732.5 Rattus norvegicus 97 0.0 3126
WERAM-Paa-0041 ENSPANP00000005715.1 Papio anubis 93 0.0 3055
WERAM-Cap-0209 ENSCPOP00000020779.1 Cavia porcellus 93 0.0 3018
WERAM-Fec-0069 ENSFCAP00000005872.3 Felis catus 95 0.0 3010
WERAM-Chs-0008 ENSCSAP00000017274.1 Chlorocebus sabaeus 94 0.0 3009
WERAM-Loa-0071 ENSLAFP00000005334.3 Loxodonta africana 96 0.0 3008
WERAM-Caf-0203 ENSCAFP00000028919.3 Canis familiaris 96 0.0 2995
WERAM-Ova-0139 ENSOARP00000014409.1 Ovis aries 94 0.0 2995
WERAM-Otg-0071 ENSOGAP00000005103.2 Otolemur garnettii 95 0.0 2987
WERAM-Eqc-0210 ENSECAP00000022667.1 Equus caballus 96 0.0 2987
WERAM-Gog-0009 ENSGGOP00000000697.2 Gorilla gorilla 95 0.0 2986
WERAM-Hos-0090 ENSP00000262450.3 Homo sapiens 93 0.0 2984
WERAM-Aim-0107 ENSAMEP00000010459.1 Ailuropoda melanoleuca 95 0.0 2974
WERAM-Tut-0124 ENSTTRP00000009941.1 Tursiops truncatus 94 0.0 2949
WERAM-Pat-0002 ENSPTRP00000000143.3 Pan troglodytes 93 0.0 2934
WERAM-Prc-0006 ENSPCAP00000000704.1 Procavia capensis 92 0.0 2822
WERAM-Fia-0118 ENSFALP00000010192.1 Ficedula albicollis 88 0.0 2820
WERAM-Bot-0212 ENSBTAP00000010688.3 Bos taurus 90 0.0 2795
WERAM-Meg-0008 ENSMGAP00000000587.2 Meleagris gallopavo 88 0.0 2793
WERAM-Sus-0023 ENSSSCP00000003650.2 Sus scrofa 95 0.0 2764
WERAM-Caj-0001 ENSCJAP00000000208.2 Callithrix jacchus 85 0.0 2710
WERAM-Nol-0109 ENSNLEP00000012582.2 Nomascus leucogenys 92 0.0 2707
WERAM-Gaga-0006 ENSGALP00000023295.4 Gallus gallus 88 0.0 2669
WERAM-Anc-0021 ENSACAP00000002593.3 Anolis carolinensis 84 0.0 2660
WERAM-Sah-0203 ENSSHAP00000022021.1 Sarcophilus harrisii 85 0.0 2588
WERAM-Leo-0039 ENSLOCP00000005985.1 Lepisosteus oculatus 80 0.0 2564
WERAM-Tag-0041 ENSTGUP00000002728.1 Taeniopygia guttata 82 0.0 2563
WERAM-Xet-0022 ENSXETP00000006377.3 Xenopus tropicalis 78 0.0 2553
WERAM-Anp-0142 ENSAPLP00000015426.1 Anas platyrhynchos 81 0.0 2547
WERAM-Asm-0087 ENSAMXP00000009172.1 Astyanax mexicanus 78 0.0 2538
WERAM-Pes-0048 ENSPSIP00000007224.1 Pelodiscus sinensis 83 0.0 2537
WERAM-Dar-0239 ENSDARP00000133704.1 Danio rerio 78 0.0 2516
WERAM-Mup-0078 ENSMPUP00000007065.1 Mustela putorius furo 94 0.0 2499
WERAM-Xim-0182 ENSXMAP00000014720.1 Xiphophorus maculatus 78 0.0 2485
WERAM-Orn-0005 ENSONIP00000000787.1 Oreochromis niloticus 77 0.0 2462
WERAM-Poa-0016 ENSPPYP00000002263.2 Pongo abelii 96 0.0 2449
WERAM-Orla-0187 ENSORLP00000021515.1 Oryzias latipes 75 0.0 2407
WERAM-Mam-0156 ENSMMUP00000022145.2 Macaca mulatta 96 0.0 2318
WERAM-Ict-0185 ENSSTOP00000015560.1 Ictidomys tridecemlineatus 70 0.0 2310
WERAM-Myl-0162 ENSMLUP00000013342.2 Myotis lucifugus 69 0.0 2302
WERAM-Dan-0007 ENSDNOP00000000870.3 Dasypus novemcinctus 71 0.0 2287
WERAM-Tar-0095 ENSTRUP00000018903.1 Takifugu rubripes 77 0.0 2286
WERAM-Ocp-0105 ENSOPRP00000010147.1 Ochotona princeps 70 0.0 2281
WERAM-Ptv-0138 ENSPVAP00000011854.1 Pteropus vampyrus 70 0.0 2273
WERAM-Lac-0068 ENSLACP00000009098.1 Latimeria chalumnae 70 0.0 2259
WERAM-Pof-0207 ENSPFOP00000017138.2 Poecilia formosa 76 0.0 2251
WERAM-Mod-0059 ENSMODP00000030757.4 Monodelphis domestica 71 0.0 2249
WERAM-Ten-0096 ENSTNIP00000006980.1 Tetraodon nigroviridis 69 0.0 2217
WERAM-Orc-0212 ENSOCUP00000018080.1 Oryctolagus cuniculus 67 0.0 2191
WERAM-Gaa-0200 ENSGACP00000024737.1 Gasterosteus aculeatus 66 0.0 2119
WERAM-Ect-0124 ENSETEP00000014412.1 Echinops telfairi 66 0.0 2107
WERAM-Dio-0100 ENSDORP00000010071.1 Dipodomys ordii 74 0.0 1942
WERAM-Tub-0084 ENSTBEP00000009893.1 Tupaia belangeri 70 0.0 1887
WERAM-Mim-0160 ENSMICP00000016268.1 Microcebus murinus 91 0.0 1770
WERAM-Ere-0132 ENSEEUP00000013928.1 Erinaceus europaeus 68 0.0 1736
WERAM-Ora-0020 ENSOANP00000002890.2 Ornithorhynchus anatinus 78 0.0 1694
WERAM-Tas-0061 ENSTSYP00000005557.1 Tarsius syrichta 64 0.0 1595
WERAM-Mae-0139 ENSMEUP00000013963.1 Macropus eugenii 76 0.0 1563
WERAM-Gam-0169 ENSGMOP00000016904.1 Gadus morhua 76 0.0 1474
WERAM-Drm-0093 FBpp0074688 Drosophila melanogaster 61 0.0 1409
WERAM-Cis-0034 ENSCSAVP00000007438.1 Ciona savignyi 58 0.0 1295
WERAM-Cae-0002 T14G8.1 Caenorhabditis elegans 57 0.0 1273
WERAM-Chh-0003 ENSCHOP00000000249.1 Choloepus hoffmanni 75 0.0 1234
WERAM-Sem-0031 EFJ11544 Selaginella moellendorffii 40 0.0 709
WERAM-Brr-0040 Bra007814.1-P Brassica rapa 40 0.0 697
WERAM-Bro-0158 Bo8g099350.1 Brassica oleracea 40 0.0 696
WERAM-Glm-0057 GLYMA06G06720.1 Glycine max 40 0.0 696
WERAM-Amt-0083 ERN02848 Amborella trichopoda 41 0.0 695
WERAM-Art-0045 AT2G25170.1 Arabidopsis thaliana 39 0.0 692
WERAM-Met-0079 AES73562 Medicago truncatula 41 0.0 692
WERAM-Prp-0013 EMJ26664 Prunus persica 40 0.0 684
WERAM-Php-0082 PP1S33_329V6.1 Physcomitrella patens 40 0.0 684
WERAM-Viv-0017 VIT_04s0008g05880.t01 Vitis vinifera 41 0.0 680
WERAM-Arl-0023 fgenesh1_pg.C_scaffold_4000458 Arabidopsis lyrata 39 0.0 677
WERAM-Sol-0080 Solyc06g065730.2.1 Solanum lycopersicum 40 0.0 670
WERAM-Sei-0019 Si005700m Setaria italica 40 0.0 669
WERAM-Mua-0075 GSMUA_Achr4P21270_001 Musa acuminata 39 0.0 664
WERAM-Orbr-0069 OB06G14970.1 Oryza brachyantha 40 0.0 649
WERAM-Orb-0059 OBART06G05400.1 Oryza barthii 39 0.0 640
WERAM-Orni-0056 ONIVA06G06230.1 Oryza nivara 39 0.0 640
WERAM-Org-0057 ORGLA06G0049200.1 Oryza glaberrima 39 0.0 638
WERAM-Soa-0123 ENSSARP00000011752.1 Sorex araneus 73 0.0 637
WERAM-Brd-0024 BRADI1G47367.1 Brachypodium distachyon 39 3e-180 630
WERAM-Aet-0096 EMT22305 Aegilops tauschii 39 5e-176 617
WERAM-Ori-0068 BGIOSGA021779-PA Oryza indica 40 6e-176 616
WERAM-Orr-0060 ORUFI06G05540.1 Oryza rufipogon 40 1e-175 615
WERAM-Orgl-0059 OGLUM06G05590.1 Oryza glumaepatula 40 2e-175 615
WERAM-Tru-0086 TRIUR3_31334-P1 Triticum urartu 41 2e-173 608
WERAM-Vip-0109 ENSVPAP00000010051.1 Vicugna pacos 89 3e-163 574
WERAM-Tra-0315 Traes_7BS_4FE42A949.1 Triticum aestivum 43 2e-162 572
WERAM-Orm-0057 OMERI06G06420.1 Oryza meridionalis 38 7e-156 550
WERAM-Hov-0079 MLOC_61346.1 Hordeum vulgare 44 1e-154 546
WERAM-Thc-0019 EOX96881 Theobroma cacao 41 1e-148 526
WERAM-Pot-0001 POPTR_0001s00550.1 Populus trichocarpa 40 6e-146 517
Created Date 25-Jun-2016