WERAM Information

Tag Content
WERAM ID WERAM-Art-0100
Ensembl Protein ID AT4G14700.1
Uniprot Accession Q710E8; ORC1A_ARATH; O23326; Q94G49
Genbank Protein ID NP_567440.1
Protein Name Origin of replication complex subunit 1A
Genbank Nucleotide ID NM_117553.2
Gene Name ORC1A;At4g14700;dl3390w;FCAALL.93
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT4G14700 AT4G14700.1 AT4G14700.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 19171893
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 1.40e-11 45.2 165 211
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Essential protein (PubMed:19171893). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that regulates positively the transcription of a subset of genes (PubMed:19171893).
Domain Profile
  Me_Reader PHD
      PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                   C++C k++++ ++m++Cd C   fHl+C+k+pl+++peg +w+C+ C+
  AT4G14700.1 165 DCQICFKSHTN-TIMIECDDCLGGFHLNCLKPPLKEVPEG-DWICQFCE 211
                  5****888888.57**************************.*******7 PP
Protein Sequence
(Fasta)		MASSLSSKAK TFKSPTKTPT KMYRKSYLSP SSTSLTPPQT PETLTPLRRS SRHVSRKINL 60
GNDPIDLPGK ESVEEINLIR KPRKRTNDIV VAEKSKKKKI DPEVSFSPVS PIRSETKKTK 120
KKKRVYYNKV EFDETEFEIG DDVYVKRTED ANPDEEEEED PEIEDCQICF KSHTNTIMIE 180
CDDCLGGFHL NCLKPPLKEV PEGDWICQFC EVKKSGQTLV VVPKPPEGKK LARTMKEKLL 240
SSDLWAARIE KLWKEVDDGV YWIRARWYMI PEETVLGRQR HNLKRELYLT NDFADIEMEC 300
VLRHCFVKCP KEFSKASNDG DDVFLCEYEY DVHWGSFKRV AELADGDEDS DQEWNGRKEE 360
EIDYSDEEIE FDDEESVRGV SKSKRGGANS RKGRFFGLEK VGMKRIPEHV RCHKQSELEK 420
AKATLLLATR PKSLPCRSKE MEEITAFIKG SISDDQCLGR CMYIHGVPGT GKTISVLSVM 480
KNLKAEVEAG SVSPYCFVEI NGLKLASPEN IYSVIYEGLS GHRVGWKKAL QSLNERFAEG 540
KKIGKENEKP CILLIDELDV LVTRNQSVLY NILDWPTKPN SKLVVLGIAN TMDLPEKLLP 600
RISSRMGIQR LCFGPYNHRQ LQEIISTRLE GINAFEKTAI EFASRKVAAI SGDARRALEI 660
CRRAAEVADY RLKKSNISAK SQLVIMADVE VAIQEMFQAP HIQVMKSVSK LSRIFLTAMV 720
HELYKTGMAE TSFDRVATTV SSICLTNGEA FPGWDILLKI GCDLGECRIV LCEPGEKHRL 780
QKLQLNFPSD DVAFALKDNK DLPWLANYL 809
Nucleotide Sequence
(Fasta)		CATCCATGGC TTCTTCTCTG AGTTCCAAGG CAAAAACCTT CAAATCCCCA ACCAAAACTC 60
CAACTAAAAT GTATCGCAAA TCGTATCTAT CTCCATCTTC AACTTCACTC ACTCCTCCTC 120
AAACCCCAGA AACTCTCACT CCTCTTCGTA GATCTTCTCG TCACGTTTCC CGTAAAATCA 180
ATCTGGGAAA TGACCCAATC GATCTTCCAG GAAAAGAATC AGTCGAAGAA ATCAATCTAA 240
TTCGAAAACC TAGAAAACGA ACCAATGATA TTGTTGTTGC AGAGAAGTCG AAGAAGAAGA 300
AGATAGATCC GGAAGTTTCC TTCTCTCCTG TTTCACCAAT TCGATCTGAG ACGAAGAAGA 360
CGAAGAAGAA GAAGAGAGTT TATTACAACA AAGTCGAATT CGACGAAACC GAATTCGAAA 420
TCGGTGATGA TGTTTACGTT AAAAGAACAG AAGACGCGAA TCCAGATGAA GAAGAAGAAG 480
AAGATCCAGA AATCGAAGAT TGTCAGATCT GCTTCAAATC ACATACTAAC ACAATAATGA 540
TTGAATGTGA TGATTGTTTA GGTGGATTTC ATTTGAATTG CTTGAAACCG CCATTGAAGG 600
AAGTTCCTGA AGGTGATTGG ATCTGTCAAT TCTGTGAGGT TAAAAAGTCA GGTCAAACAC 660
TTGTGGTTGT TCCTAAGCCA CCGGAAGGGA AGAAATTAGC GAGAACGATG AAGGAGAAGC 720
TTCTCTCTAG TGATTTATGG GCTGCTCGAA TTGAGAAGTT GTGGAAAGAA GTTGATGATG 780
GTGTGTATTG GATTAGAGCT CGTTGGTATA TGATACCTGA AGAGACGGTT TTAGGGAGAC 840
AACGTCATAA TCTGAAACGA GAGCTTTATT TGACGAATGA TTTTGCTGAT ATAGAGATGG 900
AATGTGTTCT TAGGCATTGT TTTGTGAAAT GTCCTAAGGA GTTTTCGAAA GCTAGTAATG 960
ATGGTGATGA TGTGTTTTTG TGTGAGTATG AGTATGATGT TCATTGGGGT AGCTTTAAGC 1020
GTGTGGCTGA ATTGGCTGAT GGAGATGAGG ATAGTGATCA AGAATGGAAT GGTAGGAAAG 1080
AGGAGGAGAT TGATTATAGT GATGAAGAGA TTGAGTTTGA TGATGAAGAG AGTGTTCGTG 1140
GGGTTTCGAA GAGTAAGCGA GGTGGTGCAA ATTCTCGTAA AGGGCGTTTC TTTGGGCTTG 1200
AGAAGGTGGG GATGAAGAGG ATTCCTGAAC ATGTGAGATG TCATAAGCAG AGTGAGTTAG 1260
AAAAGGCGAA GGCTACTTTG TTGTTGGCTA CACGTCCTAA GTCACTTCCT TGTAGAAGCA 1320
AAGAAATGGA AGAGATCACT GCGTTTATAA AAGGCTCAAT CTCTGATGAT CAGTGTTTAG 1380
GTAGATGTAT GTATATTCAT GGTGTTCCCG GTACTGGGAA GACTATTAGT GTGTTATCTG 1440
TTATGAAGAA TCTGAAAGCT GAGGTTGAAG CGGGAAGCGT AAGTCCATAT TGCTTTGTGG 1500
AGATAAATGG TCTCAAATTG GCTTCTCCTG AGAACATTTA CAGTGTTATC TATGAGGGGT 1560
TGAGTGGTCA TCGTGTAGGT TGGAAGAAAG CTCTACAGTC TCTGAATGAG AGGTTTGCAG 1620
AGGGAAAAAA GATAGGTAAA GAGAATGAAA AGCCTTGCAT ACTTCTCATC GACGAGCTTG 1680
ATGTTCTAGT CACTAGAAAT CAGTCTGTTT TATACAACAT TTTGGATTGG CCTACCAAGC 1740
CTAACTCCAA ATTGGTTGTG TTGGGAATAG CAAACACTAT GGATCTTCCA GAGAAGTTGC 1800
TTCCTCGGAT ATCAAGCCGA ATGGGTATAC AGAGACTGTG TTTCGGTCCT TATAACCACA 1860
GGCAGCTACA AGAAATCATT TCTACAAGGT TGGAAGGAAT CAATGCTTTT GAGAAGACAG 1920
CTATCGAATT TGCTTCAAGA AAAGTAGCTG CGATATCAGG AGATGCAAGA CGCGCGCTTG 1980
AGATATGCAG GCGTGCAGCG GAAGTAGCGG ATTACCGTCT AAAGAAGAGT AACATATCTG 2040
CAAAGAGTCA GCTGGTGATT ATGGCAGATG TTGAAGTAGC CATTCAAGAG ATGTTTCAGG 2100
CACCTCATAT TCAAGTTATG AAGAGTGTAT CGAAACTGAG TAGGATCTTC TTGACGGCTA 2160
TGGTTCATGA GCTTTACAAA ACAGGAATGG CAGAGACAAG CTTTGACAGA GTAGCAACAA 2220
CAGTATCGTC TATTTGCTTA ACCAATGGTG AAGCTTTTCC CGGTTGGGAC ATTCTTCTCA 2280
AAATCGGTTG TGATCTTGGT GAATGCAGAA TCGTTCTTTG TGAACCTGGA GAGAAGCACA 2340
GATTGCAGAA GCTGCAGCTT AATTTTCCAA GTGATGATGT TGCTTTTGCA TTGAAAGACA 2400
ATAAGGATCT TCCATGGTTG GCCAATTACT TGTGATTTTT TGCTAGTTTA AGGAAAACTT 2460
TGGAGAGATT GATAATGTAA CACAGTTTGA TTTCTGGAGT ATAAACTATA AATACAGTTA 2520
CAACACAACC 2531
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003593--AAA+_ATPase
IPR003959--ATPase_AAA_core
IPR001025--BAH_dom
IPR027417--P-loop_NTPase
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51038--BAH
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00004--AAA
PF01426--BAH
PF00628--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0000808--C:origin recognition complex
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0010385--F:double-stranded methylated DNA binding
GO:0008270--F:zinc ion binding
GO:0006260--P:DNA replication
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0096 fgenesh2_kg.6__ 3199__ AT4G12620.1 Arabidopsis lyrata 89 0.0 1287
WERAM-Bro-0178 Bo9g078420.1 Brassica oleracea 80 0.0 1152
WERAM-Brr-0148 Bra029471.1-P Brassica rapa 79 0.0 1146
WERAM-Thc-0110 EOY32655 Theobroma cacao 71 0.0 991
WERAM-Pot-0103 POPTR_0009s05910.1 Populus trichocarpa 66 0.0 988
WERAM-Prp-0096 EMJ14761 Prunus persica 68 0.0 967
WERAM-Glm-0175 GLYMA13G41490.1 Glycine max 67 0.0 957
WERAM-Sol-0041 Solyc03g006420.2.1 Solanum lycopersicum 70 0.0 955
WERAM-Met-0185 KEH21251 Medicago truncatula 67 0.0 951
WERAM-Viv-0033 VIT_06s0004g02050.t01 Vitis vinifera 66 0.0 942
WERAM-Amt-0031 ERN11779 Amborella trichopoda 66 0.0 909
WERAM-Mua-0132 GSMUA_Achr8P31340_001 Musa acuminata 64 0.0 907
WERAM-Zem-0094 GRMZM2G168249_P01 Zea mays 62 0.0 901
WERAM-Sob-0130 Sb10g005910.1 Sorghum bicolor 63 0.0 875
WERAM-Brd-0023 BRADI1G47050.1 Brachypodium distachyon 62 0.0 869
WERAM-Org-0058 ORGLA06G0052100.1 Oryza glaberrima 60 0.0 867
WERAM-Orgl-0060 OGLUM06G05860.1 Oryza glumaepatula 61 0.0 867
WERAM-Orm-0058 OMERI06G06700.1 Oryza meridionalis 61 0.0 865
WERAM-Sei-0023 Si005876m Setaria italica 64 0.0 863
WERAM-Lep-0062 LPERR06G05260.1 Leersia perrieri 64 0.0 861
WERAM-Orbr-0070 OB06G15250.1 Oryza brachyantha 64 0.0 848
WERAM-Orr-0061 ORUFI06G05830.1 Oryza rufipogon 61 0.0 840
WERAM-Orp-0057 OPUNC06G05470.1 Oryza punctata 62 0.0 835
WERAM-Orl-0031 KN538791.1_FGP002 Oryza longistaminata 59 0.0 833
WERAM-Orb-0060 OBART06G05680.1 Oryza barthii 59 0.0 825
WERAM-Sot-0106 PGSC0003DMT400033353 Solanum tuberosum 70 0.0 785
WERAM-Hov-0026 MLOC_18813.1 Hordeum vulgare 59 0.0 731
WERAM-Orni-0060 ONIVA06G15290.1 Oryza nivara 56 0.0 709
WERAM-Sem-0120 EFJ23163 Selaginella moellendorffii 51 0.0 659
WERAM-Php-0132 PP1S90_96V6.1 Physcomitrella patens 46 3e-179 626
WERAM-Osl-0008 ABO95923 Ostreococcus lucimarinus 35 2e-106 384
WERAM-Ova-0046 ENSOARP00000005671.1 Ovis aries 41 7e-83 306
WERAM-Eqc-0055 ENSECAP00000007647.1 Equus caballus 41 7e-77 286
WERAM-Mam-0129 ENSMMUP00000018823.2 Macaca mulatta 41 2e-76 285
WERAM-Gog-0040 ENSGGOP00000003862.2 Gorilla gorilla 41 3e-76 284
WERAM-Caf-0044 ENSCAFP00000005581.3 Canis familiaris 41 4e-76 283
WERAM-Hos-0043 ENSP00000360621.1 Homo sapiens 41 7e-76 283
WERAM-Pat-0006 ENSPTRP00000001270.2 Pan troglodytes 41 1e-75 282
WERAM-Mup-0074 ENSMPUP00000006849.1 Mustela putorius furo 40 2e-75 281
WERAM-Caj-0225 ENSCJAP00000040193.2 Callithrix jacchus 40 2e-75 281
WERAM-Paa-0148 ENSPANP00000000718.1 Papio anubis 41 2e-75 281
WERAM-Aim-0101 ENSAMEP00000009770.1 Ailuropoda melanoleuca 41 2e-75 281
WERAM-Ict-0135 ENSSTOP00000013960.2 Ictidomys tridecemlineatus 40 3e-75 280
WERAM-Chs-0014 ENSCSAP00000016740.1 Chlorocebus sabaeus 41 4e-75 280
WERAM-Orc-0009 ENSOCUP00000000831.2 Oryctolagus cuniculus 41 6e-75 280
WERAM-Poa-0010 ENSPPYP00000001568.1 Pongo abelii 40 1e-74 278
WERAM-Bot-0032 ENSBTAP00000003523.5 Bos taurus 41 1e-74 278
WERAM-Sus-0025 ENSSSCP00000004177.1 Sus scrofa 41 2e-74 278
WERAM-Cap-0056 ENSCPOP00000004564.2 Cavia porcellus 41 3e-74 277
WERAM-Fec-0027 ENSFCAP00000002316.3 Felis catus 40 1e-73 275
WERAM-Loa-0046 ENSLAFP00000003139.3 Loxodonta africana 41 2e-73 275
WERAM-Mum-0092 ENSMUSP00000099805.3 Mus musculus 41 2e-73 275
WERAM-Ran-0055 ENSRNOP00000012492.5 Rattus norvegicus 40 2e-73 274
WERAM-Tub-0063 ENSTBEP00000007929.1 Tupaia belangeri 39 8e-71 266
WERAM-Tut-0183 ENSTTRP00000015290.1 Tursiops truncatus 42 1e-68 258
WERAM-Chr-0014 EDP07857 Chlamydomonas reinhardtii 42 2e-54 211
WERAM-Ptv-0102 ENSPVAP00000009238.1 Pteropus vampyrus 36 7e-21 100
WERAM-Soa-0038 ENSSARP00000003789.1 Sorex araneus 39 9e-10 63.5
WERAM-Fia-0048 ENSFALP00000003379.1 Ficedula albicollis 42 1e-09 63.2
WERAM-Pes-0123 ENSPSIP00000014751.1 Pelodiscus sinensis 43 1e-09 63.2
WERAM-Tag-0148 ENSTGUP00000012613.1 Taeniopygia guttata 36 1e-09 62.8
WERAM-Nol-0010 ENSNLEP00000001331.1 Nomascus leucogenys 40 1e-09 62.8
WERAM-Mod-0044 ENSMODP00000006157.3 Monodelphis domestica 39 2e-09 62.4
WERAM-Mae-0106 ENSMEUP00000010312.1 Macropus eugenii 39 2e-09 62.4
WERAM-Myl-0013 ENSMLUP00000001092.2 Myotis lucifugus 40 2e-09 62.4
WERAM-Anc-0110 ENSACAP00000010444.3 Anolis carolinensis 41 2e-09 62.4
WERAM-Dan-0047 ENSDNOP00000004777.3 Dasypus novemcinctus 40 2e-09 62.0
WERAM-Ora-0064 ENSOANP00000009829.2 Ornithorhynchus anatinus 42 3e-09 61.6
WERAM-Sah-0205 ENSSHAP00000022298.1 Sarcophilus harrisii 39 3e-09 61.6
WERAM-Orla-0127 ENSORLP00000015292.1 Oryzias latipes 44 3e-09 61.6
WERAM-Vip-0030 ENSVPAP00000002775.1 Vicugna pacos 43 4e-09 61.2
WERAM-Tas-0013 ENSTSYP00000001518.1 Tarsius syrichta 43 4e-09 61.2
WERAM-Anp-0149 ENSAPLP00000015693.1 Anas platyrhynchos 43 4e-09 61.2
WERAM-Cae-0003 ZK783.4 Caenorhabditis elegans 46 4e-09 61.2
WERAM-Gaga-0116 ENSGALP00000020513.1 Gallus gallus 37 5e-09 60.8
WERAM-Dio-0057 ENSDORP00000005237.1 Dipodomys ordii 43 6e-09 60.8
WERAM-Xet-0052 ENSXETP00000016514.3 Xenopus tropicalis 38 7e-09 60.5
WERAM-Orn-0105 ENSONIP00000011234.1 Oreochromis niloticus 46 8e-09 60.1
WERAM-Meg-0125 ENSMGAP00000013670.2 Meleagris gallopavo 36 1e-08 59.7
WERAM-Leo-0054 ENSLOCP00000007276.1 Lepisosteus oculatus 41 1e-08 59.7
WERAM-Asm-0016 ENSAMXP00000002046.1 Astyanax mexicanus 46 1e-08 59.7
WERAM-Drm-0059 FBpp0078401 Drosophila melanogaster 44 1e-08 59.3
WERAM-Lac-0014 ENSLACP00000002295.1 Latimeria chalumnae 43 2e-08 59.3
WERAM-Dar-0123 ENSDARP00000101556.2 Danio rerio 39 2e-08 59.3
WERAM-Prc-0102 ENSPCAP00000009508.1 Procavia capensis 39 2e-08 58.9
WERAM-Pof-0142 ENSPFOP00000011949.1 Poecilia formosa 47 2e-08 58.9
WERAM-Ect-0112 ENSETEP00000012551.1 Echinops telfairi 47 3e-08 58.5
WERAM-Otg-0164 ENSOGAP00000013816.2 Otolemur garnettii 47 3e-08 58.5
WERAM-Mim-0001 ENSMICP00000000022.1 Microcebus murinus 47 3e-08 58.5
WERAM-Xim-0123 ENSXMAP00000010545.1 Xiphophorus maculatus 45 3e-08 58.5
WERAM-Gaa-0019 ENSGACP00000002833.1 Gasterosteus aculeatus 43 3e-08 58.5
WERAM-Gam-0003 ENSGMOP00000000211.1 Gadus morhua 43 3e-08 58.2
WERAM-Tar-0154 ENSTRUP00000033794.1 Takifugu rubripes 47 3e-08 58.2
WERAM-Ten-0199 ENSTNIP00000019903.1 Tetraodon nigroviridis 45 4e-08 58.2
WERAM-Ors-0091 OS09T0386500-01 Oryza sativa 33 4e-08 57.8
WERAM-Ori-0110 BGIOSGA030686-PA Oryza indica 33 4e-08 57.8
WERAM-Ocp-0025 ENSOPRP00000002203.1 Ochotona princeps 48 4e-08 57.8
WERAM-Tra-0227 Traes_5DL_7A53FE80E.1 Triticum aestivum 34 6e-08 57.4
Created Date 25-Jun-2016