WERAM Information

Tag Content
WERAM ID WERAM-Sac-0051
Ensembl Protein ID YPR023C
Uniprot Accession Q12432; EAF3_YEAST; D6W433
Genbank Protein ID NP_015348.1
Protein Name Chromatin modification-related protein EAF3
Genbank Nucleotide ID NM_001184120.1
Gene Name Eaf3;YPR023C;YP9367.03C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YPR023C YPR023C YPR023C
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromo-Barrel Chromo H3K4me3; H3K36me2 K 25855537
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromo-Barrel 6.30e-63 199.7 168 186
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
Domain Profile
  Me_Reader Chromo-Barrel
  MRG.txt 180 slkkstknsanalekksPv 198
              s +ks++ san+l   s +
  YPR023C 168 SGRKSGRSSANSLHPGSSL 186
              3367888888777655555 PP
  MRG.txt   2 erkitlkipekLkklledDrelikrrkklvkLPakvnivtilesyvkevavelaisikedsrrekksrgarmnkeYirveknvdllkEvvdGlriyFdvtld 103
              ++ki+l+ip+kLk++l+dD+e+++++kk+++LPa+v+++++l++y++ev+            +e +s+g++++            l+E+++Gl++yFd++l+
  YPR023C 217 TPKISLQIPIKLKSVLVDDWEYVTKDKKICRLPADVTVEMVLNKYEHEVS------------QELESPGSQSQ------------LSEYCAGLKLYFDKCLG 294
              689********************************************999............9**********............9**************** PP
  MRG.txt 104 dvLLYklErlqydel 118
              ++LLY+lErlqydel
  YPR023C 295 NMLLYRLERLQYDEL 309
              **************8 PP
  MRG.txt 222 sadkPpepsrvyGAqHLlRLlvklpellsktslsekslklLlkhlddFlkyLaenhdefFdesd........yvnateleyetka 298
               ++kP +p+r+yGA+HLlRL+++lpel+s+t+++ +s++lL+k+++dFl++L++++de+F+++d        yvn+++ +ye++a
  YPR023C 315 KDQKPLVPIRIYGAIHLLRLISVLPELISSTTMDLQSCQLLIKQTEDFLVWLLMHVDEYFNDKDpnrsddalYVNTSS-QYEGVA 398
              489***************************************************************************.**9986 PP
Protein Sequence
(Fasta)		MVDLEQEFAL GGRCLAFHGP LMYEAKILKI WDPSSKMYTS IPNDKPGGSS QATKEIKPQK 60
LGEDESIPEE IINGKCFFIH YQGWKSSWDE WVGYDRIRAY NEENIAMKKR LANEAKEAKK 120
SLLEQQKKKK LSTSLGGPSN GGKRKGDSRS NASISKSTSQ SFLTSSVSGR KSGRSSANSL 180
HPGSSLRSSS DQNGNDDRRR SSSLSPNMLH HIAGYPTPKI SLQIPIKLKS VLVDDWEYVT 240
KDKKICRLPA DVTVEMVLNK YEHEVSQELE SPGSQSQLSE YCAGLKLYFD KCLGNMLLYR 300
LERLQYDELL KKSSKDQKPL VPIRIYGAIH LLRLISVLPE LISSTTMDLQ SCQLLIKQTE 360
DFLVWLLMHV DEYFNDKDPN RSDDALYVNT SSQYEGVALG M 401
Nucleotide Sequence
(Fasta)		ATGGTTGATT TGGAGCAGGA ATTTGCGCTC GGTGGGCGGT GTCTGGCATT CCATGGTCCT 60
CTTATGTATG AAGCAAAGAT CTTGAAAATA TGGGATCCAT CTTCGAAAAT GTATACCAGC 120
ATTCCTAATG ACAAGCCAGG TGGTAGTTCA CAAGCAACTA AGGAAATAAA GCCACAAAAG 180
CTGGGAGAAG ATGAAAGCAT TCCAGAAGAG ATCATTAATG GGAAGTGTTT TTTCATACAT 240
TACCAAGGCT GGAAGTCGAG TTGGGATGAG TGGGTTGGAT ATGATAGGAT ACGGGCCTAC 300
AATGAAGAGA ATATTGCCAT GAAAAAAAGA CTGGCGAACG AGGCGAAAGA AGCTAAGAAA 360
TCGTTACTGG AACAGCAGAA AAAAAAGAAG CTCTCCACTA GTCTGGGAGG GCCTAGTAAT 420
GGTGGAAAAA GAAAGGGAGA CAGCCGCTCG AATGCTAGTA TAAGTAAGAG CACTTCACAG 480
AGTTTTTTAA CATCTTCAGT GAGCGGCAGG AAAAGCGGAA GAAGTTCCGC TAATTCCCTC 540
CATCCTGGCA GCTCTTTGCG CTCGTCATCC GACCAAAATG GGAATGATGA CCGCAGAAGA 600
TCTTCTTCGC TATCGCCAAA TATGCTACAT CATATTGCCG GCTATCCAAC CCCCAAGATT 660
TCCCTTCAAA TTCCCATAAA ATTGAAGAGC GTGTTAGTCG ACGATTGGGA ATACGTAACG 720
AAGGACAAAA AAATTTGCAG ACTACCCGCT GATGTGACGG TAGAGATGGT ACTGAATAAA 780
TACGAACATG AAGTGAGTCA AGAATTGGAA TCGCCAGGGT CCCAGTCACA GTTGAGCGAA 840
TACTGTGCCG GTCTCAAGTT GTATTTTGAC AAGTGCCTGG GTAATATGCT TTTATATAGG 900
TTGGAACGGC TGCAATATGA CGAACTTCTG AAAAAATCAT CGAAGGATCA AAAGCCACTA 960
GTACCAATTA GAATTTATGG GGCTATCCAT CTGTTAAGGT TGATAAGTGT TTTACCAGAG 1020
CTGATCTCGT CTACTACAAT GGATCTACAA AGCTGTCAGC TTTTAATCAA ACAAACCGAA 1080
GACTTCTTGG TTTGGTTGTT GATGCATGTG GACGAATACT TCAATGACAA GGATCCAAAT 1140
AGAAGTGACG ATGCTCTGTA TGTAAATACG TCTAGCCAAT ACGAAGGAGT GGCTTTAGGT 1200
ATGTGA 1207
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
IPR025995--Tudor-knot
PROSITE

PS51640--MRG
Pfam

PF05712--MRG
PF11717--Tudor-knot
Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0032221--C:Rpd3S complex
GO:0006281--P:DNA repair
GO:0016573--P:histone acetylation
GO:0016575--P:histone deacetylation
GO:0060195--P:negative regulation of antisense RNA transcription
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Asg-0009 AAS51868 Ashbya gossypii 44 2e-43 174
WERAM-Asfu-0038 CADAFUAP00008363 Aspergillus fumigatus 30 2e-36 150
WERAM-Coi-0009 EAS36116 Coccidioides immitis 30 5e-34 142
WERAM-Asf-0006 CADAFLAP00002044 Aspergillus flavus 30 2e-33 140
WERAM-Yal-0008 CAG80821 Yarrowia lipolytica 41 6e-31 132
WERAM-Asc-0018 CADACLAP00004414 Aspergillus clavatus 42 6e-30 129
WERAM-Asni-0012 CADANGAP00004222 Aspergillus niger 42 9e-30 128
WERAM-Anc-0150 ENSACAP00000014061.2 Anolis carolinensis 27 1e-29 128
WERAM-Aso-0013 CADAORAP00001673 Aspergillus oryzae 39 2e-29 127
WERAM-Asn-0032 CADANIAP00008637 Aspergillus nidulans 38 2e-29 127
WERAM-Gaga-0083 ENSGALP00000032974.3 Gallus gallus 27 1e-28 125
WERAM-Tum-0023 CAZ84135 Tuber melanosporum 43 1e-28 124
WERAM-Mua-0073 GSMUA_Achr4P12960_001 Musa acuminata 29 2e-28 124
WERAM-Ran-0248 ENSRNOP00000075745.1 Rattus norvegicus 26 2e-28 124
WERAM-Poa-0059 ENSPPYP00000007607.2 Pongo abelii 26 2e-28 124
WERAM-Caj-0017 ENSCJAP00000004116.2 Callithrix jacchus 26 2e-28 124
WERAM-Sah-0200 ENSSHAP00000021731.1 Sarcophilus harrisii 27 2e-28 123
WERAM-Meg-0107 ENSMGAP00000010790.1 Meleagris gallopavo 27 5e-28 122
WERAM-Pes-0161 ENSPSIP00000019260.1 Pelodiscus sinensis 26 5e-28 122
WERAM-Eqc-0042 ENSECAP00000006422.1 Equus caballus 26 1e-27 121
WERAM-Tut-0191 ENSTTRP00000015743.1 Tursiops truncatus 27 1e-27 121
WERAM-Arl-0141 scaffold_700360.1 Arabidopsis lyrata 26 2e-27 120
WERAM-Orc-0185 ENSOCUP00000016187.1 Oryctolagus cuniculus 26 2e-27 120
WERAM-Tag-0122 ENSTGUP00000010081.1 Taeniopygia guttata 27 3e-27 120
WERAM-Art-0111 AT4G37280.1 Arabidopsis thaliana 25 9e-27 118
WERAM-Otg-0074 ENSOGAP00000005406.2 Otolemur garnettii 27 2e-26 117
WERAM-Loa-0095 ENSLAFP00000008255.3 Loxodonta africana 27 2e-26 117
WERAM-Ict-0118 ENSSTOP00000011915.2 Ictidomys tridecemlineatus 27 2e-26 117
WERAM-Pat-0055 ENSPTRP00000051331.1 Pan troglodytes 27 2e-26 117
WERAM-Nol-0090 ENSNLEP00000010671.1 Nomascus leucogenys 27 2e-26 117
WERAM-Hos-0222 ENSP00000331310.5 Homo sapiens 27 2e-26 117
WERAM-Gog-0191 ENSGGOP00000016418.2 Gorilla gorilla 27 2e-26 117
WERAM-Mum-0212 ENSMUSP00000082346.5 Mus musculus 27 2e-26 117
WERAM-Sus-0018 ENSSSCP00000001932.2 Sus scrofa 27 2e-26 117
WERAM-Mod-0094 ENSMODP00000014403.2 Monodelphis domestica 27 4e-26 116
WERAM-Ved-0026 EGY15805 Verticillium dahliae 44 4e-26 116
WERAM-Mam-0209 ENSMMUP00000030192.2 Macaca mulatta 27 7e-26 115
WERAM-Cap-0042 ENSCPOP00000003411.2 Cavia porcellus 26 8e-26 115
WERAM-Mup-0177 ENSMPUP00000015319.1 Mustela putorius furo 27 1e-25 114
WERAM-Aim-0138 ENSAMEP00000013010.1 Ailuropoda melanoleuca 27 2e-25 114
WERAM-Vip-0092 ENSVPAP00000008230.1 Vicugna pacos 27 3e-25 113
WERAM-Caf-0148 ENSCAFP00000020818.3 Canis familiaris 26 4e-25 113
WERAM-Brr-0062 Bra011751.1-P Brassica rapa 29 1e-24 111
WERAM-Fia-0071 ENSFALP00000005346.1 Ficedula albicollis 27 1e-24 111
WERAM-Anp-0039 ENSAPLP00000004318.1 Anas platyrhynchos 27 6e-24 109
WERAM-Ten-0112 ENSTNIP00000012424.1 Tetraodon nigroviridis 38 2e-23 107
WERAM-Crn-0021 AAW44213 Cryptococcus neoformans 41 2e-22 104
WERAM-Tar-0206 ENSTRUP00000043141.1 Takifugu rubripes 37 2e-22 104
WERAM-Orn-0162 ENSONIP00000016650.1 Oreochromis niloticus 36 8e-22 102
WERAM-Xim-0217 ENSXMAP00000017577.1 Xiphophorus maculatus 35 1e-21 102
WERAM-Pof-0080 ENSPFOP00000007130.2 Poecilia formosa 35 1e-21 101
WERAM-Glm-0225 GLYMA17G18240.2 Glycine max 37 1e-21 101
WERAM-Orla-0021 ENSORLP00000002554.1 Oryzias latipes 35 2e-21 101
WERAM-Gaa-0180 ENSGACP00000022333.1 Gasterosteus aculeatus 33 2e-21 100
WERAM-Gam-0087 ENSGMOP00000008960.1 Gadus morhua 32 3e-21 100
WERAM-Asm-0023 ENSAMXP00000002832.1 Astyanax mexicanus 32 5e-21 99.8
WERAM-Drm-0029 FBpp0082579 Drosophila melanogaster 34 6e-21 99.4
WERAM-Ptv-0177 ENSPVAP00000015442.1 Pteropus vampyrus 34 1e-20 98.6
WERAM-Xet-0054 ENSXETP00000017126.3 Xenopus tropicalis 32 1e-20 98.2
WERAM-Aet-0017 EMT06876 Aegilops tauschii 39 1e-20 98.2
WERAM-Fec-0135 ENSFCAP00000024621.1 Felis catus 31 1e-20 98.2
WERAM-Leo-0142 ENSLOCP00000017293.1 Lepisosteus oculatus 32 1e-20 98.2
WERAM-Ere-0064 ENSEEUP00000005345.1 Erinaceus europaeus 33 1e-20 98.2
WERAM-Dan-0102 ENSDNOP00000010912.1 Dasypus novemcinctus 31 2e-20 97.8
WERAM-Cis-0080 ENSCSAVP00000017617.1 Ciona savignyi 32 2e-20 97.8
WERAM-Dar-0092 ENSDARP00000112985.1 Danio rerio 31 2e-20 97.8
WERAM-Chh-0066 ENSCHOP00000007156.1 Choloepus hoffmanni 31 2e-20 97.4
WERAM-Prc-0160 ENSPCAP00000015337.1 Procavia capensis 32 2e-20 97.4
WERAM-Myl-0087 ENSMLUP00000007173.1 Myotis lucifugus 33 2e-20 97.4
WERAM-Paa-0050 ENSPANP00000004934.1 Papio anubis 33 3e-20 97.1
WERAM-Tas-0045 ENSTSYP00000004433.1 Tarsius syrichta 33 3e-20 97.1
WERAM-Mim-0030 ENSMICP00000002766.1 Microcebus murinus 33 3e-20 97.1
WERAM-Sol-0036 Solyc02g092910.2.1 Solanum lycopersicum 37 3e-20 97.1
WERAM-Tub-0030 ENSTBEP00000003706.1 Tupaia belangeri 34 3e-20 97.1
WERAM-Bot-0105 ENSBTAP00000014581.5 Bos taurus 31 3e-20 96.7
WERAM-Lac-0146 ENSLACP00000016822.1 Latimeria chalumnae 32 4e-20 96.7
WERAM-Ova-0105 ENSOARP00000010687.1 Ovis aries 33 4e-20 96.7
WERAM-Chs-0006 ENSCSAP00000017681.1 Chlorocebus sabaeus 34 5e-20 95.9
WERAM-Soa-0045 ENSSARP00000004121.1 Sorex araneus 31 7e-20 95.9
WERAM-Ect-0071 ENSETEP00000007825.1 Echinops telfairi 34 7e-20 95.5
WERAM-Thc-0003 EOX91556 Theobroma cacao 36 9e-20 95.5
WERAM-Ocp-0117 ENSOPRP00000011535.1 Ochotona princeps 26 9e-20 95.1
WERAM-Pot-0089 POPTR_0007s10460.1 Populus trichocarpa 37 1e-19 95.1
WERAM-Ora-0118 ENSOANP00000023079.2 Ornithorhynchus anatinus 34 1e-19 94.7
WERAM-Sot-0079 PGSC0003DMT400064229 Solanum tuberosum 36 3e-19 93.6
WERAM-Prp-0070 EMJ06657 Prunus persica 35 1e-18 92.0
WERAM-Spr-0011 CBQ68343 Sporisorium reilianum 34 4e-18 89.7
WERAM-Mae-0068 ENSMEUP00000006768.1 Macropus eugenii 37 2e-17 87.8
WERAM-Dio-0073 ENSDORP00000007264.1 Dipodomys ordii 35 5e-17 86.3
WERAM-Pem-0072 ENSPMAP00000007740.1 Petromyzon marinus 36 2e-14 77.4
Created Date 25-Jun-2016