WERAM Information


Tag Content
WERAM ID WERAM-Hos-0222
Ensembl Protein ID ENSP00000331310.5
Uniprot Accession Q9UBU8; MO4L1_HUMAN; B4DKN6; B7Z6R1; D3DW88; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5
Genbank Protein ID NP_001252532.1; NP_001252533.1; NP_001252534.1; NP_006782.1; NP_996670.1
Protein Name Mortality factor 4-like protein 1
Genbank Nucleotide ID NM_001265603.1; NM_001265604.1; NM_001265605.1; NM_006791.3; NM_206839.2
Gene Name MRG15;MORF4L1MRG15;FWP006;HSPC008;HSPC061;PP368
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000185787.14 ENST00000331268.9 ENSP00000331310.5
ENSG00000185787.14 ENST00000379535.8 ENSP00000368850.4
ENSG00000185787.14 ENST00000426013.6 ENSP00000408880.2
ENSG00000185787.14 ENST00000559345.5 ENSP00000452717.1
ENSG00000185787.14 ENST00000558502.5 ENSP00000452808.1
ENSG00000185787.14 ENST00000558746.5 ENSP00000453231.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Chromo-Barrel Chromo H3K36me2 K 17135209
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Chromo-Barrel 1.40e-63 201.9 192 284
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
Domain Profile
  Me_Reader Chromo-Barrel

            MRG.txt   2 erkitlkipekLkklledDrelikrrkklvkLPakvnivtilesyvkevavelaisikedsrrekksrgarmnkeYirveknvdllkEvvdG 93 
+ ++++kipe+Lk++l+dD++li+r+k+l++LPak+n+++ile+y++ +kksrg+++nkeY+ ++Evv+G
ENSP00000331310.5 192 RVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYAN----------------YKKSRGNTDNKEYA--------VNEVVAG 259
689*******************************************9................99************........******* PP
MRG.txt 94 lriyFdvtlddvLLYklErlqydel 118
+++yF+v+l+++LLYk+Er+qy+e+
ENSP00000331310.5 260 IKEYFNVMLGTQLLYKFERPQYAEI 284
***********************98 PP
MRG.txt 223 adkPpeps.rvyGAqHLlRLlvklpellsktslsekslklLlkhlddFlkyLaenhdefFdesdyvnateleyetka 298
ad+P++p+ +vyGA+HLlRL+v+++++l++t+l+eksl+lLl++l+dFlkyLa+n++++F++sdy++a++ ey++ka
ENSP00000331310.5 286 ADHPDAPMsQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPP-EYHRKA 361
89*****99*************************************************************.***997 PP

Protein Sequence
(Fasta)
MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN KKSAVRPRRS 60
EKSLKTHEDI VALFPVPEGA PSVHHPLLTS SWDEWVPESR VLKYVDTNLQ KQRELQKANQ 120
EQYAEGKMRG AAPGKKTSGL QQKNVEVKTK KNKQKTPGNG DGGSTSETPQ PPRKKRARVD 180
PTVENEETFM NRVEVKVKIP EELKPWLVDD WDLITRQKQL FYLPAKKNVD SILEDYANYK 240
KSRGNTDNKE YAVNEVVAGI KEYFNVMLGT QLLYKFERPQ YAEILADHPD APMSQVYGAP 300
HLLRLFVRIG AMLAYTPLDE KSLALLLNYL HDFLKYLAKN SATLFSASDY EVAPPEYHRK 360
AV 362
Nucleotide Sequence
(Fasta)
GCGTGCGCGG CGGGCTGTCG TTGGCTGGAG CAGCGGCTGC GCGGGTCGCG GTGCTGTGAG 60
GTCTGCGGGC GCTGGCAAAT CCGGCCCAGG ATGTAGAGCT GGCAGTGCCT GACGGCGCGT 120
CTGACGCGGA GTTGGGTGGG GTAGAGAGTA GGGGGCGGTA GTCGGGGGTG GTGGGAGAAG 180
GAGGAGGCGG CGAATCACTT ATAAATGGCG CCGAAGCAGG ACCCGAAGCC TAAATTCCAG 240
GAGGGTGAGC GAGTGCTGTG CTTTCATGGG CCTCTTCTTT ATGAAGCAAA GTGTGTAAAG 300
GTTGCCATAA AGGACAAACA AGTGAAATAC TTCATACATT ACAGTGGTTG GAATAAAAAA 360
AGTGCTGTGA GGCCCAGGCG CTCTGAAAAA TCTTTGAAGA CACATGAGGA TATTGTAGCC 420
CTTTTTCCTG TTCCTGAAGG AGCTCCCTCA GTACACCACC CCCTCCTGAC CTCTAGTTGG 480
GATGAATGGG TTCCGGAGAG CAGAGTACTC AAATACGTGG ACACCAATTT GCAGAAACAG 540
CGAGAACTTC AAAAAGCCAA TCAGGAGCAG TATGCAGAGG GGAAGATGAG AGGGGCTGCC 600
CCAGGAAAGA AGACATCTGG TCTGCAACAG AAAAATGTTG AAGTGAAAAC GAAAAAGAAC 660
AAACAGAAAA CACCTGGAAA TGGAGATGGT GGCAGTACCA GTGAGACCCC TCAGCCTCCT 720
CGGAAGAAAA GGGCCCGGGT AGATCCTACT GTTGAAAATG AGGAAACATT CATGAACAGA 780
GTTGAAGTTA AAGTAAAGAT TCCTGAAGAG CTAAAACCGT GGCTTGTTGA TGACTGGGAC 840
TTAATTACCA GGCAAAAACA GCTCTTTTAT CTTCCTGCCA AGAAGAATGT GGATTCCATT 900
CTTGAGGATT ATGCAAATTA CAAGAAATCT CGTGGAAACA CAGATAATAA GGAGTATGCG 960
GTTAATGAAG TTGTGGCAGG GATAAAAGAA TACTTCAACG TAATGTTGGG TACCCAGCTA 1020
CTCTATAAAT TTGAGAGACC ACAGTATGCT GAAATTCTTG CAGATCATCC CGATGCACCC 1080
ATGTCCCAGG TGTATGGAGC GCCACATCTC CTGAGATTAT TTGTACGAAT TGGAGCAATG 1140
TTGGCTTATA CACCTCTGGA TGAGAAGAGC CTTGCTTTAT TACTCAATTA TCTTCACGAT 1200
TTCCTAAAGT ACCTGGCAAA GAATTCTGCA ACTTTGTTCA GTGCCAGCGA TTATGAAGTG 1260
GCTCCTCCTG AGTACCATCG GAAAGCTGTG TGAGAGGCAC TCTCACTCAC TTATGTTTGG 1320
ATCTCCGTAA ACACATTTTT GTTCTTAGTC TATCTCTTGT ACAAACGATG TGCTTTGAAG 1380
ATGTTAGTGT ATAACAATTG ATGTTTGTTT TCTGTTTGAT TTTAAACAGA GAAAAAATAA 1440
AAGGGGGTAA TAGCTCCTTT TTTCTTCTTT CTTTTTTTTT TTCATTTCAA AATTGCTGCC 1500
AGTGTTTTCA ATGATGGACA ACAGAGGGAT ATGCTGTAGA GTGTTTTATT GCCTAGTTGA 1560
CAAAGCTGCT TTTGAATGCT GGTGGTTCTA TTCCTTTGAC ACTACGCACT TTTATAATAC 1620
ATGTTAATGC TATATGACAA AATGCTCTGA TTCCTAGTGC CAAAGGTTCA ATTCAGTGTA 1680
TATAACTGAA CACACTCATC CATTTGTGCT TTTGTTTTTT TTTATGGTGC TTAAAGTAAA 1740
GAGCCCATCC TTTGCAAGTC ATCCATGTTG TTACTTAGGC ATTTTATCTT GGCTCAAATT 1800
GTTGAAGAAT GGTGGCTTGT TTCATGGTTT TTGTATTTGT GTCTAATGCA CGTTTTAACA 1860
TGATAGACGC AATGCATTGT GTAGCTAGTT TTCTGGAAAA GTCAATCTTT TAGGAATTGT 1920
TTTTCAGATC TTCAATAAAT TTTTTCTTTA AATTTCAAAG AACAATGTGC TTGTGTTGAT 1980
GCCTTACAAA AACCATTGTA TATTTGTGTA TTCCTTCTTG TATTTAGACA GTGGTTTTTC 2040
AGGTGCGTGC TTTGTTTTCT GGTATGGCCT TTATGGAATG AGACGCTTTA GCTTTGGTAC 2100
GTAGCGCTAA TCCATAGCAG CTTTGGCAGT TTGCTGTCTT GAGTCTTAGC TAAAAAGTTA 2160
GAAGTTTACA TGACTGTTTT TTTTATTTTC CCTAAATTAT TACTTACTCT GAGCATTAAT 2220
TAAGGGCATT TTCACCTGTG TAAAATTATG GTCAGCTTTT TTCTGTCTAT AATTGTTTAC 2280
TTTTGTGGGT TTACTCTAGA AACATGAGCC AAAAATGTCA ATAGACAACA CAGTATTAAA 2340
ATAACCCAAA AGTTGTAAA
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0341--Growth regulation
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--

Interpro

IPR016197--Chromodomain-like
IPR008676--MRG
IPR026541--MRG_dom
IPR025995--Tudor-knot

PROSITE

PS51640--MRG

Pfam

PF05712--MRG
PF11717--Tudor-knot

Gene Ontology

GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0047485--F:protein N-terminus binding
GO:0008283--P:cell proliferation
GO:0006338--P:chromatin remodeling
GO:0006342--P:chromatin silencing
GO:0000724--P:double-strand break repair via homologous recombination
GO:0016575--P:histone deacetylation
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0040008--P:regulation of growth
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0055 ENSPTRP00000051331.1 Pan troglodytes 100 0.0 749
WERAM-Nol-0090 ENSNLEP00000010671.1 Nomascus leucogenys 100 0.0 749
WERAM-Gog-0191 ENSGGOP00000016418.2 Gorilla gorilla 100 0.0 749
WERAM-Mum-0212 ENSMUSP00000082346.5 Mus musculus 100 0.0 746
WERAM-Loa-0095 ENSLAFP00000008255.3 Loxodonta africana 99 0.0 745
WERAM-Ict-0118 ENSSTOP00000011915.2 Ictidomys tridecemlineatus 99 0.0 745
WERAM-Mam-0209 ENSMMUP00000030192.2 Macaca mulatta 99 0.0 742
WERAM-Sus-0018 ENSSSCP00000001932.2 Sus scrofa 99 0.0 741
WERAM-Otg-0074 ENSOGAP00000005406.2 Otolemur garnettii 99 0.0 739
WERAM-Cap-0042 ENSCPOP00000003411.2 Cavia porcellus 99 0.0 737
WERAM-Tut-0191 ENSTTRP00000015743.1 Tursiops truncatus 98 0.0 736
WERAM-Mod-0094 ENSMODP00000014403.2 Monodelphis domestica 97 0.0 728
WERAM-Caf-0148 ENSCAFP00000020818.3 Canis familiaris 98 0.0 727
WERAM-Fec-0123 ENSFCAP00000011316.3 Felis catus 99 0.0 716
WERAM-Vip-0092 ENSVPAP00000008230.1 Vicugna pacos 99 0.0 715
WERAM-Orc-0148 ENSOCUP00000012987.3 Oryctolagus cuniculus 99 0.0 715
WERAM-Aim-0138 ENSAMEP00000013010.1 Ailuropoda melanoleuca 99 0.0 712
WERAM-Mup-0177 ENSMPUP00000015319.1 Mustela putorius furo 98 0.0 706
WERAM-Ova-0157 ENSOARP00000015639.1 Ovis aries 95 0.0 677
WERAM-Tag-0122 ENSTGUP00000010081.1 Taeniopygia guttata 89 0.0 650
WERAM-Poa-0059 ENSPPYP00000007607.2 Pongo abelii 89 0.0 649
WERAM-Caj-0017 ENSCJAP00000004116.2 Callithrix jacchus 89 0.0 649
WERAM-Ran-0248 ENSRNOP00000075745.1 Rattus norvegicus 89 0.0 647
WERAM-Fia-0071 ENSFALP00000005346.1 Ficedula albicollis 89 0.0 637
WERAM-Ect-0096 ENSETEP00000011221.1 Echinops telfairi 87 0.0 635
WERAM-Anp-0039 ENSAPLP00000004318.1 Anas platyrhynchos 89 0.0 634
WERAM-Gaga-0083 ENSGALP00000032974.3 Gallus gallus 87 0.0 634
WERAM-Eqc-0042 ENSECAP00000006422.1 Equus caballus 89 2e-178 622
WERAM-Myl-0017 ENSMLUP00000001606.2 Myotis lucifugus 87 2e-177 619
WERAM-Lac-0146 ENSLACP00000016822.1 Latimeria chalumnae 83 4e-176 614
WERAM-Ocp-0117 ENSOPRP00000011535.1 Ochotona princeps 97 4e-175 611
WERAM-Meg-0107 ENSMGAP00000010790.1 Meleagris gallopavo 86 4e-174 607
WERAM-Xet-0054 ENSXETP00000017126.3 Xenopus tropicalis 82 4e-174 607
WERAM-Anc-0150 ENSACAP00000014061.2 Anolis carolinensis 83 7e-174 607
WERAM-Sah-0200 ENSSHAP00000021731.1 Sarcophilus harrisii 83 8e-173 603
WERAM-Ptv-0004 ENSPVAP00000000660.1 Pteropus vampyrus 83 1e-171 599
WERAM-Leo-0142 ENSLOCP00000017293.1 Lepisosteus oculatus 82 2e-171 598
WERAM-Pes-0161 ENSPSIP00000019260.1 Pelodiscus sinensis 81 1e-170 596
WERAM-Orla-0021 ENSORLP00000002554.1 Oryzias latipes 79 7e-170 593
WERAM-Soa-0045 ENSSARP00000004121.1 Sorex araneus 89 3e-169 592
WERAM-Dar-0092 ENSDARP00000112985.1 Danio rerio 78 9e-168 587
WERAM-Asm-0023 ENSAMXP00000002832.1 Astyanax mexicanus 78 7e-167 583
WERAM-Gaa-0180 ENSGACP00000022333.1 Gasterosteus aculeatus 77 4e-163 571
WERAM-Tar-0185 ENSTRUP00000038533.1 Takifugu rubripes 77 4e-163 571
WERAM-Orn-0162 ENSONIP00000016650.1 Oreochromis niloticus 77 8e-163 570
WERAM-Ten-0100 ENSTNIP00000011271.1 Tetraodon nigroviridis 76 2e-160 562
WERAM-Pof-0080 ENSPFOP00000007130.2 Poecilia formosa 76 2e-160 562
WERAM-Xim-0217 ENSXMAP00000017577.1 Xiphophorus maculatus 76 2e-160 562
WERAM-Dan-0023 ENSDNOP00000002194.3 Dasypus novemcinctus 81 2e-158 555
WERAM-Bot-0105 ENSBTAP00000014581.5 Bos taurus 81 8e-158 553
WERAM-Gam-0087 ENSGMOP00000008960.1 Gadus morhua 74 2e-156 549
WERAM-Tub-0016 ENSTBEP00000001650.1 Tupaia belangeri 73 4e-137 484
WERAM-Prc-0122 ENSPCAP00000010859.1 Procavia capensis 73 1e-129 459
WERAM-Mim-0030 ENSMICP00000002766.1 Microcebus murinus 77 3e-117 419
WERAM-Paa-0050 ENSPANP00000004934.1 Papio anubis 77 4e-117 418
WERAM-Tas-0045 ENSTSYP00000004433.1 Tarsius syrichta 77 7e-117 417
WERAM-Ere-0064 ENSEEUP00000005345.1 Erinaceus europaeus 77 1e-115 413
WERAM-Chs-0006 ENSCSAP00000017681.1 Chlorocebus sabaeus 76 5e-114 408
WERAM-Chh-0066 ENSCHOP00000007156.1 Choloepus hoffmanni 78 2e-113 406
WERAM-Ora-0118 ENSOANP00000023079.2 Ornithorhynchus anatinus 98 3e-99 358
WERAM-Dio-0073 ENSDORP00000007264.1 Dipodomys ordii 77 7e-97 351
WERAM-Cis-0080 ENSCSAVP00000017617.1 Ciona savignyi 43 7e-77 285
WERAM-Drm-0029 FBpp0082579 Drosophila melanogaster 36 3e-69 259
WERAM-Pem-0072 ENSPMAP00000007740.1 Petromyzon marinus 90 2e-64 243
WERAM-Thc-0003 EOX91556 Theobroma cacao 35 1e-47 187
WERAM-Tum-0023 CAZ84135 Tuber melanosporum 36 5e-46 182
WERAM-Crn-0021 AAW44213 Cryptococcus neoformans 32 7e-45 178
WERAM-Arl-0141 scaffold_700360.1 Arabidopsis lyrata 33 2e-44 176
WERAM-Sol-0036 Solyc02g092910.2.1 Solanum lycopersicum 34 3e-44 176
WERAM-Mae-0068 ENSMEUP00000006768.1 Macropus eugenii 51 1e-43 174
WERAM-Art-0111 AT4G37280.1 Arabidopsis thaliana 32 2e-43 174
WERAM-Asf-0006 CADAFLAP00002044 Aspergillus flavus 33 3e-43 173
WERAM-Glm-0225 GLYMA17G18240.2 Glycine max 33 5e-43 172
WERAM-Pot-0089 POPTR_0007s10460.1 Populus trichocarpa 34 1e-42 171
WERAM-Asni-0012 CADANGAP00004222 Aspergillus niger 32 5e-42 169
WERAM-Mua-0073 GSMUA_Achr4P12960_001 Musa acuminata 33 1e-41 167
WERAM-Spr-0011 CBQ68343 Sporisorium reilianum 32 2e-41 166
WERAM-Aso-0013 CADAORAP00001673 Aspergillus oryzae 31 5e-41 166
WERAM-Asfu-0038 CADAFUAP00008363 Aspergillus fumigatus 32 8e-41 165
WERAM-Brr-0062 Bra011751.1-P Brassica rapa 33 1e-40 164
WERAM-Yal-0008 CAG80821 Yarrowia lipolytica 32 2e-40 164
WERAM-Asc-0018 CADACLAP00004414 Aspergillus clavatus 32 2e-39 160
WERAM-Asn-0032 CADANIAP00008637 Aspergillus nidulans 31 2e-37 153
WERAM-Sot-0079 PGSC0003DMT400064229 Solanum tuberosum 32 4e-36 149
WERAM-Prp-0070 EMJ06657 Prunus persica 32 9e-36 148
WERAM-Coi-0009 EAS36116 Coccidioides immitis 30 1e-32 137
WERAM-Sac-0051 YPR023C Saccharomyces cerevisiae 28 5e-31 132
WERAM-Aet-0017 EMT06876 Aegilops tauschii 32 6e-29 125
WERAM-Ved-0026 EGY15805 Verticillium dahliae 35 4e-26 116
WERAM-Asg-0009 AAS51868 Ashbya gossypii 25 8e-25 112
Created Date 25-Jun-2016