| Tag |
Content |
| WERAM ID |
WERAM-Sac-0043 |
| Ensembl Protein ID |
YOR244W |
| Uniprot Accession |
Q08649; ESA1_YEAST; D6W2U6
|
| Genbank Protein ID |
NP_014887.3
|
| Protein Name |
Histone acetyltransferase ESA1 |
| Genbank Nucleotide ID |
NM_001183663.3
|
| Gene Name |
ESA1;YOR244W;O5257 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H2A.ZK14; H3K14; H4K5; H4K8; H4K12; H4K16 |
K |
17694074; 24316985
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
1.50e-121 |
403.3 |
163 |
433 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me. |
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.
|
| Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCllaklfldhkt 102
+v+n+++i +gkyei++wy+sp+p el++ + +yi +f+l+y sk++++r+ kkC+lr+pPgneiyr+d +s+fe+dG+kq+++c+nlCll+klfldhkt
YOR244W 163 RVRNLNRIIMGKYEIEPWYFSPYPIELTDEDFIYIDDFTLQYFGSKKQYERYRKKCTLRHPPGNEIYRDDYVSFFEIDGRKQRTWCRNLCLLSKLFLDHKT 263
6899************************************************************************************************* PP
MYST.txt 103 lyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgllsYrsyWkevllellkek 203
lyydv+pflFY++t++de g+hlvGyFskekesa+ yn+aCil+lP+yqr+GyGklLiefsYels+ke+k+gsPekPLsdlgllsYr+yW+++l++ll
YOR244W 264 LYYDVDPFLFYCMTRRDELGHHLVGYFSKEKESADGYNVACILTLPQYQRMGYGKLLIEFSYELSKKENKVGSPEKPLSDLGLLSYRAYWSDTLITLL--V 362
**************************************************************************************************..9 PP
MYST.txt 204 eekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwkp 276
e++k+iti+e+s++t+++++Di++t ++ln+++++kgq+i++ +e+i++++++l++ kk++++d+++l wkp
YOR244W 363 EHQKEITIDEISSMTSMTTTDILHTAKTLNILRYYKGQHIIFLNEDILDRYNRLKA--KKRRTIDPNRLIWKP 433
99*************************************************88887..88999********97 PP
|
Protein Sequence
(Fasta) | MSHDGKEEPG IAKKINSVDD IIIKCQCWVQ KNDEERLAEI LSINTRKAPP KFYVHYVNYN 60
KRLDEWITTD RINLDKEVLY PKLKATDEDN KKQKKKKATN TSETPQDSLQ DGVDGFSREN 120
TDVMDLDNLN VQGIKDENIS HEDEIKKLRT SGSMTQNPHE VARVRNLNRI IMGKYEIEPW 180
YFSPYPIELT DEDFIYIDDF TLQYFGSKKQ YERYRKKCTL RHPPGNEIYR DDYVSFFEID 240
GRKQRTWCRN LCLLSKLFLD HKTLYYDVDP FLFYCMTRRD ELGHHLVGYF SKEKESADGY 300
NVACILTLPQ YQRMGYGKLL IEFSYELSKK ENKVGSPEKP LSDLGLLSYR AYWSDTLITL 360
LVEHQKEITI DEISSMTSMT TTDILHTAKT LNILRYYKGQ HIIFLNEDIL DRYNRLKAKK 420
RRTIDPNRLI WKPPVFTASQ LRFAW 445Protein Fasta Sequence
>YOR244W|ESA1;YOR244W;O5257|Saccharomyces cerevisiae
MSHDGKEEPGIAKKINSVDDIIIKCQCWVQKNDEERLAEILSINTRKAPPKFYVHYVNYNKRLDEWITTDRINLDKEVLYPKLKATDEDNKKQKKKKATNTSETPQDSLQDGVDGFSRENTDVMDLDNLNVQGIKDENISHEDEIKKLRTSGSMTQNPHEVARVRNLNRIIMGKYEIEPWYFSPYPIELTDEDFIYIDDFTLQYFGSKKQYERYRKKCTLRHPPGNEIYRDDYVSFFEIDGRKQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTRRDELGHHLVGYFSKEKESADGYNVACILTLPQYQRMGYGKLLIEFSYELSKKENKVGSPEKPLSDLGLLSYRAYWSDTLITLLVEHQKEITIDEISSMTSMTTTDILHTAKTLNILRYYKGQHIIFLNEDILDRYNRLKAKKRRTIDPNRLIWKPPVFTASQLRFAW |
Nucleotide Sequence
(Fasta) | ATGTCCCATG ACGGAAAAGA AGAACCTGGT ATTGCCAAAA AGATAAACTC AGTAGATGAT 60
ATTATTATCA AATGTCAATG CTGGGTCCAA AAAAATGATG AAGAACGATT AGCTGAAATT 120
TTATCCATAA ACACAAGAAA AGCACCACCA AAATTCTATG TTCACTATGT TAATTACAAC 180
AAGCGTTTAG ATGAGTGGAT TACCACTGAC AGAATAAACC TGGATAAAGA AGTACTATAT 240
CCGAAACTAA AGGCTACTGA TGAAGATAAT AAGAAACAAA AAAAGAAGAA GGCAACAAAT 300
ACTAGTGAAA CGCCACAAGA CTCTCTGCAA GATGGTGTAG ATGGTTTCTC AAGAGAAAAT 360
ACGGATGTTA TGGACTTAGA TAATCTAAAT GTACAGGGAA TAAAAGATGA GAACATATCA 420
CACGAGGATG AGATAAAAAA GCTTAGAACC TCCGGCTCTA TGACACAAAA TCCACATGAG 480
GTGGCTCGAG TTAGAAATCT CAATCGAATC ATTATGGGGA AATATGAAAT AGAACCATGG 540
TACTTTTCTC CATATCCTAT TGAATTAACT GATGAAGATT TTATATATAT CGACGATTTC 600
ACGTTGCAGT ATTTTGGATC TAAGAAACAA TACGAACGCT ACAGGAAGAA ATGTACATTA 660
AGACATCCGC CAGGAAATGA AATCTACAGA GACGATTATG TTTCATTCTT TGAAATCGAT 720
GGTAGAAAGC AAAGGACTTG GTGTCGAAAC TTGTGTTTAC TTTCCAAACT TTTCCTAGAT 780
CACAAAACAT TATACTATGA CGTTGATCCG TTTTTGTTTT ATTGCATGAC GAGACGAGAT 840
GAGTTGGGTC ACCATCTGGT GGGATATTTT TCCAAGGAAA AAGAATCCGC GGATGGTTAC 900
AATGTTGCAT GTATCTTAAC ACTACCACAA TACCAAAGGA TGGGATATGG TAAGTTATTG 960
ATTGAATTTT CGTATGAATT GTCGAAAAAG GAAAACAAAG TTGGTTCTCC CGAGAAACCT 1020
TTGTCTGATT TGGGTCTCTT ATCCTATAGA GCCTATTGGT CGGACACTCT CATAACGCTA 1080
TTAGTGGAAC ACCAGAAGGA AATTACTATA GACGAAATAA GCTCCATGAC TTCGATGACC 1140
ACTACAGATA TATTACACAC AGCAAAGACA CTGAATATCC TGCGATATTA CAAGGGTCAG 1200
CATATTATTT TCCTGAATGA AGATATTTTA GATAGGTACA ATCGACTTAA AGCCAAAAAG 1260
AGAAGGACAA TAGACCCTAA TAGACTCATA TGGAAACCAC CGGTATTTAC TGCCTCTCAG 1320
TTACGCTTTG CCTGGTAA
1339Nucleotide Fasta Sequence
>YOR244W|MYST|Saccharomyces cerevisiae
ATGTCCCATGACGGAAAAGAAGAACCTGGTATTGCCAAAAAGATAAACTCAGTAGATGATATTATTATCAAATGTCAATGCTGGGTCCAAAAAAATGATGAAGAACGATTAGCTGAAATTTTATCCATAAACACAAGAAAAGCACCACCAAAATTCTATGTTCACTATGTTAATTACAACAAGCGTTTAGATGAGTGGATTACCACTGACAGAATAAACCTGGATAAAGAAGTACTATATCCGAAACTAAAGGCTACTGATGAAGATAATAAGAAACAAAAAAAGAAGAAGGCAACAAATACTAGTGAAACGCCACAAGACTCTCTGCAAGATGGTGTAGATGGTTTCTCAAGAGAAAATACGGATGTTATGGACTTAGATAATCTAAATGTACAGGGAATAAAAGATGAGAACATATCACACGAGGATGAGATAAAAAAGCTTAGAACCTCCGGCTCTATGACACAAAATCCACATGAGGTGGCTCGAGTTAGAAATCTCAATCGAATCATTATGGGGAAATATGAAATAGAACCATGGTACTTTTCTCCATATCCTATTGAATTAACTGATGAAGATTTTATATATATCGACGATTTCACGTTGCAGTATTTTGGATCTAAGAAACAATACGAACGCTACAGGAAGAAATGTACATTAAGACATCCGCCAGGAAATGAAATCTACAGAGACGATTATGTTTCATTCTTTGAAATCGATGGTAGAAAGCAAAGGACTTGGTGTCGAAACTTGTGTTTACTTTCCAAACTTTTCCTAGATCACAAAACATTATACTATGACGTTGATCCGTTTTTGTTTTATTGCATGACGAGACGAGATGAGTTGGGTCACCATCTGGTGGGATATTTTTCCAAGGAAAAAGAATCCGCGGATGGTTACAATGTTGCATGTATCTTAACACTACCACAATACCAAAGGATGGGATATGGTAAGTTATTGATTGAATTTTCGTATGAATTGTCGAAAAAGGAAAACAAAGTTGGTTCTCCCGAGAAACCTTTGTCTGATTTGGGTCTCTTATCCTATAGAGCCTATTGGTCGGACACTCTCATAACGCTATTAGTGGAACACCAGAAGGAAATTACTATAGACGAAATAAGCTCCATGACTTCGATGACCACTACAGATATATTACACACAGCAAAGACACTGAATATCCTGCGATATTACAAGGGTCAGCATATTATTTTCCTGAATGAAGATATTTTAGATAGGTACAATCGACTTAAAGCCAAAAAGAGAAGGACAATAGACCCTAATAGACTCATATGGAAACCACCGGTATTTACTGCCTCTCAGTTACGCTTTGCCTGGTAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0000790--C:nuclear chromatin
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0034212--F:peptide N-acetyltransferase activity
GO:0000183--P:chromatin silencing at rDNA
GO:0006281--P:DNA repair
GO:0006354--P:DNA-templated transcription, elongation
GO:0016573--P:histone acetylation
GO:0001207--P:histone displacement
GO:0043967--P:histone H4 acetylation
GO:0018394--P:peptidyl-lysine acetylation
GO:0016239--P:positive regulation of macroautophagy
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0051726--P:regulation of cell cycle
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
