| Tag |
Content |
| WERAM ID |
WERAM-Sac-0038 |
| Ensembl Protein ID |
YNL097C |
| Uniprot Accession |
P50947; PHO23_YEAST; D6W183; Q45TZ9
|
| Genbank Protein ID |
NP_014302.3
|
| Protein Name |
Transcriptional regulatory protein PHO23 |
| Genbank Nucleotide ID |
NM_001182935.3
|
| Gene Name |
Pho23;YNL097C;N2205 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
PHD |
PHD-type |
H3K4me3 |
K |
21646424
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
7.20e-12 |
43.8 |
282 |
328 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. |
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
|
| Domain Profile |
Me_Reader PHD
PHD.txt 3 iClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCke 52
+C+ C+++ +ge mv Cd+ C+ +wfHl C++l+ +lp+g +wyC Ck+
YNL097C 282 YCY-CNQVAYGE--MVGCDGadCElEWFHLPCIGLE--TLPKG-KWYCDDCKK 328
8*9.*******6..**********************..*****.*******97 PP
|
Protein Sequence
(Fasta) | MSSPANLFPG LNDITDVLEE FPLATSRYLT LLHEIDAKCV HSMPNLNERI DKFLKKDFNK 60
DHQTQVRLLN NINKIYEELM PSLEEKMHVS SIMLDNLDRL TSRLELAYEV AIKNTEIPRG 120
LRLGVDNHPA MHLHHELMEK IESKSNSKSS QALKSESRRE AMAANRRQGE HYSASTHQQD 180
DSKNDANYGG SRHESQDHTG NNTNSRKRAN AANTNNADPE TKKRKRRVAT TAVSPSTIST 240
ATAVNNGRIG TSTASRGVSS VGNSNNSRIS RPKTNDYGEP LYCYCNQVAY GEMVGCDGAD 300
CELEWFHLPC IGLETLPKGK WYCDDCKKKL Protein Fasta Sequence
>YNL097C|Pho23;YNL097C;N2205|Saccharomyces cerevisiae
MSSPANLFPGLNDITDVLEEFPLATSRYLTLLHEIDAKCVHSMPNLNERIDKFLKKDFNKDHQTQVRLLNNINKIYEELMPSLEEKMHVSSIMLDNLDRLTSRLELAYEVAIKNTEIPRGLRLGVDNHPAMHLHHELMEKIESKSNSKSSQALKSESRREAMAANRRQGEHYSASTHQQDDSKNDANYGGSRHESQDHTGNNTNSRKRANAANTNNADPETKKRKRRVATTAVSPSTISTATAVNNGRIGTSTASRGVSSVGNSNNSRISRPKTNDYGEPLYCYCNQVAYGEMVGCDGADCELEWFHLPCIGLETLPKGKWYCDDCKKKL |
Nucleotide Sequence
(Fasta) | ATGAGTTCAC CAGCGAACCT ATTCCCTGGA TTAAACGACA TAACTGACGT GCTGGAGGAA 60
TTCCCACTGG CCACCTCCAG ATATTTAACA TTACTACACG AAATAGATGC AAAATGTGTG 120
CATTCTATGC CGAATTTGAA CGAGAGGATA GATAAGTTCT TGAAGAAAGA CTTCAATAAA 180
GATCACCAAA CACAAGTAAG ACTGCTCAAT AATATCAACA AGATTTATGA AGAACTGATG 240
CCATCGCTGG AGGAGAAAAT GCATGTCTCA TCCATTATGC TGGATAATCT AGACAGATTG 300
ACGTCCCGGT TAGAATTGGC GTATGAAGTC GCAATCAAGA ACACAGAAAT TCCTAGAGGT 360
TTAAGACTGG GTGTGGACAA CCATCCAGCA ATGCACCTCC ATCATGAACT AATGGAAAAA 420
ATAGAGAGCA AATCAAACAG CAAATCGTCG CAGGCACTGA AGAGCGAATC AAGAAGAGAA 480
GCCATGGCTG CCAACAGGAG GCAGGGCGAA CATTACTCCG CCAGCACACA CCAACAAGAC 540
GACTCAAAGA ACGACGCAAA CTACGGAGGC AGCAGGCACG AGAGCCAAGA CCACACTGGT 600
AACAACACAA ACTCAAGAAA AAGAGCCAAC GCTGCCAATA CCAACAACGC CGATCCAGAG 660
ACCAAAAAAC GCAAGAGGAG AGTTGCCACC ACAGCCGTTT CACCAAGCAC TATCAGCACG 720
GCAACTGCCG TCAATAATGG CAGGATAGGT ACATCTACAG CGTCCAGGGG AGTTAGCAGC 780
GTCGGAAACA GCAACAACAG CAGGATATCA AGACCAAAAA CCAACGACTA CGGCGAACCG 840
CTCTACTGCT ACTGTAACCA AGTGGCATAC GGGGAAATGG TGGGGTGTGA TGGCGCAGAC 900
TGTGAGCTAG AATGGTTCCA TTTGCCATGT ATTGGACTCG AAACTCTACC TAAGGGCAAG 960
TGGTATTGCG ACGACTGCAA AAAAAAACTG TGA
994Nucleotide Fasta Sequence
>YNL097C|PHD|Saccharomyces cerevisiae
ATGAGTTCACCAGCGAACCTATTCCCTGGATTAAACGACATAACTGACGTGCTGGAGGAATTCCCACTGGCCACCTCCAGATATTTAACATTACTACACGAAATAGATGCAAAATGTGTGCATTCTATGCCGAATTTGAACGAGAGGATAGATAAGTTCTTGAAGAAAGACTTCAATAAAGATCACCAAACACAAGTAAGACTGCTCAATAATATCAACAAGATTTATGAAGAACTGATGCCATCGCTGGAGGAGAAAATGCATGTCTCATCCATTATGCTGGATAATCTAGACAGATTGACGTCCCGGTTAGAATTGGCGTATGAAGTCGCAATCAAGAACACAGAAATTCCTAGAGGTTTAAGACTGGGTGTGGACAACCATCCAGCAATGCACCTCCATCATGAACTAATGGAAAAAATAGAGAGCAAATCAAACAGCAAATCGTCGCAGGCACTGAAGAGCGAATCAAGAAGAGAAGCCATGGCTGCCAACAGGAGGCAGGGCGAACATTACTCCGCCAGCACACACCAACAAGACGACTCAAAGAACGACGCAAACTACGGAGGCAGCAGGCACGAGAGCCAAGACCACACTGGTAACAACACAAACTCAAGAAAAAGAGCCAACGCTGCCAATACCAACAACGCCGATCCAGAGACCAAAAAACGCAAGAGGAGAGTTGCCACCACAGCCGTTTCACCAAGCACTATCAGCACGGCAACTGCCGTCAATAATGGCAGGATAGGTACATCTACAGCGTCCAGGGGAGTTAGCAGCGTCGGAAACAGCAACAACAGCAGGATATCAAGACCAAAAACCAACGACTACGGCGAACCGCTCTACTGCTACTGTAACCAAGTGGCATACGGGGAAATGGTGGGGTGTGATGGCGCAGACTGTGAGCTAGAATGGTTCCATTTGCCATGTATTGGACTCGAAACTCTACCTAAGGGCAAGTGGTATTGCGACGACTGCAAAAAAAAACTGTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
|
| Pfam |
PF12998--ING
|
| Gene Ontology |
GO:0000118--C:histone deacetylase complex
GO:0033698--C:Rpd3L complex
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0016479--P:negative regulation of transcription from RNA polymerase I promoter
GO:2000219--P:positive regulation of invasive growth in response to glucose limitation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0061408--P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
