WERAM Information

Tag Content
WERAM ID WERAM-Sac-0028
Ensembl Protein ID YLL002W
Uniprot Accession Q07794; RT109_YEAST; D6VY01
Genbank Protein ID NP_013099.1
Protein Name Histone acetyltransferase RTT109
Genbank Nucleotide ID NM_001181822.1
Gene Name RTT109;KIM2;REM50;YLL002W;L1377
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLL002W YLL002W YLL002W
Details
Type Family Domain Substrates AA References (PMIDs)
HAT HAT_other Rtt109-type HAT H3K56 K 17272723
Status Reviewed
Classification
Type Family E-value Score Start End
HAT HAT_other 0 871
HAT HAT_other 4.00e-15 77
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. H3K56 acetylation weakens of the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly. Involved in regulation of Ty1 transposition.
Domain Profile
  HAT HAT_other
Query: 1   MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQHFFSLFHQGK 60
           MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQHFFSLFHQGK
Sbjct: 1   MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQHFFSLFHQGK 60
Query: 61  VFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIILEFILSIDPNYYL 120
           VFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIILEFILSIDPNYYL
Sbjct: 61  VFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIILEFILSIDPNYYL 120
Query: 121 QKVKPAIRSYKKISPELISAASTPARTLRILARRLKQSGSTVLKEIESPRFQQDLYLSFT 180
           QKVKPAIRSYKKISPELISAASTPARTLRILARRLKQSGSTVLKEIESPRFQQDLYLSFT
Sbjct: 121 QKVKPAIRSYKKISPELISAASTPARTLRILARRLKQSGSTVLKEIESPRFQQDLYLSFT 180
Query: 181 CPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLLIECFQNDTQA 240
           CPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLLIECFQNDTQA
Sbjct: 181 CPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLLIECFQNDTQA 240
Query: 241 KLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEE 300
           KLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEE
Sbjct: 241 KLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEE 300
Query: 301 DRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRA 360
           DRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRA
Sbjct: 301 DRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRA 360
Query: 361 IKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREHRERNQPVPASNINTLA 420
           IKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREHRERNQPVPASNINTLA
Sbjct: 361 IKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREHRERNQPVPASNINTLA 420
Query: 421 ITM 423
           ITM
Sbjct: 421 ITM 423
  HAT HAT_other
Query: 189 ICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLL-----------IECFQND 237
           + LF     QYLFP+S  N +KH+LN   L++WW   L++L             E  +N 
Sbjct: 114 LTLFAIAQGQYLFPESVDNGQKHVLNDSGLLRWWVNCLEKLRKYYTDSEAPNDSEKQKNS 173
Query: 238 T---QAKLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFI 294
           T   +A L +PG +   +RSYL       W   +  T+ +   AV  +P FPDDPK R++
Sbjct: 174 TLLPKAYLFVPGLE--NIRSYLPNRH---WIESNAITTGK---AVEELPRFPDDPKCRYL 225
Query: 295 HQLAEEDRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLA--------TPSLFPSS 346
            +L +E     +S+  FW  L  RQE     +  ++G     L             F  S
Sbjct: 226 CELQDEKS--DMSVEEFWDTLTYRQE---CSSGKLVGFFTLQLQFYQTREFIAKDNFGDS 280
Query: 347 ADVIVPKS--RKQFRAIKKYITGEEYDTE-------EGAIEAFTNIRDFLLLRMATNLQS 397
             V++P    R  +  + K+  G   D +          + A  N++DF   R   ++  
Sbjct: 281 G-VMIPAKLYRVTYDTLLKHPFGSLSDAQSSTEKFLSNTLSAVQNLKDFHYKRYKLDICG 339
Query: 398 LTGKREHRERNQPVPASNINTL 419
           L  + + +  N   PA+  N L
Sbjct: 340 LAKRDDRKNHNHSKPATQANIL 361
Query: 51  HFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIIL 108
           H F +  Q    F +E  VY     E + E ++FVSKAD+ G+ +  VS   +    L
Sbjct: 45  HLFLVEEQNVFIFGMECIVY-----EKNKEFIVFVSKADSTGFGSKGVSCNSLAFCCL 97
Protein Sequence
(Fasta)		MSLNDFLSSV LPVSEQFEYL SLQSIPLETH AVVTPNKDDK RVPKSTIKTQ HFFSLFHQGK 60
VFFSLEVYVY VTLWDEADAE RLIFVSKADT NGYCNTRVSV RDITKIILEF ILSIDPNYYL 120
QKVKPAIRSY KKISPELISA ASTPARTLRI LARRLKQSGS TVLKEIESPR FQQDLYLSFT 180
CPREILTKIC LFTRPASQYL FPDSSKNSKK HILNGEELMK WWGFILDRLL IECFQNDTQA 240
KLRIPGEDPA RVRSYLRGMK YPLWQVGDIF TSKENSLAVY NIPLFPDDPK ARFIHQLAEE 300
DRLLKVSLSS FWIELQERQE FKLSVTSSVM GISGYSLATP SLFPSSADVI VPKSRKQFRA 360
IKKYITGEEY DTEEGAIEAF TNIRDFLLLR MATNLQSLTG KREHRERNQP VPASNINTLA 420
ITMLKPRKKA KALPKT 436
Nucleotide Sequence
(Fasta)		ATGTCACTGA ATGACTTCCT AAGTTCCGTG CTACCTGTCA GTGAACAATT TGAATACTTA 60
TCGTTGCAAT CTATTCCGTT AGAAACCCAT GCTGTCGTAA CCCCAAATAA GGACGACAAA 120
AGGGTCCCAA AAAGCACGAT CAAGACTCAA CACTTCTTTA GTCTATTTCA CCAAGGAAAA 180
GTTTTTTTTT CATTAGAAGT GTATGTGTAT GTCACGCTTT GGGATGAAGC AGATGCCGAA 240
CGGTTAATAT TTGTATCAAA GGCAGACACT AATGGTTATT GTAATACGAG GGTAAGCGTT 300
AGAGATATTA CAAAAATAAT ATTAGAATTT ATATTATCAA TCGACCCGAA TTACTATCTT 360
CAAAAAGTAA AACCGGCAAT AAGATCATAT AAGAAGATAT CCCCCGAGCT GATTAGCGCA 420
GCCAGTACGC CAGCAAGAAC TTTAAGGATT TTGGCTAGAA GGCTTAAACA GTCAGGCAGC 480
ACCGTTTTGA AAGAAATAGA ATCTCCACGT TTTCAACAAG ATCTTTATCT CTCATTCACC 540
TGTCCTCGTG AGATTTTGAC CAAAATTTGT TTATTTACTA GACCTGCATC CCAGTACCTC 600
TTCCCAGATT CTTCAAAAAA CAGCAAAAAG CATATACTAA ATGGCGAGGA ACTAATGAAA 660
TGGTGGGGCT TTATTTTGGA TAGATTACTA ATTGAATGCT TTCAAAATGA TACACAAGCA 720
AAATTAAGGA TACCGGGCGA AGATCCTGCT CGAGTAAGAT CATACCTAAG AGGGATGAAA 780
TATCCACTAT GGCAAGTGGG TGATATATTT ACCTCTAAAG AAAATTCTCT TGCGGTATAT 840
AATATTCCAT TATTCCCAGA CGATCCTAAG GCTAGATTTA TACACCAATT GGCAGAGGAA 900
GATCGCCTCC TCAAAGTAAG CTTATCATCC TTCTGGATTG AACTACAAGA GCGTCAAGAG 960
TTCAAATTAA GTGTCACATC ATCTGTAATG GGTATTTCGG GATACTCTCT TGCCACTCCA 1020
TCTTTATTTC CATCTAGTGC CGATGTTATT GTACCGAAGT CAAGGAAGCA GTTTAGGGCA 1080
ATCAAGAAGT ACATTACTGG AGAGGAATAC GATACAGAGG AAGGCGCAAT AGAAGCTTTC 1140
ACCAATATTC GTGATTTTCT ATTGCTCAGA ATGGCAACAA ATCTTCAATC TTTAACAGGG 1200
AAGAGGGAGC ATCGGGAGAG AAATCAGCCG GTTCCTGCAA GCAACATCAA CACGTTGGCG 1260
ATAACAATGC TAAAACCGCG TAAAAAAGCT AAAGCCTTGC CTAAAACTTG A 1312
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR016849--Rtt109
PROSITE

PS51728--RTT109_HAT
Pfam

PF08214--HAT_KAT11
Gene Ontology

GO:0005634--C:nucleus
GO:0010484--F:H3 histone acetyltransferase activity
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0016573--P:histone acetylation
GO:0043966--P:histone H3 acetylation
GO:0043007--P:maintenance of rDNA
GO:0010526--P:negative regulation of transposition, RNA-mediated
GO:0010468--P:regulation of gene expression
GO:0043618--P:regulation of transcription from RNA polymerase II promoter in response to stress
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0010 CAG58572 Candida glabrata 46 3e-102 369
WERAM-Kll-0029 CAG98369 Kluyveromyces lactis 45 2e-100 363
WERAM-Asg-0001 AAS50193 Ashbya gossypii 40 1e-78 291
WERAM-Kop-0027 CAY70799 Komagataella pastoris 38 2e-59 227
WERAM-Caa-0030 KGT64625 Candida albicans 33 9e-39 158
WERAM-Yal-0033 CAG78300 Yarrowia lipolytica 38 9e-36 148
WERAM-Tum-0031 CAZ86312 Tuber melanosporum 30 8e-22 102
WERAM-Aso-0025 CADAORAP00006900 Aspergillus oryzae 25 1e-15 81.6
WERAM-Asf-0032 CADAFLAP00011583 Aspergillus flavus 25 1e-15 81.6
WERAM-Ved-0016 EGY23544 Verticillium dahliae 31 6e-15 79.3
WERAM-Scp-0032 SPBC342.06c.1:pep Schizosaccharomyces pombe 27 3e-14 77.0
WERAM-Zyt-0009 Mycgr3P12793 Zymoseptoria tritici 35 3e-13 73.9
WERAM-Scj-0008 EEB06165 Schizosaccharomyces japonicus 31 4e-13 73.2
WERAM-Nec-0035 EFNCRP00000009612 Neurospora crassa 25 1e-12 71.6
WERAM-Asni-0017 CADANGAP00005500 Aspergillus niger 24 5e-11 66.2
WERAM-Trv-0024 EHK25922 Trichoderma virens 30 7e-11 65.9
WERAM-Coi-0030 EAS31131 Coccidioides immitis 31 1e-10 65.5
WERAM-Asc-0006 CADACLAP00001140 Aspergillus clavatus 31 1e-10 65.1
WERAM-Asfu-0025 CADAFUAP00005943 Aspergillus fumigatus 31 3e-10 64.3
WERAM-Asn-0026 CADANIAP00006255 Aspergillus nidulans 30 3e-10 63.9
WERAM-Lem-0002 CBY01680 Leptosphaeria maculans 29 1e-09 62.0
WERAM-Trr-0027 EGR49578 Trichoderma reesei 29 1e-09 62.0
WERAM-Ast-0027 CADATEAP00008187 Aspergillus terreus 30 2e-09 61.2
WERAM-Mao-0018 MGG_05969T0 Magnaporthe oryzae 24 3e-09 60.5
WERAM-Map-0009 MAPG_02939T0 Magnaporthe poae 28 3e-08 57.4
WERAM-Gag-0028 GGTG_09850T0 Gaeumannomyces graminis 28 5e-07 53.1
Created Date 25-Jun-2016