WERAM Information

Tag Content
WERAM ID WERAM-Scp-0032
Ensembl Protein ID SPBC342.06c.1:pep
Uniprot Accession Q9Y7Y5; RT109_SCHPO
Genbank Protein ID NP_596749.1
Protein Name Histone acetyltransferase rtt109
Genbank Nucleotide ID NM_001023769.2
Gene Name RTT109;kat11;SPBC342.06c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC342.06c SPBC342.06c.1 SPBC342.06c.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
HAT HAT_other Rtt109-type HAT H3K56 K 26223950
Status Reviewed
Classification
Type Family E-value Score Start End
HAT HAT_other 0 767
HAT HAT_other 1.00e-16 82
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 Required for acetylation of 'Lys-56' of histone H3 (H3K56ac), which occurs predominantly in newly synthesized H3 molecule during G1, S-phase and G2/M of cell cycle. Histone H3 'Lys-56' acetylation is required for S-phase-linked DNA damage tolerance and proper silencing in pericentromeric heterochromatin.
Domain Profile
  HAT HAT_other
Query: 1   MPDLWSESILEGRKLSIYHLKSTLEKCPFLFGQSKKSKDFQFGSHLFLVEEQNVFIFGME 60
           MPDLWSESILEGRKLSIYHLKSTLEKCPFLFGQSKKSKDFQFGSHLFLVEEQNVFIFGME
Sbjct: 1   MPDLWSESILEGRKLSIYHLKSTLEKCPFLFGQSKKSKDFQFGSHLFLVEEQNVFIFGME 60
Query: 61  CIVYEKNKEFIVFVSKADSTGFGSKGVSCNSLAFCCLVTLIDGLRKQGAENVTLTLFAIA 120
           CIVYEKNKEFIVFVSKADSTGFGSKGVSCNSLAFCCLVTLIDGLRKQGAENVTLTLFAIA
Sbjct: 61  CIVYEKNKEFIVFVSKADSTGFGSKGVSCNSLAFCCLVTLIDGLRKQGAENVTLTLFAIA 120
Query: 121 QGQYLFPESVDNGQKHVLNDSGLLRWWVNCLEKLRKYYTDSEAPNDSEKQKNSTLLPKAY 180
           QGQYLFPESVDNGQKHVLNDSGLLRWWVNCLEKLRKYYTDSEAPNDSEKQKNSTLLPKAY
Sbjct: 121 QGQYLFPESVDNGQKHVLNDSGLLRWWVNCLEKLRKYYTDSEAPNDSEKQKNSTLLPKAY 180
Query: 181 LFVPGLENIRSYLPNRHWIESNAITTGKAVEELPRFPDDPKCRYLCELQDEKSDMSVEEF 240
           LFVPGLENIRSYLPNRHWIESNAITTGKAVEELPRFPDDPKCRYLCELQDEKSDMSVEEF
Sbjct: 181 LFVPGLENIRSYLPNRHWIESNAITTGKAVEELPRFPDDPKCRYLCELQDEKSDMSVEEF 240
Query: 241 WDTLTYRQECSSGKLVGFFTLQLQFYQTREFIAKDNFGDSGVMIPAKLYRVTYDTLLKHP 300
           WDTLTYRQECSSGKLVGFFTLQLQFYQTREFIAKDNFGDSGVMIPAKLYRVTYDTLLKHP
Sbjct: 241 WDTLTYRQECSSGKLVGFFTLQLQFYQTREFIAKDNFGDSGVMIPAKLYRVTYDTLLKHP 300
Query: 301 FGSLSDAQSSTEKFLSNTLSAVQNLKDFHYKRYKLDICGLAKRDDRKNHNHSKPATQANI 360
           FGSLSDAQSSTEKFLSNTLSAVQNLKDFHYKRYKLDICGLAKRDDRKNHNHSKPATQANI
Sbjct: 301 FGSLSDAQSSTEKFLSNTLSAVQNLKDFHYKRYKLDICGLAKRDDRKNHNHSKPATQANI 360
Query: 361 LQPRKKVKK 369
           LQPRKKVKK
Sbjct: 361 LQPRKKVKK 369
  HAT HAT_other
Query: 114 LTLFAIAQGQYLFPESVDNGQKHVLNDSGLLRWWVNCLEKLRKYYTDSEAPNDSEKQKNS 173
           + LF     QYLFP+S  N +KH+LN   L++WW   L++L             E  +N 
Sbjct: 189 ICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLL-----------IECFQND 237
Query: 174 TLLPKAYLFVPGLE--NIRSYLPNRH---WIESNAITTGK---AVEELPRFPDDPKCRYL 225
           T   +A L +PG +   +RSYL       W   +  T+ +   AV  +P FPDDPK R++
Sbjct: 238 T---QAKLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFI 294
Query: 226 CELQDEKS--DMSVEEFWDTLTYRQE---CSSGKLVGFFTLQLQFYQTREFIAKDNFGDS 280
            +L +E     +S+  FW  L  RQE     +  ++G     L             F  S
Sbjct: 295 HQLAEEDRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLA--------TPSLFPSS 346
Query: 281 G-VMIPAKLYRVTYDTLLKHPFGSLSDAQSSTEKFLSNTLSAVQNLKDFHYKRYKLDICG 339
             V++P    R  +  + K+  G   D +          + A  N++DF   R   ++  
Sbjct: 347 ADVIVPKS--RKQFRAIKKYITGEEYDTE-------EGAIEAFTNIRDFLLLRMATNLQS 397
Query: 340 LAKRDDRKNHNHSKPATQAN-----ILQPRKKVK 368
           L  + + +  N   PA+  N     +L+PRKK K
Sbjct: 398 LTGKREHRERNQPVPASNINTLAITMLKPRKKAK 431
Query: 45  HLFLVEEQNVFIFGMECIVY-----EKNKEFIVFVSKADSTGFGSKGVSCNSLAFCCL 97
           H F +  Q    F +E  VY     E + E ++FVSKAD+ G+ +  VS   +    L
Sbjct: 51  HFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIIL 108
Protein Sequence
(Fasta)		MPDLWSESIL EGRKLSIYHL KSTLEKCPFL FGQSKKSKDF QFGSHLFLVE EQNVFIFGME 60
CIVYEKNKEF IVFVSKADST GFGSKGVSCN SLAFCCLVTL IDGLRKQGAE NVTLTLFAIA 120
QGQYLFPESV DNGQKHVLND SGLLRWWVNC LEKLRKYYTD SEAPNDSEKQ KNSTLLPKAY 180
LFVPGLENIR SYLPNRHWIE SNAITTGKAV EELPRFPDDP KCRYLCELQD EKSDMSVEEF 240
WDTLTYRQEC SSGKLVGFFT LQLQFYQTRE FIAKDNFGDS GVMIPAKLYR VTYDTLLKHP 300
FGSLSDAQSS TEKFLSNTLS AVQNLKDFHY KRYKLDICGL AKRDDRKNHN HSKPATQANI 360
LQPRKKVKK 369
Nucleotide Sequence
(Fasta)		CGTTAACTCT CTTTATCCTT TAAACTAAAG AATATGCCGG ATCTTTGGTC AGAAAGTATA 60
TTAGAAGGCA GAAAATTGAG TATTTATCAT CTTAAAAGTA CTTTAGAGAA ATGTCCATTT 120
CTATTTGGTC AAAGTAAGAA GTCTAAGGAT TTTCAATTTG GGAGTCATCT TTTTTTGGTA 180
GAGGAACAAA ATGTATTTAT TTTTGGCATG GAATGCATAG TTTACGAAAA AAACAAAGAG 240
TTTATAGTAT TTGTATCTAA AGCAGATTCT ACCGGATTCG GCAGCAAAGG GGTATCTTGT 300
AACTCTCTTG CTTTTTGCTG CTTAGTGACA CTTATTGACG GTCTTAGAAA ACAAGGAGCC 360
GAAAATGTAA CTTTGACTCT GTTTGCGATT GCTCAAGGTC AATATTTATT TCCTGAGTCG 420
GTGGACAATG GACAAAAGCA TGTGCTGAAT GATTCTGGTT TGTTACGCTG GTGGGTAAAT 480
TGTTTGGAAA AACTCAGGAA GTATTATACT GACAGTGAAG CACCAAACGA TTCCGAAAAG 540
CAAAAGAATT CCACATTACT TCCTAAGGCT TATTTATTTG TTCCTGGACT TGAAAATATT 600
CGTTCGTACT TACCCAATCG TCATTGGATT GAAAGCAACG CTATAACAAC TGGAAAAGCA 660
GTTGAAGAAT TACCAAGATT TCCAGATGAC CCAAAATGTA GGTATTTATG CGAGCTTCAA 720
GATGAGAAAA GTGACATGTC CGTTGAAGAG TTTTGGGATA CGCTGACTTA TAGACAAGAG 780
TGCTCCTCAG GTAAACTAGT TGGCTTTTTC ACATTACAGC TACAGTTCTA TCAAACAAGA 840
GAATTTATTG CTAAAGATAA TTTTGGTGAT TCTGGTGTAA TGATTCCAGC TAAATTATAC 900
AGAGTCACTT ACGATACTTT ATTGAAGCAT CCATTTGGCT CTTTATCTGA TGCACAGTCG 960
TCAACAGAAA AGTTTCTTAG TAACACACTT TCCGCTGTAC AAAATTTAAA GGATTTTCAT 1020
TATAAGCGCT ACAAGCTAGA TATATGTGGG TTGGCAAAAC GTGATGATCG TAAAAATCAC 1080
AACCATTCGA AACCTGCTAC GCAAGCCAAT ATTCTACAGC CACGAAAAAA AGTGAAAAAA 1140
TAAAGGACTT TAAGTTCGTT GAAAATTTTT AATAATCCCA ATCAATCCTC TCATGTAGAT 1200
TTTTAGAGAA AGTTTTTGTT TAATATTGAA ATTGACACTT TTCGTCAGTA TTGCAAATAA 1260
ATTAATAAAC AACAAATATC TAAAATTAAT AAAAAGC 1298
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR016849--Rtt109
PROSITE

PS51728--RTT109_HAT
Pfam

PF08214--HAT_KAT11
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005634--C:nucleus
GO:0032931--F:histone acetyltransferase activity (H3-K56 specific)
GO:0006974--P:cellular response to DNA damage stimulus
GO:0030702--P:chromatin silencing at centromere
GO:0097043--P:histone H3-K56 acetylation
GO:0043618--P:regulation of transcription from RNA polymerase II promoter in response to stress
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Scj-0008 EEB06165 Schizosaccharomyces japonicus 35 9e-63 238
WERAM-Asni-0017 CADANGAP00005500 Aspergillus niger 32 3e-35 146
WERAM-Asfu-0025 CADAFUAP00005943 Aspergillus fumigatus 32 1e-34 144
WERAM-Asn-0026 CADANIAP00006255 Aspergillus nidulans 31 2e-33 140
WERAM-Asf-0032 CADAFLAP00011583 Aspergillus flavus 29 3e-33 140
WERAM-Ast-0027 CADATEAP00008187 Aspergillus terreus 31 3e-33 139
WERAM-Aso-0025 CADAORAP00006900 Aspergillus oryzae 30 4e-33 139
WERAM-Asc-0006 CADACLAP00001140 Aspergillus clavatus 29 4e-31 132
WERAM-Nec-0035 EFNCRP00000009612 Neurospora crassa 32 1e-29 128
WERAM-Trv-0024 EHK25922 Trichoderma virens 32 4e-29 126
WERAM-Tum-0031 CAZ86312 Tuber melanosporum 29 5e-29 125
WERAM-Pytr-0034 EDU44061 Pyrenophora triticirepentis 30 6e-29 125
WERAM-Pyt-0027 EFQ88818 Pyrenophora teres 32 7e-29 125
WERAM-Lem-0002 CBY01680 Leptosphaeria maculans 32 9e-29 125
WERAM-Trr-0027 EGR49578 Trichoderma reesei 33 3e-28 123
WERAM-Coi-0030 EAS31131 Coccidioides immitis 29 3e-28 123
WERAM-Phn-0030 SNOT_15503 Phaeosphaeria nodorum 29 2e-27 120
WERAM-Zyt-0009 Mycgr3P12793 Zymoseptoria tritici 30 3e-27 120
WERAM-Ved-0016 EGY23544 Verticillium dahliae 32 3e-26 116
WERAM-Mao-0018 MGG_05969T0 Magnaporthe oryzae 28 3e-26 116
WERAM-Map-0009 MAPG_02939T0 Magnaporthe poae 28 6e-26 115
WERAM-Gag-0028 GGTG_09850T0 Gaeumannomyces graminis 36 2e-23 107
WERAM-Yal-0033 CAG78300 Yarrowia lipolytica 31 6e-23 105
WERAM-Sac-0028 YLL002W Saccharomyces cerevisiae 28 7e-16 82.4
WERAM-Miv-0017 MVLG_02574T0 Microbotryum violaceum 24 8e-16 82.0
WERAM-Lab-0031 EDR13403 Laccaria bicolor 25 5e-14 76.3
WERAM-Kop-0027 CAY70799 Komagataella pastoris 25 5e-14 76.3
WERAM-Kll-0029 CAG98369 Kluyveromyces lactis 27 3e-13 73.2
WERAM-Asg-0001 AAS50193 Ashbya gossypii 35 2e-12 71.2
WERAM-Caa-0030 KGT64625 Candida albicans 29 2e-12 70.5
WERAM-Cag-0010 CAG58572 Candida glabrata 33 7e-11 65.9
WERAM-Chg-0044 EAQ83001 Chaetomium globosum 45 1e-08 58.2
WERAM-Fuo-0028 FOXG_09072P0 Fusarium oxysporum 33 3e-08 57.0
WERAM-Spr-0022 CBQ71013 Sporisorium reilianum 23 3e-07 53.5
WERAM-Usm-0013 UM02284P0 Ustilago maydis 24 8e-07 52.0
Created Date 25-Jun-2016