WERAM Information

Tag Content
WERAM ID WERAM-Sac-0027
Ensembl Protein ID YKR029C
Uniprot Accession P36124; SET3_YEAST; D6VX94
Genbank Protein ID NP_012954.3
Protein Name SET domain-containing protein 3
Genbank Nucleotide ID NM_001179819.3
Gene Name Set3;YKR029C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YKR029C YKR029C YKR029C
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me K 17142463
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 5.50e-10 37.8 119 164
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.
Domain Profile
  Me_Reader PHD
  PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
              +C+ C + ++++ + +qCd+C++w H+ C++++   +  + +++C+sC 
  YKR029C 119 TCI-C-DLNDDDGFTIQCDHCNRWQHAICYGIKDIGMAPD-DYLCNSCD 164
              698.*.66666679*******************6666666.8******7 PP
Protein Sequence
(Fasta)		MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE KKGAIEMAAA 60
ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ PQWPVPDSYI VDPDAGIITC 120
ICDLNDDDGF TIQCDHCNRW QHAICYGIKD IGMAPDDYLC NSCDPREVDI NLARKIQQER 180
INVKTVEPSS SNNSASNKNN GRDRASSTTI SDVGDSFSTD QDNTNHRDKR RKRNPSNNSI 240
DSKNESASVN SSDGLTSMPK KKEHFLSAKD AYGAIYLPLK DNVFKSDLIE PFLNKHMDDN 300
WVIQYPHKTF KSVSIEVKPY ADIAYSRTYP GFTKLGVYLK KDCIKGDFIQ EILGELDFYK 360
NYLTDPRNHY RIWGTAKRRV IFHSHWPIYI DARLSGNSTR YLRRSCQPNV ELVTIKLQDT 420
DNRNDKSSGR KSSRIKFVLR ALRDISEDEE LYIKWQWDSK HPILKLIKGM TIDSLDDLER 480
YGLINSVETI LSNGECGCGN NSKDCYLLKV KRYAQSLYKS VKSRGKMNNR YKLNEILNQY 540
NCKKRREPPI LHRLEEKAQN TIERAPILLN NFYRQKFLNR NNGPKIPQKN TIDSTNNPDD 600
IAKPFKFALF AQHSSNISVP KKNETSEKPL IITKSTDYDE SHITNIEELP IPVLLPINKT 660
SRQTANDVEE SQSKNEHKLS RTPSLSNFNK ELSKEAQHSQ AKTKEIMTEA SVNSRRESTP 720
ESIMHLSDFS SSQLHSKKKL SFADYRKKLL K 751
Nucleotide Sequence
(Fasta)		ATGTCAGTAC CTAATTCCAA AGAGCAGTCG CTCCTAGATG ATGCATCCAC ATTGTTATTG 60
TTTTCAAAAG GGAAAAAAAG AGCTGAAGAA GCTTCAAAAA TAGGCTCTAA AACAGATACT 120
ATTGAGCATG ATGAGTCTCA TGAGAGAGAA AAAAAAGGAG CAATAGAAAT GGCAGCAGCA 180
GCACTGGCTA CAGCATCCAC AGTTTCTTTA CCTTTAAAGA AAGCTACTGA GCAATCGGCG 240
GCAGAAGCAG CAACATCCAC GGCAGCAAAA GAAGAGACCG AAAATCAACC TCAAAAGCAA 300
CCTCAATGGC CGGTACCTGA TTCGTATATA GTCGATCCTG ACGCGGGTAT AATTACATGT 360
ATATGTGATT TAAATGATGA TGATGGATTC ACTATCCAAT GTGACCACTG CAACAGATGG 420
CAGCATGCTA TTTGCTATGG CATCAAAGAT ATTGGGATGG CACCTGATGA TTACCTTTGC 480
AACTCATGTG ATCCAAGAGA GGTAGACATT AACTTGGCTA GGAAAATACA GCAGGAACGC 540
ATAAACGTAA AAACAGTAGA ACCTTCTTCA TCAAACAATA GTGCTAGTAA TAAGAATAAC 600
GGTCGGGACA GAGCATCGAG TACAACTATT AGTGACGTTG GCGATAGCTT TTCAACGGAT 660
CAGGACAATA CTAACCACAG GGACAAAAGA AGGAAAAGAA ACCCATCAAA TAATAGTATA 720
GACTCCAAAA ACGAAAGCGC TTCTGTCAAT TCTTCCGATG GATTGACTTC TATGCCCAAG 780
AAAAAAGAGC ATTTCCTGAG TGCAAAAGAC GCATATGGTG CAATATACTT GCCCTTGAAA 840
GACAATGTGT TTAAAAGTGA TCTGATCGAA CCGTTCTTAA ATAAACATAT GGATGATAAT 900
TGGGTCATAC AATATCCTCA TAAGACCTTT AAATCTGTGT CAATTGAAGT CAAACCGTAT 960
GCTGACATTG CATATTCCAG GACTTACCCA GGCTTCACGA AATTAGGAGT TTATCTCAAA 1020
AAGGACTGCA TAAAAGGTGA TTTCATTCAA GAAATTTTAG GCGAATTGGA CTTCTATAAA 1080
AATTATCTCA CTGACCCACG AAACCATTAC AGGATATGGG GTACAGCTAA AAGAAGGGTC 1140
ATTTTCCATT CCCATTGGCC GATATATATA GATGCACGCT TATCAGGCAA TTCAACTAGG 1200
TATTTGAGAA GAAGTTGCCA GCCGAATGTT GAATTAGTAA CTATAAAACT GCAAGATACA 1260
GACAATAGGA ATGACAAAAG CAGTGGAAGA AAATCAAGTA GAATAAAATT TGTTTTAAGA 1320
GCTTTGAGAG ATATTTCAGA GGATGAGGAG TTATACATCA AATGGCAGTG GGATTCAAAA 1380
CATCCTATAT TAAAATTAAT AAAGGGCATG ACAATAGACT CTTTAGATGA CCTTGAAAGG 1440
TATGGGCTGA TAAATTCGGT AGAAACAATT TTGAGTAACG GCGAATGCGG CTGTGGAAAT 1500
AATTCTAAAG ATTGTTATTT ATTGAAAGTG AAGAGATACG CGCAAAGTCT TTATAAATCT 1560
GTGAAATCCA GAGGAAAAAT GAACAACAGA TATAAATTAA ATGAAATTCT CAACCAATAT 1620
AATTGCAAAA AGAGACGTGA GCCACCAATT TTGCATAGGC TAGAAGAAAA GGCTCAAAAT 1680
ACTATAGAAA GAGCTCCAAT ACTTTTGAAT AATTTTTATC GACAAAAATT CCTTAATCGA 1740
AATAATGGTC CAAAAATTCC TCAAAAGAAT ACTATTGATA GTACAAATAA TCCTGATGAT 1800
ATTGCAAAAC CCTTCAAATT CGCCTTATTT GCACAACATT CTTCTAATAT TTCTGTTCCC 1860
AAAAAAAATG AAACTTCAGA AAAACCTTTA ATAATTACGA AGAGCACAGA TTATGACGAA 1920
TCACACATTA CCAATATTGA AGAATTACCA ATTCCAGTTC TTTTACCAAT AAACAAGACG 1980
TCAAGGCAAA CTGCAAACGA TGTCGAAGAG AGTCAATCAA AGAATGAACA TAAATTAAGT 2040
AGAACCCCTT CTCTTTCAAA TTTCAATAAA GAACTGTCAA AGGAAGCACA ACACAGTCAA 2100
GCAAAAACAA AAGAAATCAT GACAGAAGCT TCGGTTAATT CAAGGCGAGA ATCCACTCCA 2160
GAAAGTATAA TGCACTTATC AGATTTTTCG TCCTCACAAC TGCATTCGAA AAAGAAATTA 2220
AGCTTTGCGG ATTACAGAAA AAAACTACTG AAATAA 2257
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
Gene Ontology

GO:0034967--C:Set3 complex
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016575--P:histone deacetylation
GO:0051321--P:meiotic cell cycle
GO:0045835--P:negative regulation of meiotic nuclear division
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0025 CAG61876 Candida glabrata 45 6e-155 545
WERAM-Asg-0025 AAS53448 Ashbya gossypii 41 3e-132 470
WERAM-Scp-0010 SPAC22E12.11c.1:pep Schizosaccharomyces pombe 26 2e-32 138
WERAM-Scj-0037 EEB09211 Schizosaccharomyces japonicus 29 3e-19 94.7
WERAM-Mel-0025 EGG01272 Melampsora laricipopulina 44 6e-14 77.0
WERAM-Tum-0014 CAZ82803 Tuber melanosporum 44 4e-13 74.3
WERAM-Pem-0028 ENSPMAP00000004022.1 Petromyzon marinus 45 1e-11 69.3
WERAM-Dan-0045 ENSDNOP00000004456.3 Dasypus novemcinctus 44 2e-11 68.9
WERAM-Drm-0057 FBpp0075510 Drosophila melanogaster 45 3e-11 68.2
WERAM-Anp-0017 ENSAPLP00000002772.1 Anas platyrhynchos 47 4e-11 67.8
WERAM-Ect-0013 ENSETEP00000000939.1 Echinops telfairi 51 4e-11 67.8
WERAM-Aim-0150 ENSAMEP00000013827.1 Ailuropoda melanoleuca 43 5e-11 67.4
WERAM-Mod-0157 ENSMODP00000021650.4 Monodelphis domestica 44 5e-11 67.4
WERAM-Fec-0122 ENSFCAP00000011217.3 Felis catus 47 6e-11 67.4
WERAM-Eqc-0129 ENSECAP00000015121.1 Equus caballus 44 6e-11 67.0
WERAM-Mup-0063 ENSMPUP00000005424.1 Mustela putorius furo 47 6e-11 67.0
WERAM-Caf-0179 ENSCAFP00000024919.4 Canis familiaris 47 6e-11 67.0
WERAM-Bot-0086 ENSBTAP00000012129.5 Bos taurus 44 6e-11 67.0
WERAM-Prc-0142 ENSPCAP00000013150.1 Procavia capensis 44 6e-11 67.0
WERAM-Anc-0072 ENSACAP00000006960.3 Anolis carolinensis 45 7e-11 67.0
WERAM-Sus-0197 ENSSSCP00000024064.1 Sus scrofa 44 7e-11 67.0
WERAM-Mum-0094 ENSMUSP00000092569.2 Mus musculus 44 7e-11 67.0
WERAM-Dio-0018 ENSDORP00000002187.1 Dipodomys ordii 44 7e-11 67.0
WERAM-Ptv-0028 ENSPVAP00000003472.1 Pteropus vampyrus 44 7e-11 67.0
WERAM-Loa-0050 ENSLAFP00000003655.3 Loxodonta africana 44 7e-11 67.0
WERAM-Ova-0014 ENSOARP00000002440.1 Ovis aries 43 7e-11 67.0
WERAM-Cap-0009 ENSCPOP00000001208.2 Cavia porcellus 44 7e-11 67.0
WERAM-Vip-0093 ENSVPAP00000008307.1 Vicugna pacos 44 8e-11 66.6
WERAM-Ere-0106 ENSEEUP00000011549.1 Erinaceus europaeus 44 8e-11 66.6
WERAM-Myl-0033 ENSMLUP00000002454.2 Myotis lucifugus 44 8e-11 66.6
WERAM-Caj-0166 ENSCJAP00000029516.1 Callithrix jacchus 44 8e-11 66.6
WERAM-Poa-0164 ENSPPYP00000020053.2 Pongo abelii 44 8e-11 66.6
WERAM-Otg-0038 ENSOGAP00000002538.2 Otolemur garnettii 44 9e-11 66.6
WERAM-Mam-0206 ENSMMUP00000029929.2 Macaca mulatta 44 9e-11 66.6
WERAM-Paa-0032 ENSPANP00000012164.1 Papio anubis 44 9e-11 66.6
WERAM-Chs-0143 ENSCSAP00000007759.1 Chlorocebus sabaeus 44 9e-11 66.6
WERAM-Ocp-0053 ENSOPRP00000004587.1 Ochotona princeps 49 9e-11 66.6
WERAM-Hos-0004 ENSP00000257745.4 Homo sapiens 44 9e-11 66.6
WERAM-Pat-0163 ENSPTRP00000033495.4 Pan troglodytes 44 9e-11 66.6
WERAM-Orn-0002 ENSONIP00000000116.1 Oreochromis niloticus 46 9e-11 66.6
WERAM-Tut-0016 ENSTTRP00000001387.1 Tursiops truncatus 44 9e-11 66.6
WERAM-Pes-0016 ENSPSIP00000004109.1 Pelodiscus sinensis 45 1e-10 66.6
WERAM-Gog-0007 ENSGGOP00000000573.3 Gorilla gorilla 44 1e-10 66.6
WERAM-Nol-0095 ENSNLEP00000011036.1 Nomascus leucogenys 44 1e-10 66.2
WERAM-Orc-0146 ENSOCUP00000012882.3 Oryctolagus cuniculus 49 1e-10 66.2
WERAM-Fia-0128 ENSFALP00000010775.1 Ficedula albicollis 45 1e-10 66.2
WERAM-Tas-0028 ENSTSYP00000003044.1 Tarsius syrichta 44 1e-10 66.2
WERAM-Tub-0061 ENSTBEP00000007542.1 Tupaia belangeri 44 1e-10 66.2
WERAM-Sah-0094 ENSSHAP00000010988.1 Sarcophilus harrisii 49 1e-10 66.2
WERAM-Soa-0011 ENSSARP00000001033.1 Sorex araneus 49 1e-10 66.2
WERAM-Chh-0015 ENSCHOP00000001410.1 Choloepus hoffmanni 44 1e-10 66.2
WERAM-Ran-0136 ENSRNOP00000027629.6 Rattus norvegicus 49 1e-10 66.2
WERAM-Gaga-0084 ENSGALP00000013244.4 Gallus gallus 45 1e-10 66.2
WERAM-Tag-0046 ENSTGUP00000003023.1 Taeniopygia guttata 45 1e-10 66.2
WERAM-Meg-0070 ENSMGAP00000006680.1 Meleagris gallopavo 45 1e-10 65.9
WERAM-Lac-0154 ENSLACP00000018064.1 Latimeria chalumnae 44 1e-10 65.9
WERAM-Asm-0049 ENSAMXP00000006513.1 Astyanax mexicanus 46 1e-10 65.9
WERAM-Mae-0076 ENSMEUP00000007694.1 Macropus eugenii 49 2e-10 65.5
WERAM-Orla-0168 ENSORLP00000019951.1 Oryzias latipes 46 2e-10 65.1
WERAM-Pof-0196 ENSPFOP00000016384.2 Poecilia formosa 44 3e-10 64.7
WERAM-Xim-0052 ENSXMAP00000004648.1 Xiphophorus maculatus 46 3e-10 64.7
WERAM-Leo-0158 ENSLOCP00000019058.1 Lepisosteus oculatus 46 3e-10 64.7
WERAM-Xet-0164 ENSXETP00000049953.3 Xenopus tropicalis 45 3e-10 64.7
WERAM-Ora-0121 ENSOANP00000023671.3 Ornithorhynchus anatinus 44 5e-10 63.9
WERAM-Kop-0002 CAY67515 Komagataella pastoris 46 6e-10 63.9
WERAM-Dar-0020 ENSDARP00000066902.4 Danio rerio 44 7e-10 63.5
WERAM-Ten-0136 ENSTNIP00000014334.1 Tetraodon nigroviridis 46 8e-10 63.5
WERAM-Crn-0016 AAW42860 Cryptococcus neoformans 49 8e-10 63.5
WERAM-Tar-0194 ENSTRUP00000039967.1 Takifugu rubripes 44 2e-09 62.0
WERAM-Gam-0034 ENSGMOP00000003474.1 Gadus morhua 44 3e-09 61.6
WERAM-Ict-0108 ENSSTOP00000011123.2 Ictidomys tridecemlineatus 42 1e-08 59.3
WERAM-Kll-0022 CAG99888 Kluyveromyces lactis 39 2e-08 58.5
WERAM-Pytr-0007 EDU41371 Pyrenophora triticirepentis 35 3e-08 58.2
WERAM-Cym-0018 CML250CT Cyanidioschyzon merolae 41 3e-08 58.2
WERAM-Gaa-0026 ENSGACP00000004363.3 Gasterosteus aculeatus 43 4e-08 57.8
WERAM-Osl-0024 ABO96103 Ostreococcus lucimarinus 45 5e-08 57.4
WERAM-Asc-0005 CADACLAP00000978 Aspergillus clavatus 49 6e-08 57.0
WERAM-Pyt-0024 EFQ89640 Pyrenophora teres 45 7e-08 57.0
WERAM-Mim-0035 ENSMICP00000003307.1 Microcebus murinus 42 8e-08 56.6
WERAM-Asfu-0026 CADAFUAP00006052 Aspergillus fumigatus 51 1e-07 55.8
WERAM-Ast-0023 CADATEAP00007352 Aspergillus terreus 51 2e-07 55.5
WERAM-Aso-0023 CADAORAP00006794 Aspergillus oryzae 56 3e-07 55.1
WERAM-Asf-0033 CADAFLAP00011701 Aspergillus flavus 56 3e-07 55.1
WERAM-Zem-0049 GRMZM2G068331_P01 Zea mays 45 4e-07 54.3
WERAM-Asn-0023 CADANIAP00005737 Aspergillus nidulans 56 4e-07 54.3
WERAM-Cis-0026 ENSCSAVP00000005561.1 Ciona savignyi 45 7e-07 53.5
WERAM-Lem-0009 CBY02383 Leptosphaeria maculans 41 8e-07 53.5
WERAM-Sob-0004 Sb01g010120.1 Sorghum bicolor 45 9e-07 53.1
WERAM-Amt-0086 ERM99751 Amborella trichopoda 42 9e-07 53.1
WERAM-Sei-0093 Si026053m Setaria italica 43 1e-06 52.8
WERAM-Hov-0098 MLOC_70587.10 Hordeum vulgare 43 2e-06 52.0
WERAM-Caa-0027 KGT65810 Candida albicans 46 2e-06 52.0
WERAM-Phn-0029 SNOT_14862 Phaeosphaeria nodorum 41 2e-06 52.0
WERAM-Lep-0041 LPERR03G26620.1 Leersia perrieri 42 4e-06 51.2
WERAM-Cii-0041 ENSCINP00000016215.3 Ciona intestinalis 42 7e-06 50.4
WERAM-Tra-0159 Traes_4DS_77170C64A.1 Triticum aestivum 41 7e-06 50.4
WERAM-Orp-0106 OPUNC11G07440.1 Oryza punctata 41 7e-06 50.4
WERAM-Viv-0117 VIT_18s0089g01050.t01 Vitis vinifera 44 8e-06 50.1
WERAM-Ors-0102 OS11T0234200-01 Oryza sativa 41 8e-06 50.1
WERAM-Ori-0117 BGIOSGA034246-PA Oryza indica 41 8e-06 50.1
WERAM-Orb-0114 OBART11G07640.1 Oryza barthii 41 8e-06 50.1
WERAM-Org-0107 ORGLA11G0068000.1 Oryza glaberrima 41 8e-06 50.1
WERAM-Orgl-0110 OGLUM11G07480.1 Oryza glumaepatula 41 8e-06 50.1
WERAM-Orm-0099 OMERI11G06400.1 Oryza meridionalis 41 9e-06 50.1
WERAM-Orni-0114 ONIVA11G07750.1 Oryza nivara 41 1e-05 50.1
WERAM-Mua-0061 GSMUA_Achr3P21880_001 Musa acuminata 39 1e-05 50.1
Created Date 25-Jun-2016