WERAM Information

Tag Content
WERAM ID WERAM-Hos-0004
Ensembl Protein ID ENSP00000257745.4
Uniprot Accession Q8IZD2; KMT2E_HUMAN; B6ZDE4; B6ZDM3; M4K8J3; Q6P5Y2; Q6PKG4; Q6T316; Q86TI3; Q86W12; Q86WG0; Q86WL2; Q8IV78; Q8IWR5; Q8NFF8; Q9NWE7
Genbank Protein ID NP_061152.3; NP_891847.1; XP_005250550.1; XP_006716112.1; XP_011514702.1
Protein Name Histone-lysine N-methyltransferase 2E
Genbank Nucleotide ID NM_018682.3; NM_182931.2; XM_005250493.1; XM_006716049.1; XM_011516400.1
Gene Name KMT2E;MLL5;NKp44L;HDCMC04P
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000005483.19 ENST00000257745.8 ENSP00000257745.4
ENSG00000005483.19 ENST00000311117.7 ENSP00000312379.3
ENSG00000005483.19 ENST00000334914.11 ENSP00000333986.8
ENSG00000005483.19 ENST00000334884.9 ENSP00000335398.5
ENSG00000005483.19 ENST00000476671.5 ENSP00000417888.1
ENSG00000005483.19 ENST00000478990.5 ENSP00000419883.1
ENSG00000005483.19 ENST00000495267.5 ENSP00000420415.1
ENSG00000005483.19 ENST00000622386.1 ENSP00000482147.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SET1 SET H3K4 K 25537518; 20951770; 26886794
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SET1 1.30e-25 92 331 446
Me_Reader PHD 1.40e-07 33.8 119 164
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.
Domain Profile
  HMT SET1
           SET1.txt   2 elevakskikglglvakkeiekeelviEYvGevirsevadkrek..eyekkeig.vylfrldedaevvvdatkkgniarfinhscepNceak 90 
                        ++e++ +k+k ++l+++k++  ++l+iEY+G++   ++++++e+  ++ k+ +  v+++++ +  e++vda+++gn+arfi++sc+pN+e++
  ENSP00000257745.4 331 PVESHIQKNK-KILKSAKDLPPDALIIEYRGKF---MLREQFEAngYFFKRPYPfVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVR 418
                        5777777777.89********************...78888887779999999999************************************ PP
           SET1.txt  91 vvavdgekkiviyakraIekgeeltydY 118
                        +  +dg+ +++iy+ ++I+kg+e+t+++
  ENSP00000257745.4 419 HEIQDGTIHLYIYSIHSIPKGTEITIAF 446
                        ************************9877 PP
  Me_Reader PHD
            PHD.txt   2 tiClvCg.kddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                        t C+ Cg ++d+g  +m++Cd+C+ w H++C+++ ++++p+   ++C++C+
  ENSP00000257745.4 119 TRCI-CGfTHDDG--YMICCDKCSVWQHIDCMGIDRQHIPDT--YLCERCQ 164
                        5798.*7344444..6*******************9999988..******8 PP
Protein Sequence
(Fasta)		MSIVIPLGVD TAETSYLEMA AGSEPESVEA SPVVVEKSNS YPHQLYTSSS HHSHSYIGLP 60
YADHNYGARP PPTPPASPPP SVLISKNEVG IFTTPNFDET SSATTISTSE DGSYGTDVTR 120
CICGFTHDDG YMICCDKCSV WQHIDCMGID RQHIPDTYLC ERCQPRNLDK ERAVLLQRRK 180
RENMSDGDTS ATESGDEVPV ELYTAFQHTP TSITLTASRV SKVNDKRRKK SGEKEQHISK 240
CKKAFREGSR KSSRVKGSAP EIDPSSDGSN FGWETKIKAW MDRYEEANNN QYSEGVQREA 300
QRIALRLGNG NDKKEMNKSD LNTNNLLFKP PVESHIQKNK KILKSAKDLP PDALIIEYRG 360
KFMLREQFEA NGYFFKRPYP FVLFYSKFHG LEMCVDARTF GNEARFIRRS CTPNAEVRHE 420
IQDGTIHLYI YSIHSIPKGT EITIAFDFDY GNCKYKVDCA CLKENPECPV LKRSSESMEN 480
INSGYETRRK KGKKDKDISK EKDTQNQNIT LDCEGTTNKM KSPETKQRKL SPLRLSVSNN 540
QEPDFIDDIE EKTPISNEVE MESEEQIAER KRKMTREERK MEAILQAFAR LEKREKRREQ 600
ALERISTAKT EVKTECKDTQ IVSDAEVIQE QAKEENASKP TPAKVNRTKQ RKSFSRSRTH 660
IGQQRRRHRT VSMCSDIQPS SPDIEVTSQQ NDIENTVLTI EPETETALAE IITETEVPAL 720
NKCPTKYPKT KKHLVNEWLS EKNEKTGKPS DGLSERPLRI TTDPEVLATQ LNSLPGLTYS 780
PHVYSTPKHY IRFTSPFLSE KRRRKEPTEN ISGSCKKRWL KQALEEENSA ILHRFNSPCQ 840
ERSRSPAVNG ENKSPLLLND SCSLPDLTTP LKKRRFYQLL DSVYSETSTP TPSPYATPTH 900
TDITPMDPSF ATPPRIKSDD ETCRNGYKPI YSPVTPVTPG TPGNTMHFEN ISSPESSPEI 960
KRRTYSQEGY DRSSTMLTLG PFRNSNLTEL GLQEIKTIGY TSPRSRTEVN RQCPGEKEPV 1020
SDLQLGLDAV EPTALHKTLE TPAHDRAEPN SQLDSTHSGR GTMYSSWVKS PDRTGVNFSV 1080
NSNLRDLTPS HQLEVGGGFR ISESKCLMQD DTRGMFMETT VFCTSEDGLV SGFGRTVNDN 1140
LIDGNCTPQN PPQKKKVSLL EYRKRQREAR KSGSKTENFP LISVSPHASG SLSNNGDGCA 1200
SSNDNGEQVD HTASLPLPTP ATVYNATSEE TSNNCPVKDA TASEKNEPEV QWTASTSVEQ 1260
VRERSYQRAL LLSDHRKDKD SGGESPCVSC SPSHVQSSPS SHSNHIPQLQ AKGPVPSFSE 1320
LMEDPDPENP EPTTTNECPS PDTSQNTCKS PPKMSKPGSP GSVIPAQAHG KIFTKPDPQW 1380
DSTVSASEAE NGVHLKTELQ QKQLSNNNQA LSKNHPPQTH VRNSSEQLSQ KLPSVPTKLH 1440
CPPSPHLENP PKSSTPHTPV QHGYLSPKPP SQQLGSPYRP HHSQSPQVGT PQREPQRNFY 1500
PAAQNLPANT QQATSGTLFT QTPSGQSSAT YSQFNQQSLN STAPPPPPPP PPSSSYYQNQ 1560
QPSANFQNYN QLKGSLSQQT VFTSGPNQAL PGTTSQQTVP GHHVTPGHFL PSQNPTIHHQ 1620
TAAAVVPPPP PPPPAPGPHL VQQPNSHQQH SVAHVVGPVH AVTPGSHIHS QTAGHHLPPP 1680
PPPPGPAPHH HPPPHPSTGL QGLQAQHQHV VNSAPPPPPP PPPSSVLASG HHTTSAQALH 1740
HPPHQGPPLF PSSAHPTVPP YPSQATHHTT LGPGPQHQPS GTGPHCPLPV TGPHLQPQGP 1800
NSIPTPTASG FCPHPGSVAL PHGVQGPQQA SPVPGQIPIH RAQVPPTFQN NYHGSGWH 1858
Nucleotide Sequence
(Fasta)		CGCCGCCATT TTCCCAGAGC GAGAGGCAGT GACACTGAGC GGGCGCAGGG GGCCGAGTCG 60
GAGACCGTGC CGGAGTTCGG GAGCGGCAAC AGAGTGGGCA TAGACACTCC GAGCAGCCTC 120
GCCGTCGTCT CTGCGTTCCT GTTGACTGCC TGGCTGCCCC CTCCCCTACT CCTCGGTTCC 180
TGGTGAAGAG GCTGCGCGCT GCTGTTTGGG GAGGGGGTGT GTGGAGCCGG GTCCTGTGTC 240
CGCAGTGGCT GCTGTCGGGG GGTCGCCTGT TCGCGGAGGT GCGGAGAGAC TCCTTGGGGG 300
TCGAGCACTG TGGCTGGCAT GCCCCAGTGT TTTGGATACC AATGCATAGG ACTCCATAGT 360
AATCGAATTT ACCAGAGGCG AACGTCATGA GCATAGTGAT CCCATTGGGG GTTGATACAG 420
CAGAGACGTC ATACTTGGAA ATGGCTGCAG GTTCAGAACC AGAATCCGTA GAAGCTAGCC 480
CTGTGGTAGT TGAGAAATCC AACAGTTATC CCCACCAGTT ATATACCAGC AGCTCACATC 540
ATTCACACAG TTACATTGGT TTGCCCTATG CGGACCATAA TTATGGTGCT CGTCCTCCTC 600
CGACACCTCC GGCTTCCCCT CCTCCATCAG TCCTTATTAG CAAAAATGAA GTAGGCATAT 660
TTACCACTCC TAATTTTGAT GAAACTTCCA GTGCTACTAC AATCAGCACA TCTGAGGATG 720
GAAGTTATGG TACTGATGTA ACCAGGTGCA TATGTGGTTT TACACATGAT GATGGATACA 780
TGATCTGTTG TGACAAATGC AGCGTTTGGC AACATATTGA CTGCATGGGG ATTGATAGGC 840
AGCATATTCC TGATACATAT CTATGTGAAC GTTGTCAGCC TAGGAATTTG GATAAAGAGA 900
GGGCAGTGCT ACTACAACGC CGGAAAAGGG AAAATATGTC AGATGGTGAT ACCAGTGCAA 960
CTGAGAGTGG TGATGAGGTT CCTGTGGAAT TATATACTGC ATTTCAGCAT ACTCCAACAT 1020
CAATTACTTT AACTGCTTCA AGAGTTTCCA AAGTTAATGA TAAAAGAAGG AAAAAAAGCG 1080
GGGAGAAAGA ACAACACATT TCAAAATGTA AAAAGGCATT TCGTGAAGGA TCTAGGAAGT 1140
CATCAAGAGT TAAGGGTTCA GCTCCAGAGA TTGATCCTTC ATCTGATGGT TCAAATTTTG 1200
GATGGGAGAC AAAGATCAAA GCATGGATGG ATCGATATGA AGAAGCAAAT AACAACCAGT 1260
ACAGTGAGGG TGTTCAGAGG GAGGCACAAA GAATAGCTCT GAGATTAGGC AATGGAAATG 1320
ACAAAAAAGA GATGAATAAA TCCGATTTGA ATACCAACAA TTTGCTCTTC AAACCTCCTG 1380
TAGAGAGCCA TATACAAAAG AATAAGAAAA TTCTTAAATC TGCAAAAGAT TTGCCTCCTG 1440
ATGCACTTAT CATTGAATAC AGAGGGAAGT TTATGCTGAG AGAACAGTTT GAAGCAAATG 1500
GGTATTTCTT TAAAAGACCA TACCCTTTTG TGTTATTCTA CTCTAAATTT CATGGGCTAG 1560
AAATGTGTGT TGATGCAAGG ACTTTTGGGA ATGAGGCTCG ATTCATCAGG CGGTCTTGTA 1620
CACCCAATGC AGAGGTGAGG CATGAAATTC AAGATGGAAC CATACATCTT TATATTTATT 1680
CTATACACAG TATTCCAAAG GGAACTGAAA TTACTATTGC CTTTGATTTT GACTATGGAA 1740
ATTGTAAGTA CAAGGTGGAC TGTGCATGCC TCAAAGAAAA CCCAGAGTGC CCTGTTCTAA 1800
AACGTAGTTC TGAATCCATG GAAAATATCA ATAGTGGTTA TGAGACCAGA CGGAAAAAAG 1860
GAAAAAAAGA CAAAGATATT TCAAAAGAAA AAGATACACA AAATCAGAAT ATTACTTTGG 1920
ATTGTGAAGG AACGACCAAC AAAATGAAGA GCCCAGAAAC TAAACAAAGA AAGCTTTCTC 1980
CACTGAGACT ATCAGTATCA AATAATCAGG AACCAGATTT TATTGATGAT ATAGAAGAAA 2040
AAACTCCTAT TAGTAATGAA GTAGAAATGG AATCAGAGGA GCAGATTGCA GAAAGGAAAA 2100
GGAAGATGAC AAGAGAAGAA AGAAAAATGG AAGCAATTTT GCAAGCTTTT GCCAGACTTG 2160
AAAAGAGAGA GAAAAGAAGA GAACAAGCTT TGGAAAGGAT CAGCACAGCC AAAACTGAAG 2220
TTAAAACTGA ATGTAAAGAT ACACAGATTG TCAGTGATGC TGAAGTTATT CAGGAACAAG 2280
CAAAAGAAGA AAATGCTAGC AAGCCAACCC CTGCCAAAGT AAATAGAACT AAACAGAGAA 2340
AAAGTTTTTC TCGGAGTAGG ACTCACATTG GACAGCAGCG TCGGAGACAC AGAACTGTCA 2400
GCATGTGTTC AGATATCCAG CCATCTTCTC CTGATATAGA AGTTACTTCA CAACAAAATG 2460
ATATTGAAAA TACTGTACTT ACAATAGAAC CAGAAACTGA AACTGCACTA GCAGAAATAA 2520
TTACTGAAAC TGAAGTTCCA GCACTTAATA AATGTCCTAC CAAGTACCCC AAAACAAAGA 2580
AGCACTTGGT TAATGAATGG TTAAGTGAGA AGAATGAGAA GACAGGAAAA CCTTCAGATG 2640
GCCTTTCAGA AAGGCCTCTA CGCATAACTA CAGATCCTGA AGTGTTAGCT ACACAACTCA 2700
ATTCTTTACC AGGTCTCACT TACAGCCCCC ATGTATACTC CACTCCTAAG CATTATATTA 2760
GATTTACTTC ACCATTCCTT TCAGAAAAAA GGAGAAGAAA AGAACCTACT GAAAACATTT 2820
CTGGTTCATG CAAGAAGCGA TGGTTGAAAC AAGCTCTGGA AGAAGAAAAT TCAGCAATTT 2880
TACATAGATT TAATTCACCC TGTCAAGAAA GATCCAGAAG TCCTGCAGTC AATGGTGAAA 2940
ATAAAAGTCC ACTACTATTA AATGACAGCT GTTCCCTTCC AGATTTAACT ACACCACTAA 3000
AAAAACGAAG ATTTTATCAG TTGCTAGATT CGGTTTACTC AGAAACCTCC ACACCTACTC 3060
CTTCCCCGTA TGCTACACCA ACTCACACCG ATATTACTCC TATGGACCCA TCTTTTGCCA 3120
CGCCTCCACG GATAAAATCA GATGATGAAA CTTGTAGAAA TGGTTATAAA CCCATATATT 3180
CACCAGTTAC CCCAGTAACT CCTGGTACAC CAGGAAATAC CATGCACTTT GAGAATATTT 3240
CTTCCCCAGA AAGTTCTCCA GAAATAAAGA GACGCACTTA TAGTCAAGAG GGATATGACA 3300
GATCTTCAAC CATGTTAACA TTGGGGCCTT TTAGAAATTC TAATTTAACT GAACTGGGTC 3360
TGCAAGAAAT AAAGACTATT GGTTATACGA GCCCTAGGAG TAGGACTGAA GTCAACAGGC 3420
AGTGTCCTGG AGAAAAGGAA CCTGTGTCAG ACCTTCAGCT AGGACTCGAT GCAGTTGAGC 3480
CAACTGCCCT ACATAAAACC CTGGAAACGC CTGCACATGA CAGGGCTGAG CCCAACAGCC 3540
AACTGGACTC GACTCACTCT GGACGGGGCA CAATGTATTC TTCCTGGGTA AAGAGCCCTG 3600
ACAGAACAGG AGTTAACTTC TCAGTGAACT CCAACTTGAG GGACCTGACA CCCTCGCATC 3660
AGTTGGAGGT TGGAGGAGGC TTCCGAATAA GTGAGTCAAA GTGCCTGATG CAGGATGATA 3720
CTAGAGGCAT GTTTATGGAA ACAACTGTGT TTTGTACTTC CGAAGATGGG CTTGTATCTG 3780
GTTTCGGACG GACTGTTAAT GACAATTTGA TCGACGGGAA TTGCACACCC CAGAATCCAC 3840
CACAAAAGAA AAAGGTTTCT CTATTAGAAT ACCGTAAGAG ACAACGTGAA GCTAGGAAAA 3900
GTGGCTCTAA GACAGAGAAC TTTCCACTCA TTAGTGTATC ACCCCATGCA AGTGGAAGCT 3960
TGAGCAACAA TGGTGATGGC TGTGCCAGCA GTAATGACAA TGGGGAGCAG GTGGACCACA 4020
CTGCTAGCCT ACCTTTACCA ACACCAGCTA CAGTTTATAA TGCCACTTCT GAAGAAACTA 4080
GCAATAACTG CCCTGTTAAG GATGCTACTG CTAGTGAGAA GAATGAACCA GAAGTTCAAT 4140
GGACTGCCTC AACTTCAGTG GAACAAGTCA GAGAAAGGAG TTATCAGAGA GCTTTACTTC 4200
TCAGTGATCA CCGAAAAGAT AAAGATAGTG GGGGAGAATC ACCATGTGTC TCATGTTCAC 4260
CGAGTCATGT TCAGTCTTCA CCTTCATCTC ATTCAAATCA CATACCCCAG TTGCAAGCTA 4320
AGGGCCCAGT CCCTTCTTTC AGTGAACTTA TGGAAGACCC TGATCCTGAA AATCCAGAAC 4380
CCACAACTAC GAATGAATGT CCATCCCCAG ATACTTCTCA AAATACTTGT AAAAGTCCTC 4440
CAAAAATGAG CAAGCCTGGT TCACCTGGAT CTGTAATTCC TGCTCAAGCA CACGGGAAAA 4500
TATTCACAAA ACCAGATCCC CAATGGGACT CCACAGTTAG TGCATCCGAA GCTGAAAATG 4560
GTGTTCACCT AAAAACAGAG CTCCAACAAA AACAGCTATC AAATAACAAC CAAGCACTTT 4620
CAAAGAATCA TCCTCCTCAG ACACACGTTC GTAATTCATC TGAGCAACTT TCACAAAAGC 4680
TGCCTTCTGT GCCAACAAAG TTGCACTGTC CTCCATCACC TCACCTAGAA AATCCTCCAA 4740
AGTCATCCAC GCCTCACACA CCTGTACAGC ATGGTTATCT TTCACCAAAG CCTCCTTCAC 4800
AGCAGTTAGG ATCTCCCTAC AGGCCTCATC ATTCACAGTC ACCTCAAGTT GGAACACCTC 4860
AGCGAGAGCC TCAAAGAAAC TTTTATCCAG CAGCACAGAA CCTTCCAGCC AATACTCAGC 4920
AGGCAACTTC TGGAACATTA TTTACACAGA CACCCTCAGG ACAATCTTCA GCAACATACA 4980
GTCAGTTTAA CCAACAAAGT CTGAACAGCA CGGCACCACC CCCTCCACCT CCTCCACCTC 5040
CTTCTTCGTC TTACTATCAA AACCAGCAGC CCTCTGCAAA CTTTCAGAAT TATAATCAGC 5100
TCAAAGGTAG TCTTTCTCAA CAAACTGTGT TTACATCAGG ACCAAATCAA GCACTTCCTG 5160
GCACCACAAG CCAGCAAACA GTTCCAGGAC ACCACGTGAC TCCAGGGCAT TTTTTGCCCT 5220
CTCAGAACCC TACCATTCAC CATCAAACTG CTGCTGCCGT AGTCCCCCCT CCTCCTCCAC 5280
CACCACCTGC TCCAGGACCG CACCTTGTAC AACAGCCGAA TTCCCATCAG CAACACTCTG 5340
TAGCACATGT AGTAGGGCCT GTTCATGCGG TCACCCCTGG GTCGCATATT CATTCTCAAA 5400
CTGCTGGACA CCACTTACCC CCACCCCCAC CCCCTCCTGG TCCTGCCCCT CATCACCATC 5460
CACCACCCCA TCCATCCACA GGACTCCAAG GTCTACAAGC ACAACACCAG CATGTTGTAA 5520
ATTCAGCACC CCCACCACCC CCTCCGCCGC CACCTTCCAG TGTTTTGGCT TCTGGGCATC 5580
ATACCACATC AGCTCAAGCC TTACACCACC CACCTCATCA AGGACCTCCA CTTTTTCCTT 5640
CGAGTGCTCA TCCAACTGTA CCACCGTATC CCTCACAAGC TACACATCAT ACCACTTTGG 5700
GACCGGGACC CCAGCACCAG CCTTCTGGAA CAGGGCCACA TTGTCCATTA CCTGTCACAG 5760
GTCCTCATCT CCAGCCCCAA GGACCAAACA GTATTCCAAC ACCTACTGCT TCAGGGTTCT 5820
GTCCTCATCC TGGCTCTGTG GCCCTGCCAC ATGGGGTTCA AGGACCTCAG CAGGCATCTC 5880
CAGTGCCTGG ACAGATTCCA ATTCACAGAG CACAGGTGCC ACCAACATTT CAAAACAATT 5940
ACCATGGGTC AGGGTGGCAT TAAAATGGAC TCCAAAAACA TTTTTTTAAA TGTTCTGTAA 6000
GATAAACTGT ATATTTCATA TGTACCTGTT AAGGTACTTT TTAAAGCTTG TACATGAACC 6060
TTTGTATAAA AAACACCAGT GCTCTTTCGT TGTATTTTTC TCATTTTTGC TTTTTAAAAT 6120
TCCTTTAAAA AATGTGCTGT TAAGCCAGTA TTAGGTATCT TTATTTTGTA AGTGAACATT 6180
CCAGCTGTTT TTTTCTGGCA GATCTGATGC TGATTTGATG CTGTATGATC TTTTTTTTTT 6240
TTTTAGTTAA ATTCATTTAG TGAATGTTCT ATTATTTTAT ACATACACAT TAAGTACTCA 6300
GCTAAGTAAT GGCACTATGA GGATTTTTTT TTTCTTTCCT GTCAGCAGCA GTTCTGTGAA 6360
TGCATCTTAG GTATAAAAAT GCAATACAGA TTTTTATATT TTGGTGTGGA CATGGCTCAT 6420
TTTGTTTTAC CAGTTATTTG CAAGCAAAAT GTAATTTAAT GTATAGATGA TTTCTAATGT 6480
CTCCTGACAA ACTGTAAATA CTGCATTTCT TTTGCGTATA TAATTGCTTA CAGCTTTTCT 6540
CATTTGATAT ATAGCATTGT ACATATGACA AGTCTTTTGC AAAACTGTGT GATCTTTGTG 6600
AAAGTAGTAC AGTATATGAC CTTTAATTTC TTTTTTATTT TAAATATACT GTCACACTGA 6660
AGCACTGGTT GGGCATTTTA ATTCATGTTA ATAAATCACA ATTATGTCAG TTTT 6715
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0325--Glycoprotein
KW-0338--Growth arrest
KW-0472--Membrane
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
PF00856--SET
Gene Ontology

GO:0005737--C:cytoplasm
GO:0045171--C:intercellular bridge
GO:0043231--C:intracellular membrane-bounded organelle
GO:0070688--C:MLL5-L complex
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0019899--F:enzyme binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0007050--P:cell cycle arrest
GO:0071300--P:cellular response to retinoic acid
GO:0006306--P:DNA methylation
GO:0030218--P:erythrocyte differentiation
GO:0051568--P:histone H3-K4 methylation
GO:0042119--P:neutrophil activation
GO:0002446--P:neutrophil mediated immunity
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0048384--P:retinoic acid receptor signaling pathway
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0163 ENSPTRP00000033495.4 Pan troglodytes 100 0.0 3268
WERAM-Paa-0032 ENSPANP00000012164.1 Papio anubis 99 0.0 3249
WERAM-Chs-0143 ENSCSAP00000007759.1 Chlorocebus sabaeus 99 0.0 3244
WERAM-Mam-0206 ENSMMUP00000029929.2 Macaca mulatta 99 0.0 3236
WERAM-Caj-0166 ENSCJAP00000029516.1 Callithrix jacchus 96 0.0 3154
WERAM-Bot-0086 ENSBTAP00000012129.5 Bos taurus 94 0.0 3064
WERAM-Loa-0050 ENSLAFP00000003655.3 Loxodonta africana 94 0.0 3041
WERAM-Myl-0033 ENSMLUP00000002454.2 Myotis lucifugus 92 0.0 2992
WERAM-Ptv-0028 ENSPVAP00000003472.1 Pteropus vampyrus 94 0.0 2984
WERAM-Mup-0213 ENSMPUP00000018147.1 Mustela putorius furo 92 0.0 2976
WERAM-Sus-0197 ENSSSCP00000024064.1 Sus scrofa 94 0.0 2949
WERAM-Prc-0142 ENSPCAP00000013150.1 Procavia capensis 90 0.0 2914
WERAM-Caf-0050 ENSCAFP00000006126.3 Canis familiaris 92 0.0 2902
WERAM-Aim-0150 ENSAMEP00000013827.1 Ailuropoda melanoleuca 89 0.0 2887
WERAM-Eqc-0129 ENSECAP00000015121.1 Equus caballus 90 0.0 2870
WERAM-Mum-0094 ENSMUSP00000092569.2 Mus musculus 89 0.0 2867
WERAM-Poa-0164 ENSPPYP00000020053.2 Pongo abelii 99 0.0 2859
WERAM-Sah-0030 ENSSHAP00000003493.1 Sarcophilus harrisii 86 0.0 2767
WERAM-Gog-0007 ENSGGOP00000000573.3 Gorilla gorilla 100 0.0 2725
WERAM-Dio-0018 ENSDORP00000002187.1 Dipodomys ordii 90 0.0 2684
WERAM-Fia-0128 ENSFALP00000010775.1 Ficedula albicollis 82 0.0 2663
WERAM-Nol-0095 ENSNLEP00000011036.1 Nomascus leucogenys 99 0.0 2660
WERAM-Meg-0070 ENSMGAP00000006680.1 Meleagris gallopavo 81 0.0 2652
WERAM-Gaga-0084 ENSGALP00000013244.4 Gallus gallus 81 0.0 2647
WERAM-Vip-0093 ENSVPAP00000008307.1 Vicugna pacos 91 0.0 2486
WERAM-Anc-0072 ENSACAP00000006960.3 Anolis carolinensis 78 0.0 2476
WERAM-Ova-0014 ENSOARP00000002440.1 Ovis aries 93 0.0 2448
WERAM-Mod-0157 ENSMODP00000021650.4 Monodelphis domestica 86 0.0 2438
WERAM-Dan-0045 ENSDNOP00000004456.3 Dasypus novemcinctus 90 0.0 2395
WERAM-Tag-0046 ENSTGUP00000003023.1 Taeniopygia guttata 81 0.0 2316
WERAM-Anp-0017 ENSAPLP00000002772.1 Anas platyrhynchos 81 0.0 2302
WERAM-Tut-0016 ENSTTRP00000001387.1 Tursiops truncatus 92 0.0 2236
WERAM-Ere-0106 ENSEEUP00000011549.1 Erinaceus europaeus 84 0.0 2127
WERAM-Lac-0154 ENSLACP00000018064.1 Latimeria chalumnae 68 0.0 2127
WERAM-Otg-0038 ENSOGAP00000002538.2 Otolemur garnettii 90 0.0 2053
WERAM-Soa-0044 ENSSARP00000004096.1 Sorex araneus 90 0.0 1846
WERAM-Cap-0009 ENSCPOP00000001208.2 Cavia porcellus 93 0.0 1682
WERAM-Pes-0016 ENSPSIP00000004109.1 Pelodiscus sinensis 88 0.0 1649
WERAM-Chh-0015 ENSCHOP00000001410.1 Choloepus hoffmanni 85 0.0 1324
WERAM-Tas-0028 ENSTSYP00000003044.1 Tarsius syrichta 87 0.0 1185
WERAM-Asm-0049 ENSAMXP00000006513.1 Astyanax mexicanus 54 0.0 1108
WERAM-Leo-0158 ENSLOCP00000019058.1 Lepisosteus oculatus 54 0.0 1103
WERAM-Orn-0002 ENSONIP00000000116.1 Oreochromis niloticus 64 0.0 974
WERAM-Xim-0052 ENSXMAP00000004648.1 Xiphophorus maculatus 62 0.0 959
WERAM-Pof-0196 ENSPFOP00000016384.2 Poecilia formosa 61 0.0 914
WERAM-Orla-0168 ENSORLP00000019951.1 Oryzias latipes 61 0.0 912
WERAM-Ora-0121 ENSOANP00000023671.3 Ornithorhynchus anatinus 93 0.0 866
WERAM-Tub-0061 ENSTBEP00000007542.1 Tupaia belangeri 84 0.0 847
WERAM-Xet-0164 ENSXETP00000049953.3 Xenopus tropicalis 82 0.0 748
WERAM-Ten-0136 ENSTNIP00000014334.1 Tetraodon nigroviridis 71 0.0 731
WERAM-Pem-0028 ENSPMAP00000004022.1 Petromyzon marinus 54 1e-143 509
WERAM-Ran-0145 ENSRNOP00000061252.3 Rattus norvegicus 79 3e-128 458
WERAM-Dar-0020 ENSDARP00000066902.4 Danio rerio 71 3e-109 395
WERAM-Tar-0194 ENSTRUP00000039967.1 Takifugu rubripes 76 6e-102 370
WERAM-Gam-0034 ENSGMOP00000003474.1 Gadus morhua 77 3e-87 322
WERAM-Drm-0057 FBpp0075510 Drosophila melanogaster 31 3e-47 189
WERAM-Scp-0010 SPAC22E12.11c.1:pep Schizosaccharomyces pombe 26 1e-22 107
WERAM-Scj-0037 EEB09211 Schizosaccharomyces japonicus 55 2e-18 93.2
WERAM-Cag-0025 CAG61876 Candida glabrata 24 3e-18 92.8
WERAM-Ocp-0053 ENSOPRP00000004587.1 Ochotona princeps 60 3e-15 83.2
WERAM-Ect-0013 ENSETEP00000000939.1 Echinops telfairi 60 3e-15 82.8
WERAM-Orc-0146 ENSOCUP00000012882.3 Oryctolagus cuniculus 60 3e-15 82.8
WERAM-Fec-0122 ENSFCAP00000011217.3 Felis catus 58 5e-15 82.0
WERAM-Mel-0025 EGG01272 Melampsora laricipopulina 30 8e-15 81.6
WERAM-Mae-0076 ENSMEUP00000007694.1 Macropus eugenii 60 8e-15 81.3
WERAM-Tum-0014 CAZ82803 Tuber melanosporum 46 2e-14 80.1
WERAM-Gaa-0026 ENSGACP00000004363.3 Gasterosteus aculeatus 51 5e-13 75.5
WERAM-Asg-0025 AAS53448 Ashbya gossypii 43 3e-12 73.2
WERAM-Coi-0006 EAS35986 Coccidioides immitis 46 6e-12 72.0
WERAM-Asni-0026 CADANGAP00008835 Aspergillus niger 44 9e-12 71.2
WERAM-Crn-0016 AAW42860 Cryptococcus neoformans 52 9e-12 71.2
WERAM-Asn-0031 CADANIAP00008424 Aspergillus nidulans 46 2e-11 70.1
WERAM-Ast-0018 CADATEAP00005962 Aspergillus terreus 47 3e-11 69.7
WERAM-Asf-0021 CADAFLAP00009941 Aspergillus flavus 44 6e-11 68.6
WERAM-Cym-0018 CML250CT Cyanidioschyzon merolae 45 7e-11 68.6
WERAM-Asc-0032 CADACLAP00007799 Aspergillus clavatus 47 7e-11 68.2
WERAM-Asfu-0006 CADAFUAP00001898 Aspergillus fumigatus 44 8e-11 68.2
WERAM-Aso-0002 CADAORAP00000519 Aspergillus oryzae 44 1e-10 67.8
WERAM-Sac-0027 YKR029C Saccharomyces cerevisiae 44 2e-10 66.6
WERAM-Ict-0161 ENSSTOP00000016952.1 Ictidomys tridecemlineatus 28 1e-09 64.3
WERAM-Kll-0022 CAG99888 Kluyveromyces lactis 50 2e-09 63.9
WERAM-Cis-0029 ENSCSAVP00000005982.1 Ciona savignyi 31 2e-09 63.9
WERAM-Cii-0057 ENSCINP00000025949.2 Ciona intestinalis 29 2e-09 63.9
WERAM-Mua-0138 GSMUA_Achr9P08570_001 Musa acuminata 31 2e-09 63.9
WERAM-Orr-0022 ORUFI02G21420.1 Oryza rufipogon 28 2e-09 63.5
WERAM-Orni-0022 ONIVA02G22370.1 Oryza nivara 28 2e-09 63.5
WERAM-Sei-0057 Si016071m Setaria italica 30 2e-09 63.5
WERAM-Orgl-0024 OGLUM02G20630.1 Oryza glumaepatula 28 2e-09 63.5
WERAM-Orb-0023 OBART02G20350.1 Oryza barthii 28 2e-09 63.5
WERAM-Sob-0071 Sb04g022620.1 Sorghum bicolor 30 2e-09 63.2
WERAM-Yal-0034 CAG78669 Yarrowia lipolytica 44 2e-09 63.2
WERAM-Ori-0025 BGIOSGA008417-PA Oryza indica 28 3e-09 63.2
WERAM-Lem-0036 CBX96221 Leptosphaeria maculans 42 3e-09 63.2
WERAM-Orp-0022 OPUNC02G18200.1 Oryza punctata 28 3e-09 63.2
WERAM-Viv-0117 VIT_18s0089g01050.t01 Vitis vinifera 56 3e-09 62.8
WERAM-Php-0036 PP1S183_22V6.1 Physcomitrella patens 28 4e-09 62.8
WERAM-Lep-0028 LPERR02G16340.1 Leersia perrieri 29 5e-09 62.4
WERAM-Pug-0019 EFP82446 Puccinia graminis 46 5e-09 62.0
WERAM-Ors-0021 OS02T0554000-01 Oryza sativa 28 6e-09 62.0
WERAM-Amt-0022 ERN08747 Amborella trichopoda 29 7e-09 61.6
WERAM-Scs-0008 EDN99291 Sclerotinia sclerotiorum 46 8e-09 61.6
Created Date 25-Jun-2016