WERAM Information

Tag Content
WERAM ID WERAM-Sac-0026
Ensembl Protein ID YKR008W
Uniprot Accession Q02206; RSC4_YEAST; D6VX74; Q6B1F7
Genbank Protein ID NP_012933.4
Protein Name Chromatin structure-remodeling complex subunit RSC4
Genbank Nucleotide ID NM_001179798.4
Gene Name RSC4;YKR008W;YK107
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YKR008W YKR008W YKR008W
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H3K14 K 17694091
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.10e-28 97.5 74 274
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.
Domain Profile
  Ac_Reader Bromodomain
  BROMO.txt   3 hevsepF.repvdpqleipdYydiikePmdLstikerleegnYss.peefvkDvrlifnNakaynenkss 70 
                +++ + F + p+++   +p+Yy+ i++Pm ++ ik+r  e  Y++ p++f+ Dv+l+ +N++ayne++s 
    YKR008W  74 KDIFKDFiKLPSRK--FHPQYYYKIQQPMSINEIKSRDYE--YEDgPSNFLLDVELLTKNCQAYNEYDSL 139
                56677787778887..8********************888..9999********************9986 PP
  BROMO.txt   4 evsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                ++sepF+e vd+  e+p+Yy+i++ Pm Ls +k++le g+Ys++ +f+ D+ l+f+Na  +n++++ +
    YKR008W 208 KLSEPFMELVDK-DELPEYYEIVHSPMALSIVKQNLEIGQYSKIYDFIIDMLLVFQNAHIFNDPSALI 274
                789*********.7*************************************************99866 PP
Protein Sequence
(Fasta)		MVVKKRKLAT EAGGSDERPK YLPGKHPKNQ EKTPHVDYNA PLNPKSELFL DDWHIPKFNR 60
FISFTLDVLI DKYKDIFKDF IKLPSRKFHP QYYYKIQQPM SINEIKSRDY EYEDGPSNFL 120
LDVELLTKNC QAYNEYDSLI VKNSMQVVML IEFEVLKAKN LKRNYLINSE VKAKLLHYLN 180
KLVDATEKKI NQALLGASSP KNLDDKVKLS EPFMELVDKD ELPEYYEIVH SPMALSIVKQ 240
NLEIGQYSKI YDFIIDMLLV FQNAHIFNDP SALIYKDATT LTNYFNYLIQ KEFFPELQDL 300
NERGEINLEF DKFEFENYLA IGGGGPAAAG ALAISALDND IEPESNREDL IDQADYDFNH 360
FEGLGNGYNR SLLTEDYLLN PNNFKKLIAK PETVQSEVKN ERSTTSDIEK TNSLESEHLK 420
IPKYNVIKSM QKEMQSLSEQ HTMEYKPYKL IQQIYIFSSK NLYSQATKPL LGSRPSCNQN 480
WVEYIFNGNE LSQNENAFSF MLQPMQTFLT LQSHLTSSLK DTETLLTINK EPVKSRTSNV 540
NSNLSQPQQQ ENDVIGNDTK QDIENLTIGG GNNNDIVGND NDKRNNITEI FDIRLSEGLN 600
HLMFRCEDKI SHETEFMNFW INVLP 625
Nucleotide Sequence
(Fasta)		ATGGTAGTTA AGAAGCGTAA GTTGGCAACT GAGGCCGGTG GCAGTGATGA AAGGCCTAAA 60
TACTTGCCGG GAAAACATCC TAAAAACCAA GAGAAAACTC CGCATGTGGA TTATAACGCC 120
CCATTAAACC CTAAATCTGA ACTTTTTCTA GATGACTGGC ATATACCTAA ATTTAATCGA 180
TTTATTAGTT TCACTTTGGA TGTTCTTATC GACAAATACA AAGATATTTT CAAAGATTTC 240
ATCAAACTAC CAAGTAGGAA GTTTCATCCA CAGTATTATT ACAAGATCCA GCAGCCAATG 300
TCTATTAATG AAATCAAGTC AAGAGATTAT GAATACGAAG ATGGTCCAAG TAATTTTCTT 360
TTGGATGTTG AGCTACTGAC AAAGAATTGT CAAGCTTACA ATGAATATGA CAGTTTGATT 420
GTAAAAAACT CCATGCAAGT AGTAATGTTG ATTGAATTTG AAGTATTGAA GGCAAAAAAT 480
TTGAAAAGAA ATTACTTAAT TAACAGCGAG GTCAAAGCCA AATTACTGCA CTATCTTAAT 540
AAGCTAGTTG ACGCCACGGA AAAGAAAATC AACCAGGCTC TGCTGGGTGC GTCATCTCCT 600
AAAAACTTAG ACGACAAAGT CAAGCTAAGT GAACCGTTTA TGGAATTAGT CGATAAAGAT 660
GAACTTCCTG AATATTATGA AATAGTGCAT AGCCCCATGG CTTTATCGAT CGTAAAGCAG 720
AACCTCGAAA TTGGTCAGTA TTCCAAGATA TATGATTTCA TCATTGATAT GCTTTTAGTT 780
TTTCAGAATG CTCATATATT CAATGATCCA AGCGCTTTGA TTTACAAAGA CGCAACAACT 840
TTAACAAATT ATTTTAACTA CTTAATACAA AAGGAATTCT TCCCAGAGTT ACAGGATTTA 900
AATGAACGTG GCGAAATTAA TTTAGAATTT GACAAATTCG AATTCGAAAA CTACTTAGCT 960
ATTGGTGGTG GTGGTCCAGC CGCAGCAGGT GCGTTAGCTA TATCTGCTCT TGATAATGAT 1020
ATTGAGCCAG AATCTAACCG TGAAGATCTT ATTGATCAAG CAGATTATGA TTTCAATCAT 1080
TTCGAAGGTC TCGGCAATGG TTATAATCGT TCTCTCCTAA CTGAAGATTA TTTACTGAAC 1140
CCAAACAACT TCAAAAAGTT AATAGCCAAA CCGGAAACAG TGCAATCCGA AGTCAAAAAT 1200
GAAAGATCAA CGACATCTGA TATTGAGAAG ACAAACTCCT TAGAGAGCGA ACATTTAAAA 1260
ATCCCCAAAT ACAATGTTAT AAAATCCATG CAAAAAGAAA TGCAATCACT CTCAGAGCAA 1320
CACACCATGG AGTATAAGCC CTATAAATTA ATACAACAAA TTTACATTTT TTCTTCTAAA 1380
AATTTGTATT CGCAGGCAAC TAAGCCTTTA CTGGGTTCAA GGCCATCATG CAATCAAAAT 1440
TGGGTAGAGT ATATTTTCAA TGGTAATGAA TTGAGTCAAA ATGAAAACGC TTTCTCCTTC 1500
ATGTTACAAC CCATGCAAAC TTTTTTAACA TTACAGTCTC ATTTGACCTC ATCATTAAAG 1560
GATACAGAGA CTTTATTAAC CATTAATAAA GAGCCAGTGA AGTCTAGAAC TTCAAATGTA 1620
AACAGTAACC TTTCCCAACC TCAGCAACAA GAAAATGATG TTATTGGAAA CGATACGAAG 1680
CAAGATATAG AAAATTTGAC AATCGGCGGC GGCAACAATA ACGATATTGT TGGTAACGAT 1740
AATGATAAAC GTAATAATAT AACCGAAATC TTTGATATTC GCTTATCAGA AGGTTTAAAT 1800
CATTTGATGT TTAGGTGTGA GGACAAAATA TCTCATGAAA CGGAATTCAT GAATTTCTGG 1860
ATAAATGTCT TACCATGA 1879
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
Pfam

PF00439--Bromodomain
Gene Ontology

GO:0016586--C:RSC complex
GO:0070577--F:lysine-acetylated histone binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0006337--P:nucleosome disassembly
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006368--P:transcription elongation from RNA polymerase II promoter
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0024 CAG61835 Candida glabrata 45 2e-137 486
WERAM-Asg-0019 AAS52393 Ashbya gossypii 43 7e-123 438
WERAM-Kll-0001 CAH02717 Kluyveromyces lactis 41 1e-110 397
WERAM-Kop-0023 CAY69997 Komagataella pastoris 33 4e-18 90.5
WERAM-Caa-0007 KGT71088 Candida albicans 31 7e-17 86.7
WERAM-Tar-0060 ENSTRUP00000012797.1 Takifugu rubripes 29 4e-15 80.5
WERAM-Orn-0046 ENSONIP00000005237.1 Oreochromis niloticus 28 8e-14 76.3
WERAM-Asm-0183 ENSAMXP00000017832.1 Astyanax mexicanus 30 8e-14 76.3
WERAM-Drm-0071 FBpp0084115 Drosophila melanogaster 32 8e-14 76.3
WERAM-Ten-0179 ENSTNIP00000000020.1 Tetraodon nigroviridis 29 9e-14 76.3
WERAM-Leo-0097 ENSLOCP00000012945.1 Lepisosteus oculatus 29 2e-13 75.1
WERAM-Loa-0149 ENSLAFP00000013467.3 Loxodonta africana 27 3e-13 74.3
WERAM-Pof-0215 ENSPFOP00000017402.2 Poecilia formosa 28 4e-13 74.3
WERAM-Nol-0072 ENSNLEP00000008739.1 Nomascus leucogenys 27 4e-13 74.3
WERAM-Hos-0176 ENSP00000296302.7 Homo sapiens 27 4e-13 74.3
WERAM-Tut-0097 ENSTTRP00000008126.1 Tursiops truncatus 27 4e-13 73.9
WERAM-Soa-0017 ENSSARP00000001974.1 Sorex araneus 27 4e-13 73.9
WERAM-Aim-0095 ENSAMEP00000008972.1 Ailuropoda melanoleuca 27 4e-13 73.9
WERAM-Poa-0124 ENSPPYP00000015444.1 Pongo abelii 27 4e-13 73.9
WERAM-Orc-0094 ENSOCUP00000008471.3 Oryctolagus cuniculus 27 4e-13 73.9
WERAM-Mum-0174 ENSMUSP00000022471.5 Mus musculus 27 4e-13 73.9
WERAM-Eqc-0003 ENSECAP00000002821.1 Equus caballus 27 4e-13 73.9
WERAM-Chs-0163 ENSCSAP00000009501.1 Chlorocebus sabaeus 27 4e-13 73.9
WERAM-Ran-0165 ENSRNOP00000016581.6 Rattus norvegicus 27 4e-13 73.9
WERAM-Ptv-0139 ENSPVAP00000011863.1 Pteropus vampyrus 27 4e-13 73.9
WERAM-Caj-0076 ENSCJAP00000012664.2 Callithrix jacchus 27 4e-13 73.9
WERAM-Paa-0106 ENSPANP00000005285.1 Papio anubis 27 4e-13 73.9
WERAM-Ocp-0093 ENSOPRP00000008540.1 Ochotona princeps 27 5e-13 73.9
WERAM-Caf-0099 ENSCAFP00000013411.3 Canis familiaris 27 5e-13 73.9
WERAM-Gog-0174 ENSGGOP00000015624.2 Gorilla gorilla 27 5e-13 73.9
WERAM-Dan-0006 ENSDNOP00000000791.3 Dasypus novemcinctus 27 5e-13 73.9
WERAM-Chh-0024 ENSCHOP00000002413.1 Choloepus hoffmanni 27 5e-13 73.9
WERAM-Mup-0193 ENSMPUP00000016659.1 Mustela putorius furo 27 5e-13 73.9
WERAM-Myl-0100 ENSMLUP00000008015.2 Myotis lucifugus 27 5e-13 73.6
WERAM-Mam-0166 ENSMMUP00000022859.2 Macaca mulatta 27 5e-13 73.6
WERAM-Cap-0001 ENSCPOP00000000245.2 Cavia porcellus 28 5e-13 73.6
WERAM-Lac-0004 ENSLACP00000000435.1 Latimeria chalumnae 29 5e-13 73.6
WERAM-Fec-0154 ENSFCAP00000014578.3 Felis catus 27 5e-13 73.6
WERAM-Pat-0127 ENSPTRP00000040860.3 Pan troglodytes 27 5e-13 73.6
WERAM-Otg-0052 ENSOGAP00000003653.2 Otolemur garnettii 27 6e-13 73.6
WERAM-Xim-0203 ENSXMAP00000016199.1 Xiphophorus maculatus 28 9e-13 72.8
WERAM-Scj-0030 EEB08625 Schizosaccharomyces japonicus 40 1e-12 72.8
WERAM-Xet-0091 ENSXETP00000029930.3 Xenopus tropicalis 28 1e-12 72.4
WERAM-Cis-0074 ENSCSAVP00000015952.1 Ciona savignyi 28 1e-12 72.4
WERAM-Lab-0037 EDR00710 Laccaria bicolor 46 2e-12 72.0
WERAM-Dar-0008 ENSDARP00000045970.6 Danio rerio 30 2e-12 72.0
WERAM-Anp-0045 ENSAPLP00000005113.1 Anas platyrhynchos 27 2e-12 71.6
WERAM-Pytr-0026 EDU51211 Pyrenophora triticirepentis 41 3e-12 71.2
WERAM-Pyt-0028 EFQ88722 Pyrenophora teres 41 3e-12 71.2
WERAM-Anc-0076 ENSACAP00000007182.3 Anolis carolinensis 28 3e-12 71.2
WERAM-Gaa-0008 ENSGACP00000001272.1 Gasterosteus aculeatus 28 3e-12 71.2
WERAM-Tag-0085 ENSTGUP00000006047.1 Taeniopygia guttata 26 3e-12 71.2
WERAM-Orla-0007 ENSORLP00000000719.1 Oryzias latipes 27 3e-12 71.2
WERAM-Gaga-0016 ENSGALP00000002412.3 Gallus gallus 27 3e-12 70.9
WERAM-Pes-0103 ENSPSIP00000013011.1 Pelodiscus sinensis 27 4e-12 70.9
WERAM-Meg-0004 ENSMGAP00000000289.2 Meleagris gallopavo 27 4e-12 70.9
WERAM-Sah-0062 ENSSHAP00000007287.1 Sarcophilus harrisii 27 5e-12 70.5
WERAM-Mim-0025 ENSMICP00000002632.1 Microcebus murinus 27 5e-12 70.5
WERAM-Mae-0062 ENSMEUP00000005823.1 Macropus eugenii 27 5e-12 70.5
WERAM-Fia-0110 ENSFALP00000009340.1 Ficedula albicollis 26 5e-12 70.5
WERAM-Pem-0008 ENSPMAP00000001026.1 Petromyzon marinus 27 6e-12 70.1
WERAM-Scp-0035 SPBC4B4.03.1:pep Schizosaccharomyces pombe 29 7e-12 70.1
WERAM-Mod-0092 ENSMODP00000014158.3 Monodelphis domestica 26 7e-12 70.1
WERAM-Cae-0033 C26C6.1a Caenorhabditis elegans 25 8e-12 69.7
WERAM-Bot-0136 ENSBTAP00000019672.5 Bos taurus 27 8e-12 69.7
WERAM-Ova-0018 ENSOARP00000002926.1 Ovis aries 27 8e-12 69.7
WERAM-Osl-0047 ABO97278 Ostreococcus lucimarinus 34 1e-11 69.3
WERAM-Ved-0009 EGY20303 Verticillium dahliae 33 1e-11 69.3
WERAM-Cii-0047 ENSCINP00000018331.3 Ciona intestinalis 36 1e-11 69.3
WERAM-Gam-0080 ENSGMOP00000008515.1 Gadus morhua 27 2e-11 68.6
WERAM-Tas-0069 ENSTSYP00000006269.1 Tarsius syrichta 26 4e-11 67.4
WERAM-Ere-0137 ENSEEUP00000014195.1 Erinaceus europaeus 26 4e-11 67.4
WERAM-Map-0011 MAPG_03557T0 Magnaporthe poae 31 5e-11 67.4
WERAM-Yal-0029 CAG80283 Yarrowia lipolytica 26 7e-11 66.6
WERAM-Vip-0015 ENSVPAP00000001554.1 Vicugna pacos 35 7e-11 66.6
WERAM-Ict-0012 ENSSTOP00000000650.2 Ictidomys tridecemlineatus 35 7e-11 66.6
WERAM-Cym-0031 CMS256CT Cyanidioschyzon merolae 41 1e-10 65.5
WERAM-Gag-0018 GGTG_05183T0 Gaeumannomyces graminis 31 2e-10 65.5
WERAM-Ect-0027 ENSETEP00000002030.1 Echinops telfairi 36 2e-10 65.1
WERAM-Fuo-0019 FOXG_03701P0 Fusarium oxysporum 33 2e-10 64.7
WERAM-Mao-0032 MGG_11716T0 Magnaporthe oryzae 36 3e-10 64.3
WERAM-Chg-0013 EAQ90930 Chaetomium globosum 37 3e-10 64.3
WERAM-Ast-0039 CADATEAP00010104 Aspergillus terreus 37 3e-10 64.3
WERAM-Sus-0003 ENSSSCP00000000074.2 Sus scrofa 36 4e-10 64.3
WERAM-Ora-0133 ENSOANP00000026201.2 Ornithorhynchus anatinus 37 4e-10 64.3
WERAM-Asn-0037 CADANIAP00009586 Aspergillus nidulans 35 4e-10 63.9
WERAM-Nec-0019 EFNCRP00000003186 Neurospora crassa 37 4e-10 63.9
WERAM-Prc-0143 ENSPCAP00000013247.1 Procavia capensis 37 5e-10 63.5
WERAM-Dio-0096 ENSDORP00000009643.1 Dipodomys ordii 36 5e-10 63.5
WERAM-Asni-0032 CADANGAP00011296 Aspergillus niger 39 6e-10 63.5
WERAM-Asf-0035 CADAFLAP00012117 Aspergillus flavus 34 1e-09 62.4
WERAM-Asc-0016 CADACLAP00003898 Aspergillus clavatus 38 1e-09 62.4
Created Date 25-Jun-2016