WERAM Information

Tag Content
WERAM ID WERAM-Sac-0017
Ensembl Protein ID YGR056W
Uniprot Accession P53236; RSC1_YEAST; D6VUJ1; Q45U30
Genbank Protein ID NP_011570.1
Protein Name Chromatin structure-remodeling complex subunit RSC1
Genbank Nucleotide ID NM_001181185.1
Gene Name RSC1;YGR056W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGR056W YGR056W YGR056W
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 12419247
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 2.40e-29 99.7 39 872
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in meiotic sporulation through regulating IME2 expression.
Domain Profile
  Ac_Reader Bromodomain
  BROMO.txt 12 pvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72
               p +  +e+pdYy ii++P+ L+t k+rl    Y+sp++fv+D+ +i +Na++yn ++s ++
    YGR056W 39 PPK--KEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIY 95
               333..59*********************99..************************99886 PP
  BROMO.txt   4 evsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkss 70 
                 +  +F++  d+  e p Yy +i  P+ L  i++++++++Y++ + f +D++l+++N+k y+++++s
    YGR056W 258 TLTLCFEKLPDR-NEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQS 323
                5678999999**.6*************************************************9987 PP
  BROMO.txt  30 mdLstik 36 
                mdLsti 
    YGR056W 866 MDLSTIA 872
                9****95 PP
Protein Sequence
(Fasta)		MVEQDNGFLQ KLLKTQYDAV FHLKDENGIE IYPIFNVLPP KKEYPDYYII IRNPISLNTL 60
KKRLPHYTSP QDFVNDFAQI PWNAMTYNAK DSVIYKYAIL LESFIKGKIV HNIRKHYPEV 120
TYPSLGRIPE IFAESMQPSD LSSNPINTQE NDEKAGLNPE MKMAFAKLDS SITERKPTNQ 180
DYRMQQKNSP AFPTHSASIT PQPLASPTPV VNYANITSAH PKTHVRRGRP PVIDLPYVLR 240
IKNILKMMRR EVDQNNKTLT LCFEKLPDRN EEPTYYSVIT DPICLMDIRK KVKSRKYRNF 300
HTFEEDFQLM LTNFKLYYSQ DQSNIIRAQL LEKNFNRLVR IELSKPDEDY LPEGELRYPL 360
DDVEINDEKY QIGDWVLLHN PNDINKPIVG QIFRLWSTTD GNKWLNACWY FRPEQTVHRV 420
DRLFYKNEVM KTGQYRDHPI QDIKGKCYVI HFTRFQRGDP STKVNGPQFV CEFRYNESDK 480
VFNKIRTWKA CLPEELRDQD EPTIPVNGRK FFKYPSPIAD LLPANATLND KVPEPTEGAP 540
TAPPLVGAVY LGPKLERDDL GEYSTSDDCP RYIIRPNDPP EEGKIDYETG TIITDTLTTS 600
SMPRVNSSST IRLPTLKQTK SIPSSNFRSS SNTPLLHQNF NQTSNFLKLE NMNNSSHNLL 660
SHPSVPKFQS PSLLEQSSRS KYHSAKKQTQ LSSTAPKKPA SKSFTLSSMI NTLTAHTSKY 720
NFNHIVIEAP GAFVVPVPME KNIRTIQSTE RFSRSNLKNA QNLGNTAIND INTANEQIIW 780
FKGPGVKITE RVIDSGNDLV RVPLNRWFCK NKRRKLDYED IEEDVMEPPN DFSEDMIANI 840
FNPPPSLNLD MDLNLSPSSN NSSNFMDLST IASGDNDGKE CDTAEESEDE NEDTEDEHEI 900
EDIPTTSAFG LNSSAEYLAF RLREFNKL 928
Nucleotide Sequence
(Fasta)		ATGGTGGAGC AAGATAATGG GTTTTTACAG AAGCTACTCA AAACACAATA CGATGCTGTC 60
TTCCATTTAA AGGATGAAAA TGGTATAGAA ATATATCCAA TATTCAATGT ACTGCCACCT 120
AAAAAAGAAT ATCCAGACTA TTACATTATA ATAAGGAATC CGATATCTTT AAACACTTTA 180
AAGAAACGAT TGCCCCATTA TACATCGCCA CAAGATTTTG TTAACGATTT TGCGCAAATT 240
CCTTGGAATG CAATGACATA CAATGCAAAA GATTCAGTAA TTTACAAATA TGCCATTCTT 300
CTTGAGTCTT TTATTAAAGG AAAGATCGTG CACAATATAA GAAAACATTA TCCCGAGGTG 360
ACATATCCAT CTCTAGGTCG AATTCCGGAA ATATTCGCAG AGAGTATGCA ACCCTCCGAT 420
TTATCCTCGA ACCCCATTAA TACACAGGAA AATGATGAAA AGGCTGGCTT AAATCCAGAG 480
ATGAAAATGG CTTTCGCAAA ACTAGATAGT TCGATCACTG AAAGGAAACC AACCAACCAA 540
GATTACAGGA TGCAACAAAA AAACTCACCA GCGTTTCCAA CCCATTCTGC TTCTATAACA 600
CCGCAGCCGC TGGCTTCACC TACTCCAGTT GTTAACTATG CAAATATTAC CTCGGCGCAT 660
CCCAAAACCC ATGTTAGACG CGGTAGACCA CCAGTAATTG ATCTACCCTA TGTACTGAGG 720
ATTAAGAATA TCTTGAAGAT GATGAGAAGA GAGGTCGACC AAAATAATAA GACGCTTACC 780
CTCTGTTTTG AAAAACTACC AGATAGAAAC GAGGAGCCAA CCTATTACTC TGTCATAACA 840
GATCCCATTT GTCTAATGGA TATTAGGAAA AAGGTTAAGT CCAGAAAATA TAGAAATTTC 900
CATACTTTTG AGGAAGACTT TCAATTAATG CTAACAAATT TTAAGCTTTA TTATTCTCAA 960
GATCAGAGCA ATATAATACG AGCTCAACTA TTGGAGAAAA ACTTCAATAG ATTAGTGCGA 1020
ATTGAATTAT CCAAACCTGA TGAAGACTAT TTACCTGAAG GTGAATTAAG ATATCCTCTA 1080
GATGATGTAG AAATCAATGA TGAGAAATAC CAGATAGGTG ATTGGGTTCT TTTACATAAT 1140
CCAAACGACA TCAATAAACC CATTGTTGGC CAGATTTTTA GATTATGGTC TACTACAGAT 1200
GGAAACAAAT GGTTGAATGC TTGCTGGTAT TTTAGGCCAG AACAAACCGT TCATCGGGTG 1260
GATAGGTTAT TCTACAAGAA TGAGGTCATG AAAACTGGTC AATATAGAGA TCATCCTATT 1320
CAGGATATTA AGGGAAAGTG CTACGTTATT CATTTTACCA GATTCCAGCG TGGGGATCCT 1380
AGCACGAAAG TCAATGGTCC TCAATTTGTT TGCGAATTCC GTTATAATGA AAGTGATAAG 1440
GTTTTCAACA AAATCAGGAC TTGGAAAGCT TGCCTGCCGG AAGAACTCCG TGACCAAGAT 1500
GAGCCTACGA TACCTGTTAA TGGAAGAAAA TTTTTTAAAT ACCCTTCTCC AATAGCAGAT 1560
TTGTTACCAG CAAACGCAAC TCTAAATGAC AAAGTTCCAG AACCCACGGA GGGAGCCCCA 1620
ACTGCCCCAC CTTTGGTAGG CGCTGTATAT TTAGGCCCCA AATTAGAGAG GGATGATCTG 1680
GGAGAGTATT CAACTTCTGA TGACTGCCCT CGATACATAA TCAGACCAAA TGATCCACCA 1740
GAAGAAGGTA AAATAGATTA CGAAACAGGA ACAATAATTA CAGATACCTT AACCACAAGC 1800
AGTATGCCCA GAGTGAACAG TTCCTCCACA ATACGTTTAC CCACTTTAAA GCAGACTAAA 1860
TCAATTCCCA GCTCCAATTT CAGGTCCTCA TCAAATACTC CACTATTGCA TCAGAACTTC 1920
AATCAGACTT CCAATTTTTT GAAATTAGAA AACATGAATA ATAGTTCTCA TAATTTACTA 1980
TCACATCCTT CCGTTCCTAA GTTTCAATCG CCCTCTTTAT TAGAACAGAG TAGTCGCTCT 2040
AAATACCATA GTGCAAAAAA ACAGACACAG CTATCATCAA CAGCTCCCAA AAAGCCTGCA 2100
TCTAAAAGTT TTACATTATC CTCAATGATT AATACCTTAA CTGCTCATAC CTCGAAGTAC 2160
AACTTCAACC ATATTGTTAT TGAAGCCCCG GGTGCATTTG TGGTTCCTGT ACCAATGGAA 2220
AAAAATATAA GAACCATCCA ATCGACAGAA CGTTTCAGTA GATCAAATCT AAAAAACGCT 2280
CAAAATCTCG GTAATACTGC TATTAATGAC ATAAATACTG CAAATGAGCA AATAATATGG 2340
TTCAAAGGGC CCGGTGTAAA AATCACAGAG AGAGTTATTG ATTCCGGAAA TGATTTAGTA 2400
CGGGTACCTT TGAATAGATG GTTCTGTAAA AACAAAAGGA GAAAACTGGA TTACGAAGAC 2460
ATTGAAGAAG ATGTTATGGA ACCACCAAAT GACTTCAGCG AAGATATGAT TGCTAATATT 2520
TTTAATCCTC CGCCGAGCTT GAATTTAGAT ATGGATTTAA ATCTAAGCCC ATCCTCGAAT 2580
AACTCTTCTA ATTTCATGGA TTTAAGCACA ATTGCAAGCG GTGATAACGA TGGGAAAGAA 2640
TGCGATACGG CGGAGGAGAG TGAAGACGAA AACGAAGATA CAGAAGACGA GCACGAAATT 2700
GAAGATATCC CGACCACGTC TGCTTTTGGC TTAAATTCTT CCGCTGAATA CCTTGCATTC 2760
AGATTACGAG AATTTAATAA ATTATGA 2788
Sequence Source Ensembl
Keyword

KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR001025--BAH_dom
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
PROSITE

PS51038--BAH
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
Pfam

PF01426--BAH
PF00439--Bromodomain
Gene Ontology

GO:0016586--C:RSC complex
GO:0003682--F:chromatin binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0006302--P:double-strand break repair
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0006337--P:nucleosome disassembly
GO:0042173--P:regulation of sporulation resulting in formation of a cellular spore
GO:0006355--P:regulation of transcription, DNA-templated
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0006368--P:transcription elongation from RNA polymerase II promoter
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0022 CAG61377 Candida glabrata 49 0.0 762
WERAM-Asg-0002 AAS50766 Ashbya gossypii 47 0.0 687
WERAM-Kll-0012 CAH02513 Kluyveromyces lactis 62 5e-143 506
WERAM-Caa-0002 KGT72463 Candida albicans 39 1e-110 398
WERAM-Kop-0018 CAY69884 Komagataella pastoris 32 4e-105 380
WERAM-Trr-0029 EGR48342 Trichoderma reesei 37 7e-78 290
WERAM-Yal-0009 CAG81276 Yarrowia lipolytica 45 2e-77 288
WERAM-Coi-0013 EAS36730 Coccidioides immitis 46 2e-76 285
WERAM-Nec-0019 EFNCRP00000003186 Neurospora crassa 45 3e-74 277
WERAM-Asn-0037 CADANIAP00009586 Aspergillus nidulans 45 4e-74 277
WERAM-Tum-0020 CAZ83686 Tuber melanosporum 45 2e-73 275
WERAM-Gag-0018 GGTG_05183T0 Gaeumannomyces graminis 43 2e-73 275
WERAM-Trv-0007 EHK19049 Trichoderma virens 46 3e-73 274
WERAM-Map-0011 MAPG_03557T0 Magnaporthe poae 42 9e-72 269
WERAM-Chg-0002 EAQ92149 Chaetomium globosum 45 1e-70 265
WERAM-Ast-0019 CADATEAP00006441 Aspergillus terreus 45 1e-70 265
WERAM-Pyt-0014 EFQ92509 Pyrenophora teres 43 3e-70 264
WERAM-Pytr-0022 EDU49374 Pyrenophora triticirepentis 42 6e-70 263
WERAM-Ved-0009 EGY20303 Verticillium dahliae 43 7e-70 263
WERAM-Asc-0016 CADACLAP00003898 Aspergillus clavatus 45 7e-70 263
WERAM-Lem-0030 CBX97973 Leptosphaeria maculans 43 3e-69 261
WERAM-Asfu-0020 CADAFUAP00005112 Aspergillus fumigatus 45 4e-69 260
WERAM-Phn-0023 SNOT_11997 Phaeosphaeria nodorum 42 5e-69 260
WERAM-Fuo-0019 FOXG_03701P0 Fusarium oxysporum 44 7e-69 259
WERAM-Mao-0037 MGG_13532T0 Magnaporthe oryzae 42 2e-68 258
WERAM-Asni-0028 CADANGAP00009247 Aspergillus niger 44 6e-68 256
WERAM-Asf-0035 CADAFLAP00012117 Aspergillus flavus 44 1e-67 256
WERAM-Scj-0030 EEB08625 Schizosaccharomyces japonicus 41 6e-63 240
WERAM-Scp-0035 SPBC4B4.03.1:pep Schizosaccharomyces pombe 40 5e-58 223
WERAM-Miv-0026 MVLG_03897T0 Microbotryum violaceum 29 1e-39 162
WERAM-Spr-0039 CBQ69967 Sporisorium reilianum 28 4e-37 154
WERAM-Usm-0032 UM05557P0 Ustilago maydis 27 8e-36 150
WERAM-Pug-0004 EFP75536 Puccinia graminis 29 3e-33 141
WERAM-Lab-0037 EDR00710 Laccaria bicolor 28 4e-30 130
WERAM-Ect-0069 ENSETEP00000007816.1 Echinops telfairi 32 5e-20 97.4
WERAM-Ran-0165 ENSRNOP00000016581.6 Rattus norvegicus 37 6e-20 97.4
WERAM-Bot-0136 ENSBTAP00000019672.5 Bos taurus 36 6e-20 97.4
WERAM-Ova-0018 ENSOARP00000002926.1 Ovis aries 36 6e-20 97.4
WERAM-Tag-0085 ENSTGUP00000006047.1 Taeniopygia guttata 29 8e-20 97.1
WERAM-Mod-0092 ENSMODP00000014158.3 Monodelphis domestica 32 1e-19 96.7
WERAM-Sah-0062 ENSSHAP00000007287.1 Sarcophilus harrisii 32 1e-19 96.7
WERAM-Pes-0103 ENSPSIP00000013011.1 Pelodiscus sinensis 29 1e-19 96.3
WERAM-Fia-0110 ENSFALP00000009340.1 Ficedula albicollis 30 1e-19 96.3
WERAM-Mae-0062 ENSMEUP00000005823.1 Macropus eugenii 36 1e-19 96.3
WERAM-Mup-0193 ENSMPUP00000016659.1 Mustela putorius furo 35 2e-19 95.9
WERAM-Pof-0020 ENSPFOP00000001798.2 Poecilia formosa 35 2e-19 95.9
WERAM-Aim-0095 ENSAMEP00000008972.1 Ailuropoda melanoleuca 35 2e-19 95.9
WERAM-Gaa-0008 ENSGACP00000001272.1 Gasterosteus aculeatus 35 2e-19 95.9
WERAM-Xim-0011 ENSXMAP00000001291.1 Xiphophorus maculatus 35 2e-19 95.5
WERAM-Myl-0100 ENSMLUP00000008015.2 Myotis lucifugus 35 2e-19 95.5
WERAM-Fec-0154 ENSFCAP00000014578.3 Felis catus 35 2e-19 95.5
WERAM-Tar-0060 ENSTRUP00000012797.1 Takifugu rubripes 33 2e-19 95.5
WERAM-Anc-0076 ENSACAP00000007182.3 Anolis carolinensis 29 2e-19 95.5
WERAM-Lac-0004 ENSLACP00000000435.1 Latimeria chalumnae 31 2e-19 95.5
WERAM-Caf-0099 ENSCAFP00000013411.3 Canis familiaris 35 2e-19 95.5
WERAM-Orc-0094 ENSOCUP00000008471.3 Oryctolagus cuniculus 36 2e-19 95.5
WERAM-Prc-0022 ENSPCAP00000001837.1 Procavia capensis 36 2e-19 95.5
WERAM-Chs-0163 ENSCSAP00000009501.1 Chlorocebus sabaeus 36 2e-19 95.5
WERAM-Paa-0106 ENSPANP00000005285.1 Papio anubis 36 2e-19 95.5
WERAM-Hos-0176 ENSP00000296302.7 Homo sapiens 36 2e-19 95.5
WERAM-Gog-0174 ENSGGOP00000015624.2 Gorilla gorilla 36 2e-19 95.5
WERAM-Caj-0076 ENSCJAP00000012664.2 Callithrix jacchus 36 3e-19 95.1
WERAM-Otg-0052 ENSOGAP00000003653.2 Otolemur garnettii 36 3e-19 95.1
WERAM-Nol-0072 ENSNLEP00000008739.1 Nomascus leucogenys 36 3e-19 95.1
WERAM-Loa-0149 ENSLAFP00000013467.3 Loxodonta africana 36 3e-19 95.1
WERAM-Cap-0001 ENSCPOP00000000245.2 Cavia porcellus 36 3e-19 95.1
WERAM-Eqc-0003 ENSECAP00000002821.1 Equus caballus 36 3e-19 95.1
WERAM-Poa-0124 ENSPPYP00000015444.1 Pongo abelii 36 3e-19 95.1
WERAM-Pat-0127 ENSPTRP00000040860.3 Pan troglodytes 36 3e-19 95.1
WERAM-Mam-0166 ENSMMUP00000022859.2 Macaca mulatta 36 3e-19 95.1
WERAM-Ten-0178 ENSTNIP00000017661.1 Tetraodon nigroviridis 36 3e-19 95.1
WERAM-Ptv-0139 ENSPVAP00000011863.1 Pteropus vampyrus 36 3e-19 95.1
WERAM-Orla-0007 ENSORLP00000000719.1 Oryzias latipes 31 3e-19 95.1
WERAM-Mum-0174 ENSMUSP00000022471.5 Mus musculus 36 3e-19 95.1
WERAM-Dio-0033 ENSDORP00000003590.1 Dipodomys ordii 36 3e-19 95.1
WERAM-Asm-0183 ENSAMXP00000017832.1 Astyanax mexicanus 35 4e-19 94.7
WERAM-Anp-0045 ENSAPLP00000005113.1 Anas platyrhynchos 29 4e-19 94.7
WERAM-Orn-0222 ENSONIP00000023879.1 Oreochromis niloticus 35 4e-19 94.7
WERAM-Meg-0004 ENSMGAP00000000289.2 Meleagris gallopavo 29 5e-19 94.4
WERAM-Soa-0017 ENSSARP00000001974.1 Sorex araneus 31 5e-19 94.4
WERAM-Gaga-0016 ENSGALP00000002412.3 Gallus gallus 29 5e-19 94.4
WERAM-Leo-0097 ENSLOCP00000012945.1 Lepisosteus oculatus 31 9e-19 93.6
WERAM-Vip-0074 ENSVPAP00000006860.1 Vicugna pacos 31 2e-18 92.8
WERAM-Dar-0008 ENSDARP00000045970.6 Danio rerio 36 2e-18 92.4
WERAM-Xet-0091 ENSXETP00000029930.3 Xenopus tropicalis 35 2e-18 92.4
WERAM-Pem-0008 ENSPMAP00000001026.1 Petromyzon marinus 33 4e-18 91.3
WERAM-Gam-0080 ENSGMOP00000008515.1 Gadus morhua 32 4e-16 84.7
WERAM-Dan-0006 ENSDNOP00000000791.3 Dasypus novemcinctus 35 6e-16 84.0
WERAM-Mel-0004 EGG07692 Melampsora laricipopulina 27 6e-15 80.9
WERAM-Tut-0097 ENSTTRP00000008126.1 Tursiops truncatus 25 7e-15 80.5
WERAM-Cae-0033 C26C6.1a Caenorhabditis elegans 27 9e-14 77.0
WERAM-Mim-0025 ENSMICP00000002632.1 Microcebus murinus 38 3e-13 75.1
WERAM-Chh-0024 ENSCHOP00000002413.1 Choloepus hoffmanni 38 3e-13 75.1
WERAM-Tas-0069 ENSTSYP00000006269.1 Tarsius syrichta 38 4e-13 74.7
WERAM-Ocp-0093 ENSOPRP00000008540.1 Ochotona princeps 32 4e-13 74.7
WERAM-Ere-0137 ENSEEUP00000014195.1 Erinaceus europaeus 38 4e-13 74.7
WERAM-Drm-0071 FBpp0084115 Drosophila melanogaster 28 4e-12 71.6
WERAM-Scs-0025 EDO04534 Sclerotinia sclerotiorum 36 8e-12 70.5
WERAM-Ora-0094 ENSOANP00000028835.1 Ornithorhynchus anatinus 35 3e-10 65.5
WERAM-Sus-0123 ENSSSCP00000017502.3 Sus scrofa 44 4e-10 64.7
WERAM-Aso-0019 CADAORAP00003972 Aspergillus oryzae 27 6e-10 63.9
WERAM-Ict-0033 ENSSTOP00000002659.2 Ictidomys tridecemlineatus 44 8e-10 63.9
WERAM-Cis-0074 ENSCSAVP00000015952.1 Ciona savignyi 28 1e-09 63.5
WERAM-Tub-0135 ENSTBEP00000014802.1 Tupaia belangeri 30 3e-09 61.6
WERAM-Orbr-0115 OB10G17850.1 Oryza brachyantha 41 4e-09 61.6
WERAM-Zyt-0008 Mycgr3P111322 Zymoseptoria tritici 31 6e-09 60.8
Created Date 25-Jun-2016