WERAM Information

Tag Content
WERAM ID WERAM-Cae-0032
Ensembl Protein ID VC5.4.2
Uniprot Accession Q9TYU5; TIP60_CAEEL
Genbank Protein ID NP_504796.1
Protein Name Histone acetyltransferase Tip60 homolog
Genbank Nucleotide ID NM_072395.3
Gene Name MYS-1;TIP60;VC5.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00007029 VC5.4.2 VC5.4.2
WBGene00007029 VC5.4.1 VC5.4.1
Details
Type Family Domain Substrates AA References (PMIDs)
HAT MYST MYST-type HAT H2AK5 K 20188723; 20944745
Status Reviewed
Classification
Type Family E-value Score Start End
HAT MYST 2.60e-125 417.8 169 446
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A (PubMed:15068795). Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates (PubMed:15068795, PubMed:20181741).
Domain Profile
  HAT MYST
  MYST.txt   2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCllaklfldhkt 102
               +++n+e+ielg+ +i++wy++p+p++l++l+++yicefclky ksk++lkrh++kC + +pPgn+iy +dkls+fe+dG+k+k+y+qnlCllaklfldhkt
   VC5.4.2 169 RIRNVECIELGRSRIQPWYFAPYPQQLTSLDCIYICEFCLKYLKSKTCLKRHMEKCAMCHPPGNQIYSHDKLSFFEIDGRKNKSYAQNLCLLAKLFLDHKT 269
               689************************************************************************************************** PP
  MYST.txt 103 lyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgllsYrsyWkevllell... 200
               lyyd++pflFYvlte+dekg+h+vGyFskekesae+yn+aCilvlPp+q+kGyG lLiefsYels+ e+k+gsPekPLsdlgllsYrsyW++++++ l   
   VC5.4.2 270 LYYDTDPFLFYVLTEEDEKGHHIVGYFSKEKESAEEYNVACILVLPPFQKKGYGSLLIEFSYELSKIEQKTGSPEKPLSDLGLLSYRSYWSMAIMKELfaf 370
               ************************************************************************************************99999 PP
  MYST.txt 201 kekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwkp 276
               k+++  ++it++++s++t+i+ eD+vstl++l+l+k++kg+yi++ s++  + ++k+ ++ kkk+++++  l+w+p
   VC5.4.2 371 KRRHPGEDITVQDISQSTSIKREDVVSTLQQLDLYKYYKGSYIIVISDEKRQVYEKRIEAAKKKTRINPAALQWRP 446
               999999********************************************************************87 PP
Protein Sequence
(Fasta)		MTEPKKEIIE DENHGISKKI PTDPRQYEKV TEGCRLLVMM ASQEEERWAE VISRCRAANG 60
SIKFYVHYID CNRRLDEWVQ SDRLNLASCE LPKKGGKKGA HLREENRDSN ENEGKKSGRK 120
RKIPLLPMDD LKAESVDPLQ AISTMTSGST PSLRGSMSMV GHSEDAMTRI RNVECIELGR 180
SRIQPWYFAP YPQQLTSLDC IYICEFCLKY LKSKTCLKRH MEKCAMCHPP GNQIYSHDKL 240
SFFEIDGRKN KSYAQNLCLL AKLFLDHKTL YYDTDPFLFY VLTEEDEKGH HIVGYFSKEK 300
ESAEEYNVAC ILVLPPFQKK GYGSLLIEFS YELSKIEQKT GSPEKPLSDL GLLSYRSYWS 360
MAIMKELFAF KRRHPGEDIT VQDISQSTSI KREDVVSTLQ QLDLYKYYKG SYIIVISDEK 420
RQVYEKRIEA AKKKTRINPA ALQWRPKEYG KKRAQIMF 458
Nucleotide Sequence
(Fasta)		GAGCATGATT TCACAATTAT TTCTTGCATT TTTAAAGTTT TTTATTGATA AAATAGTAAA 60
ACTAACAACG GATAATATTA TTTTAAAATT AAAAAACTAG TTTGTTCATT TTTGGATCGA 120
TTTTTAGATG TTGTTCATGG ATTATGCACG CAAGAAAGTA CTATCGTTCA CATTTGATTG 180
CTATATTATT GAATATTGAA TTTTTCACAC AAAATTGTAC TATTTCCAGA TATTTATCAT 240
GACCGAGCCG AAGAAGGAGA TTATAGAGGA CGAAAATCAT GGAATATCCA AGAAAATACC 300
AACAGATCCC AGGCAATACG AGAAAGTTAC AGAGGGATGC CGGTTATTGG TCATGATGGC 360
TTCACAAGAA GAAGAAAGAT GGGCCGAAGT TATTTCAAGA TGCCGAGCTG CAAATGGTTC 420
AATTAAATTC TATGTCCATT ATATCGATTG CAACCGAAGA CTTGACGAAT GGGTTCAGTC 480
TGATAGGCTC AATTTAGCGT CGTGTGAGCT ACCAAAAAAA GGAGGAAAGA AAGGAGCACA 540
CTTGCGGGAA GAAAATCGAG ATTCGAATGA AAATGAAGGA AAGAAAAGCG GCCGAAAACG 600
AAAGATTCCA CTACTTCCGA TGGATGATCT CAAGGCGGAA TCCGTAGATC CATTACAAGC 660
AATTTCAACG ATGACCAGCG GATCTACTCC AAGTCTTCGA GGTTCCATGT CGATGGTCGG 720
CCATAGTGAA GATGCAATGA CAAGGATCCG AAATGTCGAA TGCATTGAAC TAGGAAGATC 780
ACGAATTCAG CCATGGTACT TTGCACCTTA TCCACAACAA TTGACAAGTT TGGATTGTAT 840
TTATATTTGC GAATTTTGTC TGAAATATCT AAAGTCGAAA ACTTGTCTGA AACGGCACAT 900
GGAAAAATGT GCAATGTGTC ACCCACCTGG CAATCAAATC TACAGTCACG ATAAACTTTC 960
ATTTTTTGAA ATCGACGGCC GCAAAAACAA AAGCTATGCT CAGAATCTAT GCCTGCTTGC 1020
CAAACTTTTT CTGGATCACA AGACTCTTTA CTATGACACG GATCCATTTT TGTTCTATGT 1080
GCTAACCGAA GAAGACGAGA AGGGTCATCA TATAGTTGGA TACTTTTCAA AAGAAAAAGA 1140
ATCAGCTGAA GAATATAATG TTGCGTGTAT TCTTGTGTTA CCTCCATTTC AAAAGAAAGG 1200
ATACGGAAGT TTGCTCATCG AATTCAGCTA TGAACTCTCG AAAATTGAAC AGAAGACAGG 1260
ATCACCCGAA AAACCACTAT CAGATTTGGG ACTTCTCTCA TATCGATCGT ACTGGTCAAT 1320
GGCCATCATG AAAGAGCTTT TCGCATTCAA AAGACGACAT CCAGGCGAAG ATATCACAGT 1380
TCAGGACATT TCACAAAGTA CATCGATTAA ACGAGAAGAT GTTGTGTCAA CGTTACAGCA 1440
ACTTGATCTA TACAAATACT ATAAGGGATC ATACATAATT GTGATTAGTG ATGAAAAGCG 1500
TCAAGTTTAT GAGAAACGGA TTGAGGCTGC GAAAAAGAAG ACACGAATTA ATCCAGCAGC 1560
TCTGCAATGG CGACCCAAAG AGTACGGAAA GAAAAGAGCG CAGATCATGT TCTAGCAACA 1620
ACGACATGTG TTCTCGCCAC GACGATCTCA ACCTGTACAT TAAAATATAA CACTCCGTTT 1680
TATCTCGCAT CTACACACCG AAAAGCTTAC GCTATCCCTT TATCATTCCC ACACCGCTCA 1740
GAGAGCGTAC GCCTCATTTC ATTTCATTTG TTCTGTGTAA TAATTTGACT TATTAGTCAC 1800
TTATTTTTTT AATGAAATTA TTCTTGAAT
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
PROSITE

PS51726--MYST_HAT
Pfam

PF01853--MOZ_SAS
PF11717--Tudor-knot
Gene Ontology

GO:0005634--C:nucleus
GO:0004402--F:histone acetyltransferase activity
GO:0001708--P:cell fate specification
GO:0007275--P:multicellular organism development
GO:0071168--P:protein localization to chromatin
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pes-0012 ENSPSIP00000003033.1 Pelodiscus sinensis 51 5e-127 451
WERAM-Cis-0037 ENSCSAVP00000008033.1 Ciona savignyi 51 5e-122 435
WERAM-Drm-0026 FBpp0305388 Drosophila melanogaster 65 1e-116 417
WERAM-Pem-0095 ENSPMAP00000009877.1 Petromyzon marinus 47 3e-116 416
WERAM-Pof-0118 ENSPFOP00000010397.2 Poecilia formosa 63 3e-114 409
WERAM-Anc-0092 ENSACAP00000008731.2 Anolis carolinensis 58 4e-114 409
WERAM-Tar-0204 ENSTRUP00000042555.1 Takifugu rubripes 63 4e-114 409
WERAM-Ten-0140 ENSTNIP00000014694.1 Tetraodon nigroviridis 60 6e-114 408
WERAM-Orn-0059 ENSONIP00000006736.1 Oreochromis niloticus 63 1e-113 407
WERAM-Gaa-0220 ENSGACP00000026977.1 Gasterosteus aculeatus 62 2e-113 407
WERAM-Dar-0011 ENSDARP00000020993.7 Danio rerio 63 3e-113 405
WERAM-Loa-0148 ENSLAFP00000013105.3 Loxodonta africana 55 4e-113 405
WERAM-Mae-0059 ENSMEUP00000005661.1 Macropus eugenii 55 7e-113 404
WERAM-Asm-0090 ENSAMXP00000009337.1 Astyanax mexicanus 62 9e-113 404
WERAM-Mim-0086 ENSMICP00000008081.1 Microcebus murinus 55 9e-113 404
WERAM-Ict-0036 ENSSTOP00000002802.2 Ictidomys tridecemlineatus 55 9e-113 404
WERAM-Fec-0001 ENSFCAP00000000037.1 Felis catus 55 9e-113 404
WERAM-Caf-0141 ENSCAFP00000019618.4 Canis familiaris 55 9e-113 404
WERAM-Ran-0258 ENSRNOP00000075290.1 Rattus norvegicus 55 1e-112 404
WERAM-Ova-0185 ENSOARP00000018945.1 Ovis aries 55 1e-112 404
WERAM-Nol-0060 ENSNLEP00000007058.1 Nomascus leucogenys 55 1e-112 404
WERAM-Otg-0148 ENSOGAP00000012652.2 Otolemur garnettii 55 1e-112 404
WERAM-Chs-0094 ENSCSAP00000004254.1 Chlorocebus sabaeus 55 1e-112 404
WERAM-Myl-0099 ENSMLUP00000007984.2 Myotis lucifugus 55 1e-112 404
WERAM-Paa-0161 ENSPANP00000005348.1 Papio anubis 55 1e-112 404
WERAM-Gog-0034 ENSGGOP00000003226.1 Gorilla gorilla 55 1e-112 404
WERAM-Caj-0015 ENSCJAP00000003637.2 Callithrix jacchus 55 1e-112 404
WERAM-Ptv-0181 ENSPVAP00000015987.1 Pteropus vampyrus 55 1e-112 404
WERAM-Pat-0029 ENSPTRP00000006709.4 Pan troglodytes 55 1e-112 403
WERAM-Cap-0147 ENSCPOP00000012331.2 Cavia porcellus 55 1e-112 403
WERAM-Sus-0095 ENSSSCP00000013803.2 Sus scrofa 55 2e-112 403
WERAM-Mup-0131 ENSMPUP00000011528.1 Mustela putorius furo 55 2e-112 403
WERAM-Mum-0065 ENSMUSP00000109271.2 Mus musculus 55 2e-112 403
WERAM-Aim-0200 ENSAMEP00000018340.1 Ailuropoda melanoleuca 55 2e-112 403
WERAM-Bot-0060 ENSBTAP00000007328.5 Bos taurus 55 2e-112 403
WERAM-Mod-0075 ENSMODP00000011971.3 Monodelphis domestica 55 2e-112 403
WERAM-Poa-0029 ENSPPYP00000003532.2 Pongo abelii 55 2e-112 403
WERAM-Hos-0204 ENSP00000366245.3 Homo sapiens 55 2e-112 403
WERAM-Sah-0020 ENSSHAP00000002166.1 Sarcophilus harrisii 58 2e-112 403
WERAM-Eqc-0112 ENSECAP00000013058.1 Equus caballus 57 3e-112 402
WERAM-Orc-0139 ENSOCUP00000015475.1 Oryctolagus cuniculus 54 4e-112 402
WERAM-Orla-0072 ENSORLP00000009350.1 Oryzias latipes 62 7e-112 401
WERAM-Gam-0136 ENSGMOP00000013953.1 Gadus morhua 61 1e-110 397
WERAM-Prc-0085 ENSPCAP00000007321.1 Procavia capensis 62 1e-110 397
WERAM-Tut-0195 ENSTTRP00000016047.1 Tursiops truncatus 54 3e-109 392
WERAM-Dan-0125 ENSDNOP00000015818.2 Dasypus novemcinctus 62 9e-109 391
WERAM-Xim-0058 ENSXMAP00000005202.1 Xiphophorus maculatus 67 1e-106 384
WERAM-Sac-0043 YOR244W Saccharomyces cerevisiae 45 6e-101 365
WERAM-Cag-0019 CAG60814 Candida glabrata 45 7e-101 365
WERAM-Asg-0006 AAS51364 Ashbya gossypii 45 1e-100 364
WERAM-Zyt-0007 Mycgr3P110775 Zymoseptoria tritici 41 1e-99 361
WERAM-Ocp-0142 ENSOPRP00000014936.1 Ochotona princeps 57 2e-98 357
WERAM-Ect-0144 ENSETEP00000016281.1 Echinops telfairi 55 2e-98 357
WERAM-Kop-0031 CAY71310 Komagataella pastoris 45 5e-98 355
WERAM-Yal-0014 CAG79133 Yarrowia lipolytica 45 9e-98 354
WERAM-Mam-0183 ENSMMUP00000026085.2 Macaca mulatta 58 4e-97 352
WERAM-Scj-0023 EEB07868 Schizosaccharomyces japonicus 45 9e-97 351
WERAM-Kll-0028 CAG98298 Kluyveromyces lactis 43 1e-96 350
WERAM-Asni-0007 CADANGAP00002840 Aspergillus niger 41 4e-96 349
WERAM-Nec-0026 EFNCRP00000004952 Neurospora crassa 41 5e-96 348
WERAM-Scp-0019 SPAC637.12c.1:pep Schizosaccharomyces pombe 44 8e-96 348
WERAM-Asc-0035 CADACLAP00008330 Aspergillus clavatus 41 3e-95 346
WERAM-Asn-0006 CADANIAP00000591 Aspergillus nidulans 43 5e-95 345
WERAM-Lac-0091 ENSLACP00000011674.1 Latimeria chalumnae 54 7e-95 345
WERAM-Ast-0028 CADATEAP00008199 Aspergillus terreus 42 3e-94 342
WERAM-Tum-0017 CAZ83346 Tuber melanosporum 42 3e-94 342
WERAM-Sem-0136 EFJ32871 Selaginella moellendorffii 46 6e-94 342
WERAM-Lem-0041 CBX89959 Leptosphaeria maculans 40 7e-94 341
WERAM-Chg-0018 EAQ87183 Chaetomium globosum 41 9e-94 341
WERAM-Aso-0004 CADAORAP00000594 Aspergillus oryzae 40 1e-93 341
WERAM-Asf-0023 CADAFLAP00010026 Aspergillus flavus 40 1e-93 341
WERAM-Coi-0003 EAS35401 Coccidioides immitis 42 4e-93 338
WERAM-Caa-0014 KGT70072 Candida albicans 41 5e-93 338
WERAM-Asfu-0016 CADAFUAP00003874 Aspergillus fumigatus 41 6e-93 338
WERAM-Fuo-0033 FOXG_11372P0 Fusarium oxysporum 40 1e-92 337
WERAM-Glm-0035 GLYMA04G16180.1 Glycine max 46 1e-92 337
WERAM-Pytr-0028 EDU42207 Pyrenophora triticirepentis 40 2e-92 337
WERAM-Pyt-0015 EFQ92495 Pyrenophora teres 41 2e-92 337
WERAM-Trv-0027 EHK15825 Trichoderma virens 40 2e-92 337
WERAM-Brr-0045 Bra009399.1-P Brassica rapa 46 2e-92 336
WERAM-Pot-0065 POPTR_0005s16280.1 Populus trichocarpa 46 3e-92 336
WERAM-Viv-0113 VIT_18s0001g04100.t01 Vitis vinifera 46 3e-92 336
WERAM-Bro-0183 Bo9g173870.1 Brassica oleracea 46 3e-92 336
WERAM-Arl-0101 fgenesh2_kg.6__ 927__ AT5G09740.1 Arabidopsis lyrata 46 4e-92 336
WERAM-Gaga-0176 ENSGALP00000041010.1 Gallus gallus 70 4e-92 335
WERAM-Art-0119 AT5G09740.1 Arabidopsis thaliana 46 4e-92 335
WERAM-Met-0059 AES68391 Medicago truncatula 46 4e-92 335
WERAM-Prp-0062 EMJ23350 Prunus persica 46 5e-92 335
WERAM-Ved-0036 EGY20514 Verticillium dahliae 39 9e-92 334
WERAM-Amt-0019 ERM94321 Amborella trichopoda 46 1e-91 334
WERAM-Thc-0095 EOY16150 Theobroma cacao 46 1e-91 333
WERAM-Sol-0133 Solyc11g013520.1.1 Solanum lycopersicum 45 2e-91 333
WERAM-Zem-0080 GRMZM2G140288_P01 Zea mays 46 2e-91 333
WERAM-Php-0014 PP1S13_111V6.1 Physcomitrella patens 45 4e-91 332
WERAM-Crn-0008 AAW41586 Cryptococcus neoformans 53 6e-91 332
WERAM-Mua-0086 GSMUA_Achr6P10570_001 Musa acuminata 45 2e-90 330
WERAM-Orl-0045 KN538920.1_FGP012 Oryza longistaminata 44 2e-90 330
WERAM-Soa-0111 ENSSARP00000010510.1 Sorex araneus 48 2e-90 330
WERAM-Scs-0033 EDN98999 Sclerotinia sclerotiorum 39 2e-90 330
WERAM-Phn-0034 SNOT_16501 Phaeosphaeria nodorum 40 2e-90 330
WERAM-Sei-0114 Si029855m Setaria italica 45 4e-90 329
WERAM-Sob-0038 Sb02g039960.1 Sorghum bicolor 45 4e-90 329
WERAM-Ori-0077 BGIOSGA023877-PA Oryza indica 45 9e-90 328
WERAM-Gag-0012 GGTG_02971T0 Gaeumannomyces graminis 53 1e-89 328
WERAM-Ors-0074 OS07T0626600-01 Oryza sativa 45 1e-89 328
WERAM-Orr-0084 ORUFI07G24020.1 Oryza rufipogon 45 1e-89 328
WERAM-Orni-0080 ONIVA07G22490.1 Oryza nivara 45 1e-89 328
WERAM-Orm-0076 OMERI07G19290.1 Oryza meridionalis 45 1e-89 328
WERAM-Org-0080 ORGLA07G0178500.1 Oryza glaberrima 45 1e-89 327
WERAM-Orgl-0078 OGLUM07G22920.1 Oryza glumaepatula 45 1e-89 327
WERAM-Mel-0023 EGG10640 Melampsora laricipopulina 39 1e-89 327
WERAM-Orp-0078 OPUNC07G21500.1 Oryza punctata 45 1e-89 327
WERAM-Mao-0011 MGG_04133T0 Magnaporthe oryzae 54 1e-89 327
WERAM-Orbr-0089 OB07G28490.1 Oryza brachyantha 45 1e-89 327
WERAM-Orb-0081 OBART07G22890.1 Oryza barthii 44 1e-89 327
WERAM-Xet-0014 ENSXETP00000004144.3 Xenopus tropicalis 42 2e-89 327
WERAM-Lep-0080 LPERR07G19900.1 Leersia perrieri 45 2e-89 327
WERAM-Trr-0011 EGR51829 Trichoderma reesei 39 3e-89 326
WERAM-Tra-0047 Traes_2AS_72EE169B7.1 Triticum aestivum 45 3e-89 326
WERAM-Aet-0100 EMT32375 Aegilops tauschii 44 4e-89 326
WERAM-Tru-0098 TRIUR3_34388-P1 Triticum urartu 44 4e-89 325
WERAM-Usm-0030 UM05240P0 Ustilago maydis 47 6e-89 325
WERAM-Dio-0025 ENSDORP00000002820.1 Dipodomys ordii 42 6e-89 325
WERAM-Brd-0008 BRADI1G20770.1 Brachypodium distachyon 45 9e-89 324
WERAM-Miv-0024 MVLG_03505T0 Microbotryum violaceum 50 3e-88 322
WERAM-Osl-0032 ABO97922 Ostreococcus lucimarinus 42 4e-88 322
WERAM-Cii-0076 ENSCINP00000035214.1 Ciona intestinalis 41 5e-87 318
WERAM-Spr-0019 CBQ72444 Sporisorium reilianum 50 9e-87 318
WERAM-Leo-0131 ENSLOCP00000016384.1 Lepisosteus oculatus 53 1e-86 317
WERAM-Pug-0009 EFP77975 Puccinia graminis 50 5e-86 315
WERAM-Lab-0009 EDR11515 Laccaria bicolor 49 5e-86 315
WERAM-Fia-0073 ENSFALP00000005432.1 Ficedula albicollis 51 1e-85 314
WERAM-Tub-0141 ENSTBEP00000015132.1 Tupaia belangeri 43 1e-85 314
WERAM-Meg-0019 ENSMGAP00000001561.1 Meleagris gallopavo 51 1e-85 314
WERAM-Anp-0058 ENSAPLP00000006419.1 Anas platyrhynchos 51 1e-85 314
WERAM-Tag-0027 ENSTGUP00000001933.1 Taeniopygia guttata 51 1e-83 307
WERAM-Hov-0011 MLOC_12053.1 Hordeum vulgare 52 1e-82 304
WERAM-Chr-0034 EDP01544 Chlamydomonas reinhardtii 42 1e-82 304
Created Date 25-Jun-2016