| Tag |
Content |
| WERAM ID |
WERAM-Scp-0046 |
| Ensembl Protein ID |
SPCC4B3.12.1:pep |
| Uniprot Accession |
Q9USK2; SET9_SCHPO
|
| Genbank Protein ID |
NP_588078.1
|
| Protein Name |
Histone-lysine N-methyltransferase set9 |
| Genbank Nucleotide ID |
NM_001023070.2
|
| Gene Name |
SET9 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
HMT_other |
SET |
H4K20 |
K |
20236312
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
HMT_other |
0 |
753 |
|
|
|
| Organism |
Schizosaccharomyces pombe |
| NCBI Taxa ID |
284812 |
Functional Description
(View)Functional Description
Histone methyltransferase that specifically methylates 'Lys-20' of histone H4. H4 'Lys-20' methylation is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage. |
Histone methyltransferase that specifically methylates 'Lys-20' of histone H4. H4 'Lys-20' methylation is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage.
|
| Domain Profile |
HMT HMT_other
Query: 1 MRQTNTHLETFSLFDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYII 60
MRQTNTHLETFSLFDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYII
Sbjct: 1 MRQTNTHLETFSLFDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYII 60
Query: 61 EQTDLDQAAKNILQFRELDPXXXXXXXXXXXAFTRHLKYYLSLYLPSCKFEICSTNQYFS 120
EQTDLDQAAKNILQFRELDP AFTRHLKYYLSLYLPSCKFEICSTNQYFS
Sbjct: 61 EQTDLDQAAKNILQFRELDPLLRRLSSTSLLAFTRHLKYYLSLYLPSCKFEICSTNQYFS 120
Query: 121 SSKPEACVIARESINAGEDITDLCGTIIKLSPKEERNIGIGKDFSILHSSRLDSMCLFLG 180
SSKPEACVIARESINAGEDITDLCGTIIKLSPKEERNIGIGKDFSILHSSRLDSMCLFLG
Sbjct: 121 SSKPEACVIARESINAGEDITDLCGTIIKLSPKEERNIGIGKDFSILHSSRLDSMCLFLG 180
Query: 181 PARFVNHDCNANCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERM 240
PARFVNHDCNANCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERM
Sbjct: 181 PARFVNHDCNANCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERM 240
Query: 241 GINGFKKLFHTXXXXXXXXXXXXXXXXXXXXXXXXNRYVISEEDRSFLNIWXXXXXXXXX 300
GINGFKKLFHT NRYVISEEDRSFLNIW
Sbjct: 241 GINGFKKLFHTSATSTSCSSKSSSDVSDLSSLPQSNRYVISEEDRSFLNIWDSGGELSDA 300
Query: 301 XXXXXXXXXXXXIPRHKKRVWSREKRLLSEMAITNHSPLLNVDDYRKFREDLWKKRHGKR 360
IPRHKKRVWSREKRLLSEMAITNHSPLLNVDDYRKFREDLWKKRHGKR
Sbjct: 301 SSSDLDEEFSLFIPRHKKRVWSREKRLLSEMAITNHSPLLNVDDYRKFREDLWKKRHGKR 360
Query: 361 KVYQCSNCSQTFINEDIQNSSAFCPKCIRHSKLFSLPWPCRHKVNRELKLEKEKEINTKR 420
KVYQCSNCSQTFINEDIQNSSAFCPKCIRHSKLFSLPWPCRHKVNRELKLEKEKEINTKR
Sbjct: 361 KVYQCSNCSQTFINEDIQNSSAFCPKCIRHSKLFSLPWPCRHKVNRELKLEKEKEINTKR 420
Query: 421 NLVTSSHSMSLRHKKAVDYQS 441
NLVTSSHSMSLRHKKAVDYQS
Sbjct: 421 NLVTSSHSMSLRHKKAVDYQS 441
|
Protein Sequence
(Fasta) | MRQTNTHLET FSLFDDVCTC LLVDKVFYWS QIHKVRKLVD RSIERMESCS IINIITKYII 60
EQTDLDQAAK NILQFRELDP LLRRLSSTSL LAFTRHLKYY LSLYLPSCKF EICSTNQYFS 120
SSKPEACVIA RESINAGEDI TDLCGTIIKL SPKEERNIGI GKDFSILHSS RLDSMCLFLG 180
PARFVNHDCN ANCRFNTSGK RIWLRCVRDI KPGEEITTFY SSNYFGLENC ECLCVSCERM 240
GINGFKKLFH TSATSTSCSS KSSSDVSDLS SLPQSNRYVI SEEDRSFLNI WDSGGELSDA 300
SSSDLDEEFS LFIPRHKKRV WSREKRLLSE MAITNHSPLL NVDDYRKFRE DLWKKRHGKR 360
KVYQCSNCSQ TFINEDIQNS SAFCPKCIRH SKLFSLPWPC RHKVNRELKL EKEKEINTKR 420
NLVTSSHSMS LRHKKAVDYQ S 441Protein Fasta Sequence
>SPCC4B3.12.1:pep|SET9|Schizosaccharomyces pombe
MRQTNTHLETFSLFDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYIIEQTDLDQAAKNILQFRELDPLLRRLSSTSLLAFTRHLKYYLSLYLPSCKFEICSTNQYFSSSKPEACVIARESINAGEDITDLCGTIIKLSPKEERNIGIGKDFSILHSSRLDSMCLFLGPARFVNHDCNANCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERMGINGFKKLFHTSATSTSCSSKSSSDVSDLSSLPQSNRYVISEEDRSFLNIWDSGGELSDASSSDLDEEFSLFIPRHKKRVWSREKRLLSEMAITNHSPLLNVDDYRKFREDLWKKRHGKRKVYQCSNCSQTFINEDIQNSSAFCPKCIRHSKLFSLPWPCRHKVNRELKLEKEKEINTKRNLVTSSHSMSLRHKKAVDYQS |
Nucleotide Sequence
(Fasta) | TGAACTTGTA GTCGATCCGC CGGCAGATAT ATCGTCTTCG ACTTCGGTAG ACAAATTCAG 60
TCCGTGCATA TTTCTGATTT CTTCTTTGAG GATAGAATTG ACTAGACGGT GCTGCGCCAA 120
AGTGTTCTTC CCTTGGAAGG CTTTGCTTTT AATTGCAACT TGATACATGC TGCCACATCC 180
TCCAGAAACG TCGATAACTC TCAAAGAACT AGGTGAAAGC TTCTCAGTGA GTATGTCCTT 240
TATCCTTCGT TCTCCGGGTG TCGAATAAAA TCGTTTAGTA ATGATCAAGG GTTTCTGAGG 300
ATTTTTCAAA AATAATGGGC TTAAAAGCCT ACCGATGGCT AACTTCATAT TTAAACTTGA 360
ATATTAGAAG GAAGTAAATT AAACTGGTAT CTCAATAATG ATAAAACGGG ATTTAGGAAG 420
TTTTTTGTAT CTGCATTCGC CTATTGGGTT GCTAGTATAG TTTAGTTAAC TTCATCAGTC 480
CCGGTCCAAC CTACTGCTAT TTCTACGACC CATTTGTCTA GGTGGATTTC ATTCGAAGCA 540
AAGTCGCTCT TTATTAGTAT AACTTACAAA GATATAATAA CTAGAAAACT GTGAAAACTT 600
TTAAGGGGAC CGTCCGAGCT TGGTGTATAT TTAATTACAA CGTTCAGACT TTCGTGGATT 660
CTTTTATTTA AAACGAGAAT AATTAAATTT CGCTAATTAG TCGATTTCCT AATAAGTGAT 720
TGTGTTGAAT TGTTGTGTTC AAAAACATTT TTGTATTTGC CAACGCAGAA ATATATTACA 780
TATTTGGATA AACTATCGAG TTCCTAACCT TTATTTTCTG AGCAAACTCA TATAAACCTA 840
TAATTTATAC ATCAAGATTA CTCATCGTTG TTCAACTGGA AAGGTACTTT TAACATTGAA 900
TGTTTCATGA CATTTTGATA CCTGCCTAAC GCCTATGAAA ATGCATAATG CGCCAGACGA 960
ATACTCATCT TGAAACGTTT TCTCTTTTTG ACGATGTTTG TACTTGTTTG CTAGTTGACA 1020
AGGTGTTTTA TTGGTCCCAA ATTCATAAAG TACGAAAATT AGTGGATCGA TCAATTGAGC 1080
GAATGGAAAG CTGTTCTATT ATAAATATTA TAACCAAATA TATTATAGAG CAAACAGACC 1140
TTGACCAAGC GGCAAAAAAT ATTCTGCAAT TTCGTGAACT TGATCCATTG TTGCGGAGAT 1200
TGTCAAGCAC TTCTTTACTA GCATTTACTC GACATCTGAA GTACTACCTC TCATTATATC 1260
TACCATCATG CAAATTTGAA ATTTGTTCAA CAAACCAATA CTTTTCTTCC TCAAAGCCTG 1320
AAGCTTGCGT AATAGCGCGT GAATCAATTA ATGCTGGAGA AGATATTACA GACCTCTGTG 1380
GAACAATTAT TAAGTTATCT CCTAAAGAAG AGCGGAATAT AGGAATTGGA AAAGACTTTA 1440
GCATCCTTCA TTCAAGCCGC TTAGATTCGA TGTGTCTATT TTTGGGCCCT GCACGATTCG 1500
TTAATCATGA CTGCAATGCT AACTGTCGAT TTAACACTTC TGGTAAGCGC ATTTGGCTGC 1560
GCTGTGTAAG AGACATAAAA CCAGGTGAAG AAATTACTAC CTTTTATTCT TCTAATTACT 1620
TTGGCCTTGA AAATTGTGAA TGCCTTTGTG TCTCATGTGA ACGAATGGGC ATCAATGGTT 1680
TTAAAAAGCT TTTCCATACT AGTGCTACTT CAACAAGTTG TTCTTCCAAG AGTAGTTCTG 1740
ATGTTTCCGA TCTGTCTTCT TTGCCGCAGT CAAATCGTTA CGTGATTTCC GAGGAAGATC 1800
GTAGCTTCTT GAATATTTGG GATTCAGGTG GTGAACTGAG TGATGCGTCC AGTTCTGATT 1860
TGGATGAGGA GTTTTCACTA TTTATACCAA GGCACAAAAA AAGGGTGTGG TCTCGAGAAA 1920
AAAGGCTTTT GTCTGAGATG GCCATAACGA ACCATAGTCC GTTACTGAAT GTGGATGATT 1980
ATCGAAAATT TCGTGAAGAT CTATGGAAAA AAAGACATGG AAAAAGAAAG GTTTACCAAT 2040
GCTCAAACTG TAGCCAGACA TTTATTAATG AAGACATTCA AAATTCGAGT GCATTTTGTC 2100
CGAAATGTAT TAGACATTCT AAACTCTTTT CATTACCTTG GCCTTGTAGA CATAAAGTTA 2160
ATCGTGAATT GAAACTAGAG AAAGAAAAGG AAATTAATAC AAAAAGGAAC TTAGTTACCA 2220
GCTCGCATAG TATGTCTCTG CGACACAAAA AAGCTGTTGA TTATCAAAGT TAGTTGACTA 2280
GACTATTTAT ATTAAGATTG GAAATTTTGG TTAATTTAGG TCATTGTTAG TTGGACTTTA 2340
AAGCATTTAT TTAAAAAAAA AAAACTAAAA TCTTGCACTA TTCAGGGTAT ATCCGAAGGT 2400
GAACAATGTA CATTTGAATC ATTCCGTTCG CTAATTCAAT CTATTGTTGA TTTTTTCATG 2460
GGATTCACCA CCTCTATTAA CTAAATATTT GAATGCTTTT AAATTCAATA AATTAACGTT 2520
CAATGTATTG ACTTGTTTTA ATATACTACG TTTTTATAAC TGAGGGAAAT TTTGGTTGTG 2580
TAATATGTCA CTATATAAGC TGTGCCCGGT TGGCCTCACA AACTTTACTA GCATCCACAA 2640
2641Nucleotide Fasta Sequence
>SPCC4B3.12.1:pep|HMT_other|Schizosaccharomyces pombe
TGAACTTGTAGTCGATCCGCCGGCAGATATATCGTCTTCGACTTCGGTAGACAAATTCAGTCCGTGCATATTTCTGATTTCTTCTTTGAGGATAGAATTGACTAGACGGTGCTGCGCCAAAGTGTTCTTCCCTTGGAAGGCTTTGCTTTTAATTGCAACTTGATACATGCTGCCACATCCTCCAGAAACGTCGATAACTCTCAAAGAACTAGGTGAAAGCTTCTCAGTGAGTATGTCCTTTATCCTTCGTTCTCCGGGTGTCGAATAAAATCGTTTAGTAATGATCAAGGGTTTCTGAGGATTTTTCAAAAATAATGGGCTTAAAAGCCTACCGATGGCTAACTTCATATTTAAACTTGAATATTAGAAGGAAGTAAATTAAACTGGTATCTCAATAATGATAAAACGGGATTTAGGAAGTTTTTTGTATCTGCATTCGCCTATTGGGTTGCTAGTATAGTTTAGTTAACTTCATCAGTCCCGGTCCAACCTACTGCTATTTCTACGACCCATTTGTCTAGGTGGATTTCATTCGAAGCAAAGTCGCTCTTTATTAGTATAACTTACAAAGATATAATAACTAGAAAACTGTGAAAACTTTTAAGGGGACCGTCCGAGCTTGGTGTATATTTAATTACAACGTTCAGACTTTCGTGGATTCTTTTATTTAAAACGAGAATAATTAAATTTCGCTAATTAGTCGATTTCCTAATAAGTGATTGTGTTGAATTGTTGTGTTCAAAAACATTTTTGTATTTGCCAACGCAGAAATATATTACATATTTGGATAAACTATCGAGTTCCTAACCTTTATTTTCTGAGCAAACTCATATAAACCTATAATTTATACATCAAGATTACTCATCGTTGTTCAACTGGAAAGGTACTTTTAACATTGAATGTTTCATGACATTTTGATACCTGCCTAACGCCTATGAAAATGCATAATGCGCCAGACGAATACTCATCTTGAAACGTTTTCTCTTTTTGACGATGTTTGTACTTGTTTGCTAGTTGACAAGGTGTTTTATTGGTCCCAAATTCATAAAGTACGAAAATTAGTGGATCGATCAATTGAGCGAATGGAAAGCTGTTCTATTATAAATATTATAACCAAATATATTATAGAGCAAACAGACCTTGACCAAGCGGCAAAAAATATTCTGCAATTTCGTGAACTTGATCCATTGTTGCGGAGATTGTCAAGCACTTCTTTACTAGCATTTACTCGACATCTGAAGTACTACCTCTCATTATATCTACCATCATGCAAATTTGAAATTTGTTCAACAAACCAATACTTTTCTTCCTCAAAGCCTGAAGCTTGCGTAATAGCGCGTGAATCAATTAATGCTGGAGAAGATATTACAGACCTCTGTGGAACAATTATTAAGTTATCTCCTAAAGAAGAGCGGAATATAGGAATTGGAAAAGACTTTAGCATCCTTCATTCAAGCCGCTTAGATTCGATGTGTCTATTTTTGGGCCCTGCACGATTCGTTAATCATGACTGCAATGCTAACTGTCGATTTAACACTTCTGGTAAGCGCATTTGGCTGCGCTGTGTAAGAGACATAAAACCAGGTGAAGAAATTACTACCTTTTATTCTTCTAATTACTTTGGCCTTGAAAATTGTGAATGCCTTTGTGTCTCATGTGAACGAATGGGCATCAATGGTTTTAAAAAGCTTTTCCATACTAGTGCTACTTCAACAAGTTGTTCTTCCAAGAGTAGTTCTGATGTTTCCGATCTGTCTTCTTTGCCGCAGTCAAATCGTTACGTGATTTCCGAGGAAGATCGTAGCTTCTTGAATATTTGGGATTCAGGTGGTGAACTGAGTGATGCGTCCAGTTCTGATTTGGATGAGGAGTTTTCACTATTTATACCAAGGCACAAAAAAAGGGTGTGGTCTCGAGAAAAAAGGCTTTTGTCTGAGATGGCCATAACGAACCATAGTCCGTTACTGAATGTGGATGATTATCGAAAATTTCGTGAAGATCTATGGAAAAAAAGACATGGAAAAAGAAAGGTTTACCAATGCTCAAACTGTAGCCAGACATTTATTAATGAAGACATTCAAAATTCGAGTGCATTTTGTCCGAAATGTATTAGACATTCTAAACTCTTTTCATTACCTTGGCCTTGTAGACATAAAGTTAATCGTGAATTGAAACTAGAGAAAGAAAAGGAAATTAATACAAAAAGGAACTTAGTTACCAGCTCGCATAGTATGTCTCTGCGACACAAAAAAGCTGTTGATTATCAAAGTTAGTTGACTAGACTATTTATATTAAGATTGGAAATTTTGGTTAATTTAGGTCATTGTTAGTTGGACTTTAAAGCATTTATTTAAAAAAAAAAAACTAAAATCTTGCACTATTCAGGGTATATCCGAAGGTGAACAATGTACATTTGAATCATTCCGTTCGCTAATTCAATCTATTGTTGATTTTTTCATGGGATTCACCACCTCTATTAACTAAATATTTGAATGCTTTTAAATTCAATAAATTAACGTTCAATGTATTGACTTGTTTTAATATACTACGTTTTTATAACTGAGGGAAATTTTGGTTGTGTAATATGTCACTATATAAGCTGTGCCCGGTTGGCCTCACAAACTTTACTAGCATCCACAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
--
|
| Interpro |
IPR025783--Hist-Lys_N-MeTrfase_SET9
IPR001214--SET_dom
|
| PROSITE |
PS51567--SAM_MT43_SUVAR420_1
PS50280--SET
|
| Pfam |
PF00856--SET
|
| Gene Ontology |
GO:0032153--C:cell division site
GO:0005829--C:cytosol
GO:0044732--C:mitotic spindle pole body
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0042799--F:histone methyltransferase activity (H4-K20 specific)
GO:0031491--F:nucleosome binding
GO:0034613--P:cellular protein localization
GO:0006342--P:chromatin silencing
GO:0034770--P:histone H4-K20 methylation
GO:0044773--P:mitotic DNA damage checkpoint
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
