WERAM Information

Tag Content
WERAM ID WERAM-Cae-0051
Ensembl Protein ID C32D5.5
Uniprot Accession Q09265; SUV42_CAEEL
Genbank Protein ID NP_495272.1
Protein Name Histone-lysine N-methyltransferase Suv4-20
Genbank Nucleotide ID NM_062871.4
Gene Name SUV42;set-4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00016313 C32D5.5 C32D5.5
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SUV4-20 SET H4K20 K 12086618; 23028348
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SUV4-20 5.60e-60 201.2 128 238
HMT HMT_other 2.00e-28 120
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity).
Domain Profile
  HMT SUV4-20
  SUV4-20.txt   1 leckrysleeqkgakivstkewkkndkiellvgviaelseadedallragendfsvmystrkrcaqlwlgpaayinhdcrpnckfvstgrdtacvkvl 98 
                  +eckrys+e+++gak+vst +w+++dkie+l+gv+++ls++ded++l+++++dfsvmystrkrc++lwlgp+ayinhdcrp+c+fvs+g +ta+++vl
      C32D5.5 128 QECKRYSQEGHQGAKLVSTGVWSRGDKIERLSGVVCLLSSEDEDSILAQEGSDFSVMYSTRKRCSTLWLGPGAYINHDCRPTCEFVSHG-STAHIRVL 224
                  68***************************************************************************************.9******* PP
  SUV4-20.txt  99 rdiepgdeitcfyg 112
                  rd++pgdeitcfyg
      C32D5.5 225 RDMVPGDEITCFYG 238
                  *************9 PP
  HMT HMT_other
Query: 32  FDDFATTLVVDSVLNFT-THKMSK--KRRYLYQDEYRTARTVMKTFREQRDWTNAIYGLL 88
           FDD  T L+VD V  ++  HK+ K   R     +       + K   EQ D   A   +L
Sbjct: 14  FDDVCTCLLVDKVFYWSQIHKVRKLVDRSIERMESCSIINIITKYIIEQTDLDQAAKNIL 73
Query: 89  TLRSVSHFLSKLPPNKLFEFRDHIVRFLNMFILDSGYTIQECKRYSQEGHQGAKLVSTGV 148
             R +   L +L    L  F  H+  +L++++    + I    +Y       A +++   
Sbjct: 74  QFRELDPLLRRLSSTSLLAFTRHLKYYLSLYLPSCKFEICSTNQYFSSSKPEACVIARES 133
Query: 149 WSRGDKIERLSGVVCLLSSEDEDSILAQEGSDFSVMYSTRKRCSTLWLGPGAYINHDCRP 208
            + G+ I  L G +  LS ++E +I    G DFS+++S+R     L+LGP  ++NHDC  
Sbjct: 134 INAGEDITDLCGTIIKLSPKEERNIGI--GKDFSILHSSRLDSMCLFLGPARFVNHDCNA 191
Query: 209 TCEFVSHGSTAHIRVLRDMVPGDEITCFYGSEFFGPNNIDCECCTCEK-NMNG 260
            C F + G    +R +RD+ PG+EIT FY S +FG  N +C C +CE+  +NG
Sbjct: 192 NCRFNTSGKRIWLRCVRDIKPGEEITTFYSSNYFGLENCECLCVSCERMGING 244
Protein Sequence
(Fasta)		MQLHEQIANI SVTFNDIPRS DHSMTPTELC YFDDFATTLV VDSVLNFTTH KMSKKRRYLY 60
QDEYRTARTV MKTFREQRDW TNAIYGLLTL RSVSHFLSKL PPNKLFEFRD HIVRFLNMFI 120
LDSGYTIQEC KRYSQEGHQG AKLVSTGVWS RGDKIERLSG VVCLLSSEDE DSILAQEGSD 180
FSVMYSTRKR CSTLWLGPGA YINHDCRPTC EFVSHGSTAH IRVLRDMVPG DEITCFYGSE 240
FFGPNNIDCE CCTCEKNMNG AFSYLRGNEN AEPIISEKKT KYELRSRS 288
Nucleotide Sequence
(Fasta)		CTCACAATCT GTTATTTGAA TTTCAGAAAA TGGCTCGGAG AAATGAGTCA ACGCCTGAAC 60
GAATGCAACT ACACGAGCAA ATTGCCAACA TTTCTGTGAC GTTCAATGAC ATTCCTCGCT 120
CGGATCACTC AATGACTCCA ACAGAACTAT GTTATTTTGA TGATTTTGCT ACTACGCTTG 180
TCGTCGACTC GGTTCTCAAC TTTACTACCC ATAAAATGAG CAAAAAGCGA CGCTATTTGT 240
ATCAGGACGA GTATAGAACG GCTCGAACAG TTATGAAAAC ATTCAGAGAG CAACGAGATT 300
GGACCAATGC AATTTACGGA CTTTTGACTC TCCGAAGTGT TTCACATTTC CTCTCGAAAC 360
TTCCTCCGAA CAAGCTATTT GAATTCCGTG ATCACATTGT TCGATTTCTC AATATGTTCA 420
TACTTGATTC TGGGTACACC ATCCAAGAAT GCAAACGCTA TTCGCAAGAA GGTCATCAAG 480
GTGCAAAACT TGTTTCAACT GGGGTTTGGA GCCGCGGCGA TAAAATTGAG CGGCTCAGCG 540
GTGTCGTGTG CCTGCTATCC AGCGAAGATG AGGATTCTAT ACTGGCTCAA GAAGGAAGCG 600
ATTTCTCTGT GATGTACAGC ACAAGAAAAC GCTGTTCGAC TCTATGGCTA GGTCCAGGTG 660
CCTATATCAA TCATGACTGT CGGCCGACCT GTGAATTCGT ATCACATGGA AGTACAGCTC 720
ACATTCGAGT TCTTCGTGAC ATGGTTCCCG GTGACGAAAT CACCTGCTTC TACGGCAGTG 780
AATTCTTCGG TCCAAACAAC ATAGACTGTG AATGTTGCAC TTGCGAGAAG AACATGAATG 840
GAGCTTTCAG TTATCTCCGT GGAAACGAGA ATGCTGAACC AATAATTTCG GAGAAGAAGA 900
CCAAATATGA ACTCCGCTCA CGATCCTAAA TCATAATTTT CAATCATTTT TACAAATTAA 960
TTCATGTTCC ATGGCCAGTG TAAATACGAT ATCTTTTACG AAGAGAAGCA TTGGCTTTTC 1020
TTTTCTTTAA ATTCTGATAT CAAATTTCTA TTTTCAGTAT AGCACAGCCC CAGTACCAGT 1080
ACCGCAGTTT TCAGTACACT AGATACCTGA AATCCATAGC GATCCCAAAG AAACTTTCTT 1140
CCCCCTTTCC TTTTTGGTTC TTGTGTGTGT ACAACGATCT CTATCTGTGC TCTATTTTGT 1200
TTTCTTATTT TCATTCTTTA AAATTCCAGA TTCATTTTTG AAATTACAGT ATGTCTAATC 1260
AATAAATTAT TTATAAGAA
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR025790--Hist-Lys_N-MTase_Suvar4-20
IPR001214--SET_dom
PROSITE

PS51570--SAM_MT43_SUVAR420_2
PS50280--SET
Pfam

PF00856--SET
Gene Ontology

GO:0005694--C:chromosome
GO:0005634--C:nucleus
GO:0042799--F:histone methyltransferase activity (H4-K20 specific)
GO:0008340--P:determination of adult lifespan
GO:0034773--P:histone H4-K20 trimethylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Dar-0091 ENSDARP00000060190.3 Danio rerio 45 3e-59 225
WERAM-Asm-0222 ENSAMXP00000021268.1 Astyanax mexicanus 46 4e-59 225
WERAM-Meg-0099 ENSMGAP00000009510.1 Meleagris gallopavo 45 2e-58 223
WERAM-Fia-0155 ENSFALP00000013275.1 Ficedula albicollis 45 2e-58 223
WERAM-Gaga-0132 ENSGALP00000022853.4 Gallus gallus 45 2e-58 223
WERAM-Pes-0137 ENSPSIP00000016261.1 Pelodiscus sinensis 45 3e-58 222
WERAM-Dan-0161 ENSDNOP00000030860.1 Dasypus novemcinctus 45 4e-58 222
WERAM-Fec-0099 ENSFCAP00000008405.3 Felis catus 46 4e-58 221
WERAM-Nol-0066 ENSNLEP00000007961.2 Nomascus leucogenys 45 5e-58 221
WERAM-Chs-0108 ENSCSAP00000005218.1 Chlorocebus sabaeus 45 5e-58 221
WERAM-Paa-0018 ENSPANP00000007561.1 Papio anubis 45 6e-58 221
WERAM-Caf-0124 ENSCAFP00000016085.2 Canis familiaris 45 6e-58 221
WERAM-Myl-0090 ENSMLUP00000007496.2 Myotis lucifugus 45 7e-58 221
WERAM-Sus-0178 ENSSSCP00000023262.1 Sus scrofa 45 8e-58 221
WERAM-Ten-0031 ENSTNIP00000006027.1 Tetraodon nigroviridis 43 2e-57 219
WERAM-Leo-0015 ENSLOCP00000003102.1 Lepisosteus oculatus 44 3e-57 219
WERAM-Mum-0208 ENSMUSP00000096452.2 Mus musculus 45 3e-57 219
WERAM-Tut-0009 ENSTTRP00000000539.1 Tursiops truncatus 45 5e-57 218
WERAM-Anp-0068 ENSAPLP00000008382.1 Anas platyrhynchos 45 6e-57 218
WERAM-Orn-0183 ENSONIP00000018952.1 Oreochromis niloticus 44 1e-56 217
WERAM-Otg-0050 ENSOGAP00000003483.2 Otolemur garnettii 45 1e-56 217
WERAM-Pem-0039 ENSPMAP00000004993.1 Petromyzon marinus 46 1e-56 217
WERAM-Ran-0113 ENSRNOP00000023744.5 Rattus norvegicus 45 4e-56 215
WERAM-Ict-0011 ENSSTOP00000000609.2 Ictidomys tridecemlineatus 46 5e-56 215
WERAM-Caj-0163 ENSCJAP00000028971.2 Callithrix jacchus 42 6e-56 214
WERAM-Prc-0132 ENSPCAP00000011674.1 Procavia capensis 44 6e-56 214
WERAM-Cap-0023 ENSCPOP00000001944.2 Cavia porcellus 43 8e-56 214
WERAM-Hos-0078 ENSP00000484858.1 Homo sapiens 42 1e-55 214
WERAM-Mam-0127 ENSMMUP00000018699.2 Macaca mulatta 42 1e-55 213
WERAM-Poa-0028 ENSPPYP00000003448.2 Pongo abelii 42 1e-55 213
WERAM-Xet-0066 ENSXETP00000022104.3 Xenopus tropicalis 44 1e-55 213
WERAM-Tar-0133 ENSTRUP00000028898.1 Takifugu rubripes 42 1e-55 213
WERAM-Loa-0072 ENSLAFP00000005452.3 Loxodonta africana 43 1e-55 213
WERAM-Anc-0156 ENSACAP00000014471.3 Anolis carolinensis 41 2e-55 213
WERAM-Orc-0023 ENSOCUP00000002410.3 Oryctolagus cuniculus 43 2e-55 213
WERAM-Lac-0183 ENSLACP00000021105.1 Latimeria chalumnae 42 2e-55 213
WERAM-Mup-0082 ENSMPUP00000007507.1 Mustela putorius furo 45 2e-55 213
WERAM-Tas-0034 ENSTSYP00000003476.1 Tarsius syrichta 42 2e-55 213
WERAM-Tag-0124 ENSTGUP00000010243.1 Taeniopygia guttata 41 2e-55 213
WERAM-Gaa-0184 ENSGACP00000023105.2 Gasterosteus aculeatus 43 2e-55 213
WERAM-Pat-0031 ENSPTRP00000058287.2 Pan troglodytes 42 3e-55 213
WERAM-Bot-0009 ENSBTAP00000051412.1 Bos taurus 42 3e-55 212
WERAM-Ocp-0084 ENSOPRP00000007619.1 Ochotona princeps 43 3e-55 212
WERAM-Eqc-0090 ENSECAP00000010835.1 Equus caballus 42 4e-55 212
WERAM-Aim-0020 ENSAMEP00000001374.1 Ailuropoda melanoleuca 43 6e-55 211
WERAM-Ova-0162 ENSOARP00000016186.1 Ovis aries 43 6e-55 211
WERAM-Ptv-0113 ENSPVAP00000010106.1 Pteropus vampyrus 42 7e-55 211
WERAM-Pof-0184 ENSPFOP00000015576.1 Poecilia formosa 44 8e-55 211
WERAM-Mod-0194 ENSMODP00000026655.4 Monodelphis domestica 42 2e-54 210
WERAM-Gog-0066 ENSGGOP00000005728.2 Gorilla gorilla 44 2e-54 210
WERAM-Vip-0088 ENSVPAP00000008125.1 Vicugna pacos 41 2e-54 209
WERAM-Sah-0067 ENSSHAP00000008159.1 Sarcophilus harrisii 42 3e-54 209
WERAM-Dio-0127 ENSDORP00000012039.1 Dipodomys ordii 45 4e-54 209
WERAM-Xim-0165 ENSXMAP00000013465.1 Xiphophorus maculatus 42 5e-53 205
WERAM-Orla-0008 ENSORLP00000000741.2 Oryzias latipes 39 8e-53 204
WERAM-Cis-0010 ENSCSAVP00000001617.1 Ciona savignyi 43 4e-52 202
WERAM-Soa-0014 ENSSARP00000001556.1 Sorex araneus 44 5e-52 201
WERAM-Drm-0024 FBpp0070146 Drosophila melanogaster 45 4e-50 195
WERAM-Mae-0103 ENSMEUP00000010117.1 Macropus eugenii 48 9e-50 194
WERAM-Gam-0070 ENSGMOP00000006748.1 Gadus morhua 41 2e-49 192
WERAM-Ect-0106 ENSETEP00000011903.1 Echinops telfairi 45 5e-48 188
WERAM-Cii-0003 ENSCINP00000001120.3 Ciona intestinalis 43 1e-37 153
WERAM-Ere-0118 ENSEEUP00000012535.1 Erinaceus europaeus 39 8e-37 151
WERAM-Tub-0071 ENSTBEP00000008881.1 Tupaia belangeri 48 2e-30 129
WERAM-Ved-0035 EGY19263 Verticillium dahliae 31 4e-29 125
WERAM-Aso-0021 CADAORAP00005449 Aspergillus oryzae 29 1e-28 124
WERAM-Asf-0014 CADAFLAP00005976 Aspergillus flavus 29 1e-28 124
WERAM-Asfu-0019 CADAFUAP00004791 Aspergillus fumigatus 29 1e-27 120
WERAM-Asni-0030 CADANGAP00009644 Aspergillus niger 28 1e-27 120
WERAM-Scp-0046 SPCC4B3.12.1:pep Schizosaccharomyces pombe 31 2e-27 120
WERAM-Asc-0031 CADACLAP00007456 Aspergillus clavatus 29 2e-27 120
WERAM-Fuo-0013 FOXG_02431P0 Fusarium oxysporum 29 9e-27 117
WERAM-Pytr-0029 EDU42362 Pyrenophora triticirepentis 30 1e-26 117
WERAM-Lem-0035 CBX97497 Leptosphaeria maculans 28 1e-26 117
WERAM-Ast-0007 CADATEAP00004009 Aspergillus terreus 28 2e-26 116
WERAM-Asn-0027 CADANIAP00006863 Aspergillus nidulans 28 8e-26 114
WERAM-Coi-0004 EAS35489 Coccidioides immitis 29 1e-25 114
WERAM-Pyt-0038 EFQ86274 Pyrenophora teres 30 2e-25 113
WERAM-Yal-0021 CAG79838 Yarrowia lipolytica 30 3e-25 112
WERAM-Lab-0053 EDR08823 Laccaria bicolor 30 8e-25 111
WERAM-Map-0031 MAPG_09251T0 Magnaporthe poae 27 2e-24 110
WERAM-Gag-0038 GGTG_12747T0 Gaeumannomyces graminis 29 3e-24 109
WERAM-Chh-0089 ENSCHOP00000010005.1 Choloepus hoffmanni 54 7e-24 108
WERAM-Trr-0019 EGR45730 Trichoderma reesei 29 2e-23 106
WERAM-Phn-0027 SNOT_13760 Phaeosphaeria nodorum 27 5e-23 105
WERAM-Nec-0025 EFNCRP00000004675 Neurospora crassa 25 2e-22 103
WERAM-Ora-0140 ENSOANP00000030528.1 Ornithorhynchus anatinus 50 3e-22 103
WERAM-Chg-0017 EAQ91584 Chaetomium globosum 29 5e-22 102
WERAM-Trv-0026 EHK15263 Trichoderma virens 29 2e-21 100
WERAM-Scj-0007 EEB06106 Schizosaccharomyces japonicus 26 2e-21 100
WERAM-Zyt-0032 Mycgr3P85175 Zymoseptoria tritici 28 2e-21 100
WERAM-Mao-0023 MGG_07393T0 Magnaporthe oryzae 29 3e-21 99.8
WERAM-Miv-0008 MVLG_00947T0 Microbotryum violaceum 25 8e-21 98.2
WERAM-Tum-0007 CAZ83332 Tuber melanosporum 30 2e-20 97.1
WERAM-Spr-0012 CBQ67956 Sporisorium reilianum 46 8e-20 94.7
WERAM-Usm-0002 UM00543P0 Ustilago maydis 49 3e-19 93.2
WERAM-Mim-0147 ENSMICP00000015214.1 Microcebus murinus 50 9e-16 81.3
WERAM-Put-0024 PTTG_08954P0 Puccinia triticina 34 6e-11 65.5
WERAM-Pug-0035 EFP91874 Puccinia graminis 31 4e-10 62.4
WERAM-Mel-0024 EGG06895 Melampsora laricipopulina 32 2e-09 60.5
WERAM-Crn-0014 AAW42294 Cryptococcus neoformans 33 4e-08 55.8
Created Date 25-Jun-2016