| Tag |
Content |
| WERAM ID |
WERAM-Scp-0013 |
| Ensembl Protein ID |
SPAC29B12.02c.1:pep |
| Uniprot Accession |
O14026; SET2_SCHPO
|
| Genbank Protein ID |
NP_594980.1
|
| Protein Name |
Histone-lysine N-methyltransferase, H3 lysine-36 specific |
| Genbank Nucleotide ID |
NM_001020411.2
|
| Gene Name |
SET2;KMT3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
SET2 |
SET |
H3K36 |
K |
20236312
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SET2 |
5.20e-52 |
173 |
181 |
297 |
| HMT |
SET1 |
1.10e-30 |
104.3 |
182 |
297 |
|
| Organism |
Schizosaccharomyces pombe |
| NCBI Taxa ID |
284812 |
Functional Description
(View)Functional Description
Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. |
Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression.
|
| Domain Profile |
HMT SET2
SET2.txt 2 kveliktekkGyGlrakeeikkdefileYvGevidekeakkRlkeyeeekvkdfYlleldkdeviDatkkGnlaRfinhsCePncetqkw 91
kv+++ tekkG+Glra+++++kd+f++eY+Gevi e++++kR+++y++e++k+fY+++l+k+e+iDatk+G+laRf+nhsC+Pnc+++kw
SPAC29B12.02c.1:pep 181 KVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKW 270
799*************************************************************************************** PP
SET2.txt 92 tvegelrvglfakkkikkgeeltfdYn 118
+v ++lr+g+f+k++i +geeltfdYn
SPAC29B12.02c.1:pep 271 MVGDKLRMGIFCKRDIIRGEELTFDYN 297
**************************8 PP
HMT SET1
SET1.txt 3 levakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeig.vylfrldedaevvvdatkkgniarfinhscepNceakv 91
+ v ++kg+gl+a+ ++ k+++v EY+Gevi ++ kr ++y++++i+ y++ l++ +datk+g+ arf nhsc+pNc++
SPAC29B12.02c.1:pep 182 VDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKhFYFMMLQKG--EYIDATKRGSLARFCNHSCRPNCYVDK 269
667778899******************************************7777777777..89************************* PP
SET1.txt 92 vavdgekkiviyakraIekgeeltydYk 119
+v + +++i+ kr+I +geelt+dY+
SPAC29B12.02c.1:pep 270 WMVGDKLRMGIFCKRDIIRGEELTFDYN 297
***************************7 PP
|
Protein Sequence
(Fasta) | MQTASSLSVL TPLNEENVDR KSSWSKDTIA VQAVGSSPSS SSSHDFESKE DAEGMNKDES 60
APSPSTSSPS SASSRSQSKY VRKEALPPQL FHHLDSAKDK ALTTFEEIQE CQYASANIGK 120
PPENEAMICD CRPHWVDGVN VACGHGSNCI NRMTSIECTD EDNVCGPSCQ NQRFQRHEFA 180
KVDVFLTEKK GFGLRADANL PKDTFVYEYI GEVIPEQKFR KRMRQYDSEG IKHFYFMMLQ 240
KGEYIDATKR GSLARFCNHS CRPNCYVDKW MVGDKLRMGI FCKRDIIRGE ELTFDYNVDR 300
YGAQAQPCYC GEPCCVGYIG GKTQTEAQSK LPENVREALG IEDEEDSWEN ITARRQRRKK 360
GIDETSKIIE EVQPTPLTSE SATKVIGVLL QTKDDLLTRK LMERIFLTSD PSVCRSIIAL 420
RGYNIFGLML KKFSIDIEFI LRSIKTMLSW PRLTRNKIQD SNIEPVVQEF CDHENEEVKD 480
HAKTLLKEWE SLEIAYRIPR RKPGQVAPQS TNAEPSNNQS NPPLRDQEPQ RGDKGDIKSA 540
INNSTEDLSK KHPALHSSRP SDSRSRSKFG NDYQSHSKHN LFRKNSFPKR RRLSNSDTPS 600
ETTTPNNEQE QVSNQANKVD LNKIISAAME SVNQKNVLKA QKEEEERIAQ QKREEKRRLA 660
YEESLKRHAK KLHEKKTKSS QDATIDHHLT SHSPESIAFK AVLAKFFANK TARYQEKLGK 720
AEFKLRVKKM TEIILKKHIQ LVLSKKEKAL PDELSDSQQR KLRVWAFRYL DTVVSRSGTA 780
TTTPTDSPSI GESPKKAA 798Protein Fasta Sequence
>SPAC29B12.02c.1:pep|SET2;KMT3|Schizosaccharomyces pombe
MQTASSLSVLTPLNEENVDRKSSWSKDTIAVQAVGSSPSSSSSHDFESKEDAEGMNKDESAPSPSTSSPSSASSRSQSKYVRKEALPPQLFHHLDSAKDKALTTFEEIQECQYASANIGKPPENEAMICDCRPHWVDGVNVACGHGSNCINRMTSIECTDEDNVCGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIGGKTQTEAQSKLPENVREALGIEDEEDSWENITARRQRRKKGIDETSKIIEEVQPTPLTSESATKVIGVLLQTKDDLLTRKLMERIFLTSDPSVCRSIIALRGYNIFGLMLKKFSIDIEFILRSIKTMLSWPRLTRNKIQDSNIEPVVQEFCDHENEEVKDHAKTLLKEWESLEIAYRIPRRKPGQVAPQSTNAEPSNNQSNPPLRDQEPQRGDKGDIKSAINNSTEDLSKKHPALHSSRPSDSRSRSKFGNDYQSHSKHNLFRKNSFPKRRRLSNSDTPSETTTPNNEQEQVSNQANKVDLNKIISAAMESVNQKNVLKAQKEEEERIAQQKREEKRRLAYEESLKRHAKKLHEKKTKSSQDATIDHHLTSHSPESIAFKAVLAKFFANKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEKALPDELSDSQQRKLRVWAFRYLDTVVSRSGTATTTPTDSPSIGESPKKAA |
Nucleotide Sequence
(Fasta) | AGAGTTGTCG TTTACACTCC GGTACTGTGA GCCCCTACGA GGATTCCGCG AGTAAAGAAG 60
GAACGCCGCC AACAGCCACA ACTTCTTCCT TGAGACAATT TCCTGATCTC ACTGTTTCTT 120
TGACACGAAA CTTTGAAACG TTAGAAGATC TATATGTTAC GCATCGAGAT ATTTTCGGAA 180
ATTTTCTAAA AAGAAGATTT TCGGTGAAAT TTCAGCTGGT CTTCTTTCTA TTGTTTTGGC 240
TTCCTTCGGC AATTACTTTT TGTTCAATAA AACTGTAGAT TTTTTAACTT TCTCTTTCTT 300
TTTGTCCATT ATCATACAAT GCAGACGGCA TCATCTCTTT CTGTTTTAAC TCCTTTGAAT 360
GAGGAAAACG TTGATAGGAA GTCTTCTTGG TCAAAAGACA CAATCGCTGT CCAGGCAGTC 420
GGTTCATCAC CATCTTCTTC GTCATCTCAT GATTTCGAAA GTAAAGAGGA TGCCGAAGGG 480
ATGAATAAAG ACGAAAGTGC TCCTTCCCCT TCTACGTCCT CGCCATCGTC TGCATCCTCT 540
CGGTCTCAAA GCAAATATGT TAGAAAAGAG GCACTTCCTC CTCAACTTTT TCATCACCTG 600
GATTCTGCGA AAGATAAGGC GCTAACTACG TTCGAAGAGA TTCAAGAATG TCAGTATGCT 660
TCCGCCAATA TTGGTAAGCC TCCAGAAAAC GAAGCTATGA TTTGCGATTG TCGGCCTCAT 720
TGGGTAGATG GAGTTAATGT TGCTTGTGGG CACGGATCCA ATTGTATTAA TAGAATGACT 780
TCTATAGAGT GTACGGACGA AGATAACGTT TGTGGACCAT CCTGTCAAAA CCAACGCTTT 840
CAAAGACATG AATTTGCAAA GGTGGATGTT TTCTTAACCG AAAAGAAAGG GTTTGGTTTG 900
CGCGCTGATG CCAATTTACC CAAAGACACA TTTGTCTACG AATACATTGG AGAAGTTATA 960
CCTGAACAAA AGTTTCGTAA ACGTATGCGA CAATACGATA GTGAGGGAAT TAAACACTTT 1020
TACTTCATGA TGCTGCAAAA GGGGGAATAT ATTGATGCTA CTAAAAGGGG GTCGCTCGCA 1080
AGATTTTGCA ATCACTCTTG TAGACCTAAT TGTTATGTTG ATAAATGGAT GGTAGGAGAT 1140
AAGCTAAGAA TGGGTATATT TTGTAAAAGA GATATTATTC GCGGTGAAGA GCTTACTTTT 1200
GACTATAATG TCGATAGATA TGGTGCACAA GCCCAACCTT GTTATTGCGG AGAACCTTGC 1260
TGTGTAGGGT ATATTGGCGG AAAGACGCAA ACTGAGGCTC AATCGAAACT ACCTGAGAAT 1320
GTCCGAGAGG CTCTTGGTAT TGAAGATGAA GAGGATAGCT GGGAAAACAT CACTGCACGT 1380
CGACAACGTC GTAAAAAGGG AATTGACGAA ACTAGCAAAA TTATTGAAGA GGTGCAACCT 1440
ACTCCTCTGA CATCTGAGTC TGCTACTAAA GTGATTGGCG TTCTCCTGCA AACTAAGGAT 1500
GACTTATTAA CAAGAAAGTT AATGGAACGC ATTTTCTTGA CTTCAGATCC TAGTGTATGC 1560
CGTTCGATCA TTGCGTTACG TGGTTACAAC ATTTTTGGTT TGATGCTGAA GAAGTTCAGC 1620
ATTGATATTG AGTTTATACT ACGTTCTATA AAAACCATGT TATCTTGGCC ACGCCTAACA 1680
AGAAATAAAA TCCAAGATTC AAATATTGAG CCCGTTGTTC AAGAGTTTTG CGACCATGAG 1740
AACGAGGAGG TCAAAGATCA TGCCAAAACT CTTTTAAAAG AATGGGAATC TTTGGAGATA 1800
GCTTATCGAA TTCCCCGAAG GAAGCCTGGT CAAGTTGCTC CACAGTCAAC GAACGCAGAA 1860
CCCTCCAATA ATCAAAGTAA TCCTCCTTTA AGGGATCAGG AACCACAACG TGGCGATAAG 1920
GGAGATATAA AATCTGCAAT CAATAATTCA ACAGAAGATT TGAGCAAGAA ACATCCAGCA 1980
TTACATTCTT CTAGGCCTAG TGATAGTCGT TCACGTTCCA AGTTTGGAAA TGACTATCAA 2040
AGCCATTCAA AACACAACCT TTTTCGTAAA AATTCTTTCC CTAAACGTCG TCGTCTTTCT 2100
AACTCTGACA CTCCTTCTGA AACAACTACA CCAAATAATG AGCAAGAACA AGTCAGCAAT 2160
CAAGCTAATA AAGTAGATTT AAACAAGATT ATTTCAGCGG CAATGGAGAG TGTCAATCAG 2220
AAAAATGTGT TGAAGGCACA GAAGGAGGAA GAAGAAAGAA TAGCTCAGCA GAAAAGAGAA 2280
GAAAAGAGAC GTCTTGCTTA CGAAGAAAGT TTGAAAAGAC ATGCCAAAAA GTTGCATGAA 2340
AAGAAGACGA AAAGCTCTCA GGATGCCACA ATTGATCATC ATTTAACTTC GCATAGTCCT 2400
GAAAGCATTG CTTTTAAGGC AGTTTTGGCA AAATTTTTTG CTAACAAAAC AGCTAGATAC 2460
CAAGAGAAGC TTGGTAAAGC TGAATTTAAA TTGAGAGTAA AGAAAATGAC TGAAATTATC 2520
TTGAAAAAGC ATATTCAGTT AGTTCTATCC AAAAAAGAAA AAGCTTTACC AGATGAATTA 2580
TCAGACTCTC AGCAGCGAAA GCTGAGAGTT TGGGCATTTC GATATTTGGA CACAGTTGTA 2640
TCGCGTTCTG GCACTGCGAC TACAACTCCT ACAGATTCAC CCAGTATTGG CGAATCCCCG 2700
AAAAAAGCTG CTTAATCGCC AGTATTTTTA ACTGCGACAA GTAGCAACGT CTACCATACT 2760
ATAGTTCCAA ATATTGCATG TCTTTAATAC CTGGTGTCTA GTTTTTTTTT TCTTCCTTGA 2820
TGTAATATTT TAATACTATT TTTTTTTTTA AATACAATCT TTAATTTCCA GACATAGAAG 2880
CCGTATTTGT GTCTAAATGC ACGTCGACTG TTTACAACAT TTCATCTAAT TATATAACCC 2940
TGGACTGGAC CGG
2954Nucleotide Fasta Sequence
>SPAC29B12.02c.1:pep|SET1|Schizosaccharomyces pombe
AGAGTTGTCGTTTACACTCCGGTACTGTGAGCCCCTACGAGGATTCCGCGAGTAAAGAAGGAACGCCGCCAACAGCCACAACTTCTTCCTTGAGACAATTTCCTGATCTCACTGTTTCTTTGACACGAAACTTTGAAACGTTAGAAGATCTATATGTTACGCATCGAGATATTTTCGGAAATTTTCTAAAAAGAAGATTTTCGGTGAAATTTCAGCTGGTCTTCTTTCTATTGTTTTGGCTTCCTTCGGCAATTACTTTTTGTTCAATAAAACTGTAGATTTTTTAACTTTCTCTTTCTTTTTGTCCATTATCATACAATGCAGACGGCATCATCTCTTTCTGTTTTAACTCCTTTGAATGAGGAAAACGTTGATAGGAAGTCTTCTTGGTCAAAAGACACAATCGCTGTCCAGGCAGTCGGTTCATCACCATCTTCTTCGTCATCTCATGATTTCGAAAGTAAAGAGGATGCCGAAGGGATGAATAAAGACGAAAGTGCTCCTTCCCCTTCTACGTCCTCGCCATCGTCTGCATCCTCTCGGTCTCAAAGCAAATATGTTAGAAAAGAGGCACTTCCTCCTCAACTTTTTCATCACCTGGATTCTGCGAAAGATAAGGCGCTAACTACGTTCGAAGAGATTCAAGAATGTCAGTATGCTTCCGCCAATATTGGTAAGCCTCCAGAAAACGAAGCTATGATTTGCGATTGTCGGCCTCATTGGGTAGATGGAGTTAATGTTGCTTGTGGGCACGGATCCAATTGTATTAATAGAATGACTTCTATAGAGTGTACGGACGAAGATAACGTTTGTGGACCATCCTGTCAAAACCAACGCTTTCAAAGACATGAATTTGCAAAGGTGGATGTTTTCTTAACCGAAAAGAAAGGGTTTGGTTTGCGCGCTGATGCCAATTTACCCAAAGACACATTTGTCTACGAATACATTGGAGAAGTTATACCTGAACAAAAGTTTCGTAAACGTATGCGACAATACGATAGTGAGGGAATTAAACACTTTTACTTCATGATGCTGCAAAAGGGGGAATATATTGATGCTACTAAAAGGGGGTCGCTCGCAAGATTTTGCAATCACTCTTGTAGACCTAATTGTTATGTTGATAAATGGATGGTAGGAGATAAGCTAAGAATGGGTATATTTTGTAAAAGAGATATTATTCGCGGTGAAGAGCTTACTTTTGACTATAATGTCGATAGATATGGTGCACAAGCCCAACCTTGTTATTGCGGAGAACCTTGCTGTGTAGGGTATATTGGCGGAAAGACGCAAACTGAGGCTCAATCGAAACTACCTGAGAATGTCCGAGAGGCTCTTGGTATTGAAGATGAAGAGGATAGCTGGGAAAACATCACTGCACGTCGACAACGTCGTAAAAAGGGAATTGACGAAACTAGCAAAATTATTGAAGAGGTGCAACCTACTCCTCTGACATCTGAGTCTGCTACTAAAGTGATTGGCGTTCTCCTGCAAACTAAGGATGACTTATTAACAAGAAAGTTAATGGAACGCATTTTCTTGACTTCAGATCCTAGTGTATGCCGTTCGATCATTGCGTTACGTGGTTACAACATTTTTGGTTTGATGCTGAAGAAGTTCAGCATTGATATTGAGTTTATACTACGTTCTATAAAAACCATGTTATCTTGGCCACGCCTAACAAGAAATAAAATCCAAGATTCAAATATTGAGCCCGTTGTTCAAGAGTTTTGCGACCATGAGAACGAGGAGGTCAAAGATCATGCCAAAACTCTTTTAAAAGAATGGGAATCTTTGGAGATAGCTTATCGAATTCCCCGAAGGAAGCCTGGTCAAGTTGCTCCACAGTCAACGAACGCAGAACCCTCCAATAATCAAAGTAATCCTCCTTTAAGGGATCAGGAACCACAACGTGGCGATAAGGGAGATATAAAATCTGCAATCAATAATTCAACAGAAGATTTGAGCAAGAAACATCCAGCATTACATTCTTCTAGGCCTAGTGATAGTCGTTCACGTTCCAAGTTTGGAAATGACTATCAAAGCCATTCAAAACACAACCTTTTTCGTAAAAATTCTTTCCCTAAACGTCGTCGTCTTTCTAACTCTGACACTCCTTCTGAAACAACTACACCAAATAATGAGCAAGAACAAGTCAGCAATCAAGCTAATAAAGTAGATTTAAACAAGATTATTTCAGCGGCAATGGAGAGTGTCAATCAGAAAAATGTGTTGAAGGCACAGAAGGAGGAAGAAGAAAGAATAGCTCAGCAGAAAAGAGAAGAAAAGAGACGTCTTGCTTACGAAGAAAGTTTGAAAAGACATGCCAAAAAGTTGCATGAAAAGAAGACGAAAAGCTCTCAGGATGCCACAATTGATCATCATTTAACTTCGCATAGTCCTGAAAGCATTGCTTTTAAGGCAGTTTTGGCAAAATTTTTTGCTAACAAAACAGCTAGATACCAAGAGAAGCTTGGTAAAGCTGAATTTAAATTGAGAGTAAAGAAAATGACTGAAATTATCTTGAAAAAGCATATTCAGTTAGTTCTATCCAAAAAAGAAAAAGCTTTACCAGATGAATTATCAGACTCTCAGCAGCGAAAGCTGAGAGTTTGGGCATTTCGATATTTGGACACAGTTGTATCGCGTTCTGGCACTGCGACTACAACTCCTACAGATTCACCCAGTATTGGCGAATCCCCGAAAAAAGCTGCTTAATCGCCAGTATTTTTAACTGCGACAAGTAGCAACGTCTACCATACTATAGTTCCAAATATTGCATGTCTTTAATACCTGGTGTCTAGTTTTTTTTTTCTTCCTTGATGTAATATTTTAATACTATTTTTTTTTTTAAATACAATCTTTAATTTCCAGACATAGAAGCCGTATTTGTGTCTAAATGCACGTCGACTGTTTACAACATTTCATCTAATTATATAACCCTGGACTGGACCGG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR006560--AWS_dom
IPR025788--Hist-Lys_N-MeTrfase_SET2_fun
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR013257--SRI
IPR017923--TFIIS_N
|
| PROSITE |
PS51215--AWS
PS50868--POST_SET
PS51568--SAM_MT43_SET2_1
PS50280--SET
|
| Pfam |
PF08711--Med26
PF00856--SET
PF08236--SRI
|
| Gene Ontology |
GO:0016591--C:DNA-directed RNA polymerase II, holoenzyme
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0010452--P:histone H3-K36 methylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
