| Tag |
Content |
| WERAM ID |
WERAM-Sac-0023 |
| Ensembl Protein ID |
YJL168C |
| Uniprot Accession |
P46995; SET2_YEAST; D6VW19
|
| Genbank Protein ID |
NP_012367.2
|
| Protein Name |
Histone-lysine N-methyltransferase, H3 lysine-36 specific |
| Genbank Nucleotide ID |
NM_001181601.2
|
| Gene Name |
SET2 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
SET2 |
SET |
H3K36 |
K |
20236312; 26854085
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SET2 |
1.30e-50 |
168.9 |
62 |
716 |
| HMT |
SET1 |
5.90e-29 |
99.1 |
122 |
237 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent. |
Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent.
|
| Domain Profile |
HMT SET2
SET2.txt 62 kdeviDatkkGnlaRfinhsCePn 85
++ +++ + +++ +nh+C+ +
YJL168C 62 NNDFMECDCYEEFSDGVNHACDED 85
55555666666777789****865 PP
SET2.txt 3 veliktekkGyGlrakeeikkdefileYvGevidekeakkRlkeyeeekvkdfYlleldkdeviDatkkGnlaRfinhsCePncetqkwtvegelrvglfa 103
+ ++kt++kGyG+ra+++i++++fi+eY Gevi+e+e+++Rl +y+++++k+fY+++l+++e+iDat kG+laRf+nhsC+Pn++++kw+v+++lr+g+fa
YJL168C 122 IAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFA 222
789************************************************************************************************** PP
SET2.txt 104 kkkikkgeeltfdYn 118
++ki kgee+tfdYn
YJL168C 223 QRKILKGEEITFDYN 237
**************8 PP
SET2.txt 22 kkdefileYvGevidekeakkRlk 45
k +efi+ Y+ ++i +k+ kk l+
YJL168C 693 KVKEFINSYMDKIILKKKQKKALA 716
5679**********9999887654 PP
HMT SET1
SET1.txt 3 levakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeig.vylfrldedaevvvdatkkgniarfinhscepNceakvvavdgekkivi 102
+ + k k kg+g++a+++ie+++++ EY Gevi++++ r +y++++ + y++ l++ +dat kg+ arf nhsc+pN++++ v+ + +++i
YJL168C 122 IAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKhFYFMMLQNG--EFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGI 220
677889999**************************99999999******997777777777..99************************************ PP
SET1.txt 103 yakraIekgeeltydYk 119
+a+r+I kgee+t+dY+
YJL168C 221 FAQRKILKGEEITFDYN 237
****************7 PP
|
Protein Sequence
(Fasta) | MSKNQSVSAS EDEKEILNNN AEGHKPQRLF DQEPDLTEEA LTKFENLDDC IYANKRIGTF 60
KNNDFMECDC YEEFSDGVNH ACDEDSDCIN RLTLIECVND LCSSCGNDCQ NQRFQKKQYA 120
PIAIFKTKHK GYGVRAEQDI EANQFIYEYK GEVIEEMEFR DRLIDYDQRH FKHFYFMMLQ 180
NGEFIDATIK GSLARFCNHS CSPNAYVNKW VVKDKLRMGI FAQRKILKGE EITFDYNVDR 240
YGAQAQKCYC EEPNCIGFLG GKTQTDAASL LPQNIADALG VTVSMEKKWL KLKKLSGEPI 300
IKNENENINI EFLQSLEVQP IDSPVDVTKI MSVLLQQDNK IIASKLLKRL FTIDDDSLRH 360
QAIKLHGYTC FSKMLKLFIT EQPQVDGKGN ETEEDDIKFI KGILDFLLEL PKTTRNGIES 420
SQIDNVVKTL PAKFPFLKPN CDELLEKWSK FETYKRITKK DINVAASKMI DLRRVRLPPG 480
WEIIHENGRP LYYNAEQKTK LHYPPSGSSK VFSSRSNTQV NSPSSSGIPK TPGALDSKKH 540
KLSDEEYERK KQKRLEYERI ALERAKQEEL ESLKQKLKLE NERKSVLEDI IAEANKQKEL 600
QKEEAKKLVE AKEAKRLKRK TVSQSQRLEH NWNKFFASFV PNLIKKNPQS KQFDHENIKQ 660
CAKDIVKILT TKELKKDSSR APPDDLTKGK RHKVKEFINS YMDKIILKKK QKKALALSSA 720
STRMSSPPPS TSS 733Protein Fasta Sequence
>YJL168C|SET2|Saccharomyces cerevisiae
MSKNQSVSASEDEKEILNNNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCFSKMLKLFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFLKPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGSSKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDIIAEANKQKELQKEEAKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPNLIKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYMDKIILKKKQKKALALSSASTRMSSPPPSTSS |
Nucleotide Sequence
(Fasta) | ATGTCGAAGA ACCAAAGTGT GAGTGCGTCG GAAGATGAAA AAGAAATACT GAATAACAAC 60
GCTGAGGGCC ATAAACCTCA AAGGCTTTTT GATCAAGAGC CTGATCTCAC AGAGGAAGCA 120
TTGACCAAAT TTGAAAACTT GGATGACTGT ATATATGCGA ACAAGAGGAT CGGAACATTT 180
AAGAATAATG ATTTCATGGA ATGTGACTGT TATGAAGAAT TCTCAGATGG CGTCAACCAT 240
GCCTGTGACG AGGATTCTGA CTGTATCAAT AGACTTACGT TGATAGAATG TGTCAACGAT 300
TTGTGTTCAT CTTGTGGTAA TGATTGTCAA AATCAGAGAT TTCAAAAGAA GCAGTACGCT 360
CCGATAGCCA TATTTAAAAC AAAGCATAAA GGTTATGGCG TAAGAGCCGA ACAGGACATA 420
GAAGCCAACC AGTTCATTTA CGAGTACAAA GGTGAGGTGA TCGAGGAGAT GGAATTTAGA 480
GATAGGTTAA TAGACTATGA CCAACGTCAT TTCAAGCATT TTTATTTTAT GATGTTACAG 540
AACGGAGAAT TCATTGACGC CACAATAAAG GGTTCGTTGG CCAGATTTTG CAATCACTCT 600
TGCAGCCCCA ATGCATATGT TAATAAATGG GTTGTTAAGG ATAAGCTACG CATGGGAATA 660
TTTGCTCAAA GAAAAATTTT AAAAGGTGAG GAAATCACTT TTGATTATAA TGTGGATCGT 720
TATGGTGCTC AAGCTCAGAA ATGCTACTGT GAGGAGCCAA ATTGTATTGG GTTTCTCGGT 780
GGTAAGACTC AAACAGATGC GGCATCTTTA TTGCCCCAGA ACATCGCTGA TGCCTTGGGA 840
GTGACTGTTT CCATGGAGAA AAAATGGCTA AAGTTAAAGA AATTAAGCGG TGAGCCAATA 900
ATAAAGAATG AAAACGAGAA CATAAATATT GAATTTCTTC AATCATTGGA AGTCCAACCT 960
ATCGACAGCC CAGTGGATGT GACGAAGATC ATGAGTGTAT TACTACAGCA AGATAATAAG 1020
ATAATTGCAT CCAAACTCTT GAAGAGACTT TTTACTATCG ATGATGACTC TCTTCGTCAT 1080
CAGGCTATCA AACTACACGG TTACACCTGT TTTAGCAAAA TGCTTAAATT GTTTATCACG 1140
GAACAACCTC AGGTAGATGG AAAAGGAAAC GAGACTGAAG AAGATGATAT AAAGTTTATA 1200
AAGGGAATTT TAGATTTTTT GTTGGAATTA CCAAAGACAA CTCGAAACGG TATTGAGTCG 1260
TCACAAATTG ATAATGTAGT AAAAACTCTC CCTGCAAAGT TTCCATTTTT AAAGCCAAAC 1320
TGCGATGAGT TATTGGAGAA ATGGTCGAAA TTTGAAACAT ATAAAAGGAT AACGAAGAAA 1380
GACATAAACG TCGCAGCCAG CAAAATGATA GATTTGAGAA GGGTGAGATT ACCTCCAGGC 1440
TGGGAGATCA TTCACGAAAA CGGTCGCCCA TTGTATTATA ATGCAGAACA GAAAACGAAA 1500
CTACACTATC CACCTTCGGG ATCATCTAAG GTCTTTAGTT CAAGGTCAAA TACACAAGTA 1560
AATTCTCCGA GTAGCAGTGG AATACCAAAA ACGCCTGGCG CTTTAGACTC TAAGAAACAT 1620
AAGCTGAGTG ACGAAGAATA TGAGAGGAAG AAACAAAAAA GACTGGAATA CGAAAGAATT 1680
GCGCTAGAAA GAGCCAAACA AGAAGAATTG GAAAGCCTGA AGCAAAAGCT AAAGCTTGAG 1740
AATGAAAGAA AAAGCGTTTT GGAGGATATT ATAGCGGAGG CCAACAAACA GAAGGAGTTA 1800
CAAAAGGAAG AGGCCAAAAA ACTAGTGGAA GCAAAAGAGG CTAAGCGGTT GAAAAGAAAA 1860
ACGGTCTCCC AGTCCCAAAG ACTAGAGCAC AACTGGAATA AATTCTTTGC ATCTTTTGTA 1920
CCCAACTTAA TAAAAAAAAA CCCACAAAGT AAACAATTTG ATCATGAAAA CATTAAACAA 1980
TGTGCTAAAG ACATCGTGAA AATCCTAACT ACAAAGGAAC TTAAAAAAGA TTCTTCAAGA 2040
GCGCCGCCTG ATGACTTAAC CAAAGGAAAA AGGCATAAAG TTAAAGAATT CATAAATTCA 2100
TACATGGATA AGATTATCCT CAAGAAGAAG CAAAAAAAGG CGTTGGCATT ATCATCAGCA 2160
TCAACAAGGA TGTCTTCTCC TCCACCTTCA ACATCATCAT AA
2203Nucleotide Fasta Sequence
>YJL168C|SET1|Saccharomyces cerevisiae
ATGTCGAAGAACCAAAGTGTGAGTGCGTCGGAAGATGAAAAAGAAATACTGAATAACAACGCTGAGGGCCATAAACCTCAAAGGCTTTTTGATCAAGAGCCTGATCTCACAGAGGAAGCATTGACCAAATTTGAAAACTTGGATGACTGTATATATGCGAACAAGAGGATCGGAACATTTAAGAATAATGATTTCATGGAATGTGACTGTTATGAAGAATTCTCAGATGGCGTCAACCATGCCTGTGACGAGGATTCTGACTGTATCAATAGACTTACGTTGATAGAATGTGTCAACGATTTGTGTTCATCTTGTGGTAATGATTGTCAAAATCAGAGATTTCAAAAGAAGCAGTACGCTCCGATAGCCATATTTAAAACAAAGCATAAAGGTTATGGCGTAAGAGCCGAACAGGACATAGAAGCCAACCAGTTCATTTACGAGTACAAAGGTGAGGTGATCGAGGAGATGGAATTTAGAGATAGGTTAATAGACTATGACCAACGTCATTTCAAGCATTTTTATTTTATGATGTTACAGAACGGAGAATTCATTGACGCCACAATAAAGGGTTCGTTGGCCAGATTTTGCAATCACTCTTGCAGCCCCAATGCATATGTTAATAAATGGGTTGTTAAGGATAAGCTACGCATGGGAATATTTGCTCAAAGAAAAATTTTAAAAGGTGAGGAAATCACTTTTGATTATAATGTGGATCGTTATGGTGCTCAAGCTCAGAAATGCTACTGTGAGGAGCCAAATTGTATTGGGTTTCTCGGTGGTAAGACTCAAACAGATGCGGCATCTTTATTGCCCCAGAACATCGCTGATGCCTTGGGAGTGACTGTTTCCATGGAGAAAAAATGGCTAAAGTTAAAGAAATTAAGCGGTGAGCCAATAATAAAGAATGAAAACGAGAACATAAATATTGAATTTCTTCAATCATTGGAAGTCCAACCTATCGACAGCCCAGTGGATGTGACGAAGATCATGAGTGTATTACTACAGCAAGATAATAAGATAATTGCATCCAAACTCTTGAAGAGACTTTTTACTATCGATGATGACTCTCTTCGTCATCAGGCTATCAAACTACACGGTTACACCTGTTTTAGCAAAATGCTTAAATTGTTTATCACGGAACAACCTCAGGTAGATGGAAAAGGAAACGAGACTGAAGAAGATGATATAAAGTTTATAAAGGGAATTTTAGATTTTTTGTTGGAATTACCAAAGACAACTCGAAACGGTATTGAGTCGTCACAAATTGATAATGTAGTAAAAACTCTCCCTGCAAAGTTTCCATTTTTAAAGCCAAACTGCGATGAGTTATTGGAGAAATGGTCGAAATTTGAAACATATAAAAGGATAACGAAGAAAGACATAAACGTCGCAGCCAGCAAAATGATAGATTTGAGAAGGGTGAGATTACCTCCAGGCTGGGAGATCATTCACGAAAACGGTCGCCCATTGTATTATAATGCAGAACAGAAAACGAAACTACACTATCCACCTTCGGGATCATCTAAGGTCTTTAGTTCAAGGTCAAATACACAAGTAAATTCTCCGAGTAGCAGTGGAATACCAAAAACGCCTGGCGCTTTAGACTCTAAGAAACATAAGCTGAGTGACGAAGAATATGAGAGGAAGAAACAAAAAAGACTGGAATACGAAAGAATTGCGCTAGAAAGAGCCAAACAAGAAGAATTGGAAAGCCTGAAGCAAAAGCTAAAGCTTGAGAATGAAAGAAAAAGCGTTTTGGAGGATATTATAGCGGAGGCCAACAAACAGAAGGAGTTACAAAAGGAAGAGGCCAAAAAACTAGTGGAAGCAAAAGAGGCTAAGCGGTTGAAAAGAAAAACGGTCTCCCAGTCCCAAAGACTAGAGCACAACTGGAATAAATTCTTTGCATCTTTTGTACCCAACTTAATAAAAAAAAACCCACAAAGTAAACAATTTGATCATGAAAACATTAAACAATGTGCTAAAGACATCGTGAAAATCCTAACTACAAAGGAACTTAAAAAAGATTCTTCAAGAGCGCCGCCTGATGACTTAACCAAAGGAAAAAGGCATAAAGTTAAAGAATTCATAAATTCATACATGGATAAGATTATCCTCAAGAAGAAGCAAAAAAAGGCGTTGGCATTATCATCAGCATCAACAAGGATGTCTTCTCCTCCACCTTCAACATCATCATAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR006560--AWS_dom
IPR025788--Hist-Lys_N-MeTrfase_SET2_fun
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR013257--SRI
IPR001202--WW_dom
|
| PROSITE |
PS51215--AWS
PS50868--POST_SET
PS51568--SAM_MT43_SET2_1
PS50280--SET
|
| Pfam |
PF00856--SET
PF08236--SRI
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0042054--F:histone methyltransferase activity
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0030437--P:ascospore formation
GO:0006354--P:DNA-templated transcription, elongation
GO:0006353--P:DNA-templated transcription, termination
GO:0016575--P:histone deacetylation
GO:0016571--P:histone methylation
GO:0060195--P:negative regulation of antisense RNA transcription
GO:0071441--P:negative regulation of histone H3-K14 acetylation
GO:2000616--P:negative regulation of histone H3-K9 acetylation
GO:0045128--P:negative regulation of reciprocal meiotic recombination
GO:0035066--P:positive regulation of histone acetylation
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:1900049--P:regulation of histone exchange
GO:0006355--P:regulation of transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
