| Tag |
Content |
| WERAM ID |
WERAM-Cae-0013 |
| Ensembl Protein ID |
R06C7.7b |
| Uniprot Accession |
B2D6M2; LIN61_CAEEL; Q21769
|
| Genbank Protein ID |
NP_001122501.1; NP_492050.3
|
| Protein Name |
Protein lin-61 |
| Genbank Nucleotide ID |
NM_001129029.1; NM_059649.4
|
| Gene Name |
LIN-61;lin-61;R06C7.7 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
MBT |
MBT1 |
H3K9me2/3 |
K |
24348272
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
MBT |
6.10e-73 |
230 |
31 |
50 |
|
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View)Functional Description
Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability. |
Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability.
|
| Domain Profile |
Me_Reader MBT
MBT-2.txt 60 iggrlkvsfeesededddyW 79
++ ++++ +ed+ +W
R06C7.7b 31 FDEVFQLTVSHWEDDGNTFW 50
44555666666666666666 PP
MBT-2.txt 48 sseirvatveeviggrlkvsfeesededddyWidesspfifpv 90
+ + a++e+v+g r+ +f + d +W++ s ++f
R06C7.7b 197 IQVRWFARIEKVCGYRVLAQFIGA---DTKFWLNILSDDMFGL 236
223368***************999...788*******999965 PP
MBT-2.txt 1 sdwkeylrktldgakvapkslseklseskalls...fkvgmrlEvvdkknsseirvatveeviggrlkvs.....feese.deddd.........yWide 82
+d+++y+++++dg++v+++sls+k++e+kalls fkvg+rlE+++++ns+eirva+++e++g+r++vs f+es+ d+ddd yWide
R06C7.7b 263 NDMVNYVNNCIDGEIVGQTSLSPKFDEGKALLSkhrFKVGQRLELLNYSNSTEIRVARIQEICGRRMNVSitkkdFPESLpDADDDrqvfssgsqYWIDE 362
69*****************************9999*********************************************999999************** PP
MBT-2.txt 83 sspfifpvGwaakqgkelq 101
+s+fifpvG+aa++g++l+
R06C7.7b 363 GSFFIFPVGFAAVNGYQLN 381
*****************96 PP
MBT-2.txt 31 llsfkvgmrlEvvd..kknsseirvatveeviggr..lkvsfeesededddyWidesspfifpvGwaakqgkelqpp 103
++kvg++ E++d ++ + va++ + + + l v ++ +d + i+ ++ f+fpvG+a+k el pp
R06C7.7b 425 WRKVKVGQKFELIDplAQQFNNLHVASILKFCKTEgyLIVGMDGPDALEDSFPIHINNTFMFPVGYAEKYNLELVPP 501
4569**********55588899********997553277889999667788*****************998888765 PP
MBT-2.txt 2 dwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknsseirvatveeviggrlkvsfeesededddyWidesspfifpvGwaakqgkelq 101
w+eyl k a+++p +l++ ++++++l +fkvg rlE+ d + + i+ atv++v g+ ++v+f+++ de++d d +s +i p+Gw++ + + lq
R06C7.7b 509 RWDEYLEKE--SAETLPLDLFKPMPSQERLDKFKVGLRLEAADMCENQFICPATVKSVHGRLINVNFDGW-DEEFDELYDVDSHDILPIGWCEAHSYVLQ 605
6*******9..***********************************************************.*****999********************* PP
MBT-2.txt 102 pp 103
pp
R06C7.7b 606 PP 607
98 PP
|
Protein Sequence
(Fasta) | MLKLVILCFA LFYNTVSSTR FLFGVEVKCD FDEVFQLTVS HWEDDGNTFW DRDEDITGRM 60
TMFARKKIFF YQDGHHGFEF GKLEPYGWFL HNCTKNGNFR EYRHGLSSTS GSNGLEYIEY 120
TMSEFLKIVR ANKKSDRKLD KTYLWESYLH QFEKGKTSFI PVEAFNRNLT VNFNECVKEG 180
VIFETVVHDY DKNCDSIQVR WFARIEKVCG YRVLAQFIGA DTKFWLNILS DDMFGLANAA 240
MSDPNMDKIV YAPPLAINEE YQNDMVNYVN NCIDGEIVGQ TSLSPKFDEG KALLSKHRFK 300
VGQRLELLNY SNSTEIRVAR IQEICGRRMN VSITKKDFPE SLPDADDDRQ VFSSGSQYWI 360
DEGSFFIFPV GFAAVNGYQL NAKKEYIEHT NKIAQAIKNG ENPRYDSDDV TFDQLAKDPI 420
DPMIWRKVKV GQKFELIDPL AQQFNNLHVA SILKFCKTEG YLIVGMDGPD ALEDSFPIHI 480
NNTFMFPVGY AEKYNLELVP PDEFKGTFRW DEYLEKESAE TLPLDLFKPM PSQERLDKFK 540
VGLRLEAADM CENQFICPAT VKSVHGRLIN VNFDGWDEEF DELYDVDSHD ILPIGWCEAH 600
SYVLQPPKKY NY 612Protein Fasta Sequence
>R06C7.7b|LIN-61;lin-61;R06C7.7|Caenorhabditis elegans
MLKLVILCFALFYNTVSSTRFLFGVEVKCDFDEVFQLTVSHWEDDGNTFWDRDEDITGRMTMFARKKIFFYQDGHHGFEFGKLEPYGWFLHNCTKNGNFREYRHGLSSTSGSNGLEYIEYTMSEFLKIVRANKKSDRKLDKTYLWESYLHQFEKGKTSFIPVEAFNRNLTVNFNECVKEGVIFETVVHDYDKNCDSIQVRWFARIEKVCGYRVLAQFIGADTKFWLNILSDDMFGLANAAMSDPNMDKIVYAPPLAINEEYQNDMVNYVNNCIDGEIVGQTSLSPKFDEGKALLSKHRFKVGQRLELLNYSNSTEIRVARIQEICGRRMNVSITKKDFPESLPDADDDRQVFSSGSQYWIDEGSFFIFPVGFAAVNGYQLNAKKEYIEHTNKIAQAIKNGENPRYDSDDVTFDQLAKDPIDPMIWRKVKVGQKFELIDPLAQQFNNLHVASILKFCKTEGYLIVGMDGPDALEDSFPIHINNTFMFPVGYAEKYNLELVPPDEFKGTFRWDEYLEKESAETLPLDLFKPMPSQERLDKFKVGLRLEAADMCENQFICPATVKSVHGRLINVNFDGWDEEFDELYDVDSHDILPIGWCEAHSYVLQPPKKYNY |
Nucleotide Sequence
(Fasta) | ATGCTAAAAT TAGTCATTTT GTGCTTCGCG TTGTTCTACA ATACAGTCAG TTCGACAAGA 60
TTTCTGTTTG GCGTCGAAGT TAAGTGTGAT TTTGATGAAG TGTTCCAATT AACAGTGTCG 120
CATTGGGAAG ACGATGGCAA TACTTTTTGG GATCGCGATG AAGACATCAC TGGACGTATG 180
ACTATGTTTG CTCGAAAGAA AATATTTTTC TATCAGGACG GCCATCATGG ATTTGAATTT 240
GGAAAGCTCG AGCCTTATGG GTGGTTTCTG CACAATTGCA CGAAAAATGG AAATTTTCGC 300
GAGTATAGGC ACGGGTTGAG TAGCACCAGT GGATCCAATG GGTTGGAGTA TATTGAGTAC 360
ACTATGTCTG AATTTCTGAA AATTGTCAGA GCTAACAAAA AATCGGACAG AAAACTCGAT 420
AAGACCTACT TGTGGGAATC CTATTTACAT CAGTTCGAGA AAGGAAAAAC TTCTTTCATT 480
CCAGTTGAAG CATTCAATCG TAACCTTACA GTTAATTTTA ACGAATGCGT GAAGGAAGGA 540
GTTATCTTCG AAACAGTGGT CCATGATTAT GACAAGAACT GCGATTCGAT TCAAGTCAGA 600
TGGTTTGCAC GAATTGAAAA AGTTTGCGGA TACAGAGTTC TGGCTCAGTT TATCGGAGCT 660
GACACGAAAT TTTGGCTCAA TATTTTATCG GACGATATGT TTGGTTTGGC AAACGCCGCA 720
ATGAGTGATC CCAATATGGA TAAAATTGTA TATGCTCCGC CGCTTGCAAT CAACGAAGAA 780
TACCAAAATG ATATGGTAAA TTATGTAAAT AATTGCATTG ATGGCGAAAT CGTCGGCCAA 840
ACTTCGCTGT CTCCAAAATT CGATGAAGGG AAGGCTCTCC TAAGCAAGCA TCGTTTCAAA 900
GTTGGACAAC GTCTTGAACT ATTAAATTAT TCCAATTCTA CTGAAATACG CGTAGCGCGA 960
ATTCAAGAAA TATGTGGACG ACGAATGAAT GTATCTATCA CAAAGAAAGA CTTTCCCGAA 1020
TCGCTTCCAG ATGCAGATGA CGACAGACAA GTCTTTAGCT CTGGATCTCA ATATTGGATA 1080
GACGAGGGAA GCTTCTTCAT ATTTCCTGTT GGATTTGCAG CAGTCAATGG ATATCAACTA 1140
AATGCGAAAA AGGAATATAT TGAGCACACA AATAAAATTG CTCAAGCAAT AAAAAATGGA 1200
GAAAATCCAA GATATGACTC AGACGACGTC ACATTTGATC AATTAGCAAA AGATCCAATT 1260
GATCCCATGA TTTGGAGAAA AGTTAAGGTT GGACAAAAGT TTGAGCTCAT CGACCCCTTG 1320
GCTCAGCAAT TCAATAACCT CCACGTCGCT TCGATTCTCA AATTTTGCAA AACTGAAGGA 1380
TATCTTATTG TGGGAATGGA TGGTCCAGAT GCACTTGAAG ACAGTTTTCC TATTCATATC 1440
AATAATACAT TTATGTTCCC AGTTGGTTAT GCGGAAAAGT ATAATTTGGA ACTTGTTCCG 1500
CCAGATGAGT TCAAAGGAAC ATTCAGATGG GATGAATACT TGGAGAAAGA ATCTGCAGAA 1560
ACCCTACCGC TTGACTTGTT CAAGCCAATG CCTTCCCAAG AGAGATTAGA CAAATTTAAG 1620
GTAGGACTAC GCCTTGAAGC TGCTGACATG TGTGAAAATC AGTTTATTTG TCCAGCTACA 1680
GTGAAATCAG TTCATGGAAG ACTGATAAAT GTCAATTTCG ACGGCTGGGA TGAAGAATTT 1740
GATGAACTGT ATGATGTGGA CTCCCATGAT ATTCTACCGA TAGGATGGTG TGAAGCGCAC 1800
AGTTATGTTC TACAACCTCC GAAAAAGTAC AACTATTGAT AAAAGCTACA TTAACATAAT 1860
TTCATTCGTA TGCAGGATCT CTTATATACA CTTTCCCGTT TTGGATTGGT ATTTCCCTTA 1920
TTTTATTTAC TGTGCTATCA TTGGTGACTC TTTTTGCACC TATCGAACAT GAATCTTCAA 1980
CATTATT
1988Nucleotide Fasta Sequence
>R06C7.7b|MBT|Caenorhabditis elegans
ATGCTAAAATTAGTCATTTTGTGCTTCGCGTTGTTCTACAATACAGTCAGTTCGACAAGATTTCTGTTTGGCGTCGAAGTTAAGTGTGATTTTGATGAAGTGTTCCAATTAACAGTGTCGCATTGGGAAGACGATGGCAATACTTTTTGGGATCGCGATGAAGACATCACTGGACGTATGACTATGTTTGCTCGAAAGAAAATATTTTTCTATCAGGACGGCCATCATGGATTTGAATTTGGAAAGCTCGAGCCTTATGGGTGGTTTCTGCACAATTGCACGAAAAATGGAAATTTTCGCGAGTATAGGCACGGGTTGAGTAGCACCAGTGGATCCAATGGGTTGGAGTATATTGAGTACACTATGTCTGAATTTCTGAAAATTGTCAGAGCTAACAAAAAATCGGACAGAAAACTCGATAAGACCTACTTGTGGGAATCCTATTTACATCAGTTCGAGAAAGGAAAAACTTCTTTCATTCCAGTTGAAGCATTCAATCGTAACCTTACAGTTAATTTTAACGAATGCGTGAAGGAAGGAGTTATCTTCGAAACAGTGGTCCATGATTATGACAAGAACTGCGATTCGATTCAAGTCAGATGGTTTGCACGAATTGAAAAAGTTTGCGGATACAGAGTTCTGGCTCAGTTTATCGGAGCTGACACGAAATTTTGGCTCAATATTTTATCGGACGATATGTTTGGTTTGGCAAACGCCGCAATGAGTGATCCCAATATGGATAAAATTGTATATGCTCCGCCGCTTGCAATCAACGAAGAATACCAAAATGATATGGTAAATTATGTAAATAATTGCATTGATGGCGAAATCGTCGGCCAAACTTCGCTGTCTCCAAAATTCGATGAAGGGAAGGCTCTCCTAAGCAAGCATCGTTTCAAAGTTGGACAACGTCTTGAACTATTAAATTATTCCAATTCTACTGAAATACGCGTAGCGCGAATTCAAGAAATATGTGGACGACGAATGAATGTATCTATCACAAAGAAAGACTTTCCCGAATCGCTTCCAGATGCAGATGACGACAGACAAGTCTTTAGCTCTGGATCTCAATATTGGATAGACGAGGGAAGCTTCTTCATATTTCCTGTTGGATTTGCAGCAGTCAATGGATATCAACTAAATGCGAAAAAGGAATATATTGAGCACACAAATAAAATTGCTCAAGCAATAAAAAATGGAGAAAATCCAAGATATGACTCAGACGACGTCACATTTGATCAATTAGCAAAAGATCCAATTGATCCCATGATTTGGAGAAAAGTTAAGGTTGGACAAAAGTTTGAGCTCATCGACCCCTTGGCTCAGCAATTCAATAACCTCCACGTCGCTTCGATTCTCAAATTTTGCAAAACTGAAGGATATCTTATTGTGGGAATGGATGGTCCAGATGCACTTGAAGACAGTTTTCCTATTCATATCAATAATACATTTATGTTCCCAGTTGGTTATGCGGAAAAGTATAATTTGGAACTTGTTCCGCCAGATGAGTTCAAAGGAACATTCAGATGGGATGAATACTTGGAGAAAGAATCTGCAGAAACCCTACCGCTTGACTTGTTCAAGCCAATGCCTTCCCAAGAGAGATTAGACAAATTTAAGGTAGGACTACGCCTTGAAGCTGCTGACATGTGTGAAAATCAGTTTATTTGTCCAGCTACAGTGAAATCAGTTCATGGAAGACTGATAAATGTCAATTTCGACGGCTGGGATGAAGAATTTGATGAACTGTATGATGTGGACTCCCATGATATTCTACCGATAGGATGGTGTGAAGCGCACAGTTATGTTCTACAACCTCCGAAAAAGTACAACTATTGATAAAAGCTACATTAACATAATTTCATTCGTATGCAGGATCTCTTATATACACTTTCCCGTTTTGGATTGGTATTTCCCTTATTTTATTTACTGTGCTATCATTGGTGACTCTTTTTGCACCTATCGAACATGAATCTTCAACATTATT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
--
|
| Interpro |
IPR004092--Mbt
|
| PROSITE |
PS51079--MBT
|
| Pfam |
PF02820--MBT
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0040025--P:vulval development
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
