WERAM Information

Tag Content
WERAM ID WERAM-Hos-0056
Ensembl Protein ID ENSP00000216237.5
Uniprot Accession Q969R5; LMBL2_HUMAN; Q8TEN1; Q96SC4; Q9BQI2; Q9UGS4
Genbank Protein ID NP_113676.2
Protein Name Lethal(3)malignant brain tumor-like protein 2
Genbank Nucleotide ID NM_031488.4
Gene Name L3MBTL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100395.14 ENST00000216237.9 ENSP00000216237.5
ENSG00000100395.14 ENST00000452106.5 ENSP00000414423.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader MBT MBT1 H4K20me1/2 K 24309976
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader MBT 1.60e-101 321.9 142 155
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Domain Profile
  Me_Reader MBT
          MBT-2.txt  86 fifpvGwaakqgke 99 
                         ++ + w+ak g  
  ENSP00000216237.5 142 VLHKAAWSAKIGAF 155
                        689999**999875 PP
          MBT-2.txt   1 sdwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknss...eirvatveeviggrlkvsfeese.dedddyWidesspfif 88 
                        +dw ++l+      k+ap+s +++++   +  ++  gm++Ev++   ++     ++a+v +  g r+ +++e+ e d+++d+W++ +  +++
  ENSP00000216237.5 179 FDWGKFLKDH--SYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLpsrVYWIASVIQTAGYRVLLRYEGFEnDASHDFWCNLGTVDVH 268
                        5999***999..8999***************************99875411145789999999***************************** PP
          MBT-2.txt  89 pvGwaakqgkelqpp 103
                        p+Gw+a + k l pp
  ENSP00000216237.5 269 PIGWCAINSKILVPP 283
                        *******99998776 PP
          MBT-2.txt   1 sdwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknsseirvatveeviggrlkvsfeesededddyWidesspfifpvGw 92 
                        +dwk yl+k+l g++++p++++ k+ es++++ f++gmrlEvvdk+++s++r+a+v++viggrl++ +e+  d+ddd+W++++sp+i+pvGw
  ENSP00000216237.5 291 TDWKGYLMKRLVGSRTLPVDFHIKMVESMKYP-FRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDG-DSDDDFWCHMWSPLIHPVGW 380
                        69******************************.**************************************.******************** PP
          MBT-2.txt  93 aakqgkelqp 102
                        +++ g+ +++
  ENSP00000216237.5 381 SRRVGHGIKM 390
                        ******9987 PP
          MBT-2.txt  20 slseklseskalls.fkvgmrlEvvdkknsseirvatveev.iggrlkvsfeese.dedddyWi.desspfifpvGwaakqgkelqpp 103
                         l++k++   ++ + f+ gm+lE++d  n  +i+vatv +v  +g l +  ++    +  d+ + ++ss  ifp+ +++k+  el+pp
  ENSP00000216237.5 413 YLFKKVRAVYTEGGwFEEGMKLEAIDPLNLGNICVATVCKVlLDGYLMICVDGGPsTDGLDWFCyHASSHAIFPATFCQKNDIELTPP 500
                        577888877777778***********************98736999******9976677788883467789**********9999887 PP
          MBT-2.txt   1 sdwkeylrktldgakvapkslseklseskallsfkvgmrlEvvdkknsseirvatveeviggrlkvsfeesededddyWidesspfifpvGw 92 
                        ++w++yl kt  ++k+ap  l++    + +  +fkvgm+lE+vd +++ +i+vatv+ v+ + l ++f+++ d+++d W+d +sp+i+pvGw
  ENSP00000216237.5 508 FNWENYLEKT--KSKAAPSRLFNM---DCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGW-DSEYDQWVDCESPDIYPVGW 593
                        59********..*********975...445566**************************************.******************** PP
          MBT-2.txt  93 aakqgkelqpp 103
                        ++ +g++lqpp
  ENSP00000216237.5 594 CELTGYQLQPP 604
                        *********98 PP
Protein Sequence
(Fasta)		MEKPRSIEET PSSEPMEEEE DDDLELFGGY DSFRSYNSSV GSESSSYLEE SSEAENEDRE 60
AGELPTSPLH LLSPGTPRSL DGSGSEPAVC EMCGIVGTRE AFFSKTKRFC SVSCSRSYSS 120
NSKKASILAR LQGKPPTKKA KVLHKAAWSA KIGAFLHSQG TGQLADGTPT GQDALVLGFD 180
WGKFLKDHSY KAAPVSCFKH VPLYDQWEDV MKGMKVEVLN SDAVLPSRVY WIASVIQTAG 240
YRVLLRYEGF ENDASHDFWC NLGTVDVHPI GWCAINSKIL VPPRTIHAKF TDWKGYLMKR 300
LVGSRTLPVD FHIKMVESMK YPFRQGMRLE VVDKSQVSRT RMAVVDTVIG GRLRLLYEDG 360
DSDDDFWCHM WSPLIHPVGW SRRVGHGIKM SERRSDMAHH PTFRKIYCDA VPYLFKKVRA 420
VYTEGGWFEE GMKLEAIDPL NLGNICVATV CKVLLDGYLM ICVDGGPSTD GLDWFCYHAS 480
SHAIFPATFC QKNDIELTPP KGYEAQTFNW ENYLEKTKSK AAPSRLFNMD CPNHGFKVGM 540
KLEAVDLMEP RLICVATVKR VVHRLLSIHF DGWDSEYDQW VDCESPDIYP VGWCELTGYQ 600
LQPPVAAEPA TPLKAKEATK KKKKQFGKKR KRIPPTKTRP LRQGSKKPLL EDDPQGARKI 660
SSEPVPGEII AVRVKEEHLD VASPDKASSP ELPVSVENIK QETDD 705
Nucleotide Sequence
(Fasta)		GAATGGCGGG AGCAGGCACG GAACCGGCTT TTCCTCCTTC CTGCAGCGTG ATTGGCCCGC 60
GGCTCAGGGA GGCGACCAAT GAGTGCTCTC GCGGAGAGCG ACGGGGCAGG CCAATATGGC 120
TTCCTGCACC TGGTGACGCT TGGCGAAACT GAGGTCTCAT GGAGAAGCCC CGGAGTATTG 180
AGGAGACCCC ATCTTCAGAA CCAATGGAGG AAGAGGAAGA TGACGACTTG GAGCTGTTTG 240
GTGGCTATGA TAGTTTCCGG AGTTATAACA GCAGTGTGGG CAGTGAGAGC AGCTCCTATC 300
TGGAGGAGTC AAGTGAAGCA GAAAATGAGG ATCGGGAAGC AGGGGAACTG CCGACCTCCC 360
CGCTGCATTT GCTCAGCCCT GGGACTCCTC GCTCCTTGGA TGGCAGTGGT TCTGAGCCAG 420
CTGTCTGTGA GATGTGTGGT ATCGTGGGTA CAAGGGAAGC CTTCTTCTCC AAGACCAAGA 480
GGTTCTGCAG CGTCTCCTGC TCCAGGAGCT ACTCCTCCAA CTCCAAGAAA GCCAGTATCT 540
TGGCTAGGTT ACAGGGAAAA CCACCGACCA AAAAAGCCAA AGTCCTGCAC AAGGCTGCCT 600
GGTCTGCCAA AATTGGAGCC TTCCTCCACT CTCAAGGGAC AGGACAGCTG GCAGATGGGA 660
CACCAACAGG ACAAGACGCT CTGGTCTTGG GCTTCGACTG GGGGAAGTTC CTGAAGGATC 720
ACAGTTACAA GGCTGCTCCC GTCAGCTGTT TCAAGCACGT CCCACTCTAT GACCAGTGGG 780
AGGATGTGAT GAAAGGGATG AAGGTGGAGG TGCTCAACAG TGATGCTGTG CTCCCCAGCC 840
GGGTGTACTG GATCGCCTCT GTCATCCAGA CAGCAGGGTA TCGGGTGCTG CTTCGGTATG 900
AAGGCTTTGA AAATGACGCC AGCCATGACT TCTGGTGCAA CCTGGGAACA GTGGATGTCC 960
ACCCCATTGG CTGGTGTGCC ATCAACAGCA AGATCCTAGT GCCCCCACGG ACCATCCATG 1020
CCAAGTTCAC CGACTGGAAG GGCTACCTCA TGAAACGGCT GGTGGGCTCC AGGACGCTTC 1080
CCGTGGATTT CCACATCAAG ATGGTGGAGA GCATGAAGTA CCCCTTTAGG CAGGGCATGC 1140
GGCTGGAAGT GGTGGACAAG TCCCAGGTGT CACGCACTCG CATGGCTGTG GTGGACACAG 1200
TAATCGGGGG TCGCCTACGG CTCCTCTACG AGGATGGTGA CAGTGACGAC GACTTCTGGT 1260
GCCACATGTG GAGCCCCCTG ATCCACCCAG TGGGTTGGTC ACGACGTGTG GGCCACGGCA 1320
TCAAGATGTC AGAGAGGCGA AGTGACATGG CCCATCACCC CACCTTCCGG AAGATCTACT 1380
GTGATGCCGT TCCTTACCTC TTCAAGAAGG TACGAGCAGT CTACACAGAA GGCGGTTGGT 1440
TTGAGGAAGG GATGAAGCTG GAGGCCATTG ACCCCCTGAA TCTGGGCAAC ATCTGCGTGG 1500
CAACTGTCTG TAAGGTTCTC CTGGATGGAT ACCTGATGAT CTGTGTGGAC GGGGGGCCCT 1560
CCACAGATGG CTTGGACTGG TTCTGCTACC ATGCCTCTTC CCACGCCATC TTCCCGGCCA 1620
CCTTCTGTCA GAAGAATGAC ATTGAGCTCA CACCGCCAAA AGGTTATGAG GCACAGACTT 1680
TCAACTGGGA GAACTACTTG GAGAAGACCA AGTCGAAAGC CGCTCCATCG AGACTCTTTA 1740
ACATGGATTG CCCAAACCAT GGCTTCAAGG TGGGCATGAA GCTGGAGGCC GTGGACCTGA 1800
TGGAGCCCCG GCTCATCTGT GTGGCCACGG TGAAACGAGT GGTGCATCGG CTCCTCAGCA 1860
TCCACTTTGA CGGCTGGGAC AGCGAGTACG ACCAGTGGGT GGACTGCGAG TCCCCAGACA 1920
TCTACCCCGT CGGCTGGTGT GAGCTCACCG GCTACCAGCT CCAGCCTCCT GTGGCCGCAG 1980
AACCGGCCAC ACCGCTGAAG GCCAAAGAGG CCACAAAGAA GAAAAAGAAA CAGTTTGGGA 2040
AGAAAAGGAA AAGAATCCCG CCCACTAAGA CGCGACCCCT CAGACAGGGG TCCAAGAAGC 2100
CCCTGCTGGA GGACGACCCT CAGGGTGCCA GGAAGATCTC GTCGGAGCCT GTTCCTGGCG 2160
AGATCATTGC TGTGCGTGTG AAGGAAGAGC ATCTAGACGT GGCCTCGCCC GACAAGGCTT 2220
CAAGTCCAGA GCTGCCTGTC TCCGTCGAGA ACATCAAGCA GGAAACAGAC GACTGAGCCT 2280
TCCTGCCTCC AGCCTGGCTT CTAGCTGGAA GCCAGCCCAG CGTTTCTCTA CCACCACCAC 2340
CATGCCTCCA CCTGACTTTG GCTTGGAGAC TGATCCTCTC TGTGTAAATT CTGCCCGGTG 2400
CTGTGAAGGC TGGACGGTGG AGGACCTGCT GGGGTCTCCT GGGACCCGCC TGTTGCTTCT 2460
GCCCTCCCCT GTGGAAAGGT CTATATGACG GGCCGCCTGA GGCCCCAGAA CTCGTCTGTG 2520
AACCACCTTT TCCAGCCAGA GTTCCCAAAG CTGGAACGCT AGCTGCCTGC TCTTCCTTAA 2580
GATGGCCTCC CCCCGACCCG CCACGGCCCT CAGTTGCCAG GGATGGGGCC ACCACTGTCA 2640
CACTGTGGAA TACAAGACAG TGAACTCTGT CTGCCTGAAC GAGCCATGTA AATTAAGTTC 2700
TAGAGCAGCT CTCTGAGCAG GATAAGGTCC CCTGACAGTG AGTTGTGTGG TGGGGGCAGC 2760
CTCTGCCTCA AAAATTCACC AAGCAGAATG CCTCTCAGCC TCATGTGTTG GTCCTCTGCT 2820
CCTCCTAGCT CCCCAGGGAT GTTGGGGACC CAGCTTGTCT CGGCAGCTAA GAAGCAGTGA 2880
CCAGGATGTG GATTTTGGCG ACCTGTGTGG TGGCCTTGAG CTGCTTTCTG TGTTTGTGAG 2940
GACTGACTCC CATTTCCTAA AGGAAATGCC CCCGGGGAGG ACATTGGGAG GAAGATGGCC 3000
TGAGTGTGCA CTTTGGCTCT GCTACCTGCT CCTGAAGCCC CGCTAAAAAT AATTCATCCA 3060
AGATTCCTTT GTAGTTAAAG GGTCCAGTTC TGACTGGAGC CTCTAGAGAG CTGGGCTTGT 3120
ATGTTCTTTT GGCCTTTTGT TCCTACCTAA ATGAAGAAAC CATGCCTGGA GGGGCCGTGA 3180
ACACAGAACC CTCAAGACAA GGATGACAGA GCTGGAGGAC ACATCTAGCT GCCATTGCAA 3240
CCTCACTGGG CTCCCCAGAC TCTGTGTGTG AGAAATTAAA CCCCCTGCTT GCTTGA 3297
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR004092--Mbt
IPR012313--Znf_FCS
PROSITE

PS51079--MBT
PS51024--ZF_FCS
Pfam

PF02820--MBT
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016568--P:chromatin modification
GO:0016925--P:protein sumoylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0119 ENSPTRP00000024842.4 Pan troglodytes 100 0.0 1251
WERAM-Mam-0126 ENSMMUP00000018606.2 Macaca mulatta 99 0.0 1234
WERAM-Gog-0149 ENSGGOP00000013124.2 Gorilla gorilla 99 0.0 1234
WERAM-Chs-0065 ENSCSAP00000002147.1 Chlorocebus sabaeus 99 0.0 1234
WERAM-Paa-0014 ENSPANP00000013405.1 Papio anubis 98 0.0 1231
WERAM-Sus-0002 ENSSSCP00000000072.2 Sus scrofa 96 0.0 1212
WERAM-Mim-0023 ENSMICP00000002392.1 Microcebus murinus 96 0.0 1212
WERAM-Eqc-0067 ENSECAP00000008791.1 Equus caballus 96 0.0 1208
WERAM-Caf-0011 ENSCAFP00000001579.3 Canis familiaris 96 0.0 1206
WERAM-Ict-0004 ENSSTOP00000000214.2 Ictidomys tridecemlineatus 96 0.0 1204
WERAM-Mup-0190 ENSMPUP00000016321.1 Mustela putorius furo 96 0.0 1202
WERAM-Aim-0159 ENSAMEP00000014802.1 Ailuropoda melanoleuca 96 0.0 1199
WERAM-Otg-0009 ENSOGAP00000000385.2 Otolemur garnettii 96 0.0 1199
WERAM-Bot-0202 ENSBTAP00000037474.3 Bos taurus 95 0.0 1197
WERAM-Orc-0021 ENSOCUP00000002328.3 Oryctolagus cuniculus 96 0.0 1191
WERAM-Cap-0182 ENSCPOP00000016632.1 Cavia porcellus 95 0.0 1188
WERAM-Poa-0102 ENSPPYP00000013237.2 Pongo abelii 94 0.0 1181
WERAM-Myl-0103 ENSMLUP00000008085.2 Myotis lucifugus 94 0.0 1180
WERAM-Ere-0047 ENSEEUP00000004095.1 Erinaceus europaeus 91 0.0 1170
WERAM-Loa-0115 ENSLAFP00000010294.3 Loxodonta africana 94 0.0 1168
WERAM-Mum-0045 ENSMUSP00000023029.8 Mus musculus 91 0.0 1150
WERAM-Ran-0154 ENSRNOP00000031908.5 Rattus norvegicus 92 0.0 1147
WERAM-Fec-0042 ENSFCAP00000003381.3 Felis catus 92 0.0 1136
WERAM-Nol-0167 ENSNLEP00000018759.1 Nomascus leucogenys 95 0.0 1112
WERAM-Tut-0041 ENSTTRP00000003144.1 Tursiops truncatus 95 0.0 1094
WERAM-Ptv-0143 ENSPVAP00000012048.1 Pteropus vampyrus 89 0.0 1094
WERAM-Ova-0191 ENSOARP00000019415.1 Ovis aries 89 0.0 1085
WERAM-Ora-0112 ENSOANP00000021980.3 Ornithorhynchus anatinus 81 0.0 1068
WERAM-Caj-0073 ENSCJAP00000011937.1 Callithrix jacchus 91 0.0 1060
WERAM-Pes-0032 ENSPSIP00000005466.1 Pelodiscus sinensis 81 0.0 1050
WERAM-Gaga-0112 ENSGALP00000019511.2 Gallus gallus 80 0.0 1027
WERAM-Meg-0119 ENSMGAP00000012831.2 Meleagris gallopavo 80 0.0 1025
WERAM-Fia-0147 ENSFALP00000012563.1 Ficedula albicollis 79 0.0 1014
WERAM-Anp-0021 ENSAPLP00000003088.1 Anas platyrhynchos 78 0.0 992
WERAM-Tag-0125 ENSTGUP00000010328.1 Taeniopygia guttata 77 0.0 971
WERAM-Lac-0059 ENSLACP00000008132.1 Latimeria chalumnae 75 0.0 958
WERAM-Tub-0126 ENSTBEP00000013853.1 Tupaia belangeri 87 0.0 954
WERAM-Dio-0084 ENSDORP00000008367.1 Dipodomys ordii 88 0.0 940
WERAM-Ocp-0114 ENSOPRP00000011232.1 Ochotona princeps 94 0.0 920
WERAM-Dan-0131 ENSDNOP00000022376.1 Dasypus novemcinctus 93 0.0 837
WERAM-Anc-0048 ENSACAP00000005013.2 Anolis carolinensis 73 0.0 820
WERAM-Sah-0073 ENSSHAP00000008692.1 Sarcophilus harrisii 84 0.0 778
WERAM-Mod-0110 ENSMODP00000016374.3 Monodelphis domestica 73 0.0 746
WERAM-Asm-0196 ENSAMXP00000018585.1 Astyanax mexicanus 65 0.0 695
WERAM-Xet-0150 ENSXETP00000049711.3 Xenopus tropicalis 73 0.0 688
WERAM-Mae-0044 ENSMEUP00000004103.1 Macropus eugenii 87 0.0 678
WERAM-Dar-0115 ENSDARP00000072956.4 Danio rerio 58 0.0 675
WERAM-Leo-0101 ENSLOCP00000013546.1 Lepisosteus oculatus 63 0.0 651
WERAM-Soa-0077 ENSSARP00000007328.1 Sorex araneus 63 0.0 648
WERAM-Orla-0157 ENSORLP00000018415.1 Oryzias latipes 61 0.0 641
WERAM-Xim-0183 ENSXMAP00000014772.1 Xiphophorus maculatus 61 0.0 639
WERAM-Ten-0028 ENSTNIP00000005731.1 Tetraodon nigroviridis 60 0.0 637
WERAM-Tar-0208 ENSTRUP00000043663.1 Takifugu rubripes 60 0.0 635
WERAM-Pof-0159 ENSPFOP00000012993.2 Poecilia formosa 61 0.0 635
WERAM-Orn-0165 ENSONIP00000017092.1 Oreochromis niloticus 61 0.0 633
WERAM-Gam-0096 ENSGMOP00000009925.1 Gadus morhua 60 0.0 632
WERAM-Gaa-0161 ENSGACP00000020119.1 Gasterosteus aculeatus 60 0.0 631
WERAM-Pem-0002 ENSPMAP00000000143.1 Petromyzon marinus 61 1e-180 630
WERAM-Vip-0042 ENSVPAP00000003789.1 Vicugna pacos 58 4e-169 592
WERAM-Tas-0088 ENSTSYP00000008989.1 Tarsius syrichta 71 2e-145 513
WERAM-Ect-0095 ENSETEP00000011137.1 Echinops telfairi 96 7e-138 488
WERAM-Drm-0045 FBpp0080069 Drosophila melanogaster 49 7e-124 442
WERAM-Prc-0151 ENSPCAP00000014086.1 Procavia capensis 86 1e-111 401
WERAM-Cii-0022 ENSCINP00000008702.3 Ciona intestinalis 62 8e-73 272
WERAM-Chh-0053 ENSCHOP00000006228.1 Choloepus hoffmanni 65 2e-70 264
WERAM-Cis-0019 ENSCSAVP00000004315.1 Ciona savignyi 66 6e-68 256
Created Date 25-Jun-2016