| Tag |
Content |
| WERAM ID |
WERAM-Drm-0026 |
| Ensembl Protein ID |
FBpp0305388 |
| Uniprot Accession |
Q960X4; TIP60_DROME; O97425
|
| Genbank Protein ID |
NP_001259234.1; NP_572151.1
|
| Protein Name |
Histone acetyltransferase Tip60 |
| Genbank Nucleotide ID |
NM_001272305.1; NM_131923.4
|
| Gene Name |
TIP60;CG6121 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H2AK4; H4K5; H4K8; H4K12 |
K |
24639513; 18022374
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
4.90e-129 |
430 |
256 |
533 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-4' and exchanges it with unmodified H2AV. |
Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-4' and exchanges it with unmodified H2AV.
|
| Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCllaklfld 99
++kn+e+ielg+++ik+wy+sp+p+el +++++yicefclky ks+++l+rhl+kC+lr+pPgneiyrk+++s+fe+dG+k+k+y+qnlCllaklfld
FBpp0305388 256 RMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLD 353
789*********************************************************************************************** PP
MYST.txt 100 hktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgllsYrsyWkevll 197
hktlyyd++pflFYv+te d++g+h+vGyFskekes+e+yn+aCil++PpyqrkGyGklLiefsYels+ egk+gsPekPLsdlgllsYrsyW++++l
FBpp0305388 354 HKTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQTIL 451
************************************************************************************************** PP
MYST.txt 198 ell.....kekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklkwkp 276
e++ ++ ek +iti+++++ t+i++eD++stl++lnli+++kgqyi++ ++ i+e++++++ k+k+++d+++l+w+p
FBpp0305388 452 EIFisqnpSTDGEKPTITINDICECTSIKKEDVISTLQNLNLINYYKGQYIVCINRVIIEQHRRAMD--KRKIRIDSKCLHWTP 533
***877766677778***********************************************88777..999**********97 PP
|
Protein Sequence
(Fasta) | MKINHKYEFD DDVASICEST AALTEGCRLP VRMHKTDDWP LAEIVSIKEL DGRRQFYVHY 60
VDFNKRLDEW VNEEDLYTRK VQFPRRDGSQ TGTSTGVTTP QRHHSLAGSV SRPTSPQHPG 120
SGALAAIPQT PTGASGSVPP PAGIPNSVAP PGTPSSGGEL VNGNNLAAAL QKRINRKRKN 180
HGGSAHGHHS LTSQQQQSHP HPTTPQTPTA TPVHVTGDGL ISGAANDDGD GSQDGKTPTP 240
RQSGSMVTHQ DDVVTRMKNV EMIELGRHRI KPWYFSPYPQ ELCQMPCIYI CEFCLKYRKS 300
RKCLERHLSK CNLRHPPGNE IYRKHTISFF EIDGRKNKVY AQNLCLLAKL FLDHKTLYYD 360
TDPFLFYVMT EFDSRGFHIV GYFSKEKEST EDYNVACILT MPPYQRKGYG KLLIEFSYEL 420
SKFEGKTGSP EKPLSDLGLL SYRSYWAQTI LEIFISQNPS TDGEKPTITI NDICECTSIK 480
KEDVISTLQN LNLINYYKGQ YIVCINRVII EQHRRAMDKR KIRIDSKCLH WTPKDWSKRS 540
K 541Protein Fasta Sequence
>FBpp0305388|TIP60;CG6121|Drosophila melanogaster
MKINHKYEFDDDVASICESTAALTEGCRLPVRMHKTDDWPLAEIVSIKELDGRRQFYVHYVDFNKRLDEWVNEEDLYTRKVQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASGSVPPPAGIPNSVAPPGTPSSGGELVNGNNLAAALQKRINRKRKNHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGAANDDGDGSQDGKTPTPRQSGSMVTHQDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVISTLQNLNLINYYKGQYIVCINRVIIEQHRRAMDKRKIRIDSKCLHWTPKDWSKRSK |
Nucleotide Sequence
(Fasta) | CACTGTGGCG GTAATCGATT GGTCGATAGT TATTTACGTT TCGCTATCTG GCAATACTGC 60
TGTTTTAGGA AAAAAAAAAC GCGTAAAATA TAAACAAATG AAAATTAACC ACAAATATGA 120
GTTCGACGAC GATGTGGCCT CCATATGCGA GTCAACGGCC GCCCTAACCG AGGGATGTCG 180
TTTACCCGTC AGGATGCACA AAACGGACGA CTGGCCACTA GCGGAGATTG TGAGCATCAA 240
GGAGTTGGAT GGGCGCCGGC AGTTTTACGT GCACTATGTG GACTTCAACA AGCGCTTGGA 300
CGAGTGGGTC AACGAGGAGG ATCTGTACAC GCGAAAGGTG CAATTTCCGC GGAGAGACGG 360
CTCACAAACA GGCACCAGCA CTGGAGTGAC CACGCCACAG CGCCACCATT CCCTAGCGGG 420
CAGCGTTTCT CGGCCTACAT CACCGCAACA CCCTGGTTCC GGGGCTCTGG CAGCCATCCC 480
CCAGACTCCT ACTGGTGCAT CAGGCAGTGT TCCTCCCCCT GCTGGCATTC CAAACTCTGT 540
GGCTCCACCC GGAACACCAA GCAGTGGGGG AGAGCTTGTG AATGGCAACA ATCTGGCCGC 600
AGCCCTTCAG AAACGCATCA ATCGCAAGCG AAAAAACCAC GGAGGCTCGG CCCATGGACA 660
CCACAGTCTG ACCAGTCAAC AGCAGCAGTC ACATCCGCAT CCTACAACTC CGCAGACACC 720
CACGGCTACG CCCGTGCATG TGACCGGCGA CGGTTTAATA AGCGGAGCGG CCAATGATGA 780
TGGTGATGGA TCGCAGGATG GCAAGACGCC CACGCCGAGG CAATCAGGCA GCATGGTTAC 840
GCACCAGGAC GACGTGGTCA CCCGCATGAA GAACGTGGAG ATGATCGAGC TGGGCAGGCA 900
TCGCATTAAG CCCTGGTATT TCTCACCCTA TCCGCAAGAG CTGTGTCAAA TGCCCTGCAT 960
CTACATCTGC GAGTTCTGCC TGAAGTACAG GAAGAGCAGG AAGTGCCTGG AGAGGCACCT 1020
GTCCAAGTGC AATCTTAGGC ATCCACCGGG AAACGAGATC TATCGCAAAC ATACAATTTC 1080
CTTCTTTGAA ATCGATGGAC GCAAAAACAA GGTGTATGCC CAGAACTTGT GCCTGCTTGC 1140
CAAACTCTTT CTCGACCACA AGACACTCTA CTATGATACC GATCCGTTTC TCTTCTACGT 1200
AATGACAGAG TTCGACTCGC GCGGCTTCCA CATAGTAGGG TACTTCTCCA AGGAGAAGGA 1260
GAGCACAGAG GACTACAACG TGGCCTGCAT TCTCACAATG CCTCCGTATC AGCGCAAGGG 1320
CTACGGCAAG CTGCTCATTG AGTTCAGCTA CGAGTTGTCC AAGTTCGAGG GCAAGACGGG 1380
ATCGCCGGAG AAACCATTGT CTGATCTGGG TTTGCTGTCC TATCGATCGT ACTGGGCGCA 1440
AACCATACTG GAGATCTTTA TCAGCCAAAA CCCGAGCACG GACGGCGAAA AGCCCACTAT 1500
AACTATAAAC GACATCTGCG AATGCACATC CATCAAAAAA GAGGACGTGA TCTCAACGCT 1560
GCAGAACCTG AACCTGATCA ACTACTACAA GGGCCAGTAC ATCGTGTGCA TCAACCGGGT 1620
TATCATCGAG CAACACCGGC GAGCAATGGA CAAGCGCAAG ATCCGCATCG ACTCGAAATG 1680
CCTGCACTGG ACACCCAAAG ACTGGTCCAA GCGCTCCAAA TGATTTCCGC TACCAATATT 1740
CTTCATCGGA TGATCCTGGC TTCGTTGTAG CTTGTAGTTT TCATTTACAG TTTCCGTTTT 1800
TAATGTTATA AACTAGTTTA TATCATACAA TATTATATAT ACTTTTGAGA CG
1853Nucleotide Fasta Sequence
>FBpp0305388|MYST|Drosophila melanogaster
CACTGTGGCGGTAATCGATTGGTCGATAGTTATTTACGTTTCGCTATCTGGCAATACTGCTGTTTTAGGAAAAAAAAAACGCGTAAAATATAAACAAATGAAAATTAACCACAAATATGAGTTCGACGACGATGTGGCCTCCATATGCGAGTCAACGGCCGCCCTAACCGAGGGATGTCGTTTACCCGTCAGGATGCACAAAACGGACGACTGGCCACTAGCGGAGATTGTGAGCATCAAGGAGTTGGATGGGCGCCGGCAGTTTTACGTGCACTATGTGGACTTCAACAAGCGCTTGGACGAGTGGGTCAACGAGGAGGATCTGTACACGCGAAAGGTGCAATTTCCGCGGAGAGACGGCTCACAAACAGGCACCAGCACTGGAGTGACCACGCCACAGCGCCACCATTCCCTAGCGGGCAGCGTTTCTCGGCCTACATCACCGCAACACCCTGGTTCCGGGGCTCTGGCAGCCATCCCCCAGACTCCTACTGGTGCATCAGGCAGTGTTCCTCCCCCTGCTGGCATTCCAAACTCTGTGGCTCCACCCGGAACACCAAGCAGTGGGGGAGAGCTTGTGAATGGCAACAATCTGGCCGCAGCCCTTCAGAAACGCATCAATCGCAAGCGAAAAAACCACGGAGGCTCGGCCCATGGACACCACAGTCTGACCAGTCAACAGCAGCAGTCACATCCGCATCCTACAACTCCGCAGACACCCACGGCTACGCCCGTGCATGTGACCGGCGACGGTTTAATAAGCGGAGCGGCCAATGATGATGGTGATGGATCGCAGGATGGCAAGACGCCCACGCCGAGGCAATCAGGCAGCATGGTTACGCACCAGGACGACGTGGTCACCCGCATGAAGAACGTGGAGATGATCGAGCTGGGCAGGCATCGCATTAAGCCCTGGTATTTCTCACCCTATCCGCAAGAGCTGTGTCAAATGCCCTGCATCTACATCTGCGAGTTCTGCCTGAAGTACAGGAAGAGCAGGAAGTGCCTGGAGAGGCACCTGTCCAAGTGCAATCTTAGGCATCCACCGGGAAACGAGATCTATCGCAAACATACAATTTCCTTCTTTGAAATCGATGGACGCAAAAACAAGGTGTATGCCCAGAACTTGTGCCTGCTTGCCAAACTCTTTCTCGACCACAAGACACTCTACTATGATACCGATCCGTTTCTCTTCTACGTAATGACAGAGTTCGACTCGCGCGGCTTCCACATAGTAGGGTACTTCTCCAAGGAGAAGGAGAGCACAGAGGACTACAACGTGGCCTGCATTCTCACAATGCCTCCGTATCAGCGCAAGGGCTACGGCAAGCTGCTCATTGAGTTCAGCTACGAGTTGTCCAAGTTCGAGGGCAAGACGGGATCGCCGGAGAAACCATTGTCTGATCTGGGTTTGCTGTCCTATCGATCGTACTGGGCGCAAACCATACTGGAGATCTTTATCAGCCAAAACCCGAGCACGGACGGCGAAAAGCCCACTATAACTATAAACGACATCTGCGAATGCACATCCATCAAAAAAGAGGACGTGATCTCAACGCTGCAGAACCTGAACCTGATCAACTACTACAAGGGCCAGTACATCGTGTGCATCAACCGGGTTATCATCGAGCAACACCGGCGAGCAATGGACAAGCGCAAGATCCGCATCGACTCGAAATGCCTGCACTGGACACCCAAAGACTGGTCCAAGCGCTCCAAATGATTTCCGCTACCAATATTCTTCATCGGATGATCCTGGCTTCGTTGTAGCTTGTAGTTTTCATTTACAGTTTCCGTTTTTAATGTTATAAACTAGTTTATATCATACAATATTATATATACTTTTGAGACG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0000123--C:histone acetyltransferase complex
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0005705--C:polytene chromosome interband
GO:0004402--F:histone acetyltransferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016573--P:histone acetylation
GO:0043486--P:histone exchange
GO:0043967--P:histone H4 acetylation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0007399--P:nervous system development
GO:0010468--P:regulation of gene expression
GO:0048167--P:regulation of synaptic plasticity
GO:2000331--P:regulation of terminal button organization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
