WERAM Information

Tag Content
WERAM ID WERAM-Cae-0023
Ensembl Protein ID F46G10.7a
Uniprot Accession Q20480; SIR41_CAEEL; D1MN70; Q7JMD3
Genbank Protein ID NP_001024672.1; NP_001024673.1; NP_001257218.1
Protein Name NAD-dependent protein deacylase sir-2.2
Genbank Nucleotide ID NM_001029501.3; NM_001029502.1; NM_001270289.1
Gene Name SIR-2.2;SIR41;F46G10.7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004801 F46G10.7a F46G10.7a
WBGene00004801 F46G10.7b F46G10.7b
WBGene00004801 F46G10.7c F46G10.7c
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type K 12466527
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 7.80e-75 252.1 19 287
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Domain Profile
  HDAC SIR2
   SIR2.txt   2 klakllkkskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkv..fyalakelyp.lgsakPtktHyflaelekkgkllr 97 
                k+++l+ +++k++v++GAGiSt++GIPD+Rs + Gly++++++      +i+ +d++r+++++  +++++   +p +g+a P+ +Hy+l+++e ++++++
  F46G10.7a  19 KFISLIGTVDKLLVISGAGISTESGIPDYRSkDVGLYARIAHK------PIYFQDYMRSNRCRqrYWSRNFLAWPrFGQAAPNINHYALSKWEASDRFQW 112
                78999**************************99*********9......9**********99999*********************************** PP
   SIR2.txt  98 lytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkak.............................ekvpkCekCkgvlkpdivff 168
                l+tQN+DgL++kag+k  +++elHGs+ +++Ct+C++  +r++++++l  +                             +++p+C++C+g++k+d++ff
  F46G10.7a 113 LITQNVDGLHLKAGSK--MVTELHGSALQVKCTTCDYIESRQTYQDRLDYAnpgfkeehvapgelapdgdiilplgtekgFQIPECPSCGGLMKTDVTFF 210
                ***************9..******************************9999************************************************ PP
   SIR2.txt 169 genlpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveel 245
                gen+++++++ + e+++e+d +l lGtSl+v + ++++++a +kk+p+++vn+++++ad++a++kl++++++v++e+
  F46G10.7a 211 GENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRADHMATMKLDYKISDVLKEM 287
                *************************************************************************9875 PP
Protein Sequence
(Fasta)		MAQKFVPEAA ELCENSLKKF ISLIGTVDKL LVISGAGIST ESGIPDYRSK DVGLYARIAH 60
KPIYFQDYMR SNRCRQRYWS RNFLAWPRFG QAAPNINHYA LSKWEASDRF QWLITQNVDG 120
LHLKAGSKMV TELHGSALQV KCTTCDYIES RQTYQDRLDY ANPGFKEEHV APGELAPDGD 180
IILPLGTEKG FQIPECPSCG GLMKTDVTFF GENVNMDKVN FCYEKVNECD GILSLGTSLA 240
VLSGFRFIHH ANMKKKPIFI VNIGPTRADH MATMKLDYKI SDVLKEM 287
Nucleotide Sequence
(Fasta)		GCATGGCTCA AAAGTTTGTA CCGGAGGCCG CCGAGCTCTG TGAAAATTCC TTGAAAAAGT 60
TCATATCTTT GATTGGAACA GTGGACAAGC TGCTTGTCAT CTCTGGAGCA GGAATATCTA 120
CAGAATCTGG TATCCCAGAT TACCGCTCGA AAGATGTGGG GCTGTACGCA AGAATTGCAC 180
ACAAGCCAAT TTATTTTCAA GATTACATGA GGTCCAACCG TTGTAGACAA AGATACTGGT 240
CTCGCAATTT TTTAGCCTGG CCGAGATTTG GTCAAGCTGC TCCTAACATC AATCACTACG 300
CACTATCGAA ATGGGAAGCT TCCGATAGAT TCCAATGGTT AATCACACAA AACGTGGATG 360
GGCTTCACTT AAAAGCGGGC TCAAAAATGG TAACGGAACT TCATGGCAGT GCTCTTCAAG 420
TAAAATGTAC AACATGTGAT TACATTGAAT CAAGACAAAC GTACCAAGAC CGACTTGATT 480
ACGCAAATCC TGGGTTTAAA GAAGAACACG TGGCTCCAGG AGAGCTGGCG CCAGATGGTG 540
ACATTATTCT ACCGTTGGGA ACTGAGAAAG GTTTCCAAAT TCCCGAGTGC CCAAGTTGTG 600
GGGGACTTAT GAAGACAGAT GTCACGTTTT TTGGAGAGAA CGTTAACATG GACAAAGTCA 660
ATTTTTGTTA CGAGAAAGTG AATGAATGTG ATGGGATTTT ATCACTTGGC ACGTCGTTGG 720
CGGTGTTATC TGGATTTCGG TTTATCCATC ATGCTAACAT GAAGAAGAAA CCAATTTTCA 780
TAGTCAATAT AGGACCTACA AGAGCTGATC ACATGGCGAC GATGAAGTTA GATTATAAAA 840
TCTCTGACGT TTTAAAAGAA ATGTAGACTA AGACGTGTAG TTTTGGAATT TGATAATATT 900
GTGTTGACGA CAGTTTTTTG GGTACTTTCC GTTTGTATTT TGAAACTTTT TTTTATTGTT 960
TGAATAGAAT GGCAATTTGT TTCATGTTAA TTGGAATAAA CAATTTTT 1009
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026587--Sirtuin_class_II
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0045087--P:innate immune response
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ict-0083 ENSSTOP00000008774.2 Ictidomys tridecemlineatus 51 1e-78 290
WERAM-Loa-0028 ENSLAFP00000001879.2 Loxodonta africana 50 2e-77 286
WERAM-Ova-0127 ENSOARP00000012850.1 Ovis aries 50 3e-77 285
WERAM-Ran-0010 ENSRNOP00000001523.4 Rattus norvegicus 50 6e-77 284
WERAM-Tas-0026 ENSTSYP00000002962.1 Tarsius syrichta 50 9e-77 284
WERAM-Sus-0071 ENSSSCP00000010568.2 Sus scrofa 49 1e-76 283
WERAM-Mup-0031 ENSMPUP00000003126.1 Mustela putorius furo 50 2e-76 283
WERAM-Mum-0098 ENSMUSP00000107697.1 Mus musculus 50 2e-76 283
WERAM-Bot-0183 ENSBTAP00000028210.3 Bos taurus 50 2e-76 283
WERAM-Asm-0019 ENSAMXP00000002317.1 Astyanax mexicanus 43 8e-76 280
WERAM-Caj-0096 ENSCJAP00000015889.2 Callithrix jacchus 50 1e-75 280
WERAM-Fec-0171 ENSFCAP00000020847.1 Felis catus 50 1e-75 280
WERAM-Sah-0071 ENSSHAP00000008646.1 Sarcophilus harrisii 48 2e-75 280
WERAM-Aim-0062 ENSAMEP00000005483.1 Ailuropoda melanoleuca 49 2e-75 280
WERAM-Caf-0113 ENSCAFP00000015057.3 Canis familiaris 49 2e-75 279
WERAM-Otg-0098 ENSOGAP00000008496.1 Otolemur garnettii 49 2e-75 279
WERAM-Cap-0138 ENSCPOP00000011117.2 Cavia porcellus 49 2e-75 279
WERAM-Paa-0081 ENSPANP00000005490.1 Papio anubis 49 3e-75 279
WERAM-Tar-0187 ENSTRUP00000038866.1 Takifugu rubripes 47 3e-75 279
WERAM-Chs-0026 ENSCSAP00000015768.1 Chlorocebus sabaeus 49 3e-75 279
WERAM-Lac-0179 ENSLACP00000020887.1 Latimeria chalumnae 46 3e-75 278
WERAM-Pat-0044 ENSPTRP00000009383.4 Pan troglodytes 50 3e-75 278
WERAM-Chh-0046 ENSCHOP00000005172.1 Choloepus hoffmanni 49 4e-75 278
WERAM-Hos-0046 ENSP00000202967.4 Homo sapiens 50 4e-75 278
WERAM-Gog-0207 ENSGGOP00000025620.1 Gorilla gorilla 50 4e-75 278
WERAM-Poa-0046 ENSPPYP00000005727.2 Pongo abelii 49 6e-75 278
WERAM-Orn-0178 ENSONIP00000018093.1 Oreochromis niloticus 46 8e-75 277
WERAM-Dar-0026 ENSDARP00000027611.6 Danio rerio 45 1e-74 277
WERAM-Eqc-0095 ENSECAP00000011260.1 Equus caballus 49 2e-74 276
WERAM-Orc-0113 ENSOCUP00000009744.3 Oryctolagus cuniculus 48 2e-74 276
WERAM-Orla-0208 ENSORLP00000024753.1 Oryzias latipes 45 2e-74 275
WERAM-Gaa-0017 ENSGACP00000001945.1 Gasterosteus aculeatus 45 3e-74 275
WERAM-Ora-0041 ENSOANP00000006568.2 Ornithorhynchus anatinus 50 5e-74 275
WERAM-Pem-0012 ENSPMAP00000001780.1 Petromyzon marinus 46 1e-73 273
WERAM-Ect-0086 ENSETEP00000009903.1 Echinops telfairi 48 1e-73 273
WERAM-Meg-0094 ENSMGAP00000009092.2 Meleagris gallopavo 47 2e-73 273
WERAM-Gaga-0078 ENSGALP00000011706.4 Gallus gallus 47 3e-73 272
WERAM-Ocp-0148 ENSOPRP00000015399.1 Ochotona princeps 48 2e-72 270
WERAM-Pes-0110 ENSPSIP00000013404.1 Pelodiscus sinensis 47 2e-72 269
WERAM-Pof-0223 ENSPFOP00000018246.2 Poecilia formosa 45 2e-72 269
WERAM-Xim-0194 ENSXMAP00000015621.1 Xiphophorus maculatus 45 3e-72 269
WERAM-Ptv-0014 ENSPVAP00000002101.1 Pteropus vampyrus 48 3e-72 269
WERAM-Fia-0095 ENSFALP00000007922.1 Ficedula albicollis 46 8e-72 267
WERAM-Tag-0120 ENSTGUP00000009802.1 Taeniopygia guttata 47 3e-71 265
WERAM-Gam-0012 ENSGMOP00000001231.1 Gadus morhua 42 4e-71 265
WERAM-Nol-0169 ENSNLEP00000018942.2 Nomascus leucogenys 52 7e-71 264
WERAM-Anp-0117 ENSAPLP00000013436.1 Anas platyrhynchos 46 1e-70 263
WERAM-Tub-0044 ENSTBEP00000005291.1 Tupaia belangeri 46 2e-69 259
WERAM-Xet-0032 ENSXETP00000009271.1 Xenopus tropicalis 44 3e-69 258
WERAM-Drm-0032 FBpp0070817 Drosophila melanogaster 45 9e-69 257
WERAM-Anc-0024 ENSACAP00000002561.3 Anolis carolinensis 44 2e-68 256
WERAM-Cii-0061 ENSCINP00000027422.2 Ciona intestinalis 43 2e-65 246
WERAM-Soa-0051 ENSSARP00000004940.1 Sorex araneus 45 5e-65 244
WERAM-Tut-0072 ENSTTRP00000005343.1 Tursiops truncatus 49 8e-64 241
WERAM-Dan-0155 ENSDNOP00000033669.1 Dasypus novemcinctus 49 1e-60 230
WERAM-Sem-0074 EFJ28669 Selaginella moellendorffii 40 1e-55 214
WERAM-Amt-0023 ERN08785 Amborella trichopoda 38 3e-55 212
WERAM-Thc-0008 EOX92647 Theobroma cacao 40 4e-55 212
WERAM-Mua-0095 GSMUA_Achr6P25880_001 Musa acuminata 39 9e-55 211
WERAM-Sei-0033 Si009965m Setaria italica 38 1e-54 210
WERAM-Glm-0041 GLYMA04G38730.1 Glycine max 40 1e-54 210
WERAM-Brd-0118 BRADI4G41127.1 Brachypodium distachyon 38 2e-54 209
WERAM-Pot-0061 POPTR_0005s06930.1 Populus trichocarpa 38 3e-54 209
WERAM-Lep-0113 LPERR12G04350.1 Leersia perrieri 38 4e-54 208
WERAM-Viv-0046 VIT_07s0031g02510.t01 Vitis vinifera 38 6e-54 207
WERAM-Orbr-0122 OB12G14620.1 Oryza brachyantha 39 1e-53 206
WERAM-Tra-0230 Traes_5DL_84C49FB59.2 Triticum aestivum 38 2e-53 206
WERAM-Art-0118 AT5G09230.7 Arabidopsis thaliana 39 4e-53 205
WERAM-Arl-0027 fgenesh1_pg.C_scaffold_6000741 Arabidopsis lyrata 39 5e-53 205
WERAM-Ors-0107 OS12T0179800-01 Oryza sativa 38 6e-53 204
WERAM-Sot-0097 PGSC0003DMT400082473 Solanum tuberosum 39 7e-53 204
WERAM-Orl-0007 KN538685.1_FGP039 Oryza longistaminata 38 8e-53 204
WERAM-Orm-0103 OMERI12G03020.1 Oryza meridionalis 38 9e-53 204
WERAM-Sob-0114 Sb08g004900.1 Sorghum bicolor 37 1e-52 204
WERAM-Orr-0119 ORUFI12G05460.1 Oryza rufipogon 38 1e-52 204
WERAM-Orp-0109 OPUNC12G04720.1 Oryza punctata 38 1e-52 204
WERAM-Ori-0126 BGIOSGA036526-PA Oryza indica 38 1e-52 203
WERAM-Sol-0062 Solyc04g009430.2.1 Solanum lycopersicum 38 2e-52 203
WERAM-Met-0074 AES72910 Medicago truncatula 38 3e-52 202
WERAM-Php-0025 PP1S15_90V6.1 Physcomitrella patens 37 3e-52 202
WERAM-Prp-0069 EMJ12669 Prunus persica 37 2e-51 199
WERAM-Orni-0118 ONIVA12G04440.1 Oryza nivara 40 3e-51 199
WERAM-Orgl-0114 OGLUM12G05580.1 Oryza glumaepatula 40 3e-51 199
WERAM-Aet-0050 EMT19694 Aegilops tauschii 35 2e-50 196
WERAM-Brr-0142 Bra028643.1-P Brassica rapa 39 3e-49 192
WERAM-Bro-0024 Bo2g009270.1 Brassica oleracea 39 3e-49 192
WERAM-Chr-0008 EDP00705 Chlamydomonas reinhardtii 40 1e-48 190
WERAM-Zem-0150 GRMZM5G807054_P01 Zea mays 35 2e-47 186
WERAM-Myl-0161 ENSMLUP00000013308.2 Myotis lucifugus 28 2e-21 100
WERAM-Cis-0081 ENSCSAVP00000017799.1 Ciona savignyi 30 3e-20 96.3
WERAM-Mam-0069 ENSMMUP00000011380.2 Macaca mulatta 27 4e-20 95.9
WERAM-Ere-0059 ENSEEUP00000005136.1 Erinaceus europaeus 27 2e-19 93.6
WERAM-Dio-0050 ENSDORP00000004937.1 Dipodomys ordii 26 6e-19 92.0
WERAM-Ten-0147 ENSTNIP00000015282.1 Tetraodon nigroviridis 27 1e-18 91.3
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 31 2e-18 90.5
WERAM-Trv-0012 EHK19002 Trichoderma virens 28 5e-18 89.0
WERAM-Trr-0018 EGR46788 Trichoderma reesei 30 7e-18 88.6
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 31 8e-18 88.2
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 31 8e-18 88.2
WERAM-Leo-0013 ENSLOCP00000002849.1 Lepisosteus oculatus 30 9e-18 87.8
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 29 2e-17 87.0
WERAM-Coi-0005 EAS35645 Coccidioides immitis 31 2e-16 83.2
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 29 3e-16 83.2
WERAM-Mao-0029 MGG_10267T0 Magnaporthe oryzae 27 3e-16 83.2
WERAM-Asfu-0001 CADAFUAP00000229 Aspergillus fumigatus 29 3e-16 82.8
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 30 9e-16 81.3
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 30 1e-15 81.3
WERAM-Caa-0033 KGT64755 Candida albicans 26 1e-15 80.9
WERAM-Aso-0017 CADAORAP00002263 Aspergillus oryzae 28 1e-15 80.9
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 28 5e-15 79.0
WERAM-Asc-0026 CADACLAP00005809 Aspergillus clavatus 30 7e-15 78.6
WERAM-Cag-0026 CAG62123 Candida glabrata 29 1e-14 77.8
Created Date 25-Jun-2016