WERAM Information

Tag Content
WERAM ID WERAM-Cae-0024
Ensembl Protein ID F46G10.3
Uniprot Accession Q20481; SIR42_CAEEL
Genbank Protein ID NP_510220.1
Protein Name NAD-dependent protein deacylase sir-2.3
Genbank Nucleotide ID NM_077819.1
Gene Name SIR-2.3;SIR42;F46G10.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004802 F46G10.3 F46G10.3
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type K 12466527
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 3.20e-73 246.9 19 287
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Domain Profile
  HDAC SIR2
  SIR2.txt   2 klakllkkskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkv..fyalakelyp.lgsakPtktHyflaelekkgkllrl 98 
               k+++l+ +++k++++tGAGiSt++GIPD+Rs + Gly+k++ e      +i+ +df+++++++  ++++++  +p + +a P+ +Hy+l+++e ++k+++l
  F46G10.3  19 KFKSLVGTVDKLLIITGAGISTESGIPDYRSkDVGLYTKTALE------PIYFQDFMKSKKCRqrYWSRSYLNWPrFAQALPNFNHYALSKWEAANKFHWL 113
               7899999************************99******8887......9999999999999889************************************ PP
  SIR2.txt  99 ytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkak.............................ekvpkCekCkgvlkpdivffge 170
               +tQN+DgL++kag+k  +++elHG++ +++Ct+C++  +r++++++l+ +                             +k+p+C +C+g++k+d+++fge
  F46G10.3 114 ITQNVDGLHLKAGSK--MITELHGNALQVKCTSCEYIETRQTYQDRLNYAnpgfkeqfvspgqqeldadtalplgseqgFKIPECLNCGGLMKTDVTLFGE 212
               **************9..*******************************99*************************************************** PP
  SIR2.txt 171 nlpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveel 245
               nl++++++ + ++++e++ +l+lGtSl+v + +++v++a+++++p+++vn+++++ad++a++kl++++++v++e+
  F46G10.3 213 NLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAHMQNKPIFIVNIGPTRADQMATMKLDYRISDVLKEM 287
               ***********************************************************************9875 PP
Protein Sequence
(Fasta)		MARKYVPHTT ELCENSLKKF KSLVGTVDKL LIITGAGIST ESGIPDYRSK DVGLYTKTAL 60
EPIYFQDFMK SKKCRQRYWS RSYLNWPRFA QALPNFNHYA LSKWEAANKF HWLITQNVDG 120
LHLKAGSKMI TELHGNALQV KCTSCEYIET RQTYQDRLNY ANPGFKEQFV SPGQQELDAD 180
TALPLGSEQG FKIPECLNCG GLMKTDVTLF GENLNTDKIK VCGKKVNECN GVLTLGTSLE 240
VLSGYQIVNH AHMQNKPIFI VNIGPTRADQ MATMKLDYRI SDVLKEM 287
Nucleotide Sequence
(Fasta)		ATGGCACGAA AGTATGTACC ACATACGACA GAGCTTTGTG AAAACTCCCT AAAAAAGTTT 60
AAGTCACTGG TAGGGACTGT GGATAAGCTT CTCATCATCA CTGGAGCAGG AATTTCTACA 120
GAATCAGGAA TACCAGATTA TCGATCGAAA GATGTCGGAT TGTACACAAA GACTGCACTT 180
GAACCAATTT ATTTCCAGGA TTTTATGAAA TCAAAGAAAT GTAGGCAGAG ATACTGGTCT 240
CGTAGCTACT TGAATTGGCC AAGATTTGCT CAAGCTTTAC CTAACTTCAA TCATTACGCC 300
TTATCAAAAT GGGAAGCTGC TAACAAATTT CATTGGTTGA TCACACAAAA TGTGGATGGA 360
CTTCACTTAA AAGCGGGCTC GAAAATGATA ACGGAACTTC ATGGCAACGC TCTTCAAGTA 420
AAATGCACAT CATGTGAATA CATCGAGACA AGACAAACGT ATCAAGACCG CCTGAATTAT 480
GCAAATCCTG GCTTCAAAGA GCAGTTTGTA TCTCCTGGAC AGCAAGAGCT AGATGCTGAC 540
ACTGCCTTGC CGTTGGGTAG CGAACAAGGG TTCAAGATTC CCGAGTGTTT AAATTGTGGG 600
GGACTTATGA AGACAGATGT AACGTTGTTT GGGGAGAACC TAAACACTGA CAAAATTAAA 660
GTTTGTGGCA AGAAGGTGAA TGAATGCAAT GGAGTTTTAA CACTTGGGAC ATCGTTGGAA 720
GTGCTTTCCG GATATCAGAT TGTCAATCAT GCCCATATGC AAAACAAACC AATTTTCATC 780
GTGAACATTG GACCTACTAG AGCTGATCAG ATGGCAACAA TGAAGTTAGA CTACAGAATT 840
TCGGATGTTT TGAAAGAAAT GTAA 865
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026587--Sirtuin_class_II
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ict-0083 ENSSTOP00000008774.2 Ictidomys tridecemlineatus 44 7e-71 264
WERAM-Asm-0019 ENSAMXP00000002317.1 Astyanax mexicanus 42 1e-70 263
WERAM-Tas-0026 ENSTSYP00000002962.1 Tarsius syrichta 44 2e-70 262
WERAM-Ran-0010 ENSRNOP00000001523.4 Rattus norvegicus 45 3e-70 262
WERAM-Mum-0098 ENSMUSP00000107697.1 Mus musculus 45 3e-70 262
WERAM-Sah-0071 ENSSHAP00000008646.1 Sarcophilus harrisii 44 4e-70 261
WERAM-Caj-0096 ENSCJAP00000015889.2 Callithrix jacchus 44 8e-70 261
WERAM-Ova-0127 ENSOARP00000012850.1 Ovis aries 44 9e-70 260
WERAM-Otg-0098 ENSOGAP00000008496.1 Otolemur garnettii 44 2e-69 259
WERAM-Bot-0183 ENSBTAP00000028210.3 Bos taurus 44 4e-69 258
WERAM-Loa-0028 ENSLAFP00000001879.2 Loxodonta africana 44 5e-69 258
WERAM-Chh-0046 ENSCHOP00000005172.1 Choloepus hoffmanni 44 6e-69 258
WERAM-Cap-0138 ENSCPOP00000011117.2 Cavia porcellus 44 1e-68 257
WERAM-Sus-0071 ENSSSCP00000010568.2 Sus scrofa 43 1e-68 256
WERAM-Orn-0178 ENSONIP00000018093.1 Oreochromis niloticus 43 2e-68 256
WERAM-Orc-0113 ENSOCUP00000009744.3 Oryctolagus cuniculus 43 2e-68 256
WERAM-Ora-0041 ENSOANP00000006568.2 Ornithorhynchus anatinus 44 2e-68 256
WERAM-Mup-0031 ENSMPUP00000003126.1 Mustela putorius furo 43 3e-68 255
WERAM-Gog-0207 ENSGGOP00000025620.1 Gorilla gorilla 43 5e-68 254
WERAM-Orla-0208 ENSORLP00000024753.1 Oryzias latipes 42 6e-68 254
WERAM-Aim-0062 ENSAMEP00000005483.1 Ailuropoda melanoleuca 43 7e-68 254
WERAM-Tar-0187 ENSTRUP00000038866.1 Takifugu rubripes 43 8e-68 254
WERAM-Caf-0113 ENSCAFP00000015057.3 Canis familiaris 43 1e-67 253
WERAM-Pat-0044 ENSPTRP00000009383.4 Pan troglodytes 43 1e-67 253
WERAM-Fec-0171 ENSFCAP00000020847.1 Felis catus 43 2e-67 253
WERAM-Hos-0046 ENSP00000202967.4 Homo sapiens 43 2e-67 253
WERAM-Paa-0081 ENSPANP00000005490.1 Papio anubis 43 3e-67 252
WERAM-Chs-0026 ENSCSAP00000015768.1 Chlorocebus sabaeus 43 4e-67 251
WERAM-Gam-0012 ENSGMOP00000001231.1 Gadus morhua 42 5e-67 251
WERAM-Poa-0046 ENSPPYP00000005727.2 Pongo abelii 43 5e-67 251
WERAM-Eqc-0095 ENSECAP00000011260.1 Equus caballus 43 1e-66 250
WERAM-Gaa-0017 ENSGACP00000001945.1 Gasterosteus aculeatus 42 1e-66 250
WERAM-Lac-0179 ENSLACP00000020887.1 Latimeria chalumnae 43 1e-66 249
WERAM-Ect-0086 ENSETEP00000009903.1 Echinops telfairi 41 2e-66 249
WERAM-Pof-0223 ENSPFOP00000018246.2 Poecilia formosa 43 3e-66 248
WERAM-Pem-0012 ENSPMAP00000001780.1 Petromyzon marinus 41 4e-66 248
WERAM-Xim-0194 ENSXMAP00000015621.1 Xiphophorus maculatus 43 5e-66 248
WERAM-Ocp-0148 ENSOPRP00000015399.1 Ochotona princeps 42 5e-66 248
WERAM-Dar-0026 ENSDARP00000027611.6 Danio rerio 40 6e-66 248
WERAM-Ptv-0014 ENSPVAP00000002101.1 Pteropus vampyrus 41 2e-65 246
WERAM-Pes-0110 ENSPSIP00000013404.1 Pelodiscus sinensis 41 4e-65 245
WERAM-Tub-0044 ENSTBEP00000005291.1 Tupaia belangeri 41 5e-64 241
WERAM-Gaga-0078 ENSGALP00000011706.4 Gallus gallus 41 6e-64 241
WERAM-Meg-0094 ENSMGAP00000009092.2 Meleagris gallopavo 40 2e-63 239
WERAM-Nol-0169 ENSNLEP00000018942.2 Nomascus leucogenys 45 2e-63 239
WERAM-Fia-0095 ENSFALP00000007922.1 Ficedula albicollis 40 7e-63 238
WERAM-Xet-0032 ENSXETP00000009271.1 Xenopus tropicalis 40 8e-63 237
WERAM-Tag-0120 ENSTGUP00000009802.1 Taeniopygia guttata 41 2e-62 236
WERAM-Drm-0032 FBpp0070817 Drosophila melanogaster 40 3e-62 236
WERAM-Anc-0024 ENSACAP00000002561.3 Anolis carolinensis 41 4e-62 235
WERAM-Cii-0061 ENSCINP00000027422.2 Ciona intestinalis 40 1e-61 233
WERAM-Anp-0117 ENSAPLP00000013436.1 Anas platyrhynchos 40 2e-61 233
WERAM-Soa-0051 ENSSARP00000004940.1 Sorex araneus 39 1e-57 220
WERAM-Sem-0074 EFJ28669 Selaginella moellendorffii 40 3e-57 219
WERAM-Tut-0072 ENSTTRP00000005343.1 Tursiops truncatus 43 4e-57 218
WERAM-Sei-0033 Si009965m Setaria italica 36 3e-56 215
WERAM-Mua-0095 GSMUA_Achr6P25880_001 Musa acuminata 38 6e-55 211
WERAM-Orbr-0122 OB12G14620.1 Oryza brachyantha 36 8e-55 211
WERAM-Dan-0155 ENSDNOP00000033669.1 Dasypus novemcinctus 44 1e-54 210
WERAM-Ors-0107 OS12T0179800-01 Oryza sativa 36 2e-54 209
WERAM-Brd-0118 BRADI4G41127.1 Brachypodium distachyon 36 2e-54 209
WERAM-Sob-0114 Sb08g004900.1 Sorghum bicolor 36 2e-54 209
WERAM-Orp-0109 OPUNC12G04720.1 Oryza punctata 36 3e-54 209
WERAM-Lep-0113 LPERR12G04350.1 Leersia perrieri 35 3e-54 209
WERAM-Orl-0007 KN538685.1_FGP039 Oryza longistaminata 36 3e-54 209
WERAM-Orm-0102 OMERI12G03010.1 Oryza meridionalis 36 3e-54 209
WERAM-Orr-0119 ORUFI12G05460.1 Oryza rufipogon 36 4e-54 208
WERAM-Ori-0126 BGIOSGA036526-PA Oryza indica 36 4e-54 208
WERAM-Amt-0023 ERN08785 Amborella trichopoda 37 5e-54 208
WERAM-Tra-0230 Traes_5DL_84C49FB59.2 Triticum aestivum 35 5e-54 208
WERAM-Thc-0008 EOX92647 Theobroma cacao 38 1e-53 207
WERAM-Orni-0118 ONIVA12G04440.1 Oryza nivara 38 4e-53 205
WERAM-Orgl-0114 OGLUM12G05580.1 Oryza glumaepatula 38 4e-53 205
WERAM-Sot-0097 PGSC0003DMT400082473 Solanum tuberosum 37 3e-52 202
WERAM-Aet-0050 EMT19694 Aegilops tauschii 34 3e-52 202
WERAM-Sol-0062 Solyc04g009430.2.1 Solanum lycopersicum 36 7e-52 201
WERAM-Art-0118 AT5G09230.7 Arabidopsis thaliana 37 1e-51 200
WERAM-Viv-0046 VIT_07s0031g02510.t01 Vitis vinifera 37 4e-51 199
WERAM-Arl-0027 fgenesh1_pg.C_scaffold_6000741 Arabidopsis lyrata 37 5e-51 198
WERAM-Pot-0061 POPTR_0005s06930.1 Populus trichocarpa 36 5e-51 198
WERAM-Php-0025 PP1S15_90V6.1 Physcomitrella patens 37 1e-50 197
WERAM-Prp-0069 EMJ12669 Prunus persica 39 2e-50 196
WERAM-Zem-0150 GRMZM5G807054_P01 Zea mays 35 3e-50 196
WERAM-Glm-0041 GLYMA04G38730.1 Glycine max 36 9e-50 194
WERAM-Met-0074 AES72910 Medicago truncatula 37 6e-49 191
WERAM-Brr-0142 Bra028643.1-P Brassica rapa 38 8e-49 191
WERAM-Bro-0024 Bo2g009270.1 Brassica oleracea 38 1e-48 190
WERAM-Chr-0008 EDP00705 Chlamydomonas reinhardtii 38 7e-47 184
WERAM-Myl-0161 ENSMLUP00000013308.2 Myotis lucifugus 30 2e-23 107
WERAM-Ere-0059 ENSEEUP00000005136.1 Erinaceus europaeus 28 5e-21 99.0
WERAM-Mam-0069 ENSMMUP00000011380.2 Macaca mulatta 28 6e-21 98.6
WERAM-Cis-0081 ENSCSAVP00000017799.1 Ciona savignyi 30 9e-20 94.7
WERAM-Ten-0147 ENSTNIP00000015282.1 Tetraodon nigroviridis 26 1e-19 94.4
WERAM-Dio-0050 ENSDORP00000004937.1 Dipodomys ordii 27 2e-18 90.1
WERAM-Scj-0035 EEB09012 Schizosaccharomyces japonicus 28 1e-16 84.3
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 26 1e-16 84.0
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 27 1e-16 84.0
WERAM-Org-0043 ORGLA04G0042700.1 Oryza glaberrima 25 4e-16 82.4
WERAM-Asfu-0001 CADAFUAP00000229 Aspergillus fumigatus 28 1e-15 81.3
WERAM-Scp-0024 SPBC16D10.07c.1:pep Schizosaccharomyces pombe 30 1e-15 80.9
WERAM-Leo-0013 ENSLOCP00000002849.1 Lepisosteus oculatus 27 2e-15 80.5
WERAM-Aso-0017 CADAORAP00002263 Aspergillus oryzae 27 5e-15 79.0
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 27 6e-15 78.6
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 28 1e-14 77.8
WERAM-Cag-0021 CAG61249 Candida glabrata 26 1e-14 77.4
WERAM-Kop-0003 CAY67751 Komagataella pastoris 28 2e-14 76.6
WERAM-Trv-0012 EHK19002 Trichoderma virens 26 3e-14 76.6
WERAM-Mao-0029 MGG_10267T0 Magnaporthe oryzae 28 4e-14 75.9
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 27 5e-14 75.5
WERAM-Asc-0026 CADACLAP00005809 Aspergillus clavatus 27 6e-14 75.5
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 28 6e-14 75.1
Created Date 25-Jun-2016