WERAM Information
Tag | Content | ||||||||||||
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WERAM ID | WERAM-Hos-0121 | ||||||||||||
Ensembl Protein ID | ENSP00000412513.2 | ||||||||||||
Uniprot Accession | O15054; KDM6B_HUMAN; C9IZ40; Q96G33 | ||||||||||||
Genbank Protein ID | NP_001073893.1; XP_005256606.1; XP_005256607.1; XP_005256608.1; XP_005256609.1; XP_005256611.1; XP_006721546.1; XP_011522052.1; XP_011522053.1; XP_011522054.1; XP_011522055.1 | ||||||||||||
Protein Name | Lysine-specific demethylase 6B | ||||||||||||
Genbank Nucleotide ID | NM_001080424.1; XM_005256549.2; XM_005256550.3; XM_005256551.2; XM_005256552.3; XM_005256554.3; XM_006721483.2; XM_011523750.1; XM_011523751.1; XM_011523752.1; XM_011523753.1 | ||||||||||||
Gene Name | KDM6B;JMJD3 | ||||||||||||
Ensembl Information |
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Details |
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Status | Reviewed | ||||||||||||
Classification |
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Organism | Homo sapiens | ||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||
Functional Description (View) |
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. | ||||||||||||
Domain Profile | HDM UTX_UTY UTX.txt 1 kwkkqlkelsklpafvrvisaanllshvghtilgmntvqlymkvpgsrtpghqennnlcsvninigpgdcewfavpeeywgklsdlcekn 90 |
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Protein Sequence (Fasta) | MHRAVDPPGA RAAREAFALG GLSCAGAWSS CPPHPPPRSA WLPGGRCSAS IGQPPLPAPL 60 PPSHGSSSGH PSKPYYAPGA PTPRPLHGKL ESLHGCVQAL LREPAQPGLW EQLGQLYESE 120 HDSEEATRCY HSALRYGGSF AELGPRIGRL QQAQLWNFHT GSCQHRAKVL PPLEQVWNLL 180 HLEHKRNYGA KRGGPPVKRA AEPPVVQPVP PAALSGPSGE EGLSPGGKRR RGCNSEQTGL 240 PPGLPLPPPP LPPPPPPPPP PPPPLPGLAT SPPFQLTKPG LWSTLHGDAW GPERKGSAPP 300 ERQEQRHSLP HPYPYPAPAY TAHPPGHRLV PAAPPGPGPR PPGAESHGCL PATRPPGSDL 360 RESRVQRSRM DSSVSPAATT ACVPYAPSRP PGLPGTTTSS SSSSSSNTGL RGVEPNPGIP 420 GADHYQTPAL EVSHHGRLGP SAHSSRKPFL GAPAATPHLS LPPGPSSPPP PPCPRLLRPP 480 PPPAWLKGPA CRAAREDGEI LEELFFGTEG PPRPAPPPLP HREGFLGPPA SRFSVGTQDS 540 HTPPTPPTPT TSSSNSNSGS HSSSPAGPVS FPPPPYLARS IDPLPRPPSP AQNPQDPPLV 600 PLTLALPPAP PSSCHQNTSG SFRRPESPRP RVSFPKTPEV GPGPPPGPLS KAPQPVPPGV 660 GELPARGPRL FDFPPTPLED QFEEPAEFKI LPDGLANIMK MLDESIRKEE EQQQHEAGVA 720 PQPPLKEPFA SLQSPFPTDT APTTTAPAVA VTTTTTTTTT TTATQEEEKK PPPALPPPPP 780 LAKFPPPSQP QPPPPPPPSP ASLLKSLASV LEGQKYCYRG TGAAVSTRPG PLPTTQYSPG 840 PPSGATALPP TSAAPSAQGS PQPSASSSSQ FSTSGGPWAR ERRAGEEPVP GPMTPTQPPP 900 PLSLPPARSE SEVLEEISRA CETLVERVGR SATDPADPVD TAEPADSGTE RLLPPAQAKE 960 EAGGVAAVSG SCKRRQKEHQ KEHRRHRRAC KDSVGRRPRE GRAKAKAKVP KEKSRRVLGN 1020 LDLQSEEIQG REKSRPDLGG ASKAKPPTAP APPSAPAPSA QPTPPSASVP GKKAREEAPG 1080 PPGVSRADML KLRSLSEGPP KELKIRLIKV ESGDKETFIA SEVEERRLRM ADLTISHCAA 1140 DVVRASRNAK VKGKFRESYL SPAQSVKPKI NTEEKLPREK LNPPTPSIYL ESKRDAFSPV 1200 LLQFCTDPRN PITVIRGLAG SLRLNLGLFS TKTLVEASGE HTVEVRTQVQ QPSDENWDLT 1260 GTRQIWPCES SRSHTTIAKY AQYQASSFQE SLQEEKESED EESEEPDSTT GTPPSSAPDP 1320 KNHHIIKFGT NIDLSDAKRW KPQLQELLKL PAFMRVTSTG NMLSHVGHTI LGMNTVQLYM 1380 KVPGSRTPGH QENNNFCSVN INIGPGDCEW FAVHEHYWET ISAFCDRHGV DYLTGSWWPI 1440 LDDLYASNIP VYRFVQRPGD LVWINAGTVH WVQATGWCNN IAWNVGPLTA YQYQLALERY 1500 EWNEVKNVKS IVPMIHVSWN VARTVKISDP DLFKMIKFCL LQSMKHCQVQ RESLVRAGKK 1560 IAYQGRVKDE PAYYCNECDV EVFNILFVTS ENGSRNTYLV HCEGCARRRS AGLQGVVVLE 1620 QYRTEELAQA YDAFTLAPAS TSR 1643 |
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Nucleotide Sequence (Fasta) | TCTGTTGTAC CCCACTGCTG GGGTGGTGGT TCCAATGAGA CAGGGCACAC CAAACTCCAT 60 CTGGCTGTTA CTGAGGCGGA GACACGGGTG ATGATTGGCT TTCTGGGGAG AGAGGAAGTC 120 CTGTGATTGG CCAGATCTCT GGAGCTTGCC GACGCGGTGT GAGGACGCTC CCACGGAGGC 180 CGGAATTGGC TGTGAAAGGA CTGAGGCAGC CATCTGGGGG TAGCGGGCAC TCTTATCAGA 240 GCGGCTGGAG CCGGACCATC GTCCCAGAGA GCTGGGGCAG GGGGCCGTGC CCAATCTCCA 300 GGGCTCCTGG GGCCACTGCT GACCTGGCTG GATGCATCGG GCAGTGGACC CTCCAGGGGC 360 CCGCGCTGCA CGGGAAGCCT TTGCCCTTGG GGGCCTGAGC TGTGCTGGGG CCTGGAGCTC 420 CTGCCCGCCT CATCCCCCTC CTCGTAGCGC ATGGCTGCCT GGAGGCAGAT GCTCAGCCAG 480 CATTGGGCAG CCCCCGCTTC CTGCTCCCCT ACCCCCTTCA CATGGCAGTA GTTCTGGGCA 540 CCCCAGCAAA CCATATTATG CTCCAGGGGC GCCCACTCCA AGACCCCTCC ATGGGAAGCT 600 GGAATCCCTG CATGGCTGTG TGCAGGCATT GCTCCGGGAG CCAGCCCAGC CAGGGCTTTG 660 GGAACAGCTT GGGCAACTGT ACGAGTCAGA GCACGATAGT GAGGAGGCCA CACGCTGCTA 720 CCACAGCGCC CTTCGATACG GAGGAAGCTT CGCTGAGCTG GGGCCCCGCA TTGGCCGACT 780 GCAGCAGGCC CAGCTCTGGA ACTTTCATAC TGGCTCCTGC CAGCACCGAG CCAAGGTCCT 840 GCCCCCACTG GAGCAAGTGT GGAACTTGCT ACACCTTGAG CACAAACGGA ACTATGGAGC 900 CAAGCGGGGA GGTCCCCCGG TGAAGCGAGC TGCTGAACCC CCAGTGGTGC AGCCTGTGCC 960 TCCTGCAGCA CTCTCAGGCC CCTCAGGGGA GGAGGGCCTC AGCCCTGGAG GCAAGCGAAG 1020 GAGAGGCTGC AACTCTGAAC AGACTGGCCT TCCCCCAGGG CTGCCACTGC CTCCACCACC 1080 ATTACCACCA CCACCACCAC CACCACCACC ACCACCACCA CCCCTGCCTG GCCTGGCTAC 1140 CAGCCCCCCA TTTCAGCTAA CCAAGCCAGG GCTGTGGAGT ACCCTGCATG GAGATGCCTG 1200 GGGCCCAGAG CGCAAGGGTT CAGCACCCCC AGAGCGCCAG GAGCAGCGGC ACTCGCTGCC 1260 TCACCCATAT CCATACCCAG CTCCAGCGTA CACCGCGCAC CCCCCTGGCC ACCGGCTGGT 1320 CCCGGCTGCT CCCCCAGGCC CAGGCCCCCG CCCCCCAGGA GCAGAGAGCC ATGGCTGCCT 1380 GCCTGCCACC CGTCCCCCCG GAAGTGACCT TAGAGAGAGC AGAGTTCAGA GGTCGCGGAT 1440 GGACTCCAGC GTTTCACCAG CAGCAACCAC CGCCTGCGTG CCTTACGCCC CTTCCCGGCC 1500 CCCTGGCCTC CCCGGCACCA CCACCAGCAG CAGCAGTAGC AGCAGCAGCA ACACTGGTCT 1560 CCGGGGCGTG GAGCCGAACC CAGGCATTCC CGGCGCTGAC CATTACCAAA CTCCCGCGCT 1620 GGAGGTCTCT CACCATGGCC GCCTGGGGCC CTCGGCACAC AGCAGTCGGA AACCGTTCTT 1680 GGGGGCTCCC GCTGCCACTC CCCACCTATC CCTGCCACCT GGACCTTCCT CACCCCCTCC 1740 ACCCCCCTGT CCCCGCCTCT TACGCCCCCC ACCACCCCCT GCCTGGTTGA AGGGTCCGGC 1800 CTGCCGGGCA GCCCGAGAGG ATGGAGAGAT CTTAGAAGAG CTCTTCTTTG GGACTGAGGG 1860 ACCCCCCCGC CCTGCCCCAC CACCCCTCCC CCATCGCGAG GGCTTCTTGG GGCCTCCGGC 1920 CTCCCGCTTT TCTGTGGGCA CTCAGGATTC TCACACCCCT CCCACTCCCC CAACCCCAAC 1980 CACCAGCAGT AGCAACAGCA ACAGTGGCAG CCACAGCAGC AGCCCTGCTG GGCCTGTGTC 2040 CTTTCCCCCA CCACCCTATC TGGCCAGAAG TATAGACCCC CTTCCCCGGC CTCCCAGCCC 2100 AGCACAGAAC CCCCAGGACC CACCTCTTGT ACCCCTGACT CTTGCCCTGC CTCCAGCCCC 2160 TCCTTCCTCC TGCCACCAAA ATACCTCAGG AAGCTTCAGG CGCCCGGAGA GCCCCCGGCC 2220 CAGGGTCTCC TTCCCAAAGA CCCCCGAGGT GGGGCCGGGG CCACCCCCAG GCCCCCTGAG 2280 TAAAGCCCCC CAGCCTGTGC CGCCCGGGGT TGGGGAGCTG CCTGCCCGAG GCCCTCGACT 2340 CTTTGATTTT CCCCCCACTC CGCTGGAGGA CCAGTTTGAG GAGCCAGCCG AATTCAAGAT 2400 CCTACCTGAT GGGCTGGCCA ACATCATGAA GATGCTGGAC GAATCCATTC GCAAGGAAGA 2460 GGAACAGCAA CAACACGAAG CAGGCGTGGC CCCCCAACCC CCGCTGAAGG AGCCCTTTGC 2520 ATCTCTGCAG TCTCCTTTCC CCACCGACAC AGCCCCCACC ACTACTGCTC CTGCTGTCGC 2580 CGTCACCACC ACCACCACCA CCACCACCAC CACCACGGCC ACCCAGGAAG AGGAGAAGAA 2640 GCCACCACCA GCCCTACCAC CACCACCGCC TCTAGCCAAG TTCCCTCCAC CCTCTCAGCC 2700 ACAGCCACCA CCACCCCCAC CCCCCAGCCC GGCCAGCCTG CTCAAATCCT TGGCCTCCGT 2760 GCTGGAGGGA CAAAAGTACT GTTATCGGGG GACTGGAGCA GCTGTTTCCA CCCGGCCTGG 2820 GCCCTTGCCC ACCACTCAGT ATTCCCCTGG CCCCCCATCA GGTGCTACCG CCCTGCCGCC 2880 CACCTCAGCG GCCCCTAGCG CCCAGGGCTC CCCACAGCCC TCTGCTTCCT CGTCATCTCA 2940 GTTCTCTACC TCAGGCGGGC CCTGGGCCCG GGAGCGCAGG GCGGGCGAAG AGCCAGTCCC 3000 GGGCCCCATG ACCCCCACCC AACCGCCCCC ACCCCTATCT CTGCCCCCTG CTCGCTCTGA 3060 GTCTGAGGTG CTAGAAGAGA TCAGCCGGGC TTGCGAGACC CTTGTGGAGC GGGTGGGCCG 3120 GAGTGCCACT GACCCAGCCG ACCCAGTGGA CACAGCAGAG CCAGCGGACA GTGGGACTGA 3180 GCGACTGCTG CCCCCCGCAC AGGCCAAGGA GGAGGCTGGC GGGGTGGCGG CAGTGTCAGG 3240 CAGCTGTAAG CGGCGACAGA AGGAGCATCA GAAGGAGCAT CGGCGGCACA GGCGGGCCTG 3300 TAAGGACAGT GTGGGTCGTC GGCCCCGTGA GGGCAGGGCA AAGGCCAAGG CCAAGGTCCC 3360 CAAAGAAAAG AGCCGCCGGG TGCTGGGGAA CCTGGACCTG CAGAGCGAGG AGATCCAGGG 3420 TCGTGAGAAG TCCCGGCCCG ATCTTGGCGG GGCCTCCAAG GCCAAGCCAC CCACAGCTCC 3480 AGCCCCTCCA TCAGCTCCTG CACCTTCTGC CCAGCCCACA CCCCCGTCAG CCTCTGTCCC 3540 TGGAAAGAAG GCTCGGGAGG AAGCCCCAGG GCCACCGGGT GTCAGCCGGG CCGACATGCT 3600 GAAGCTGCGC TCACTTAGTG AGGGGCCCCC CAAGGAGCTG AAGATCCGGC TCATCAAGGT 3660 AGAGAGTGGT GACAAGGAGA CCTTTATCGC CTCTGAGGTG GAAGAGCGGC GGCTGCGCAT 3720 GGCAGACCTC ACCATCAGCC ACTGTGCTGC TGACGTCGTG CGCGCCAGCA GGAATGCCAA 3780 GGTGAAAGGG AAGTTTCGAG AGTCCTACCT TTCCCCTGCC CAGTCTGTGA AACCGAAGAT 3840 CAACACTGAG GAGAAGCTGC CCCGGGAAAA ACTCAACCCC CCTACACCCA GCATCTATCT 3900 GGAGAGCAAA CGGGATGCCT TCTCACCTGT CCTGCTGCAG TTCTGTACAG ACCCTCGAAA 3960 TCCCATCACA GTGATCCGGG GCCTGGCGGG CTCCCTGCGG CTCAACTTGG GCCTCTTCTC 4020 CACCAAGACC CTGGTGGAAG CGAGTGGCGA ACACACCGTG GAAGTTCGCA CCCAGGTGCA 4080 GCAGCCCTCA GATGAGAACT GGGATCTGAC AGGCACTCGG CAGATCTGGC CTTGTGAGAG 4140 CTCCCGTTCC CACACCACCA TTGCCAAGTA CGCACAGTAC CAGGCCTCAT CCTTCCAGGA 4200 GTCTCTGCAG GAGGAGAAGG AGAGTGAGGA TGAGGAGTCA GAGGAGCCAG ACAGCACCAC 4260 TGGAACCCCT CCTAGCAGCG CACCAGACCC GAAGAACCAT CACATCATCA AGTTTGGCAC 4320 CAACATCGAC TTGTCTGATG CTAAGCGGTG GAAGCCCCAG CTGCAGGAGC TGCTGAAGCT 4380 GCCCGCCTTC ATGCGGGTAA CATCCACGGG CAACATGCTG AGCCACGTGG GCCACACCAT 4440 CCTGGGCATG AACACGGTGC AGCTGTACAT GAAGGTGCCC GGCAGCCGAA CGCCAGGCCA 4500 CCAGGAGAAT AACAACTTCT GCTCCGTCAA CATCAACATT GGCCCAGGCG ACTGCGAGTG 4560 GTTCGCGGTG CACGAGCACT ACTGGGAGAC CATCAGCGCT TTCTGTGATC GGCACGGCGT 4620 GGACTACTTG ACGGGTTCCT GGTGGCCAAT CCTGGATGAT CTCTATGCAT CCAATATTCC 4680 TGTGTACCGC TTCGTGCAGC GACCCGGAGA CCTCGTGTGG ATTAATGCGG GGACTGTGCA 4740 CTGGGTGCAG GCCACCGGCT GGTGCAACAA CATTGCCTGG AACGTGGGGC CCCTCACCGC 4800 CTATCAGTAC CAGCTGGCCC TGGAACGATA CGAGTGGAAT GAGGTGAAGA ACGTCAAATC 4860 CATCGTGCCC ATGATTCACG TGTCATGGAA CGTGGCTCGC ACGGTCAAAA TCAGCGACCC 4920 CGACTTGTTC AAGATGATCA AGTTCTGCCT GCTGCAGTCC ATGAAGCACT GCCAGGTGCA 4980 ACGCGAGAGC CTGGTGCGGG CAGGGAAGAA AATCGCTTAC CAGGGCCGTG TCAAGGACGA 5040 GCCAGCCTAC TACTGCAACG AGTGCGATGT GGAGGTGTTT AACATCCTGT TCGTGACAAG 5100 TGAGAATGGC AGCCGCAACA CGTACCTGGT ACACTGCGAG GGCTGTGCCC GGCGCCGCAG 5160 CGCAGGCCTG CAGGGCGTGG TGGTGCTGGA GCAGTACCGC ACTGAGGAGC TGGCTCAGGC 5220 CTACGACGCC TTCACGCTGG CCCCAGCCAG CACGTCGCGA TGAGGCCGGA CGCCCCGCCC 5280 GCCTGCCTGC CCGCGCAAGG CGCCGCGGGG CCACCAGCAC ATGCCTGGGC TGGACCTAGG 5340 TCCCGCCTGT GGCCGAGAAG GGGGTCGGGC CCAGCCCTTC CACCCCATTG GCAGCTCCCC 5400 TCACTTAATT TATTAAGAAA AA 5423 |
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Sequence Source | Ensembl | ||||||||||||
Keyword | KW-0002--3D-structure |
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Interpro | |||||||||||||
PROSITE | PS51184--JMJC |
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Pfam | PF02373--JmjC |
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Gene Ontology | GO:0005654--C:nucleoplasm |
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Orthology | |||||||||||||
Created Date | 25-Jun-2016 |