WERAM Information

Tag Content
WERAM ID WERAM-Drm-0090
Ensembl Protein ID FBpp0079664
Uniprot Accession Q76NQ3; Q76NQ3_DROME
Genbank Protein ID NP_723550.2; NP_723551.2
Protein Name Utx histone demethylase, isoform B
Genbank Nucleotide ID NM_164907.4; NM_164908.4
Gene Name UTX(isoformB);CG5640;Dmel_CG5640
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0260749 FBtr0080075 FBpp0079664
FBgn0260749 FBtr0303903 FBpp0292906
FBgn0260749 FBtr0333410 FBpp0305602
FBgn0260749 FBtr0080076 FBpp0079665
FBgn0260749 FBtr0080077 FBpp0079666
Details
Type Family Domain Substrates AA References (PMIDs)
HDM UTX_UTY Jmjc H3K27 K 26207949
Status Reviewed
Classification
Type Family E-value Score Start End
HDM UTX_UTY 1.40e-105 350.6 832 995
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)
Domain Profile
  HDM UTX_UTY
      UTX.txt   1 kwkkqlkelsklpafvrvisaanllshvghtilgmntvqlymkvpgsrtpghqennnlcsvninigpgdcewfavpeeywgklsdlceknnvdyltgs 98 
                  kwk+ql+el+klpaf+rvisaan+lshvgh+ilgmntvqlymkvpgsrtpghqennn+cs+ninigpgdcewfavp++ywg +++lceknn++yl+gs
  FBpp0079664 832 KWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGS 929
                  8************************************************************************************************* PP
      UTX.txt  99 wwpvledlyeanipvyrfiqkpgdlvyvnagtvhwvqaigwcnniawnvgpltakqyklaleryey 164
                  wwpvledly++nipvyrfiqkpgdlv+vnag+vhwvq+igwcnniawnvgplta+qy+la+erye+
  FBpp0079664 930 WWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEW 995
                  *****************************************************************9 PP
Protein Sequence
(Fasta)		MGQLTFEDDC LIRELDSRYY GFLDLSNSKN AELRNLVQQT ITNLQNYIAN GQVHESKNSS 60
DNKNAIQKFE PSTQAGEHME NTSSRNNDDT KPFEQDAKEK VSIIEEKHQD EHYVNALCKL 120
GHLHLLLGEY SEALSAYQKY LRFRENNYWT NHAFIYGIGV AYFKLRCFKW AIKSFQELLY 180
LSPNFTCANE VHLRLGLMLK HCGEFHIALK HLQLALLYTY PSTFSELQVK FQIAHLYEVQ 240
NKHKAAKDGY EFLLNEKNIS LELKADVYRQ LGWMYHCVEC LGEKKEREAN ALNFLQKSIE 300
ADPKSGQSLY LLGRCYAGIN KVHDAFLAYR NSVEKSEGNA DTWCSIGVLY QQQNQPTDAL 360
QAYICAVQLD KDHKAAWTNL GILYESCGQL RDAYACYLNA TKQISFQKSS LIRKKQAIRM 420
KKDTIGLSKG LSQRITFLEG QLSQAPLPSI TSKRRQLCSI EEAWNLPISL EMNSRQQQTA 480
QMLPRQVTKQ SPVQGPPPPY PHSQLSQSPI PSKRIKEDGT SQQEVTQNNS QTSAQNLINI 540
SESLNQRNFN AMPESNKSSE QSVLDTFDDI SNDIYKQNES IKLERLSQDA LSNNEDSRHD 600
FIGGDNADIS TTFKIQMDSK QLMVAVKLLP IDEPPVHCTI LQVNAPPPSP PDCPPQKLTR 660
DQLLPPTPSV HLENKKHAFS PQLQEFCLKH PIAVVRGLAG VLKLDLGLFS TKTLVEANPD 720
HSVEVRTQVH QSPDENWDTS QGKRVWACIS HRSHTTIAKY AQYQASSFQD SLKLILPQDE 780
SDKGFPGSQA MSDSDSKDSV SNSNIVLKRK KHKINSKMLR FGTNVDLSDE KKWKPQLTEL 840
QKLPAFARVI SAANMLSHVG HVILGMNTVQ LYMKVPGSRT PGHQENNNFC SININIGPGD 900
CEWFAVPDAY WGGVHNLCEK NNISYLHGSW WPVLEDLYKE NIPVYRFIQK PGDLVWVNAG 960
CVHWVQSIGW CNNIAWNVGP LTARQYSLAI ERYEWNKVQA FKSIVPMVHL SWNLARNIKV 1020
SDTKLFELIK MCLLQTLKNV LHIQEYVKSK GVEIRFNGRG KNEASHYCGQ CEVEVFNVLF 1080
IKEQEKRHVV HCLSCALKLS PSLQGIVCLE EYRLSELQRV YDSFTLHRTQ GLAYTQ 1136
Nucleotide Sequence
(Fasta)		AATATTTTAG TGTCATCTCT AAACTAAAAA TATAAATAAA AAAATATTTT AAAAACTACG 60
CTGTATTTTG CCCACGCTTC TAAAACCCAG TAGATTTAAC AGTTGGTTTA AAAATGGGGC 120
AACTAACTTT CGAAGATGAT TGCCTGATCC GCGAACTGGA TAGTCGATAC TACGGCTTTT 180
TGGATTTGTC CAATTCGAAA AATGCGGAAT TAAGGAATCT CGTTCAGCAG ACCATCACAA 240
ACTTACAAAA CTACATTGCA AATGGTCAGG TTCACGAATC AAAGAACAGC AGTGATAATA 300
AAAATGCTAT ACAAAAGTTT GAGCCATCAA CTCAAGCAGG TGAACATATG GAAAACACAT 360
CTTCCCGAAA CAATGACGAC ACCAAACCTT TCGAGCAAGA TGCCAAGGAA AAGGTGTCCA 420
TCATTGAAGA AAAACACCAG GATGAACACT ACGTTAACGC TCTTTGCAAA CTTGGCCACC 480
TGCATCTTCT TCTTGGCGAA TACTCCGAAG CTTTATCAGC GTACCAAAAG TATTTAAGAT 540
TCCGAGAAAA CAATTACTGG ACAAATCATG CATTTATCTA TGGAATAGGC GTTGCTTATT 600
TTAAACTTCG GTGCTTTAAA TGGGCCATCA AATCGTTTCA GGAGCTTTTA TACCTAAGTC 660
CCAATTTTAC ATGTGCAAAT GAAGTTCATT TGCGTCTAGG TCTTATGCTA AAACACTGCG 720
GGGAGTTCCA TATTGCCCTA AAACATTTAC AATTGGCGCT GCTTTATACA TATCCTTCGA 780
CCTTTTCGGA ACTTCAGGTC AAATTTCAAA TCGCGCATTT GTACGAAGTT CAAAACAAGC 840
ACAAGGCGGC AAAGGATGGC TACGAATTTC TTCTAAATGA GAAAAACATC TCCTTGGAGC 900
TCAAAGCAGA TGTTTATCGA CAATTAGGAT GGATGTACCA TTGCGTAGAA TGCCTAGGCG 960
AAAAAAAGGA ACGTGAAGCA AACGCATTAA ATTTTCTACA AAAATCAATC GAAGCTGACC 1020
CAAAGAGTGG ACAATCATTA TATTTACTAG GAAGGTGTTA CGCCGGCATC AATAAGGTTC 1080
ATGATGCTTT CCTAGCATAT CGCAACTCGG TGGAAAAAAG TGAGGGGAAT GCTGATACTT 1140
GGTGCTCAAT CGGCGTCTTA TATCAGCAAC AAAATCAACC CACGGATGCC CTTCAAGCCT 1200
ACATATGTGC TGTGCAACTG GATAAAGACC ATAAAGCCGC GTGGACCAAC CTGGGTATAC 1260
TTTATGAGAG CTGTGGTCAA TTACGAGATG CCTATGCTTG CTACTTAAAT GCAACCAAAC 1320
AAATATCATT CCAGAAGTCT TCGTTAATTC GAAAAAAACA AGCAATACGT ATGAAAAAGG 1380
ACACAATTGG ACTGTCGAAA GGCCTGTCTC AGAGAATCAC TTTCCTGGAG GGCCAGCTCA 1440
GTCAAGCACC ATTGCCAAGT ATTACATCCA AGCGCCGCCA GCTGTGTTCA ATCGAAGAAG 1500
CTTGGAACCT GCCAATATCA TTAGAAATGA ACTCTCGCCA ACAACAAACA GCGCAGATGC 1560
TACCAAGACA GGTCACAAAG CAAAGTCCAG TACAGGGACC GCCACCACCT TATCCGCATA 1620
GCCAACTCAG CCAAAGTCCC ATACCTTCGA AACGTATTAA GGAAGATGGC ACAAGCCAAC 1680
AAGAAGTAAC ACAAAACAAC AGTCAGACAT CAGCGCAAAA TCTAATAAAC ATTTCGGAAT 1740
CTTTAAACCA GCGCAACTTC AACGCCATGC CGGAGAGCAA CAAAAGTTCG GAGCAAAGTG 1800
TTCTTGACAC CTTCGACGAC ATCTCGAATG ATATTTATAA ACAGAATGAG AGCATCAAGC 1860
TCGAACGTTT GAGCCAGGAT GCACTGAGTA ACAATGAGGA CTCGAGGCAT GATTTTATTG 1920
GCGGTGACAA CGCCGACATC TCGACCACGT TCAAAATACA AATGGACTCG AAGCAGTTGA 1980
TGGTAGCTGT GAAGCTGCTG CCGATTGATG AACCGCCCGT GCACTGTACC ATTTTGCAAG 2040
TGAATGCGCC GCCGCCATCT CCGCCCGATT GCCCACCGCA GAAACTGACG CGAGATCAAC 2100
TCCTGCCTCC CACACCCTCT GTTCATTTAG AAAATAAGAA GCACGCGTTC AGCCCACAGT 2160
TGCAGGAGTT TTGCCTGAAA CATCCGATTG CCGTTGTACG CGGCTTAGCG GGCGTCTTGA 2220
AGCTAGATCT CGGTCTCTTT TCGACCAAAA CGTTGGTGGA AGCCAACCCG GACCATAGTG 2280
TTGAGGTTCG GACACAAGTG CACCAGTCTC CCGATGAAAA TTGGGACACT TCGCAGGGTA 2340
AGCGCGTCTG GGCCTGCATT TCCCATCGGT CTCACACAAC CATAGCCAAA TATGCCCAAT 2400
ATCAGGCATC CAGTTTTCAA GACAGCTTGA AGCTTATTTT ACCGCAGGAT GAAAGCGATA 2460
AAGGTTTCCC CGGCTCGCAA GCAATGTCGG ATTCAGACTC AAAGGACTCG GTATCCAATT 2520
CGAACATTGT TCTCAAACGT AAAAAACACA AAATAAACAG CAAAATGTTG AGGTTCGGGA 2580
CCAACGTGGA CCTCTCCGAT GAAAAGAAAT GGAAACCACA ATTAACAGAG CTACAAAAAC 2640
TGCCAGCTTT TGCGCGAGTT ATATCCGCTG CCAATATGCT ATCACACGTG GGCCACGTCA 2700
TTTTGGGCAT GAACACCGTT CAGCTGTACA TGAAGGTGCC CGGAAGTAGG ACGCCTGGCC 2760
ACCAAGAGAA CAACAACTTC TGCTCAATCA ACATCAACAT CGGTCCTGGC GACTGTGAAT 2820
GGTTTGCCGT CCCTGACGCC TACTGGGGCG GAGTTCACAA TCTTTGCGAG AAGAACAACA 2880
TTAGCTATCT GCACGGCTCG TGGTGGCCCG TCCTGGAGGA TTTATACAAG GAGAATATAC 2940
CAGTTTATAG ATTTATACAA AAGCCCGGTG ACTTGGTTTG GGTGAATGCC GGATGCGTCC 3000
ATTGGGTTCA GTCGATCGGT TGGTGCAACA ACATTGCGTG GAATGTTGGA CCCTTGACTG 3060
CCCGTCAGTA TTCTCTTGCC ATCGAGCGAT ATGAGTGGAA TAAAGTGCAG GCCTTCAAGA 3120
GCATTGTGCC GATGGTGCAT TTAAGCTGGA ATCTTGCAAG GAATATTAAA GTGTCTGATA 3180
CCAAACTTTT CGAGCTGATA AAAATGTGTT TGCTGCAAAC GTTGAAAAAC GTATTGCACA 3240
TACAAGAGTA TGTCAAATCG AAAGGTGTGG AAATACGTTT CAATGGACGC GGAAAGAACG 3300
AAGCATCCCA TTACTGCGGA CAATGCGAGG TTGAGGTTTT CAATGTGCTG TTCATCAAGG 3360
AGCAGGAGAA ACGACATGTG GTCCACTGCC TATCGTGCGC GCTGAAGCTA TCTCCGTCGC 3420
TCCAGGGAAT CGTTTGCCTG GAGGAGTATC GTCTGTCTGA GCTGCAGCGC GTGTACGATT 3480
CGTTTACTTT ACACAGAACC CAAGGACTAG CATACACTCA GTAGTTGTAA TACGAGGAAT 3540
CATTTTAAGT AATGCAGATT TAATATATGT ATATTTTACA ACGTACAATA TACTCTCTAT 3600
TGTTTTGAT
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
--
Interpro

IPR003347--JmjC_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS51184--JMJC
PS50005--TPR
PS50293--TPR_REGION
Pfam

PF02373--JmjC
Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0005705--C:polytene chromosome interband
GO:0001047--F:core promoter binding
GO:0032452--F:histone demethylase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0008168--F:methyltransferase activity
GO:0071390--P:cellular response to ecdysone
GO:0071480--P:cellular response to gamma radiation
GO:0035072--P:ecdysone-mediated induction of salivary gland cell autophagic cell death
GO:0016577--P:histone demethylation
GO:0071557--P:histone H3-K27 demethylation
GO:0051568--P:histone H3-K4 methylation
GO:0035078--P:induction of programmed cell death by ecdysone
GO:0008285--P:negative regulation of cell proliferation
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:1902465--P:negative regulation of histone H3-K27 trimethylation
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0010508--P:positive regulation of autophagy
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:1990248--P:regulation of transcription from RNA polymerase II promoter in response to DNA damage
GO:0045498--P:sex comb development
GO:0042060--P:wound healing
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Dar-0142 ENSDARP00000082902.5 Danio rerio 64 0.0 647
WERAM-Leo-0012 ENSLOCP00000002191.1 Lepisosteus oculatus 64 0.0 646
WERAM-Gam-0072 ENSGMOP00000007617.1 Gadus morhua 63 0.0 645
WERAM-Ten-0176 ENSTNIP00000017565.1 Tetraodon nigroviridis 63 0.0 642
WERAM-Tar-0130 ENSTRUP00000028532.1 Takifugu rubripes 63 0.0 642
WERAM-Nol-0027 ENSNLEP00000003398.1 Nomascus leucogenys 64 0.0 640
WERAM-Gaga-0147 ENSGALP00000026095.3 Gallus gallus 63 0.0 640
WERAM-Tag-0092 ENSTGUP00000006298.1 Taeniopygia guttata 64 0.0 640
WERAM-Sah-0181 ENSSHAP00000019619.1 Sarcophilus harrisii 64 0.0 639
WERAM-Orn-0197 ENSONIP00000020522.1 Oreochromis niloticus 63 0.0 639
WERAM-Mod-0190 ENSMODP00000026365.3 Monodelphis domestica 64 0.0 639
WERAM-Anp-0094 ENSAPLP00000010853.1 Anas platyrhynchos 64 0.0 638
WERAM-Caj-0114 ENSCJAP00000020276.1 Callithrix jacchus 64 0.0 638
WERAM-Loa-0137 ENSLAFP00000012409.3 Loxodonta africana 64 0.0 638
WERAM-Pat-0183 ENSPTRP00000037456.5 Pan troglodytes 64 0.0 638
WERAM-Hos-0151 ENSP00000367203.4 Homo sapiens 64 0.0 638
WERAM-Fia-0019 ENSFALP00000001531.1 Ficedula albicollis 64 0.0 638
WERAM-Mam-0026 ENSMMUP00000004425.2 Macaca mulatta 64 0.0 638
WERAM-Gog-0077 ENSGGOP00000006480.2 Gorilla gorilla 64 0.0 638
WERAM-Caf-0151 ENSCAFP00000021559.4 Canis familiaris 64 0.0 637
WERAM-Mup-0146 ENSMPUP00000012827.1 Mustela putorius furo 64 0.0 637
WERAM-Xet-0034 ENSXETP00000010467.3 Xenopus tropicalis 63 0.0 637
WERAM-Paa-0055 ENSPANP00000002155.1 Papio anubis 64 0.0 637
WERAM-Chs-0171 ENSCSAP00000010028.1 Chlorocebus sabaeus 64 0.0 637
WERAM-Eqc-0037 ENSECAP00000006528.1 Equus caballus 64 0.0 637
WERAM-Mum-0148 ENSMUSP00000045862.6 Mus musculus 64 0.0 637
WERAM-Sus-0086 ENSSSCP00000013049.2 Sus scrofa 64 0.0 637
WERAM-Gaa-0095 ENSGACP00000012288.1 Gasterosteus aculeatus 63 0.0 636
WERAM-Dan-0148 ENSDNOP00000019265.1 Dasypus novemcinctus 63 0.0 636
WERAM-Bot-0217 ENSBTAP00000056061.1 Bos taurus 62 0.0 635
WERAM-Xim-0077 ENSXMAP00000007121.1 Xiphophorus maculatus 62 0.0 635
WERAM-Orc-0144 ENSOCUP00000012682.3 Oryctolagus cuniculus 63 0.0 635
WERAM-Lac-0046 ENSLACP00000006800.1 Latimeria chalumnae 63 0.0 634
WERAM-Ora-0070 ENSOANP00000010350.2 Ornithorhynchus anatinus 64 0.0 634
WERAM-Aim-0069 ENSAMEP00000006135.1 Ailuropoda melanoleuca 63 0.0 634
WERAM-Pof-0084 ENSPFOP00000008526.2 Poecilia formosa 62 0.0 634
WERAM-Ict-0022 ENSSTOP00000001438.2 Ictidomys tridecemlineatus 63 0.0 632
WERAM-Fec-0103 ENSFCAP00000008761.3 Felis catus 63 0.0 632
WERAM-Ova-0032 ENSOARP00000004275.1 Ovis aries 63 0.0 632
WERAM-Myl-0016 ENSMLUP00000001587.2 Myotis lucifugus 64 0.0 632
WERAM-Otg-0165 ENSOGAP00000013915.2 Otolemur garnettii 63 0.0 632
WERAM-Cap-0157 ENSCPOP00000013041.2 Cavia porcellus 63 0.0 632
WERAM-Orla-0140 ENSORLP00000016899.1 Oryzias latipes 63 1e-180 631
WERAM-Ran-0230 ENSRNOP00000073763.1 Rattus norvegicus 63 2e-180 630
WERAM-Asm-0021 ENSAMXP00000002540.1 Astyanax mexicanus 62 3e-180 630
WERAM-Tut-0077 ENSTTRP00000006394.1 Tursiops truncatus 63 4e-180 629
WERAM-Anc-0039 ENSACAP00000004438.2 Anolis carolinensis 60 2e-176 617
WERAM-Dio-0094 ENSDORP00000009558.1 Dipodomys ordii 59 2e-174 611
WERAM-Ocp-0085 ENSOPRP00000007644.1 Ochotona princeps 59 2e-174 611
WERAM-Poa-0211 ENSPPYP00000023681.1 Pongo abelii 59 2e-174 610
WERAM-Prc-0139 ENSPCAP00000012640.1 Procavia capensis 59 4e-174 610
WERAM-Ptv-0175 ENSPVAP00000015419.1 Pteropus vampyrus 59 2e-170 597
WERAM-Tub-0075 ENSTBEP00000009338.1 Tupaia belangeri 58 2e-168 590
WERAM-Mim-0136 ENSMICP00000013798.1 Microcebus murinus 57 3e-166 583
WERAM-Soa-0034 ENSSARP00000003229.1 Sorex araneus 60 2e-165 581
WERAM-Cii-0043 ENSCINP00000023576.2 Ciona intestinalis 56 2e-164 578
WERAM-Meg-0148 ENSMGAP00000015468.2 Meleagris gallopavo 68 1e-154 545
WERAM-Vip-0032 ENSVPAP00000002998.1 Vicugna pacos 55 4e-152 536
WERAM-Pes-0096 ENSPSIP00000011716.1 Pelodiscus sinensis 53 9e-147 518
WERAM-Ere-0131 ENSEEUP00000013778.1 Erinaceus europaeus 63 3e-146 517
WERAM-Ect-0058 ENSETEP00000006399.1 Echinops telfairi 64 1e-130 465
WERAM-Cis-0015 ENSCSAVP00000002905.1 Ciona savignyi 56 8e-126 449
WERAM-Cae-0055 D2021.1 Caenorhabditis elegans 43 4e-117 420
Created Date 25-Jun-2016