| Tag |
Content |
| WERAM ID |
WERAM-Hos-0082 |
| Ensembl Protein ID |
ENSP00000380024.4 |
| Uniprot Accession |
Q9UNL4; ING4_HUMAN; A4KYM4; A4KYM6; D3DUR8; Q0EF62; Q0EF63; Q4VBQ6; Q96E15; Q9H3J0
|
| Genbank Protein ID |
NP_001121054.1; NP_001121055.1; NP_001121056.1; NP_001121057.1; NP_001121058.1; NP_057246.2
|
| Protein Name |
Inhibitor of growth protein 4 |
| Genbank Nucleotide ID |
NM_001127582.1; NM_001127583.1; NM_001127584.1; NM_001127585.1; NM_001127586.1; NM_016162.3
|
| Gene Name |
ING4;My036 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
PHD |
PHD-type |
H3K4me3 |
K |
24631869
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
3.60e-11 |
45.3 |
197 |
244 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance aopotosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). |
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance aopotosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
|
| Domain Profile |
Me_Reader PHD
PHD.txt 2 tiClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCke 52
t+Cl C+++++ge m+ Cd+ C+ +wfH Cv+l+ + p g +w+Cp+C +
ENSP00000380024.4 197 TYCL-CHQVSYGE--MIGCDNpdCSiEWFHFACVGLT--TKPRG-KWFCPRCSQ 244
89*9.*******6..**********************..*****.*******86 PP
|
Protein Sequence
(Fasta) | MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE 60
KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120
YDSSSSKGKK KGRTQKEKKA ARARSKGKNS DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS 180
VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP 240
RCSQERKKK 249Protein Fasta Sequence
>ENSP00000380024.4|ING4;My036|Homo sapiens
MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK |
Nucleotide Sequence
(Fasta) | TTCCGGGGCG GATCGGAAGT TGCTTTGTTT TGCTTCGAGA TGGCTGCGGG GATGTATTTG 60
GAACATTATC TGGACAGTAT TGAAAACCTT CCCTTTGAAT TACAGAGAAA CTTTCAGCTC 120
ATGAGGGACC TAGACCAAAG AACAGAGGAC CTGAAGGCTG AAATTGACAA GTTGGCCACT 180
GAGTATATGA GTAGTGCCCG CAGCCTGAGC TCCGAGGAAA AATTGGCCCT TCTCAAACAG 240
ATCCAGGAAG CCTATGGCAA GTGCAAGGAA TTTGGTGACG ACAAGGTGCA GCTTGCCATG 300
CAGACCTATG AGATGGTGGA CAAACACATT CGGCGGCTGG ACACAGACCT GGCCCGTTTT 360
GAGGCTGATC TCAAGGAGAA ACAGATTGAG TCAAGTGACT ATGACAGCTC TTCCAGCAAA 420
GGCAAAAAGA AAGGCCGGAC TCAAAAGGAG AAGAAAGCTG CTCGTGCTCG TTCCAAAGGG 480
AAAAACTCGG ATGAAGAAGC CCCCAAGACT GCCCAGAAGA AGTTAAAGCT CGTGCGCACA 540
AGTCCTGAGT ATGGGATGCC CTCAGTGACC TTTGGCAGTG TCCACCCCTC TGATGTGTTG 600
GATATGCCTG TGGATCCCAA CGAACCCACC TATTGCCTTT GTCACCAGGT CTCCTATGGA 660
GAGATGATTG GCTGTGACAA CCCTGATTGT TCCATTGAGT GGTTCCATTT TGCCTGTGTG 720
GGGCTGACAA CCAAGCCTCG GGGGAAATGG TTTTGCCCAC GCTGCTCCCA AGAACGGAAG 780
AAGAAATAGA TAAGGGCCTT GGATTCCAAC ACAGTTTCTT CCACATCCCC TGACTTGGGC 840
TAGTGGGCAG AGGAATGCCT GTGCTGGGGC CAGGGGTTCA GGGAGGAGTG GATGGCACAG 900
TGCTGTCATC CCTTCTCCTC CCCTCTCCCC ACTCCCGGTG CTGAGGCTGC ATCAGACCCT 960
GGTAGGGAGG GGTGCCGCAG CCACTAACGG TATGTGCTCT CCTTCAGCCC TCTCCCTTCG 1020
GAGGGACGTG GTCTTGCCCA CTGTCCTTTT GCCTCCATGC TGAGGTCGGT GCTGTATTTC 1080
AGAGGGAGGG TCCTTTTCAT TCTCCTTGCT TTGTATTTAA GGACTGGGGC ATAGCATGGG 1140
GGCAGTCCCC CAGACCTCTT CATTCCCCCT CCTGTGGTGA GGGCTAGGTG TGATCAACAC 1200
TTTTCTTCTC CATTCCCTTC CTGCTTTTTT CATGGTGGGG GATCCACCAG GTCATCTAGG 1260
CTCTGGCCCT AGTTGAAGGG GCACCCCTTC CTCTGTGCCA AGAGGATTCA TCCTGGGAGA 1320
GGGGGCAAGG TGGAATGCAG ATAACTCACA TGTAAAAGGA ACTTGGGTAG GTAAATAAAA 1380
GCTATACATG TTG
1394Nucleotide Fasta Sequence
>ENSP00000380024.4|PHD|Homo sapiens
TTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACAGTATTGAAAACCTTCCCTTTGAATTACAGAGAAACTTTCAGCTCATGAGGGACCTAGACCAAAGAACAGAGGACCTGAAGGCTGAAATTGACAAGTTGGCCACTGAGTATATGAGTAGTGCCCGCAGCCTGAGCTCCGAGGAAAAATTGGCCCTTCTCAAACAGATCCAGGAAGCCTATGGCAAGTGCAAGGAATTTGGTGACGACAAGGTGCAGCTTGCCATGCAGACCTATGAGATGGTGGACAAACACATTCGGCGGCTGGACACAGACCTGGCCCGTTTTGAGGCTGATCTCAAGGAGAAACAGATTGAGTCAAGTGACTATGACAGCTCTTCCAGCAAAGGCAAAAAGAAAGGCCGGACTCAAAAGGAGAAGAAAGCTGCTCGTGCTCGTTCCAAAGGGAAAAACTCGGATGAAGAAGCCCCCAAGACTGCCCAGAAGAAGTTAAAGCTCGTGCGCACAAGTCCTGAGTATGGGATGCCCTCAGTGACCTTTGGCAGTGTCCACCCCTCTGATGTGTTGGATATGCCTGTGGATCCCAACGAACCCACCTATTGCCTTTGTCACCAGGTCTCCTATGGAGAGATGATTGGCTGTGACAACCCTGATTGTTCCATTGAGTGGTTCCATTTTGCCTGTGTGGGGCTGACAACCAAGCCTCGGGGGAAATGGTTTTGCCCACGCTGCTCCCAAGAACGGAAGAAGAAATAGATAAGGGCCTTGGATTCCAACACAGTTTCTTCCACATCCCCTGACTTGGGCTAGTGGGCAGAGGAATGCCTGTGCTGGGGCCAGGGGTTCAGGGAGGAGTGGATGGCACAGTGCTGTCATCCCTTCTCCTCCCCTCTCCCCACTCCCGGTGCTGAGGCTGCATCAGACCCTGGTAGGGAGGGGTGCCGCAGCCACTAACGGTATGTGCTCTCCTTCAGCCCTCTCCCTTCGGAGGGACGTGGTCTTGCCCACTGTCCTTTTGCCTCCATGCTGAGGTCGGTGCTGTATTTCAGAGGGAGGGTCCTTTTCATTCTCCTTGCTTTGTATTTAAGGACTGGGGCATAGCATGGGGGCAGTCCCCCAGACCTCTTCATTCCCCCTCCTGTGGTGAGGGCTAGGTGTGATCAACACTTTTCTTCTCCATTCCCTTCCTGCTTTTTTCATGGTGGGGGATCCACCAGGTCATCTAGGCTCTGGCCCTAGTTGAAGGGGCACCCCTTCCTCTGTGCCAAGAGGATTCATCCTGGGAGAGGGGGCAAGGTGGAATGCAGATAACTCACATGTAAAAGGAACTTGGGTAGGTAAATAAAAGCTATACATGTTG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
|
| Pfam |
PF12998--ING
|
| Gene Ontology |
GO:0000123--C:histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0006473--P:protein acetylation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
