| Tag |
Content |
| WERAM ID |
WERAM-Hos-0103 |
| Ensembl Protein ID |
ENSP00000379670.2 |
| Uniprot Accession |
Q13185; CBX3_HUMAN; Q96CD7; Q99409; Q9BVS3; Q9P0Z6
|
| Genbank Protein ID |
NP_009207.2; NP_057671.2; XP_005249668.1
|
| Protein Name |
Chromobox protein homolog 3 |
| Genbank Nucleotide ID |
NM_007276.4; NM_016587.3; XM_005249611.2
|
| Gene Name |
Cbx3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
DCD |
Chromo1 |
H1.4K25me2; H3K9me3 |
K |
22514736
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
Chromodomain |
8.50e-18 |
66.5 |
30 |
169 |
| Me_Reader |
DCD |
2.40e-35 |
107.5 |
32 |
81 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. |
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
|
| Domain Profile |
Me_Reader Chromodomain
Chromodomain.txt 1 FeverivdkkelrkgeveYlVrWkGynksddtWepeenLlckelleefekkkek 54
F ve+++ ++++ +g+veY+ +WkG+++ d+tWepeenL c+el+e+f + ++
ENSP00000379670.2 30 FVVEKVL-DRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKA 82
78*****.9**************************************9765544 PP
Chromodomain.txt 13 rkgeveYlVrWkGynksddtWepeenLlckelleefek 50
ge +l +Wk ++ d e n++c++++ +f +
ENSP00000379670.2 132 SSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYE 169
56788899999988877777778888889888888866 PP
Me_Reader DCD
Chromo-2.txt 3 verIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeere 55
ve++++ +G+++y++kWk+ a+ + +en ++p+l+++f ++++
ENSP00000379670.2 32 VEKVLDRR-VVNGKVEYFLKWKGF--TDADNTWEPEENLDCPELIEAFLNSQK 81
67777777.679***********7..77777777789***********99876 PP
Chromo-2.txt 2 mverIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61
+erIi+++ d++Gel++L+kWkd+ dea+++ a+++n+k+pq+v++fyeer+++++++
ENSP00000379670.2 122 DPERIIGAT-DSSGELMFLMKWKDS--DEADLVLAKEANMKCPQIVIAFYEERLTWHSCP 178
69*******.***************..******************************987 PP
|
Protein Sequence
(Fasta) | MASNKTTLQK MGKKQNGKSK KVEEAEPEEF VVEKVLDRRV VNGKVEYFLK WKGFTDADNT 60
WEPEENLDCP ELIEAFLNSQ KAGKEKDGTK RKSLSDSESD DSKSKKKRDA ADKPRGFARG 120
LDPERIIGAT DSSGELMFLM KWKDSDEADL VLAKEANMKC PQIVIAFYEE RLTWHSCPED 180
EAQ 183Protein Fasta Sequence
>ENSP00000379670.2|Cbx3|Homo sapiens
MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ |
Nucleotide Sequence
(Fasta) | GGTGCCACCC CTCCCCCCGG CGGCCCCGCG CGCAGCTCCC GGCTCCCTCC CCCTTCGGAT 60
GTGGCTTGAG CTGTAGGCGC GGAGGGCCGG AGACGCTGCA GACCCGCGAC CCGGAGCAGC 120
TCGGAGGCGG TGAATAATAG CTCTTCAAGT CTGCAATAAA AAATGGCCTC CAACAAAACT 180
ACATTGCAAA AAATGGGAAA AAAACAGAAT GGAAAGAGTA AAAAAGTTGA AGAGGCAGAG 240
CCTGAAGAAT TTGTCGTGGA AAAAGTACTA GATCGACGTG TAGTGAATGG GAAAGTGGAA 300
TATTTCCTGA AGTGGAAGGG ATTTACAGAT GCTGACAATA CTTGGGAACC TGAAGAAAAT 360
TTAGATTGTC CAGAATTGAT TGAAGCGTTT CTTAACTCTC AGAAAGCTGG CAAAGAAAAA 420
GATGGTACAA AAAGAAAATC TTTATCTGAC AGTGAATCTG ATGACAGCAA ATCAAAGAAG 480
AAAAGAGATG CTGCTGACAA ACCAAGAGGA TTTGCCAGAG GTCTTGATCC TGAAAGAATA 540
ATTGGTGCCA CAGACAGCAG TGGAGAATTG ATGTTTCTCA TGAAATGGAA AGATTCAGAT 600
GAGGCAGACT TGGTGCTGGC GAAAGAGGCA AATATGAAGT GTCCTCAAAT TGTAATTGCT 660
TTTTATGAAG AGAGACTAAC TTGGCATTCT TGTCCAGAAG ATGAAGCTCA ATAATTGTTC 720
ACATTGTTCT TTTATATATA TTTATATATA TATATAAAAA TTGGGTCTTA GATTTTGATT 780
TACTAGTGTG ACAAAATAAC TACATCCTAA TGAAAATCAA GTTTGATATG TTTGTTTTGA 840
AAGTAGCGTT GGAAGAGTTG TTGGGGGTTT TTTGCATCCA TAGCACTGGT TACTTTGAAC 900
AAATAAATAA AAGCTTTCTG TAGTTGCTTC CTTTATCAGA AAAGAACATT TGATACCATG 960
GTATATCATT TCCTCTTCAT TAAAGAACAG CTTTTCTAAA TGTTGGGGGA AATGTCCATA 1020
GTCATTACTC AGTCAAAACT TGTGTTCTCA TGAGCCTAAG GACCATTCTA GATTTATTAC 1080
GTGTTTTTTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTA TCCATAAAAT GCATATGTAA 1140
ATTTTTTTTT GTTTTTAAGC ATTCACCCAA ACAAAAAAAT CACAGGTAAA CCCATGTTTC 1200
TGAGATGCCA TTATTCCAAG CAAAATAAGA GATAATCCCT TCAAGTTAAA TTGAAAATTT 1260
TCCTGAAACC ATACATTTCA AGTGAAATAA GTAATTCTAG ATAGGACAAT TTAAATTGGA 1320
TAATTTTAAA GTGTCTATAA TTGCAGTGGT TTATTTGCAA AATTCCTAAA AGGAAAAATT 1380
TTATCACTGC CATCACAGCA GGTTTCCTCA TCCAGATGAG GAAACTAGAC AAATGCTAGT 1440
GTGTTTTAAC TAGCTAAACA AAACTAAGTT AAATGAACAT TTAAAAGTTT CCCTAGCGGG 1500
CCATTCCTTA GCAAAATGTT GGAATCCCTG TTGCTACATT GACTAAAAGG TCATGATGAA 1560
TGGAATATGT AAGACTTGGC TCATAGAAAC CTAATCAGAT GGTTAGAGGT GTTGGCAGTT 1620
TAGGACCTGC TGTCATAAAT GTGTGAACAA CCTTTTGTAA CCTAACCTAT TGACCTGCAT 1680
GTTTTTTCTT TACCCCAATT CATTACATGG AGGCTCAATC TTGAGTTTGC TTTACTGGTT 1740
CAGCAAAAGC CAGGAAGAAC AACTTTGTAG TAATCAAAAT GTTATCCAAC TGTATATTGT 1800
TTACTTTATT GTAAATACTG GTGAACAGTG GTTAATAAAT AGTTTTATAT TCCTTTA
1858Nucleotide Fasta Sequence
>ENSP00000379670.2|DCD|Homo sapiens
GGTGCCACCCCTCCCCCCGGCGGCCCCGCGCGCAGCTCCCGGCTCCCTCCCCCTTCGGATGTGGCTTGAGCTGTAGGCGCGGAGGGCCGGAGACGCTGCAGACCCGCGACCCGGAGCAGCTCGGAGGCGGTGAATAATAGCTCTTCAAGTCTGCAATAAAAAATGGCCTCCAACAAAACTACATTGCAAAAAATGGGAAAAAAACAGAATGGAAAGAGTAAAAAAGTTGAAGAGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTAGTGAATGGGAAAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACTTGGGAACCTGAAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGTTTCTTAACTCTCAGAAAGCTGGCAAAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTGACAGTGAATCTGATGACAGCAAATCAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATTTGCCAGAGGTCTTGATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATGAAATGGAAAGATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGTCCTCAAATTGTAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGATGAAGCTCAATAATTGTTCACATTGTTCTTTTATATATATTTATATATATATATAAAAATTGGGTCTTAGATTTTGATTTACTAGTGTGACAAAATAACTACATCCTAATGAAAATCAAGTTTGATATGTTTGTTTTGAAAGTAGCGTTGGAAGAGTTGTTGGGGGTTTTTTGCATCCATAGCACTGGTTACTTTGAACAAATAAATAAAAGCTTTCTGTAGTTGCTTCCTTTATCAGAAAAGAACATTTGATACCATGGTATATCATTTCCTCTTCATTAAAGAACAGCTTTTCTAAATGTTGGGGGAAATGTCCATAGTCATTACTCAGTCAAAACTTGTGTTCTCATGAGCCTAAGGACCATTCTAGATTTATTACGTGTTTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATCCATAAAATGCATATGTAAATTTTTTTTTGTTTTTAAGCATTCACCCAAACAAAAAAATCACAGGTAAACCCATGTTTCTGAGATGCCATTATTCCAAGCAAAATAAGAGATAATCCCTTCAAGTTAAATTGAAAATTTTCCTGAAACCATACATTTCAAGTGAAATAAGTAATTCTAGATAGGACAATTTAAATTGGATAATTTTAAAGTGTCTATAATTGCAGTGGTTTATTTGCAAAATTCCTAAAAGGAAAAATTTTATCACTGCCATCACAGCAGGTTTCCTCATCCAGATGAGGAAACTAGACAAATGCTAGTGTGTTTTAACTAGCTAAACAAAACTAAGTTAAATGAACATTTAAAAGTTTCCCTAGCGGGCCATTCCTTAGCAAAATGTTGGAATCCCTGTTGCTACATTGACTAAAAGGTCATGATGAATGGAATATGTAAGACTTGGCTCATAGAAACCTAATCAGATGGTTAGAGGTGTTGGCAGTTTAGGACCTGCTGTCATAAATGTGTGAACAACCTTTTGTAACCTAACCTATTGACCTGCATGTTTTTTCTTTACCCCAATTCATTACATGGAGGCTCAATCTTGAGTTTGCTTTACTGGTTCAGCAAAAGCCAGGAAGAACAACTTTGTAGTAATCAAAATGTTATCCAACTGTATATTGTTTACTTTATTGTAAATACTGGTGAACAGTGGTTAATAAATAGTTTTATATTCCTTTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
|
| Pfam |
PF00385--Chromo
PF01393--Chromo_shadow
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0000775--C:chromosome, centromeric region
GO:0000779--C:condensed chromosome, centromeric region
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005635--C:nuclear envelope
GO:0005719--C:nuclear euchromatin
GO:0005720--C:nuclear heterochromatin
GO:0005637--C:nuclear inner membrane
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0035985--C:senescence-associated heterochromatin focus
GO:0005819--C:spindle
GO:0019899--F:enzyme binding
GO:1990226--F:histone methyltransferase binding
GO:0042802--F:identical protein binding
GO:0019904--F:protein domain specific binding
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0006338--P:chromatin remodeling
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
