| Tag |
Content |
| WERAM ID |
WERAM-Hos-0038 |
| Ensembl Protein ID |
ENSP00000371638.1 |
| Uniprot Accession |
P51531; SMCA2_HUMAN; B1ALG3; B1ALG4; D3DRH4; D3DRH5
|
| Genbank Protein ID |
NP_001276325.1; NP_001276326.1; NP_003061.3; NP_620614.2
|
| Protein Name |
Probable global transcription activator SNF2L2 |
| Genbank Nucleotide ID |
NM_001289396.1; NM_001289397.1; NM_003070.4; NM_139045.3
|
| Gene Name |
SMARCA2;BAF190B;BRM;SNF2A;SNF2L2 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Bromodomain |
Bromodomain |
H3K9; H3K14; H4K5; H4K8; H4K12; H4K16 |
K |
22464331
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Ac_Reader |
Bromodomain |
5.10e-17 |
64 |
1421 |
1489 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
|
| Domain Profile |
Ac_Reader Bromodomain
BROMO.txt 3 hevsepF.repvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72
+++se+F + p+++ e+p+Yy++i++P+d+++iker+++++Y+s+ ++ kDv l+++Na+++n ++s+++
ENSP00000371638.1 1421 RQLSEVFiQLPSRK--ELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIY 1489
789****7777777..9***********************************************9999886 PP
|
Protein Sequence
(Fasta) | MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPMPTM 60
GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR PPHPGMGPPQ SPMDQHSQGY 120
MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP SQPGALIPGD PQAMSQPNRG PSPFSPVQLH 180
QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ 240
QQPPQPQTQQ QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPPAA 300
AVPGPSVPQP APGQPSPVLQ LQQKQSRISP IQKPQGLDPV EILQEREYRL QARIAHRIQE 360
LENLPGSLPP DLRTKATVEL KALRLLNFQR QLRQEVVACM RRDTTLETAL NSKAYKRSKR 420
QTLREARMTE KLEKQQKIEQ ERKRRQKHQE YLNSILQHAK DFKEYHRSVA GKIQKLSKAV 480
ATWHANTERE QKKETERIEK ERMRRLMAED EEGYRKLIDQ KKDRRLAYLL QQTDEYVANL 540
TNLVWEHKQA QAAKEKKKRR RRKKKAEENA EGGESALGPD GEPIDESSQM SDLPVKVTHT 600
ETGKVLFGPE APKASQLDAW LEMNPGYEVA PRSDSEESDS DYEEEDEEEE SSRQETEEKI 660
LLDPNSEEVS EKDAKQIIET AKQDVDDEYS MQYSARGSQS YYTVAHAISE RVEKQSALLI 720
NGTLKHYQLQ GLEWMVSLYN NNLNGILADE MGLGKTIQTI ALITYLMEHK RLNGPYLIIV 780
PLSTLSNWTY EFDKWAPSVV KISYKGTPAM RRSLVPQLRS GKFNVLLTTY EYIIKDKHIL 840
AKIRWKYMIV DEGHRMKNHH CKLTQVLNTH YVAPRRILLT GTPLQNKLPE LWALLNFLLP 900
TIFKSCSTFE QWFNAPFAMT GERVDLNEEE TILIIRRLHK VLRPFLLRRL KKEVESQLPE 960
KVEYVIKCDM SALQKILYRH MQAKGILLTD GSEKDKKGKG GAKTLMNTIM QLRKICNHPY 1020
MFQHIEESFA EHLGYSNGVI NGAELYRASG KFELLDRILP KLRATNHRVL LFCQMTSLMT 1080
IMEDYFAFRN FLYLRLDGTT KSEDRAALLK KFNEPGSQYF IFLLSTRAGG LGLNLQAADT 1140
VVIFDSDWNP HQDLQAQDRA HRIGQQNEVR VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ 1200
AGMFDQKSSS HERRAFLQAI LEHEEENEEE DEVPDDETLN QMIARREEEF DLFMRMDMDR 1260
RREDARNPKR KPRLMEEDEL PSWIIKDDAE VERLTCEEEE EKIFGRGSRQ RRDVDYSDAL 1320
TEKQWLRAIE DGNLEEMEEE VRLKKRKRRR NVDKDPAKED VEKAKKRRGR PPAEKLSPNP 1380
PKLTKQMNAI IDTVINYKDR CNVEKVPSNS QLEIEGNSSG RQLSEVFIQL PSRKELPEYY 1440
ELIRKPVDFK KIKERIRNHK YRSLGDLEKD VMLLCHNAQT FNLEGSQIYE DSIVLQSVFK 1500
SARQKIAKEE ESEDESNEEE EEEDEEESES EAKSVKVKIK LNKKDDKGRD KGKGKKRPNR 1560
GKAKPVVSDF DSDEEQDERE QSEGSGTDDE Protein Fasta Sequence
>ENSP00000371638.1|SMARCA2;BAF190B;BRM;SNF2A;SNF2L2|Homo sapiens
MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTMGSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAAAVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNRGKAKPVVSDFDSDEEQDEREQSEGSGTDDE |
Nucleotide Sequence
(Fasta) | TCAGAAGAAA GCCCCGAGAT CACAGAGACC CGGCGAGATC ACAGAGACCC GGCCTGAAGG 60
AACGTGGAAA GACCAATGTA CCTGTTTTGA CCGGTTGCCT GGAGCAAGAA GTTCCAGTTG 120
GGGAGAATTT TCAGAAGATA AAGTCGGAGA TTGTGGAAAG ACTTGACTTG CAGCATTACT 180
CTACTGACTG GCAGAGACAG GAGAGGTAGA TGTCCACGCC CACAGACCCT GGTGCGATGC 240
CCCACCCAGG GCCTTCGCCG GGGCCTGGGC CTTCCCCTGG GCCAATTCTT GGGCCTAGTC 300
CAGGACCAGG ACCATCCCCA GGTTCCGTCC ACAGCATGAT GGGGCCAAGT CCTGGACCTC 360
CAAGTGTCTC CCATCCTATG CCGACGATGG GGTCCACAGA CTTCCCACAG GAAGGCATGC 420
ATCAAATGCA TAAGCCCATC GATGGTATAC ATGACAAGGG GATTGTAGAA GACATCCATT 480
GTGGATCCAT GAAGGGCACT GGTATGCGAC CACCTCACCC AGGCATGGGC CCTCCCCAGA 540
GTCCAATGGA TCAACACAGC CAAGGTTATA TGTCACCACA CCCATCTCCA TTAGGAGCCC 600
CAGAGCACGT CTCCAGCCCT ATGTCTGGAG GAGGCCCAAC TCCACCTCAG ATGCCACCAA 660
GCCAGCCGGG GGCCCTCATC CCAGGTGATC CGCAGGCCAT GAGCCAGCCC AACAGAGGTC 720
CCTCACCTTT CAGTCCTGTC CAGCTGCATC AGCTTCGAGC TCAGATTTTA GCTTATAAAA 780
TGCTGGCCCG AGGCCAGCCC CTCCCCGAAA CGCTGCAGCT TGCAGTCCAG GGGAAAAGGA 840
CGTTGCCTGG CTTGCAGCAA CAACAGCAGC AGCAACAGCA GCAGCAGCAG CAGCAGCAGC 900
AGCAGCAGCA GCAGCAACAG CAGCCGCAGC AGCAGCCGCC GCAACCACAG ACGCAGCAAC 960
AACAGCAGCC GGCCCTTGTT AACTACAACA GACCATCTGG CCCGGGGCCG GAGCTGAGCG 1020
GCCCGAGCAC CCCGCAGAAG CTGCCGGTGC CCGCGCCCGG CGGCCGGCCC TCGCCCGCGC 1080
CCCCCGCAGC CGCGCAGCCG CCCGCGGCCG CAGTGCCCGG GCCCTCAGTG CCGCAGCCGG 1140
CCCCGGGGCA GCCCTCGCCC GTCCTCCAGC TGCAGCAGAA GCAGAGCCGC ATCAGCCCCA 1200
TCCAGAAACC GCAAGGCCTG GACCCCGTGG AAATTCTGCA AGAGCGGGAA TACAGACTTC 1260
AGGCCCGCAT AGCTCATAGG ATACAAGAAC TGGAAAATCT GCCTGGCTCT TTGCCACCAG 1320
ATTTAAGAAC CAAAGCAACC GTGGAACTAA AAGCACTTCG GTTACTCAAT TTCCAGCGTC 1380
AGCTGAGACA GGAGGTGGTG GCCTGCATGC GCAGGGACAC GACCCTGGAG ACGGCTCTCA 1440
ACTCCAAAGC ATACAAACGG AGCAAGCGCC AGACTCTGAG AGAAGCTCGC ATGACCGAGA 1500
AGCTGGAGAA GCAGCAGAAG ATTGAGCAGG AGAGGAAACG CCGTCAGAAA CACCAGGAAT 1560
ACCTGAACAG TATTTTGCAA CATGCAAAAG ATTTTAAGGA ATATCATCGG TCTGTGGCCG 1620
GAAAGATCCA GAAGCTCTCC AAAGCAGTGG CAACTTGGCA TGCCAACACT GAAAGAGAGC 1680
AGAAGAAGGA GACAGAGCGG ATTGAAAAGG AGAGAATGCG GCGACTGATG GCTGAAGATG 1740
AGGAGGGTTA TAGAAAACTG ATTGATCAAA AGAAAGACAG GCGTTTAGCT TACCTTTTGC 1800
AGCAGACCGA TGAGTATGTA GCCAATCTGA CCAATCTGGT TTGGGAGCAC AAGCAAGCCC 1860
AGGCAGCCAA AGAGAAGAAG AAGAGGAGGA GGAGGAAGAA GAAGGCTGAG GAGAATGCAG 1920
AGGGTGGGGA GTCTGCCCTG GGACCGGATG GAGAGCCCAT AGATGAGAGC AGCCAGATGA 1980
GTGACCTCCC TGTCAAAGTG ACTCACACAG AAACCGGCAA GGTTCTGTTC GGACCAGAAG 2040
CACCCAAAGC AAGTCAGCTG GACGCCTGGC TGGAAATGAA TCCTGGTTAT GAAGTTGCCC 2100
CTAGATCTGA CAGTGAAGAG AGTGATTCTG ATTATGAGGA AGAGGATGAG GAAGAAGAGT 2160
CCAGTAGGCA GGAAACCGAA GAGAAAATAC TCCTGGATCC AAATAGCGAA GAAGTTTCTG 2220
AGAAGGATGC TAAGCAGATC ATTGAGACAG CTAAGCAAGA CGTGGATGAT GAATACAGCA 2280
TGCAGTACAG TGCCAGGGGC TCCCAGTCCT ACTACACCGT GGCTCATGCC ATCTCGGAGA 2340
GGGTGGAGAA ACAGTCTGCC CTCCTAATTA ATGGGACCCT AAAGCATTAC CAGCTCCAGG 2400
GCCTGGAATG GATGGTTTCC CTGTATAATA ACAACTTGAA CGGAATCTTA GCCGATGAAA 2460
TGGGGCTTGG AAAGACCATA CAGACCATTG CACTCATCAC TTATCTGATG GAGCACAAAA 2520
GACTCAATGG CCCCTATCTC ATCATTGTTC CCCTTTCGAC TCTATCTAAC TGGACATATG 2580
AATTTGACAA ATGGGCTCCT TCTGTGGTGA AGATTTCTTA CAAGGGTACT CCTGCCATGC 2640
GTCGCTCCCT TGTCCCCCAG CTACGGAGTG GCAAATTCAA TGTCCTCTTG ACTACTTATG 2700
AGTATATTAT AAAAGACAAG CACATTCTTG CAAAGATTCG GTGGAAATAC ATGATAGTGG 2760
ACGAAGGCCA CCGAATGAAG AATCACCACT GCAAGCTGAC TCAGGTCTTG AACACTCACT 2820
ATGTGGCCCC CAGAAGGATC CTCTTGACTG GGACCCCGCT GCAGAATAAG CTCCCTGAAC 2880
TCTGGGCCCT CCTCAACTTC CTCCTCCCAA CAATTTTTAA GAGCTGCAGC ACATTTGAAC 2940
AATGGTTCAA TGCTCCATTT GCCATGACTG GTGAAAGGGT GGACTTAAAT GAAGAAGAAA 3000
CTATATTGAT CATCAGGCGT CTACATAAGG TGTTAAGACC ATTTTTACTA AGGAGACTGA 3060
AGAAAGAAGT TGAATCCCAG CTTCCCGAAA AAGTGGAATA TGTGATCAAG TGTGACATGT 3120
CAGCTCTGCA GAAGATTCTG TATCGCCATA TGCAAGCCAA GGGGATCCTT CTCACAGATG 3180
GTTCTGAGAA AGATAAGAAG GGGAAAGGAG GTGCTAAGAC ACTTATGAAC ACTATTATGC 3240
AGTTGAGAAA AATCTGCAAC CACCCATATA TGTTTCAGCA CATTGAGGAA TCCTTTGCTG 3300
AACACCTAGG CTATTCAAAT GGGGTCATCA ATGGGGCTGA ACTGTATCGG GCCTCAGGGA 3360
AGTTTGAGCT GCTTGATCGT ATTCTGCCAA AATTGAGAGC GACTAATCAC CGAGTGCTGC 3420
TTTTCTGCCA GATGACATCT CTCATGACCA TCATGGAGGA TTATTTTGCT TTTCGGAACT 3480
TCCTTTACCT ACGCCTTGAT GGCACCACCA AGTCTGAAGA TCGTGCTGCT TTGCTGAAGA 3540
AATTCAATGA ACCTGGATCC CAGTATTTCA TTTTCTTGCT GAGCACAAGA GCTGGTGGCC 3600
TGGGCTTAAA TCTTCAGGCA GCTGATACAG TGGTCATCTT TGACAGCGAC TGGAATCCTC 3660
ATCAGGATCT GCAGGCCCAA GACCGAGCTC ACCGCATCGG GCAGCAGAAC GAGGTCCGGG 3720
TACTGAGGCT CTGTACCGTG AACAGCGTGG AGGAAAAGAT CCTCGCGGCC GCAAAATACA 3780
AGCTGAACGT GGATCAGAAA GTGATCCAGG CGGGCATGTT TGACCAAAAG TCTTCAAGCC 3840
ACGAGCGGAG GGCATTCCTG CAGGCCATCT TGGAGCATGA GGAGGAAAAT GAGGAAGAAG 3900
ATGAAGTACC GGACGATGAG ACTCTGAACC AAATGATTGC TCGACGAGAA GAAGAATTTG 3960
ACCTTTTTAT GCGGATGGAC ATGGACCGGC GGAGGGAAGA TGCCCGGAAC CCGAAACGGA 4020
AGCCCCGTTT AATGGAGGAG GATGAGCTGC CCTCCTGGAT CATTAAGGAT GACGCTGAAG 4080
TAGAAAGGCT CACCTGTGAA GAAGAGGAGG AGAAAATATT TGGGAGGGGG TCCCGCCAGC 4140
GCCGTGACGT GGACTACAGT GACGCCCTCA CGGAGAAGCA GTGGCTAAGG GCCATCGAAG 4200
ACGGCAATTT GGAGGAAATG GAAGAGGAAG TACGGCTTAA GAAGCGAAAA AGACGAAGAA 4260
ATGTGGATAA AGATCCTGCA AAAGAAGATG TGGAAAAAGC TAAGAAGAGA AGAGGCCGCC 4320
CTCCCGCTGA GAAACTGTCA CCAAATCCCC CCAAACTGAC AAAGCAGATG AACGCTATCA 4380
TCGATACTGT GATAAACTAC AAAGATAGGT GTAACGTGGA GAAGGTGCCC AGTAATTCTC 4440
AGTTGGAAAT AGAAGGAAAC AGTTCAGGGC GACAGCTCAG TGAAGTCTTC ATTCAGTTAC 4500
CTTCAAGGAA AGAATTACCA GAATACTATG AATTAATTAG GAAGCCAGTG GATTTCAAAA 4560
AAATAAAGGA AAGGATTCGT AATCATAAGT ACCGGAGCCT AGGCGACCTG GAGAAGGATG 4620
TCATGCTTCT CTGTCACAAC GCTCAGACGT TCAACCTGGA GGGATCCCAG ATCTATGAAG 4680
ACTCCATCGT CTTACAGTCA GTGTTTAAGA GTGCCCGGCA GAAAATTGCC AAAGAGGAAG 4740
AGAGTGAGGA TGAAAGCAAT GAAGAGGAGG AAGAGGAAGA TGAAGAAGAG TCAGAGTCCG 4800
AGGCAAAATC AGTCAAGGTG AAAATTAAGC TCAATAAAAA AGATGACAAA GGCCGGGACA 4860
AAGGGAAAGG CAAGAAAAGG CCAAATCGAG GAAAAGCCAA ACCTGTAGTG AGCGATTTTG 4920
ACAGCGATGA GGAGCAGGAT GAACGTGAAC AGTCAGAAGG AAGTGGGACG GATGATGAGT 4980
GATCAGTATG GACCTTTTTC CTTGGTAGAA CTGAATTCCT TCCTCCCCTG TCTCATTTCT 5040
ACCCAGTGAG TTCATTTGTC ATATAGGCAC TGGGTTGTTT CTATATCATC ATCGTCTATA 5100
AACTAGCTTT AGGATAGTGC CAGACAAACA TATGATATCA TGGTGTAAAA AACACACACA 5160
TACACAAATA TTTGTAACAT ATTGTGACCA AATGGGCCTC AAAGATTCAG ATTGAAACAA 5220
ACAAAAAGCT TTTGATGGAA AATATGTGGG TGGATAGTAT ATTTCTATGG GTGGGTCTAA 5280
TTTGGTAACG GTTTGATTGT GCCTGGTTTT ATCACCTGTT CAGATGAGAA GATTTTTGTC 5340
TTTTGTAGCA CTGATAACCA GGAGAAGCCA TTAAAAGCCA CTGGTTATTT TATTTTTCAT 5400
CAGGCAATTT TCGAGGTTTT TATTTGTTCG GTATTGTTTT TTTACACTGT GGTACATATA 5460
AGCAACTTTA ATAGGTGATA AATGTACAGT AGTTAGATTT CACCTGCATA TACATTTTTC 5520
CATTTTATGC TCTATGATCT GAACAAAAGC TTTTTGAATT GTATAAGATT TATGTCTACT 5580
GTAAACATTG CTTAATTTTT TTGCTCTTGA TTTAAAAAAA AGTTTTGTTG AAAGCGCTAT 5640
TGAATATTGC AATCTATATA GTGTATTGGA TGGCTTCTTT TGTCACCCTG ATCTCCTATG 5700
TTACCAATGT GTATCGTCTC CTTCTCCCTA AAGTGTACTT AATCTTTGCT TTCTTTGCAC 5760
AATGTCTTTG GTTGCAAGTC ATAAGCCTGA GGCAAATAAA ATTCCAGTAA TTTCGAAGAA 5820
TGTGGTGTTG GTGCTTTCCT AATAAAGAAA TAATTTAGCT TGACAAA
5868Nucleotide Fasta Sequence
>ENSP00000371638.1|Bromodomain|Homo sapiens
TCAGAAGAAAGCCCCGAGATCACAGAGACCCGGCGAGATCACAGAGACCCGGCCTGAAGGAACGTGGAAAGACCAATGTACCTGTTTTGACCGGTTGCCTGGAGCAAGAAGTTCCAGTTGGGGAGAATTTTCAGAAGATAAAGTCGGAGATTGTGGAAAGACTTGACTTGCAGCATTACTCTACTGACTGGCAGAGACAGGAGAGGTAGATGTCCACGCCCACAGACCCTGGTGCGATGCCCCACCCAGGGCCTTCGCCGGGGCCTGGGCCTTCCCCTGGGCCAATTCTTGGGCCTAGTCCAGGACCAGGACCATCCCCAGGTTCCGTCCACAGCATGATGGGGCCAAGTCCTGGACCTCCAAGTGTCTCCCATCCTATGCCGACGATGGGGTCCACAGACTTCCCACAGGAAGGCATGCATCAAATGCATAAGCCCATCGATGGTATACATGACAAGGGGATTGTAGAAGACATCCATTGTGGATCCATGAAGGGCACTGGTATGCGACCACCTCACCCAGGCATGGGCCCTCCCCAGAGTCCAATGGATCAACACAGCCAAGGTTATATGTCACCACACCCATCTCCATTAGGAGCCCCAGAGCACGTCTCCAGCCCTATGTCTGGAGGAGGCCCAACTCCACCTCAGATGCCACCAAGCCAGCCGGGGGCCCTCATCCCAGGTGATCCGCAGGCCATGAGCCAGCCCAACAGAGGTCCCTCACCTTTCAGTCCTGTCCAGCTGCATCAGCTTCGAGCTCAGATTTTAGCTTATAAAATGCTGGCCCGAGGCCAGCCCCTCCCCGAAACGCTGCAGCTTGCAGTCCAGGGGAAAAGGACGTTGCCTGGCTTGCAGCAACAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCCGCAGCAGCAGCCGCCGCAACCACAGACGCAGCAACAACAGCAGCCGGCCCTTGTTAACTACAACAGACCATCTGGCCCGGGGCCGGAGCTGAGCGGCCCGAGCACCCCGCAGAAGCTGCCGGTGCCCGCGCCCGGCGGCCGGCCCTCGCCCGCGCCCCCCGCAGCCGCGCAGCCGCCCGCGGCCGCAGTGCCCGGGCCCTCAGTGCCGCAGCCGGCCCCGGGGCAGCCCTCGCCCGTCCTCCAGCTGCAGCAGAAGCAGAGCCGCATCAGCCCCATCCAGAAACCGCAAGGCCTGGACCCCGTGGAAATTCTGCAAGAGCGGGAATACAGACTTCAGGCCCGCATAGCTCATAGGATACAAGAACTGGAAAATCTGCCTGGCTCTTTGCCACCAGATTTAAGAACCAAAGCAACCGTGGAACTAAAAGCACTTCGGTTACTCAATTTCCAGCGTCAGCTGAGACAGGAGGTGGTGGCCTGCATGCGCAGGGACACGACCCTGGAGACGGCTCTCAACTCCAAAGCATACAAACGGAGCAAGCGCCAGACTCTGAGAGAAGCTCGCATGACCGAGAAGCTGGAGAAGCAGCAGAAGATTGAGCAGGAGAGGAAACGCCGTCAGAAACACCAGGAATACCTGAACAGTATTTTGCAACATGCAAAAGATTTTAAGGAATATCATCGGTCTGTGGCCGGAAAGATCCAGAAGCTCTCCAAAGCAGTGGCAACTTGGCATGCCAACACTGAAAGAGAGCAGAAGAAGGAGACAGAGCGGATTGAAAAGGAGAGAATGCGGCGACTGATGGCTGAAGATGAGGAGGGTTATAGAAAACTGATTGATCAAAAGAAAGACAGGCGTTTAGCTTACCTTTTGCAGCAGACCGATGAGTATGTAGCCAATCTGACCAATCTGGTTTGGGAGCACAAGCAAGCCCAGGCAGCCAAAGAGAAGAAGAAGAGGAGGAGGAGGAAGAAGAAGGCTGAGGAGAATGCAGAGGGTGGGGAGTCTGCCCTGGGACCGGATGGAGAGCCCATAGATGAGAGCAGCCAGATGAGTGACCTCCCTGTCAAAGTGACTCACACAGAAACCGGCAAGGTTCTGTTCGGACCAGAAGCACCCAAAGCAAGTCAGCTGGACGCCTGGCTGGAAATGAATCCTGGTTATGAAGTTGCCCCTAGATCTGACAGTGAAGAGAGTGATTCTGATTATGAGGAAGAGGATGAGGAAGAAGAGTCCAGTAGGCAGGAAACCGAAGAGAAAATACTCCTGGATCCAAATAGCGAAGAAGTTTCTGAGAAGGATGCTAAGCAGATCATTGAGACAGCTAAGCAAGACGTGGATGATGAATACAGCATGCAGTACAGTGCCAGGGGCTCCCAGTCCTACTACACCGTGGCTCATGCCATCTCGGAGAGGGTGGAGAAACAGTCTGCCCTCCTAATTAATGGGACCCTAAAGCATTACCAGCTCCAGGGCCTGGAATGGATGGTTTCCCTGTATAATAACAACTTGAACGGAATCTTAGCCGATGAAATGGGGCTTGGAAAGACCATACAGACCATTGCACTCATCACTTATCTGATGGAGCACAAAAGACTCAATGGCCCCTATCTCATCATTGTTCCCCTTTCGACTCTATCTAACTGGACATATGAATTTGACAAATGGGCTCCTTCTGTGGTGAAGATTTCTTACAAGGGTACTCCTGCCATGCGTCGCTCCCTTGTCCCCCAGCTACGGAGTGGCAAATTCAATGTCCTCTTGACTACTTATGAGTATATTATAAAAGACAAGCACATTCTTGCAAAGATTCGGTGGAAATACATGATAGTGGACGAAGGCCACCGAATGAAGAATCACCACTGCAAGCTGACTCAGGTCTTGAACACTCACTATGTGGCCCCCAGAAGGATCCTCTTGACTGGGACCCCGCTGCAGAATAAGCTCCCTGAACTCTGGGCCCTCCTCAACTTCCTCCTCCCAACAATTTTTAAGAGCTGCAGCACATTTGAACAATGGTTCAATGCTCCATTTGCCATGACTGGTGAAAGGGTGGACTTAAATGAAGAAGAAACTATATTGATCATCAGGCGTCTACATAAGGTGTTAAGACCATTTTTACTAAGGAGACTGAAGAAAGAAGTTGAATCCCAGCTTCCCGAAAAAGTGGAATATGTGATCAAGTGTGACATGTCAGCTCTGCAGAAGATTCTGTATCGCCATATGCAAGCCAAGGGGATCCTTCTCACAGATGGTTCTGAGAAAGATAAGAAGGGGAAAGGAGGTGCTAAGACACTTATGAACACTATTATGCAGTTGAGAAAAATCTGCAACCACCCATATATGTTTCAGCACATTGAGGAATCCTTTGCTGAACACCTAGGCTATTCAAATGGGGTCATCAATGGGGCTGAACTGTATCGGGCCTCAGGGAAGTTTGAGCTGCTTGATCGTATTCTGCCAAAATTGAGAGCGACTAATCACCGAGTGCTGCTTTTCTGCCAGATGACATCTCTCATGACCATCATGGAGGATTATTTTGCTTTTCGGAACTTCCTTTACCTACGCCTTGATGGCACCACCAAGTCTGAAGATCGTGCTGCTTTGCTGAAGAAATTCAATGAACCTGGATCCCAGTATTTCATTTTCTTGCTGAGCACAAGAGCTGGTGGCCTGGGCTTAAATCTTCAGGCAGCTGATACAGTGGTCATCTTTGACAGCGACTGGAATCCTCATCAGGATCTGCAGGCCCAAGACCGAGCTCACCGCATCGGGCAGCAGAACGAGGTCCGGGTACTGAGGCTCTGTACCGTGAACAGCGTGGAGGAAAAGATCCTCGCGGCCGCAAAATACAAGCTGAACGTGGATCAGAAAGTGATCCAGGCGGGCATGTTTGACCAAAAGTCTTCAAGCCACGAGCGGAGGGCATTCCTGCAGGCCATCTTGGAGCATGAGGAGGAAAATGAGGAAGAAGATGAAGTACCGGACGATGAGACTCTGAACCAAATGATTGCTCGACGAGAAGAAGAATTTGACCTTTTTATGCGGATGGACATGGACCGGCGGAGGGAAGATGCCCGGAACCCGAAACGGAAGCCCCGTTTAATGGAGGAGGATGAGCTGCCCTCCTGGATCATTAAGGATGACGCTGAAGTAGAAAGGCTCACCTGTGAAGAAGAGGAGGAGAAAATATTTGGGAGGGGGTCCCGCCAGCGCCGTGACGTGGACTACAGTGACGCCCTCACGGAGAAGCAGTGGCTAAGGGCCATCGAAGACGGCAATTTGGAGGAAATGGAAGAGGAAGTACGGCTTAAGAAGCGAAAAAGACGAAGAAATGTGGATAAAGATCCTGCAAAAGAAGATGTGGAAAAAGCTAAGAAGAGAAGAGGCCGCCCTCCCGCTGAGAAACTGTCACCAAATCCCCCCAAACTGACAAAGCAGATGAACGCTATCATCGATACTGTGATAAACTACAAAGATAGGTGTAACGTGGAGAAGGTGCCCAGTAATTCTCAGTTGGAAATAGAAGGAAACAGTTCAGGGCGACAGCTCAGTGAAGTCTTCATTCAGTTACCTTCAAGGAAAGAATTACCAGAATACTATGAATTAATTAGGAAGCCAGTGGATTTCAAAAAAATAAAGGAAAGGATTCGTAATCATAAGTACCGGAGCCTAGGCGACCTGGAGAAGGATGTCATGCTTCTCTGTCACAACGCTCAGACGTTCAACCTGGAGGGATCCCAGATCTATGAAGACTCCATCGTCTTACAGTCAGTGTTTAAGAGTGCCCGGCAGAAAATTGCCAAAGAGGAAGAGAGTGAGGATGAAAGCAATGAAGAGGAGGAAGAGGAAGATGAAGAAGAGTCAGAGTCCGAGGCAAAATCAGTCAAGGTGAAAATTAAGCTCAATAAAAAAGATGACAAAGGCCGGGACAAAGGGAAAGGCAAGAAAAGGCCAAATCGAGGAAAAGCCAAACCTGTAGTGAGCGATTTTGACAGCGATGAGGAGCAGGATGAACGTGAACAGTCAGAAGGAAGTGGGACGGATGATGAGTGATCAGTATGGACCTTTTTCCTTGGTAGAACTGAATTCCTTCCTCCCCTGTCTCATTTCTACCCAGTGAGTTCATTTGTCATATAGGCACTGGGTTGTTTCTATATCATCATCGTCTATAAACTAGCTTTAGGATAGTGCCAGACAAACATATGATATCATGGTGTAAAAAACACACACATACACAAATATTTGTAACATATTGTGACCAAATGGGCCTCAAAGATTCAGATTGAAACAAACAAAAAGCTTTTGATGGAAAATATGTGGGTGGATAGTATATTTCTATGGGTGGGTCTAATTTGGTAACGGTTTGATTGTGCCTGGTTTTATCACCTGTTCAGATGAGAAGATTTTTGTCTTTTGTAGCACTGATAACCAGGAGAAGCCATTAAAAGCCACTGGTTATTTTATTTTTCATCAGGCAATTTTCGAGGTTTTTATTTGTTCGGTATTGTTTTTTTACACTGTGGTACATATAAGCAACTTTAATAGGTGATAAATGTACAGTAGTTAGATTTCACCTGCATATACATTTTTCCATTTTATGCTCTATGATCTGAACAAAAGCTTTTTGAATTGTATAAGATTTATGTCTACTGTAAACATTGCTTAATTTTTTTGCTCTTGATTTAAAAAAAAGTTTTGTTGAAAGCGCTATTGAATATTGCAATCTATATAGTGTATTGGATGGCTTCTTTTGTCACCCTGATCTCCTATGTTACCAATGTGTATCGTCTCCTTCTCCCTAAAGTGTACTTAATCTTTGCTTTCTTTGCACAATGTCTTTGGTTGCAAGTCATAAGCCTGAGGCAAATAAAATTCCAGTAATTTCGAAGAATGTGGTGTTGGTGCTTTCCTAATAAAGAAATAATTTAGCTTGACAAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-1063--Hypotrichosis
KW-0991--Mental retardation
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-1211--Schizophrenia
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR006576--BRK_domain
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR014978--Gln-Leu-Gln_QLQ
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014012--HSA_dom
IPR027417--P-loop_NTPase
IPR030088--SMARCA2
IPR029295--SnAC
IPR000330--SNF2_N
|
| PROSITE |
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51204--HSA
PS51666--QLQ
|
| Pfam |
PF07533--BRK
PF00439--Bromodomain
PF00271--Helicase_C
PF07529--HSA
PF08880--QLQ
PF14619--SnAC
PF00176--SNF2_N
|
| Gene Ontology |
GO:0045111--C:intermediate filament cytoskeleton
GO:0043231--C:intracellular membrane-bounded organelle
GO:0071565--C:nBAF complex
GO:0071564--C:npBAF complex
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016514--C:SWI/SNF complex
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0004386--F:helicase activity
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0003713--F:transcription coactivator activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0006338--P:chromatin remodeling
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007286--P:spermatid development
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
