WERAM Information

Tag Content
WERAM ID WERAM-Hos-0178
Ensembl Protein ID ENSP00000370109.4
Uniprot Accession O75475; PSIP1_HUMAN; D3DRI9; O00256; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6
Genbank Protein ID NP_001121689.1; NP_001304827.1; NP_001304829.1; NP_066967.3; NP_150091.2; XP_011516001.1
Protein Name PC4 and SFRS1-interacting protein
Genbank Nucleotide ID NM_001128217.2; NM_001317898.1; NM_001317900.1; NM_021144.3; NM_033222.4; XM_011517699.1
Gene Name PSIP1;DFS70;LEDGF;PSIP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164985.14 ENST00000380733.8 ENSP00000370109.4
ENSG00000164985.14 ENST00000380715.5 ENSP00000370091.1
ENSG00000164985.14 ENST00000380716.8 ENSP00000370092.4
ENSG00000164985.14 ENST00000380738.8 ENSP00000370114.4
ENSG00000164985.14 ENST00000397519.6 ENSP00000380653.2
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PWWP PWWP H3K36me3 K 22615581
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PWWP 1.50e-22 81.8 7 64
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Domain Profile
  Me_Reader PWWP
           PWWP.txt  1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpysen 64
                       +gdL++aK+kgYp+WPa+v+++p++a+k+     ++nk++++FFg +he+a++++k+++pysen
  ENSP00000370109.4  7 PGDLIFAKMKGYPHWPARVDEVPDGAVKP-----PTNKLPIFFFG-THETAFLGPKDIFPYSEN 64
                       69***************************.....***********.****************97 PP
Protein Sequence
(Fasta)		MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP 60
YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK QSNASSDVEV EEKETSVSKE 120
DTDHEEKASN EDVTKAVDIT TPKAARRGRK RKAEKQVETE EAGVVTTATA SVNLKVSPKR 180
GRPAATEVKI PKPRGRPKMV KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE 240
EDKPRKEPDK KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR 300
NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS RLQRIHAEIK 360
NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL KKIRRFKVSQ VIMEKSTMLY 420
NKFKNMFLVG EGDSVITQVL NKSLAEQRQH EEANKTKDQG KKGPNKKLEK EQTGSKTLNG 480
GSDAQDGNQP QHNGESNEDS KDNHEASTKK KPSSEERETE ISLKDSTLDN
Nucleotide Sequence
(Fasta)		AGTTGGTCGC GCCCCAGTGC TAGCGGGCGC CGAGCGGGAG CCGCGCGGGA GCAGCGCAGC 60
TACGGCGGCG GCAGCGGCGG CGCGGTTGCG ATTCCGAGCC GTTGAGACGC CTCTGCGGCA 120
GCTGGTGGCG CAGGTGGCTT GCGTGGACGC GGGTAGAGGC GACCGGCCAG CAACCGCAGC 180
GTCGGCGCCC GCGGCCCCGG CAGCAGGCGC GTCGGGACGC CCCGAGGCAT CCTCCCCCGC 240
CCGCGGGCCC GGTAGCTGGG CCCGCGTCCG CCGCCCGCAT CCCCGCGCCG CCGCATCTCC 300
TCGCCGCCTC CCGGGCTTCG GACCCCCGGT CTCGCCCCCG AAACATGACT CGCGATTTCA 360
AACCTGGAGA CCTCATCTTC GCCAAGATGA AAGGTTATCC CCATTGGCCA GCTCGAGTAG 420
ACGAAGTTCC TGATGGAGCT GTAAAGCCAC CCACAAACAA ACTACCCATT TTCTTTTTTG 480
GAACTCATGA GACTGCTTTT TTAGGACCAA AGGATATATT TCCTTACTCA GAAAATAAGG 540
AAAAGTATGG CAAACCAAAT AAAAGAAAAG GTTTTAATGA AGGTTTATGG GAGATAGATA 600
ACAATCCAAA AGTGAAATTT TCAAGTCAAC AGGCAGCAAC TAAACAATCA AATGCATCAT 660
CTGATGTTGA AGTTGAAGAA AAGGAAACTA GTGTTTCAAA GGAAGATACC GACCATGAAG 720
AAAAAGCCAG CAATGAGGAT GTGACTAAAG CAGTTGACAT AACTACTCCA AAAGCTGCCA 780
GAAGGGGGAG AAAGAGAAAG GCAGAAAAAC AAGTAGAAAC TGAGGAGGCA GGAGTAGTGA 840
CAACAGCAAC AGCATCTGTT AATCTAAAAG TGAGTCCTAA AAGAGGACGA CCTGCAGCTA 900
CAGAAGTCAA GATTCCAAAA CCAAGAGGCA GACCCAAAAT GGTAAAACAG CCCTGTCCTT 960
CAGAGAGTGA CATCATTACT GAAGAGGACA AAAGTAAGAA AAAGGGGCAA GAGGAAAAAC 1020
AACCTAAAAA GCAGCCTAAG AAGGATGAAG AGGGCCAGAA GGAAGAAGAT AAGCCAAGAA 1080
AAGAGCCGGA TAAAAAAGAG GGGAAGAAAG AAGTTGAATC AAAAAGGAAA AATTTAGCTA 1140
AAACAGGGGT TACTTCAACC TCCGATTCTG AAGAAGAAGG AGATGATCAA GAAGGTGAAA 1200
AGAAGAGAAA AGGTGGGAGG AACTTTCAGA CTGCTCACAG AAGGAATATG CTGAAAGGCC 1260
AACATGAGAA AGAAGCAGCA GATCGAAAAC GCAAGCAAGA GGAACAAATG GAAACTGAGC 1320
AGCAGAATAA AGATGAAGGA AAGAAGCCAG AAGTTAAGAA AGTGGAGAAG AAGCGAGAAA 1380
CATCAATGGA TTCTCGACTT CAAAGGATAC ATGCTGAGAT TAAAAATTCA CTCAAAATTG 1440
ATAATCTTGA TGTGAACAGA TGCATTGAGG CCTTGGATGA ACTTGCTTCA CTTCAGGTCA 1500
CAATGCAACA AGCTCAGAAA CACACAGAGA TGATTACTAC ACTGAAAAAA ATACGGCGAT 1560
TCAAAGTTAG TCAGGTAATC ATGGAAAAGT CTACAATGTT GTATAACAAG TTTAAGAACA 1620
TGTTCTTGGT TGGTGAAGGA GATTCCGTGA TCACCCAAGT GCTGAATAAA TCTCTTGCTG 1680
AACAAAGACA GCATGAGGAA GCGAATAAAA CCAAAGATCA AGGGAAGAAA GGGCCAAACA 1740
AAAAGCTAGA GAAGGAACAA ACAGGGTCAA AGACTCTAAA TGGAGGATCT GATGCTCAAG 1800
ATGGTAATCA GCCACAACAT AACGGGGAGA GCAATGAAGA CAGCAAAGAC AACCATGAAG 1860
CCAGCACGAA GAAAAAGCCA TCCAGTGAAG AGAGAGAGAC TGAAATATCT CTGAAGGATT 1920
CTACACTAGA TAACTAGGTT GACATACCTG GAATATAGAG AACACTTGAG AAGTTTGTAA 1980
TGGTTTTCAT TTGAAATAGA CTGCTGAAAG TTTTAAATTT TTATAAGCAT AGGTTTGATG 2040
TTGAAAACTT GTTTTGAGGG AGAAAATCCC TTTGTTTTAA AGTAAAGTAA ACATTATCGC 2100
TAAGTGTACT TGTGCAGTAT TAACAGCTAC ATTATACAGT AAATGTGGGA TAAAATCCAT 2160
TTAGAAAATG TTAAACTGCT TTTCCAGACA TGGTTGTAGC ATATTTTCAA TTAGTGTGTG 2220
TATGTTAATG TGTAATTGAT AGTAGAACAA AGTTACATTT TTAAAACTGC TACTTGTATA 2280
AACCTTGCCT CTTTTCCCAA ATACTGTGGG TTTTGTGCAT AGTTTTTACA AACCTTGGAT 2340
TTACCAGACT GTCTTTTCAC TGTTTGTGGG TTTTGTAGAA GTTACACATT TTTATGGTAG 2400
ATAAAATGTT ACTTCTATAC AAGTACTCAC TCCCTTTTTA TCAAAAGTTA ATTTTAATCT 2460
CACAGTCTAC ATTGTGCTAC ATTATCCAGC TTCTTTGGAA CAATGTGTGC TCTGTATGGT 2520
TTTTTTTGGT ATGACAACTA ATTAAGCAAC TGACATGGAA CTGAGAATTC TACAAACTAT 2580
AAAACATTAA TTTTTGAAGG TAATTTAGTT TTGTGGCTGG GCATTCAGTG AAGTCTTAGG 2640
ACTTCTTTGC AGACAACTGA CTGGGTATAT ATAGGAATGA ATCTGGCTTT AGGGTTAAAT 2700
CATTTAAGGT CCTTTTATAG GCAGGCACTA GTAACTAAAA CTGAAAACTA AGTAAGTTTA 2760
TTTTTGAGGA ATGTTGTTAA AAATGTCTTT AGGAAGTCAC TAAAACTTAA TTGGAAGAAA 2820
AAATCATGAT GCTTATACAA TAAATATGAA TAAATGTTAT ATAAGGAAAC TCACCTATTT 2880
GAAATCATGG CTATATTGTT TTTATTTTCT AGATTCCAAA AATACAAACA CTAGTTGTTC 2940
CAGCATTGTA CTTTGATAAG TCTGTACATT GACGTGTATG GACTAAATCC AGGGTAAAAT 3000
CAATGTTACA AAATTTAAGG GTATGTTAAC TAAAGGATAG CATTTCTAAG ATATTTTGAA 3060
TATTAGGGTC ATTTGGCACT TCTCAGCAAG TAGGATACTT CTCATGTTTT GAAATTATAT 3120
GAATATGGAA AAAAATGGCT TAAGACCAGC GTCTCTGTAT GACATTGTGT GGTTGACCCT 3180
CTGAGATAAC TGTTTTCATC TACAGAATTG CATTTTTGCT TTTAAAGAGG TCTTATAATG 3240
GAACTAGGAA TCACCGTTTT GAGAGAACCT GCATATATAC CAGTCATTAT CTGTTTGGTC 3300
CTTATACAGT TTTAACTTAC TTAGATTTAT TCTAGTTAAG CCATAAGTTC AACGTGTAAA 3360
CTTGTTTTCA TTAAAGAATT TTTCTATCAA A 3392
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR021567--LEDGF
IPR000313--PWWP_dom
IPR017859--Treacle-like_TCS
PROSITE

PS50812--PWWP
Pfam

PF11467--LEDGF
PF00855--PWWP
Gene Ontology

GO:0005829--C:cytosol
GO:0005720--C:nuclear heterochromatin
GO:0034399--C:nuclear periphery
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035327--C:transcriptionally active chromatin
GO:0033613--F:activating transcription factor binding
GO:0003682--F:chromatin binding
GO:0044822--F:poly(A) RNA binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0097100--F:supercoiled DNA binding
GO:0075713--P:establishment of integrated proviral latency
GO:0000395--P:mRNA 5'-splice site recognition
GO:0051169--P:nuclear transport
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009408--P:response to heat
GO:0006979--P:response to oxidative stress
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0175 ENSPTRP00000035550.4 Pan troglodytes 100 0.0 759
WERAM-Gog-0178 ENSGGOP00000015764.2 Gorilla gorilla 100 0.0 759
WERAM-Poa-0179 ENSPPYP00000021512.2 Pongo abelii 100 0.0 758
WERAM-Paa-0207 ENSPANP00000019205.1 Papio anubis 99 0.0 757
WERAM-Chs-0113 ENSCSAP00000005502.1 Chlorocebus sabaeus 99 0.0 756
WERAM-Nol-0190 ENSNLEP00000021346.2 Nomascus leucogenys 99 0.0 755
WERAM-Caj-0127 ENSCJAP00000022889.2 Callithrix jacchus 99 0.0 750
WERAM-Ova-0151 ENSOARP00000015030.1 Ovis aries 98 0.0 746
WERAM-Eqc-0084 ENSECAP00000010935.1 Equus caballus 97 0.0 743
WERAM-Vip-0058 ENSVPAP00000005409.1 Vicugna pacos 97 0.0 740
WERAM-Caf-0022 ENSCAFP00000002245.3 Canis familiaris 97 0.0 739
WERAM-Loa-0126 ENSLAFP00000011622.3 Loxodonta africana 96 0.0 736
WERAM-Fec-0187 ENSFCAP00000020694.1 Felis catus 96 0.0 734
WERAM-Orc-0087 ENSOCUP00000008046.2 Oryctolagus cuniculus 95 0.0 729
WERAM-Otg-0031 ENSOGAP00000001950.2 Otolemur garnettii 97 0.0 729
WERAM-Bot-0081 ENSBTAP00000010356.5 Bos taurus 90 0.0 726
WERAM-Aim-0030 ENSAMEP00000002180.1 Ailuropoda melanoleuca 91 0.0 722
WERAM-Cap-0057 ENSCPOP00000004583.2 Cavia porcellus 95 0.0 722
WERAM-Ict-0027 ENSSTOP00000001961.2 Ictidomys tridecemlineatus 98 0.0 717
WERAM-Mup-0042 ENSMPUP00000004024.1 Mustela putorius furo 95 0.0 706
WERAM-Mum-0091 ENSMUSP00000030207.8 Mus musculus 91 0.0 694
WERAM-Ran-0072 ENSRNOP00000016130.1 Rattus norvegicus 90 0.0 689
WERAM-Mod-0133 ENSMODP00000018686.2 Monodelphis domestica 88 0.0 687
WERAM-Prc-0051 ENSPCAP00000004722.1 Procavia capensis 89 0.0 664
WERAM-Tub-0006 ENSTBEP00000000628.1 Tupaia belangeri 90 0.0 657
WERAM-Ptv-0182 ENSPVAP00000016019.1 Pteropus vampyrus 97 2e-179 625
WERAM-Ocp-0037 ENSOPRP00000003310.1 Ochotona princeps 83 6e-178 621
WERAM-Tag-0062 ENSTGUP00000004673.1 Taeniopygia guttata 71 5e-164 575
WERAM-Pes-0177 ENSPSIP00000020643.1 Pelodiscus sinensis 70 2e-161 566
WERAM-Fia-0084 ENSFALP00000006824.1 Ficedula albicollis 67 9e-161 564
WERAM-Sus-0032 ENSSSCP00000005572.2 Sus scrofa 97 3e-112 402
WERAM-Sah-0196 ENSSHAP00000021263.1 Sarcophilus harrisii 92 3e-110 396
WERAM-Tut-0132 ENSTTRP00000010642.1 Tursiops truncatus 98 4e-108 389
WERAM-Gaga-0139 ENSGALP00000024326.4 Gallus gallus 72 4e-98 356
WERAM-Chh-0048 ENSCHOP00000005452.1 Choloepus hoffmanni 82 1e-87 321
WERAM-Anc-0181 ENSACAP00000017487.3 Anolis carolinensis 73 3e-83 306
WERAM-Mim-0124 ENSMICP00000012708.1 Microcebus murinus 99 2e-72 270
WERAM-Xet-0026 ENSXETP00000007169.3 Xenopus tropicalis 68 3e-71 266
WERAM-Lac-0070 ENSLACP00000009345.1 Latimeria chalumnae 71 7e-68 255
WERAM-Leo-0117 ENSLOCP00000014590.1 Lepisosteus oculatus 84 9e-52 202
WERAM-Orn-0213 ENSONIP00000022051.1 Oreochromis niloticus 79 5e-48 189
WERAM-Ten-0211 ENSTNIP00000021181.1 Tetraodon nigroviridis 79 1e-47 188
WERAM-Dar-0236 ENSDARP00000140292.1 Danio rerio 79 2e-47 187
WERAM-Tar-0121 ENSTRUP00000025252.1 Takifugu rubripes 84 3e-47 187
WERAM-Gam-0191 ENSGMOP00000018363.1 Gadus morhua 82 6e-47 186
WERAM-Pof-0144 ENSPFOP00000011987.2 Poecilia formosa 83 7e-47 186
WERAM-Xim-0120 ENSXMAP00000010138.1 Xiphophorus maculatus 82 2e-46 184
WERAM-Gaa-0183 ENSGACP00000022995.2 Gasterosteus aculeatus 83 4e-46 183
WERAM-Mam-0076 ENSMMUP00000011922.2 Macaca mulatta 75 5e-46 182
WERAM-Orla-0212 ENSORLP00000025329.1 Oryzias latipes 78 2e-45 181
WERAM-Dio-0144 ENSDORP00000013380.1 Dipodomys ordii 78 3e-45 180
WERAM-Myl-0128 ENSMLUP00000010400.2 Myotis lucifugus 78 8e-44 175
WERAM-Soa-0134 ENSSARP00000013183.1 Sorex araneus 78 3e-43 174
WERAM-Pem-0101 ENSPMAP00000010356.1 Petromyzon marinus 74 9e-43 172
WERAM-Dan-0001 ENSDNOP00000000334.2 Dasypus novemcinctus 70 5e-41 166
WERAM-Asm-0194 ENSAMXP00000018465.1 Astyanax mexicanus 74 8e-40 162
WERAM-Cii-0068 ENSCINP00000030018.1 Ciona intestinalis 62 1e-35 148
WERAM-Cis-0031 ENSCSAVP00000006479.1 Ciona savignyi 40 5e-09 60.1
WERAM-Php-0123 PP1S81_182V6.1 Physcomitrella patens 38 2e-07 54.7
Created Date 25-Jun-2016