WERAM Information

Tag Content
WERAM ID WERAM-Mum-0091
Ensembl Protein ID ENSMUSP00000030207.8
Uniprot Accession Q99JF8; PSIP1_MOUSE; A2BI10; A2BI11; Q3TEJ7; Q3TTD7; Q3UTA1; Q80WQ7; Q99JF7; Q99LR4; Q9CT03
Genbank Protein ID NP_001277456.1; NP_598709.1
Protein Name PC4 and SFRS1-interacting protein
Genbank Nucleotide ID NM_001290527.1; NM_133948.5
Gene Name Psip1;Ledgf
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028484.16 ENSMUST00000030207.14 ENSMUSP00000030207.8
ENSMUSG00000028484.16 ENSMUST00000107214.8 ENSMUSP00000102832.2
ENSMUSG00000028484.16 ENSMUST00000107215.8 ENSMUSP00000102833.2
ENSMUSG00000028484.16 ENSMUST00000130626.1 ENSMUSP00000121950.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PWWP PWWP H3K36me3 K 22615581
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PWWP 8.30e-23 81.8 7 64
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).
Domain Profile
  Me_Reader PWWP
              PWWP.txt  1 agdLVwaKlkgYpwWPalvisppleakklktqeaeenkylVlFFgnkherawvkrkklvpysen 64
                          +gdL++aK+kgYp+WPa+v+++p++a+k+     ++nk++++FFg +he+a++++k+++pysen
  ENSMUSP00000030207.8  7 PGDLIFAKMKGYPHWPARVDEVPDGAVKP-----PTNKLPIFFFG-THETAFLGPKDIFPYSEN 64
                          69***************************.....***********.****************97 PP
Protein Sequence
(Fasta)		MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP 60
YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQASTK QSNASSDVEV EEKETNVSKE 120
DTDQEEKASN EDVTKAVDIT TPKAARRGRK RKAEKQVDTE EAGMVTAATA SNVKASPKRG 180
RPAATEVKIP KPRGRPKVVK QPCPSDGDMV IDEDKSKKKG PEEKQPKKQL KKEEEGQKEE 240
EKPRKEPDKK EGKKEVESKR KNLAKPGVTS TSDSEDEDDQ EGEKKRKGGR NFQAAHRRNM 300
LKGQHEKEAG DRKRKQEEQM ETEQQNKDEG KKPEVKKVEK KRETSMDSRL QRIHAEIKNS 360
LKIDNLDVNR CIEALDELAS LQVTMQQAQK HTEMITTLKK IRRFKVSQVI MEKSTMLYNK 420
FKNMFLVGEG DSVITQVLNK SLAEQRQHEE ANKTKDQGKK GPNKKLEKEP TGTKSLNGGS 480
DAQESNHPQH NGDSNEDGKD SREASSKTKP PGEEREAEIS LKESTLDN 528
Nucleotide Sequence
(Fasta)		GCGGGCGCCG AGCGGGAGCC GCGCGGGAGC GGCGTAGCGA CATCGGCGGC GGTGGCGGTG 60
GCGGTGGCGG TTGCAGCTCG GAGCCGTTGA GACGCCTCTG CGGCAGCTGG TGGCGCAGGT 120
GGCCGGCGTG GACGTGGGCA GGAGCGGCCA GCGCGCCCCG CAGCCCCAGC GCCGCCGCCC 180
GGCAGGCGCG TCGGGACACC CCGAGGCATC CTCCCCCGCC CGCGGGCCCG CCAGTCCCAG 240
CTCGCGTCTG TGCTCTCGCA TCTCCTGATC GCGGCTGCGC TGCTCCCCCT TCTGGTCTTG 300
GGACTCCCGG CGTCGCCCCT CAAACATGAC TCGCGATTTC AAACCTGGAG ACCTCATCTT 360
CGCCAAGATG AAAGGTTATC CTCATTGGCC AGCTCGAGTA GATGAAGTTC CTGATGGAGC 420
TGTAAAACCA CCCACAAACA AACTACCCAT TTTCTTTTTT GGAACCCATG AGACTGCTTT 480
TTTAGGACCA AAGGACATAT TTCCTTATTC AGAAAATAAG GAAAAGTATG GCAAACCAAA 540
TAAACGGAAA GGTTTTAATG AAGGATTGTG GGAGATAGAT AACAATCCGA AAGTGAAATT 600
TTCAAGTCAA CAGGCATCAA CTAAACAATC CAATGCATCG TCTGATGTTG AAGTGGAAGA 660
AAAAGAGACT AACGTTTCAA AGGAAGACAC TGATCAGGAA GAAAAGGCCA GCAATGAGGA 720
TGTGACTAAA GCAGTTGACA TAACCACTCC AAAAGCTGCC AGGCGAGGAA GAAAGAGAAA 780
GGCTGAAAAA CAAGTAGACA CTGAAGAGGC GGGAATGGTG ACTGCAGCAA CCGCTTCTAA 840
TGTGAAAGCA AGTCCTAAGA GAGGACGACC TGCAGCTACT GAAGTCAAGA TTCCCAAACC 900
AAGAGGCAGA CCTAAAGTGG TAAAGCAGCC TTGTCCTTCA GACGGTGACA TGGTTATTGA 960
TGAAGATAAA AGTAAAAAAA AGGGACCAGA GGAGAAACAA CCTAAAAAGC AGCTTAAAAA 1020
AGAGGAAGAA GGCCAAAAGG AAGAAGAGAA GCCAAGAAAA GAACCAGATA AGAAAGAAGG 1080
GAAGAAAGAA GTTGAATCTA AACGGAAAAA TTTAGCTAAA CCAGGGGTTA CATCAACCTC 1140
TGATTCAGAA GACGAAGACG ATCAAGAGGG TGAAAAGAAG AGAAAGGGTG GAAGGAACTT 1200
CCAGGCTGCT CACAGGAGGA ACATGCTAAA AGGCCAACAT GAGAAAGAAG CTGGAGATCG 1260
GAAACGCAAG CAGGAGGAAC AAATGGAAAC TGAGCAGCAG AATAAAGATG AAGGAAAGAA 1320
GCCAGAAGTT AAGAAAGTGG AGAAGAAGCG AGAAACATCA ATGGATTCTC GACTTCAAAG 1380
GATACATGCT GAAATTAAAA ATTCACTCAA AATTGATAAT CTAGACGTGA ACAGATGCAT 1440
AGAGGCCCTG GATGAACTCG CTTCACTTCA GGTAACAATG CAGCAAGCTC AGAAACACAC 1500
AGAGATGATC ACAACCCTGA AGAAAATACG GCGGTTCAAA GTCAGTCAAG TTATCATGGA 1560
AAAGTCTACA ATGTTATATA ACAAGTTTAA GAATATGTTT TTGGTTGGTG AAGGAGATTC 1620
AGTCATCACC CAAGTGCTGA ACAAATCTCT TGCTGAACAG AGACAGCATG AGGAAGCAAA 1680
TAAAACCAAA GATCAGGGGA AGAAAGGGCC AAACAAAAAG CTAGAGAAGG AACCAACAGG 1740
TACGAAGAGC CTAAATGGTG GATCTGATGC TCAAGAGAGT AATCATCCAC AGCATAATGG 1800
TGATAGTAAC GAAGACGGCA AAGACAGCCG CGAGGCCAGC AGTAAGACAA AGCCACCTGG 1860
AGAAGAGAGA GAGGCTGAAA TATCTCTGAA AGAGTCTACA CTAGATAACT AGGTCGGCAG 1920
ACTTCAGATG TAAAGAGTGT GAGAAGTCTT GTGAGTGACT TCATTTGAAA TACTTAGGCT 1980
GCTGAAAGGT TTAAAGTTTT ATAAGCATAG GTTTTGATGT TTAAGTAGTT GGGGGAAAAG 2040
AAAAACCCTT TATATTTGTG TAAAAGTCAA TTATTCCTAA TTTTCCGTGT GCAGTATTAA 2100
CAGCTCCGTC GTTTAGTTTA AGAGCAAGGG AAACCTACTT AGAAAGGTCA GCCTGCTTTA 2160
TGACTGCAGT GTATTTTCAG TTAGTGTGTA TGTTAATGTG TAATTGGTAG TGGGGCAGTT 2220
ATATTTTAAA ACTGCTACTT GTATAAATCT TTCCCAAATA CCGTGGGTTT TGTGCATAGT 2280
TTTTACAGAT ATGGATTTAG CAGACTGTCT TTTCACTGTT ATGGGTTTTT TAGAAGTTGA 2340
GCATTTTTAT GGCTGATAAA GTGAATGTTA CTTCTAAGTG CTCACTTCTT TTATCAGAAG 2400
TGACCCTCAG TCCATTGTGC TACGTTAGCT TGCCTCTTTG TAATAATGCG TAGTCTGTAT 2460
GACAGCTAGA TAGCCACCAG GTTGTTATAG AAGGTACAAA TTTGTTTACT TTCCAAAGTA 2520
ATTTAGTTTT AGGACTGGGA TTTCAGTGGC ATTAGAACTA AAGAGAACAG ACTGGTATAT 2580
CTACATATAG AAAGTCCACC TACAATCCTT TATAGCTACT AGTCACAAAA AGCTAAAACT 2640
AGTTTGTTTT GAATCTTACA CTCACTAAGA AAGTCACTCA TTAAGGTGTG TGTTTTCTTT 2700
TTTTAATTAG AATCAATCCA TGATGCTTGT AAGTGATAAA TGATAAATAA GGAAACTAGC 2760
TTAATTGAAA ACATGGCCAT ATTGGAATGG GATTTTTAGT TTTTCTATCA GACATATTAG 2820
AGGATACATC AGTTGCTCTA AGGTAGTAAC CAGATAGTCC ACACACACAA ACATGAACTA 2880
TCACTCTGTC CCGTCTAGGG AGGACATGTC ACAGGTGTTC TGAGCGATCA GGCCAGCTGT 2940
TGGTTTTTAT CAGGCAGGAT AGTTCATCCT TAGGCTTTGG AATTCCATTG GAAAGTGACT 3000
TCATACCAGG GTTTTTGTGC GATGTGATTA AATATGTTCT TGATTTCTCA GATAATTATT 3060
TTCATCTATG TAAAAATTAC TTCAATAATT GGACTTTTAC AACTTGACTG TTTTGAGCAA 3120
ACGCTGTACA TTATATACAC ACCAGTCTTT TGCTTTGTCC TTAGTACATT TTTAACTTGG 3180
ACAAAAATTA TTCTAGTTAA GCCATAAGTG TCAATGTGTA AATTGTTTTA ATTAAAGTTT 3240
TTTCTACCAA A 3252
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR021567--LEDGF
IPR000313--PWWP_dom
IPR017859--Treacle-like_TCS
PROSITE

PS50812--PWWP
Pfam

PF11467--LEDGF
PF00855--PWWP
Gene Ontology

GO:0005720--C:nuclear heterochromatin
GO:0034399--C:nuclear periphery
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035327--C:transcriptionally active chromatin
GO:0033613--F:activating transcription factor binding
GO:0003682--F:chromatin binding
GO:0044822--F:poly(A) RNA binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0097100--F:supercoiled DNA binding
GO:0000395--P:mRNA 5'-splice site recognition
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0009408--P:response to heat
GO:0006979--P:response to oxidative stress
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0072 ENSRNOP00000016130.1 Rattus norvegicus 96 0.0 803
WERAM-Eqc-0084 ENSECAP00000010935.1 Equus caballus 91 0.0 773
WERAM-Otg-0031 ENSOGAP00000001950.2 Otolemur garnettii 91 0.0 769
WERAM-Ova-0151 ENSOARP00000015030.1 Ovis aries 91 0.0 768
WERAM-Pat-0175 ENSPTRP00000035550.4 Pan troglodytes 91 0.0 766
WERAM-Hos-0178 ENSP00000370109.4 Homo sapiens 91 0.0 766
WERAM-Gog-0178 ENSGGOP00000015764.2 Gorilla gorilla 91 0.0 766
WERAM-Chs-0113 ENSCSAP00000005502.1 Chlorocebus sabaeus 91 0.0 765
WERAM-Nol-0190 ENSNLEP00000021346.2 Nomascus leucogenys 90 0.0 764
WERAM-Paa-0207 ENSPANP00000019205.1 Papio anubis 90 0.0 764
WERAM-Poa-0179 ENSPPYP00000021512.2 Pongo abelii 90 0.0 764
WERAM-Caj-0127 ENSCJAP00000022889.2 Callithrix jacchus 91 0.0 763
WERAM-Caf-0022 ENSCAFP00000002245.3 Canis familiaris 91 0.0 762
WERAM-Fec-0187 ENSFCAP00000020694.1 Felis catus 90 0.0 760
WERAM-Orc-0087 ENSOCUP00000008046.2 Oryctolagus cuniculus 89 0.0 759
WERAM-Vip-0058 ENSVPAP00000005409.1 Vicugna pacos 90 0.0 759
WERAM-Loa-0126 ENSLAFP00000011622.3 Loxodonta africana 90 0.0 755
WERAM-Bot-0081 ENSBTAP00000010356.5 Bos taurus 85 0.0 751
WERAM-Cap-0057 ENSCPOP00000004583.2 Cavia porcellus 89 0.0 748
WERAM-Aim-0030 ENSAMEP00000002180.1 Ailuropoda melanoleuca 85 0.0 744
WERAM-Ict-0027 ENSSTOP00000001961.2 Ictidomys tridecemlineatus 91 0.0 741
WERAM-Mup-0042 ENSMPUP00000004024.1 Mustela putorius furo 89 0.0 737
WERAM-Sah-0196 ENSSHAP00000021263.1 Sarcophilus harrisii 84 0.0 720
WERAM-Mod-0133 ENSMODP00000018686.2 Monodelphis domestica 84 0.0 718
WERAM-Tub-0006 ENSTBEP00000000628.1 Tupaia belangeri 86 0.0 688
WERAM-Ptv-0182 ENSPVAP00000016019.1 Pteropus vampyrus 92 0.0 665
WERAM-Ocp-0037 ENSOPRP00000003310.1 Ochotona princeps 80 0.0 637
WERAM-Pes-0177 ENSPSIP00000020643.1 Pelodiscus sinensis 68 3e-166 582
WERAM-Tag-0062 ENSTGUP00000004673.1 Taeniopygia guttata 73 9e-166 580
WERAM-Fia-0084 ENSFALP00000006824.1 Ficedula albicollis 67 3e-163 572
WERAM-Gaga-0139 ENSGALP00000024326.4 Gallus gallus 66 1e-152 537
WERAM-Sus-0032 ENSSSCP00000005572.2 Sus scrofa 89 8e-125 444
WERAM-Tut-0132 ENSTTRP00000010642.1 Tursiops truncatus 90 6e-121 431
WERAM-Prc-0051 ENSPCAP00000004722.1 Procavia capensis 88 1e-107 387
WERAM-Chh-0048 ENSCHOP00000005452.1 Choloepus hoffmanni 76 1e-88 325
WERAM-Anc-0181 ENSACAP00000017487.3 Anolis carolinensis 72 2e-82 303
WERAM-Mim-0124 ENSMICP00000012708.1 Microcebus murinus 98 3e-82 303
WERAM-Xet-0026 ENSXETP00000007169.3 Xenopus tropicalis 71 2e-69 260
WERAM-Lac-0070 ENSLACP00000009345.1 Latimeria chalumnae 60 5e-67 253
WERAM-Leo-0117 ENSLOCP00000014590.1 Lepisosteus oculatus 57 1e-56 218
WERAM-Ten-0211 ENSTNIP00000021181.1 Tetraodon nigroviridis 67 8e-49 192
WERAM-Orn-0213 ENSONIP00000022051.1 Oreochromis niloticus 77 4e-48 189
WERAM-Dar-0236 ENSDARP00000140292.1 Danio rerio 47 8e-48 189
WERAM-Tar-0121 ENSTRUP00000025252.1 Takifugu rubripes 84 3e-47 187
WERAM-Gam-0191 ENSGMOP00000018363.1 Gadus morhua 82 6e-47 186
WERAM-Pof-0144 ENSPFOP00000011987.2 Poecilia formosa 74 6e-47 186
WERAM-Mam-0076 ENSMMUP00000011922.2 Macaca mulatta 66 2e-46 184
WERAM-Xim-0120 ENSXMAP00000010138.1 Xiphophorus maculatus 82 2e-46 184
WERAM-Gaa-0183 ENSGACP00000022995.2 Gasterosteus aculeatus 83 3e-46 183
WERAM-Orla-0212 ENSORLP00000025329.1 Oryzias latipes 65 1e-45 181
WERAM-Dio-0144 ENSDORP00000013380.1 Dipodomys ordii 78 2e-45 181
WERAM-Myl-0128 ENSMLUP00000010400.2 Myotis lucifugus 78 6e-44 176
WERAM-Soa-0134 ENSSARP00000013183.1 Sorex araneus 78 2e-43 174
WERAM-Pem-0101 ENSPMAP00000010356.1 Petromyzon marinus 76 3e-43 173
WERAM-Dan-0001 ENSDNOP00000000334.2 Dasypus novemcinctus 57 4e-42 170
WERAM-Asm-0194 ENSAMXP00000018465.1 Astyanax mexicanus 74 5e-40 162
WERAM-Cii-0068 ENSCINP00000030018.1 Ciona intestinalis 55 2e-35 147
WERAM-Cis-0031 ENSCSAVP00000006479.1 Ciona savignyi 40 5e-09 60.1
WERAM-Php-0123 PP1S81_182V6.1 Physcomitrella patens 38 2e-07 55.1
WERAM-Miv-0038 MVLG_05412T0 Microbotryum violaceum 37 1e-06 52.4
WERAM-Drm-0081 FBpp0079520 Drosophila melanogaster 32 6e-06 50.1
Created Date 25-Jun-2016