WERAM Information
Tag | Content | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
WERAM ID | WERAM-Hos-0151 | ||||||||||||
Ensembl Protein ID | ENSP00000367203.4 | ||||||||||||
Uniprot Accession | O15550; KDM6A_HUMAN; Q52LL9; Q5JVQ7 | ||||||||||||
Genbank Protein ID | NP_066963.2 | ||||||||||||
Protein Name | Lysine-specific demethylase 6A | ||||||||||||
Genbank Nucleotide ID | NM_021140.3 | ||||||||||||
Gene Name | KDM6A;UTX | ||||||||||||
Ensembl Information | |||||||||||||
Details |
|
||||||||||||
Status | Reviewed | ||||||||||||
Classification |
|
||||||||||||
Organism | Homo sapiens | ||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||
Functional Description (View) |
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. | ||||||||||||
Domain Profile | HDM UTX_UTY UTX.txt 1 kwkkqlkelsklpafvrvisaanllshvghtilgmntvqlymkvpgsrtpghqennnlcsvninigpgdcewfavpeeywgklsdlcekn 90 |
||||||||||||
Protein Sequence (Fasta) | MKSCGVSLAT AAAAAAAFGD EEKKMAAGKA SGESEEASPS LTAEEREALG GLDSRLFGFV 60 RFHEDGARTK ALLGKAVRCY ESLILKAEGK VESDFFCQLG HFNLLLEDYP KALSAYQRYY 120 SLQSDYWKNA AFLYGLGLVY FHYNAFQWAI KAFQEVLYVD PSFCRAKEIH LRLGLMFKVN 180 TDYESSLKHF QLALVDCNPC TLSNAEIQFH IAHLYETQRK YHSAKEAYEQ LLQTENLSAQ 240 VKATVLQQLG WMHHTVDLLG DKATKESYAI QYLQKSLEAD PNSGQSWYFL GRCYSSIGKV 300 QDAFISYRQS IDKSEASADT WCSIGVLYQQ QNQPMDALQA YICAVQLDHG HAAAWMDLGT 360 LYESCNQPQD AIKCYLNATR SKSCSNTSAL AARIKYLQAQ LCNLPQGSLQ NKTKLLPSIE 420 EAWSLPIPAE LTSRQGAMNT AQQNTSDNWS GGHAVSHPPV QQQAHSWCLT PQKLQHLEQL 480 RANRNNLNPA QKLMLEQLES QFVLMQQHQM RPTGVAQVRS TGIPNGPTAD SSLPTNSVSG 540 QQPQLALTRV PSVSQPGVRP ACPGQPLANG PFSAGHVPCS TSRTLGSTDT ILIGNNHITG 600 SGSNGNVPYL QRNALTLPHN RTNLTSSAEE PWKNQLSNST QGLHKGQSSH SAGPNGERPL 660 SSTGPSQHLQ AAGSGIQNQN GHPTLPSNSV TQGAALNHLS SHTATSGGQQ GITLTKESKP 720 SGNILTVPET SRHTGETPNS TASVEGLPNH VHQMTADAVC SPSHGDSKSP GLLSSDNPQL 780 SALLMGKANN NVGTGTCDKV NNIHPAVHTK TDNSVASSPS SAISTATPSP KSTEQTTTNS 840 VTSLNSPHSG LHTINGEGME ESQSPMKTDL LLVNHKPSPQ IIPSMSVSIY PSSAEVLKAC 900 RNLGKNGLSN SSILLDKCPP PRPPSSPYPP LPKDKLNPPT PSIYLENKRD AFFPPLHQFC 960 TNPNNPVTVI RGLAGALKLD LGLFSTKTLV EANNEHMVEV RTQLLQPADE NWDPTGTKKI 1020 WHCESNRSHT TIAKYAQYQA SSFQESLREE NEKRSHHKDH SDSESTSSDN SGRRRKGPFK 1080 TIKFGTNIDL SDDKKWKLQL HELTKLPAFV RVVSAGNLLS HVGHTILGMN TVQLYMKVPG 1140 SRTPGHQENN NFCSVNINIG PGDCEWFVVP EGYWGVLNDF CEKNNLNFLM GSWWPNLEDL 1200 YEANVPVYRF IQRPGDLVWI NAGTVHWVQA IGWCNNIAWN VGPLTACQYK LAVERYEWNK 1260 LQSVKSIVPM VHLSWNMARN IKVSDPKLFE MIKYCLLRTL KQCQTLREAL IAAGKEIIWH 1320 GRTKEEPAHY CSICEVEVFD LLFVTNESNS RKTYIVHCQD CARKTSGNLE NFVVLEQYKM 1380 EDLMQVYDQF TLAPPLPSAS S 1401 |
||||||||||||
Nucleotide Sequence (Fasta) | GGGGGGTGTC GGCGTTGGAG TTGTGAATTC GCTGCGTTTC CATGAAATCC TGCGGAGTGT 60 CGCTCGCTAC CGCCGCCGCT GCCGCCGCCG CTTTCGGTGA TGAGGAAAAG AAAATGGCGG 120 CGGGAAAAGC GAGCGGCGAG AGCGAGGAGG CGTCCCCCAG CCTGACAGCC GAGGAGAGGG 180 AGGCGCTCGG CGGACTGGAC AGCCGCCTCT TTGGGTTCGT GAGATTTCAT GAAGATGGCG 240 CCAGGACGAA GGCCCTACTG GGCAAGGCTG TTCGCTGCTA TGAATCTCTA ATCTTAAAAG 300 CTGAAGGAAA AGTGGAGTCT GATTTCTTTT GTCAATTAGG TCACTTCAAC CTCTTATTGG 360 AAGATTATCC AAAAGCATTA TCTGCATACC AGAGGTACTA CAGTTTACAG TCTGACTACT 420 GGAAGAATGC TGCCTTTTTA TATGGTCTTG GTTTGGTCTA CTTCCATTAT AATGCATTTC 480 AGTGGGCAAT TAAAGCATTT CAGGAGGTGC TTTATGTTGA TCCCAGCTTT TGTCGAGCCA 540 AGGAAATTCA TTTACGACTT GGGCTTATGT TCAAAGTGAA CACAGACTAT GAGTCTAGTT 600 TAAAGCATTT TCAGTTAGCT TTGGTTGACT GTAATCCCTG CACTTTGTCC AATGCTGAAA 660 TTCAATTTCA CATTGCCCAC TTATATGAAA CCCAGAGGAA ATATCATTCT GCAAAAGAAG 720 CTTATGAACA ACTTTTGCAG ACAGAGAATC TTTCTGCACA AGTAAAAGCA ACTGTCTTAC 780 AACAGTTAGG TTGGATGCAT CACACTGTAG ATCTCCTGGG AGATAAAGCC ACCAAGGAAA 840 GCTATGCTAT TCAGTATCTC CAAAAGTCCT TGGAAGCAGA TCCTAATTCT GGCCAGTCCT 900 GGTATTTCCT CGGAAGGTGC TATTCAAGTA TTGGGAAAGT TCAGGATGCC TTTATATCTT 960 ACAGGCAGTC TATTGATAAA TCAGAAGCAA GTGCAGATAC ATGGTGTTCA ATAGGTGTGC 1020 TATATCAGCA GCAAAATCAG CCCATGGATG CTTTACAGGC CTATATTTGT GCTGTACAAT 1080 TGGACCATGG CCATGCTGCA GCCTGGATGG ACCTAGGCAC TCTCTATGAA TCCTGCAACC 1140 AGCCTCAGGA TGCCATTAAA TGCTACTTAA ATGCAACTAG AAGCAAAAGT TGTAGTAATA 1200 CCTCTGCACT TGCAGCACGA ATTAAGTATT TACAGGCTCA GTTGTGTAAC CTTCCACAAG 1260 GTAGTCTACA GAATAAAACT AAATTACTTC CTAGTATTGA GGAGGCGTGG AGCCTACCAA 1320 TTCCCGCAGA GCTTACCTCC AGGCAGGGTG CCATGAACAC AGCACAGCAG AATACTTCTG 1380 ACAATTGGAG TGGTGGACAT GCTGTGTCAC ATCCTCCAGT ACAGCAACAA GCTCATTCAT 1440 GGTGTTTGAC ACCACAGAAA TTACAGCATT TGGAACAGCT CCGCGCAAAT AGAAATAATT 1500 TAAATCCAGC ACAGAAACTG ATGCTGGAAC AGCTGGAAAG TCAGTTTGTC TTAATGCAAC 1560 AACACCAAAT GAGACCAACA GGAGTTGCAC AGGTACGATC TACTGGAATT CCTAATGGGC 1620 CAACAGCTGA CTCATCACTG CCTACAAACT CAGTCTCTGG CCAGCAGCCA CAGCTTGCTC 1680 TGACCAGAGT GCCTAGCGTC TCTCAGCCTG GAGTCCGTCC TGCCTGCCCT GGGCAGCCTT 1740 TGGCCAATGG ACCCTTTTCT GCAGGCCATG TTCCCTGTAG CACATCAAGA ACGCTGGGAA 1800 GTACAGACAC TATTTTGATA GGCAATAATC ATATAACAGG AAGTGGAAGT AATGGAAACG 1860 TGCCTTACCT GCAGCGAAAC GCACTCACTC TACCTCATAA CCGCACAAAC CTGACCAGCA 1920 GCGCAGAGGA GCCGTGGAAA AACCAACTAT CTAACTCCAC TCAGGGGCTT CACAAAGGTC 1980 AGAGTTCACA TTCGGCAGGT CCTAATGGTG AACGACCTCT CTCTTCCACT GGGCCTTCCC 2040 AGCATCTCCA GGCAGCTGGC TCTGGTATTC AGAATCAGAA CGGACATCCC ACCCTGCCTA 2100 GCAATTCAGT AACACAGGGG GCTGCTCTCA ATCACCTCTC CTCTCACACT GCTACCTCAG 2160 GTGGACAACA AGGCATTACC TTAACCAAAG AGAGCAAGCC TTCAGGAAAC ATATTGACGG 2220 TGCCTGAAAC AAGCAGGCAC ACTGGAGAGA CACCTAACAG CACTGCCAGT GTCGAGGGAC 2280 TTCCTAATCA TGTCCATCAG ATGACGGCAG ATGCTGTTTG CAGTCCTAGC CATGGAGATT 2340 CTAAGTCACC AGGTTTACTA AGTTCAGACA ATCCTCAGCT CTCTGCCTTG TTGATGGGAA 2400 AAGCCAATAA CAATGTGGGT ACTGGAACCT GTGACAAAGT CAATAACATC CACCCAGCTG 2460 TTCATACAAA GACTGATAAC TCTGTTGCCT CTTCACCATC TTCAGCCATT TCAACAGCAA 2520 CACCTTCTCC AAAATCCACT GAGCAGACAA CCACAAACAG TGTTACCAGC CTTAACAGCC 2580 CTCACAGTGG GCTACACACA ATTAATGGAG AAGGGATGGA AGAATCTCAG AGCCCCATGA 2640 AAACAGATCT GCTTCTGGTT AACCACAAAC CTAGTCCACA GATCATACCA TCAATGTCTG 2700 TGTCCATATA CCCCAGCTCA GCAGAAGTTC TGAAGGCATG CAGGAATCTA GGTAAAAATG 2760 GCTTATCTAA CAGTAGCATT TTGTTGGATA AATGTCCACC TCCAAGACCA CCATCTTCAC 2820 CATACCCTCC CTTGCCAAAG GACAAGTTGA ATCCACCTAC ACCTAGTATT TACTTGGAAA 2880 ATAAACGTGA TGCTTTCTTT CCTCCATTAC ATCAATTTTG TACAAATCCG AACAACCCTG 2940 TTACAGTAAT ACGTGGCCTT GCTGGAGCTC TTAAGTTAGA CCTGGGACTT TTCTCTACTA 3000 AAACTTTGGT GGAAGCTAAC AATGAACATA TGGTAGAAGT GAGGACACAG TTGTTGCAGC 3060 CAGCAGATGA AAACTGGGAT CCCACTGGAA CAAAGAAAAT CTGGCATTGT GAAAGTAATA 3120 GATCTCATAC TACAATTGCT AAATATGCAC AGTACCAGGC CTCCTCATTC CAGGAATCAT 3180 TGAGAGAAGA AAATGAAAAA AGAAGTCATC ATAAAGACCA CTCAGATAGT GAATCTACAT 3240 CGTCAGATAA TTCTGGGAGG AGGAGGAAAG GACCCTTTAA AACCATAAAG TTTGGGACCA 3300 ATATTGACCT ATCTGATGAC AAAAAGTGGA AGTTGCAGCT ACATGAGCTG ACTAAACTTC 3360 CTGCTTTTGT GCGTGTCGTA TCAGCAGGAA ATCTTCTAAG CCATGTTGGT CATACCATAT 3420 TGGGCATGAA CACAGTTCAA CTATACATGA AAGTTCCAGG GAGCAGAACA CCAGGTCATC 3480 AGGAAAATAA CAACTTCTGT TCAGTTAACA TAAATATTGG CCCAGGTGAC TGTGAATGGT 3540 TTGTTGTTCC TGAAGGTTAC TGGGGTGTTC TGAATGACTT CTGTGAAAAA AATAATTTGA 3600 ATTTCCTAAT GGGTTCTTGG TGGCCCAATC TTGAAGATCT TTATGAAGCA AATGTTCCAG 3660 TGTATAGGTT TATTCAGCGA CCTGGAGATT TGGTCTGGAT AAATGCAGGC ACTGTTCATT 3720 GGGTTCAGGC TATTGGCTGG TGCAACAACA TTGCTTGGAA TGTTGGTCCA CTTACAGCCT 3780 GCCAGTATAA ATTGGCAGTG GAACGGTACG AATGGAACAA ATTGCAAAGT GTGAAGTCAA 3840 TAGTACCCAT GGTTCATCTT TCCTGGAATA TGGCACGAAA TATCAAGGTC TCAGATCCAA 3900 AGCTTTTTGA AATGATTAAG TATTGTCTTC TAAGAACTCT GAAGCAATGT CAGACATTGA 3960 GGGAAGCTCT CATTGCTGCA GGAAAAGAGA TTATATGGCA TGGGCGGACA AAAGAAGAAC 4020 CAGCTCATTA CTGTAGCATT TGTGAAGTGG AGGTTTTTGA TCTGCTTTTT GTCACTAATG 4080 AGAGTAATTC ACGAAAGACC TACATAGTAC ATTGCCAAGA TTGTGCACGA AAAACAAGCG 4140 GAAACTTGGA AAACTTTGTG GTGCTAGAAC AGTACAAAAT GGAGGACCTG ATGCAAGTCT 4200 ATGACCAATT TACATTAGCT CCTCCATTAC CATCCGCCTC ATCTTGATAT TGTTCCATGG 4260 ACATTAAATG AGACCTTTTC TGCTATTCAG GAAATAACCC AGTTCTGCAC CACTGGTTTT 4320 TGTAGCTATC TCGTAAGGCT GCTGGCTGAA AACTGTGTCT ATGCAACCTT CCAAGTGCGG 4380 AGTGTCAACC AACTGGACGG GAGAGAGTAC TGCTCCTACT CCAGGACTCT CACAAAGCTG 4440 ATGAGCTGTA CTTCAGAAAA AAATAATAAT TTCCATGTTT TGTATATATC TGACAAAACT 4500 GGCAACATCT TACAGACTAC TGACTTGAAG ACAACCTCTT TTATATTTCT CTATTTCTGG 4560 GCTGATGAAT TTGTTTTCAT CTGTCTTTTC CCCCTTCAGA ATTTTCCTTG GAAAAAAAAT 4620 ACTAGCCTAG CTGGTCATTT CTTTGTAAGG TAGTTAGCAA TTTTAAGTCT TTCTTTGGTC 4680 AACTTTTTTT TAATGTGAAA AGTTAGGTAA GACACTTTTT TACTGCTTTT ATGTTTTTCT 4740 GTCTTGTTTT GAGACCATGA TGGTTACACT TTTGGTTCCT AAATAAAATT TAAAAAATTA 4800 ACAGCCAAGT CACAAAGGTA ATGGATTGCA CATAGACTAA GGAATAAACT TCAGATTTGT 4860 GATTTTTGTT TCTAATCTTG ATGTAAATTT ACACTATTTA TAAATACATA TTTATTGCTT 4920 GAAAATATTT GTGAATGGAA TGCTGTTATT TTTTCCAGAT TTACCTGCCA TTGAAATTTT 4980 AAGGAGTTCT GTAATTTCAA ACACTACTCC TATTACATTT TCTATGTGTA AATAAAACTG 5040 CTTAGCATTG TACAGAAACT TTTATTAAAA TTGTTTAATG TTTAAAGAGT TTTCTATTGT 5100 TTGAGTTTTA AAAAAGACTT TATGTACAGT GCCCAGTTTT TGTTCATTTT TGAAATCTGA 5160 TTATATATAT TTTATATATA CTTATGTATG TATATATAAT ATATATAGAA ATCTGGATAT 5220 ATATGTATAA ATCTTTAGAA CTTAAATTTT TCTCGTTTTA AGTTTCACAT CTATGGTAGA 5280 TTTTTGAGGT GTCTACTGTA AAGTATTGCT TACAAAAAGT ATGATTATTT TTAAAGAAAT 5340 ATATATGGTA TGTATCCTCA AGACCTAAAA TGTCAGACTG GTTTATTGTT AAGTTGCAAT 5400 TACTGCAATG ACAGACCAAT AAACAATTGC TGCCAAAA 5439 |
||||||||||||
Sequence Source | Ensembl | ||||||||||||
Keyword | KW-0002--3D-structure |
||||||||||||
Interpro | IPR003347--JmjC_dom |
||||||||||||
PROSITE | |||||||||||||
Pfam | |||||||||||||
Gene Ontology | GO:0035097--C:histone methyltransferase complex |
||||||||||||
Orthology | |||||||||||||
Created Date | 25-Jun-2016 |