| Tag |
Content |
| WERAM ID |
WERAM-Hos-0204 |
| Ensembl Protein ID |
ENSP00000366245.3 |
| Uniprot Accession |
Q92993; KAT5_HUMAN; B4E3C7; C9JL99; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q9BWK7
|
| Genbank Protein ID |
NP_001193762.1; NP_006379.2; NP_874368.1; NP_874369.1
|
| Protein Name |
Histone acetyltransferase KAT5 |
| Genbank Nucleotide ID |
NM_001206833.1; NM_006388.3; NM_182709.2; NM_182710.2
|
| Gene Name |
KAT5;HTATIP;TIP60 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H2AK5; H2A.ZK4; H2A.ZK7; H2A.ZK11; H2A.ZK13; H3K14; H4K5; H4K8; H4K12; H4K16 |
K |
17694074; 19698979; 24316985
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
6.80e-127 |
424.7 |
228 |
504 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). |
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).
|
| Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnlCll 93
++knie+ielg++++k+wy+sp+p+el++l++ly+cefclky +s ++l+rhl+kC+lr+pPgneiyrk+++s+fe+dG+k+k+y+qnlCll
ENSP00000366245.3 228 RMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLL 319
789***************************************************************************************** PP
MYST.txt 94 aklfldhktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekPLsdlgl 185
ak+fldhktlyyd++pflFYv+te d kg+h+vGyFskekes+e+yn+aCil+lPpyqr+GyGklLiefsYels++egk+g+PekPLsdlgl
ENSP00000366245.3 320 AKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGL 411
******************************************************************************************** PP
MYST.txt 186 lsYrsyWkevllell....kekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkklkvdeeklk 273
lsYrsyW++++le+l +e+ e+ +iti+e+s+ t+i++eD++stl+ lnli+++kgqyil+ se+iv+ +++++ k+ l++d+++l+
ENSP00000366245.3 412 LSYRSYWSQTILEILmglkSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAML--KRLLRIDSKCLH 501
***************88877777888***********************************************88887..99********** PP
MYST.txt 274 wkp 276
++p
ENSP00000366245.3 502 FTP 504
987 PP
|
Protein Sequence
(Fasta) | MAEVGEIIEG CRLPVLRRNQ DNEDEWPLAE ILSVKDISGR KLFYVHYIDF NKRLDEWVTH 60
ERLDLKKIQF PKKEAKTPTK NGLPGSRPGS PEREVPASAQ ASGKTLPIPV QITLRFNLPK 120
EREAIPGGEP DQPLSSSSCL QPNHRSTKRK VEVVSPATPV PSETAPASVF PQNGAARRAV 180
AAQPGRKRKS NCLGTDEDSQ DSSDGIPSAP RMTGSLVSDR SHDDIVTRMK NIECIELGRH 240
RLKPWYFSPY PQELTTLPVL YLCEFCLKYG RSLKCLQRHL TKCDLRHPPG NEIYRKGTIS 300
FFEIDGRKNK SYSQNLCLLA KCFLDHKTLY YDTDPFLFYV MTEYDCKGFH IVGYFSKEKE 360
STEDYNVACI LTLPPYQRRG YGKLLIEFSY ELSKVEGKTG TPEKPLSDLG LLSYRSYWSQ 420
TILEILMGLK SESGERPQIT INEISEITSI KKEDVISTLQ YLNLINYYKG QYILTLSEDI 480
VDGHERAMLK RLLRIDSKCL HFTPKDWSKR GKW 513Protein Fasta Sequence
>ENSP00000366245.3|KAT5;HTATIP;TIP60|Homo sapiens
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW |
Nucleotide Sequence
(Fasta) | AGCTTCGCAC CCGGTGGGCG TCACGTGACG GACTCAGTAG ACCGCCACTG GCTGTGCACG 60
TTATGGGGTT TCCACCTAGG GCTCGGCCTG AGGCTTGTAA CACTCCGTTT TCCCCCGAGT 120
CACAGGGGCA GTCTTGCCCC TCGCAGCTGG GTCGCGGTGT CTCTCAAAGG TCCCCCTCTA 180
CAGGGGCTTC GTGAGGCCCG GGCCCACAGG GCGCTCGGTC CCGGAAGTGA CGTCTCCCAG 240
AGGGGCCGGA AGTGGCAGTG GAGGGAGGGA AGATGGCGGA GGTGGGGGAG ATAATCGAGG 300
GCTGCCGCCT ACCCGTGCTG CGGCGGAACC AGGACAACGA AGATGAGTGG CCCCTGGCCG 360
AGATCCTGAG CGTGAAGGAC ATCAGTGGCC GGAAGCTTTT CTACGTCCAT TACATTGACT 420
TCAACAAACG TCTGGATGAA TGGGTGACGC ATGAGCGGCT GGACCTAAAG AAGATCCAGT 480
TCCCCAAGAA AGAGGCCAAG ACCCCCACTA AGAACGGACT TCCTGGGTCC CGTCCTGGCT 540
CTCCAGAGAG AGAGGTGCCG GCCTCGGCGC AGGCCAGCGG GAAGACCTTG CCAATCCCGG 600
TCCAGATCAC ACTCCGCTTC AACCTGCCCA AGGAGCGGGA GGCCATTCCC GGTGGCGAGC 660
CTGACCAGCC GCTCTCCTCC AGCTCCTGCC TGCAGCCCAA CCACCGCTCA ACGAAACGGA 720
AGGTGGAGGT GGTTTCACCA GCAACTCCAG TGCCCAGCGA GACAGCCCCG GCCTCGGTTT 780
TTCCCCAGAA TGGAGCCGCC CGTAGGGCAG TGGCAGCCCA GCCAGGACGG AAGCGAAAAT 840
CGAATTGTTT GGGCACTGAT GAGGACTCCC AGGACAGCTC TGATGGAATA CCGTCAGCAC 900
CACGCATGAC TGGCAGCCTG GTGTCTGATC GAAGCCACGA CGACATCGTC ACCCGGATGA 960
AGAACATTGA GTGCATTGAG CTGGGCCGGC ACCGCCTCAA GCCGTGGTAC TTCTCCCCGT 1020
ACCCACAGGA ACTCACCACA TTGCCTGTCC TCTACCTGTG CGAGTTCTGC CTCAAGTACG 1080
GCCGTAGTCT CAAGTGTCTT CAGCGTCATT TGACCAAGTG TGACCTACGA CATCCTCCAG 1140
GCAATGAGAT TTACCGCAAG GGCACCATCT CCTTCTTTGA GATTGATGGA CGTAAGAACA 1200
AGAGTTATTC CCAGAACCTG TGTCTTTTGG CCAAGTGTTT CCTTGACCAT AAGACACTGT 1260
ACTATGACAC AGACCCTTTC CTCTTCTACG TCATGACAGA GTATGACTGT AAGGGCTTCC 1320
ACATCGTGGG CTACTTCTCC AAGGAGAAAG AATCAACGGA AGACTACAAT GTGGCCTGCA 1380
TCCTAACCCT GCCTCCCTAC CAGCGCCGGG GCTACGGCAA GCTGCTGATC GAGTTCAGCT 1440
ATGAACTCTC CAAAGTGGAA GGGAAAACAG GGACCCCTGA GAAGCCCCTC TCAGACCTTG 1500
GCCTCCTATC CTATCGAAGC TACTGGTCCC AGACCATCCT GGAGATCCTG ATGGGGCTGA 1560
AGTCGGAGAG CGGGGAGAGG CCACAGATCA CCATCAATGA GATTAGTGAA ATCACCAGCA 1620
TCAAGAAGGA GGATGTCATC TCCACTCTGC AGTACCTCAA TCTCATCAAC TACTACAAGG 1680
GCCAGTACAT CCTCACACTG TCAGAGGACA TCGTGGATGG CCATGAGCGG GCCATGCTCA 1740
AGCGGCTCCT GCGGATCGAC TCCAAGTGTC TGCACTTCAC TCCCAAGGAC TGGAGCAAGA 1800
GGGGGAAGTG GTGACCAGAC ACTGCCCACT GCAGTGCCAA GACGGCAGCA GGACTGGGGC 1860
TGATAGCCCA CCCCGCCCCC ACTGCAGCTC CCACAAAGCA CTCTAAGGGA GATGGGGCTG 1920
AGGACAGCTC AAAAAGGAGA GGACAGGCCT GGCAGGGGCC CACTGGTGCC CAGCACCAAG 1980
GCGAGCTCCG GGCTCAGACC AACTCCAAGG TCAGCTGGCC ACAGGCCCAG GCCTCCTCTG 2040
AAGCAGGGAC CAGAGGGAGC CAGGCAGCTG TGTACAGTGA GAAGGGATCC GGATGGGGGA 2100
GCTCTGTACA GAGGGCTGGT GATTGTAAAA ATTTCTTTTG TAAAGTAGAA GTTGGGGGTG 2160
GGGTGGGTGC TGGCTGCAAA AATTTCTGGC TTCTCTTACC CCTATTGCCC CCGGCAATAA 2220
ATTGTTTCTA TATGCCA
2238Nucleotide Fasta Sequence
>ENSP00000366245.3|MYST|Homo sapiens
AGCTTCGCACCCGGTGGGCGTCACGTGACGGACTCAGTAGACCGCCACTGGCTGTGCACGTTATGGGGTTTCCACCTAGGGCTCGGCCTGAGGCTTGTAACACTCCGTTTTCCCCCGAGTCACAGGGGCAGTCTTGCCCCTCGCAGCTGGGTCGCGGTGTCTCTCAAAGGTCCCCCTCTACAGGGGCTTCGTGAGGCCCGGGCCCACAGGGCGCTCGGTCCCGGAAGTGACGTCTCCCAGAGGGGCCGGAAGTGGCAGTGGAGGGAGGGAAGATGGCGGAGGTGGGGGAGATAATCGAGGGCTGCCGCCTACCCGTGCTGCGGCGGAACCAGGACAACGAAGATGAGTGGCCCCTGGCCGAGATCCTGAGCGTGAAGGACATCAGTGGCCGGAAGCTTTTCTACGTCCATTACATTGACTTCAACAAACGTCTGGATGAATGGGTGACGCATGAGCGGCTGGACCTAAAGAAGATCCAGTTCCCCAAGAAAGAGGCCAAGACCCCCACTAAGAACGGACTTCCTGGGTCCCGTCCTGGCTCTCCAGAGAGAGAGGTGCCGGCCTCGGCGCAGGCCAGCGGGAAGACCTTGCCAATCCCGGTCCAGATCACACTCCGCTTCAACCTGCCCAAGGAGCGGGAGGCCATTCCCGGTGGCGAGCCTGACCAGCCGCTCTCCTCCAGCTCCTGCCTGCAGCCCAACCACCGCTCAACGAAACGGAAGGTGGAGGTGGTTTCACCAGCAACTCCAGTGCCCAGCGAGACAGCCCCGGCCTCGGTTTTTCCCCAGAATGGAGCCGCCCGTAGGGCAGTGGCAGCCCAGCCAGGACGGAAGCGAAAATCGAATTGTTTGGGCACTGATGAGGACTCCCAGGACAGCTCTGATGGAATACCGTCAGCACCACGCATGACTGGCAGCCTGGTGTCTGATCGAAGCCACGACGACATCGTCACCCGGATGAAGAACATTGAGTGCATTGAGCTGGGCCGGCACCGCCTCAAGCCGTGGTACTTCTCCCCGTACCCACAGGAACTCACCACATTGCCTGTCCTCTACCTGTGCGAGTTCTGCCTCAAGTACGGCCGTAGTCTCAAGTGTCTTCAGCGTCATTTGACCAAGTGTGACCTACGACATCCTCCAGGCAATGAGATTTACCGCAAGGGCACCATCTCCTTCTTTGAGATTGATGGACGTAAGAACAAGAGTTATTCCCAGAACCTGTGTCTTTTGGCCAAGTGTTTCCTTGACCATAAGACACTGTACTATGACACAGACCCTTTCCTCTTCTACGTCATGACAGAGTATGACTGTAAGGGCTTCCACATCGTGGGCTACTTCTCCAAGGAGAAAGAATCAACGGAAGACTACAATGTGGCCTGCATCCTAACCCTGCCTCCCTACCAGCGCCGGGGCTACGGCAAGCTGCTGATCGAGTTCAGCTATGAACTCTCCAAAGTGGAAGGGAAAACAGGGACCCCTGAGAAGCCCCTCTCAGACCTTGGCCTCCTATCCTATCGAAGCTACTGGTCCCAGACCATCCTGGAGATCCTGATGGGGCTGAAGTCGGAGAGCGGGGAGAGGCCACAGATCACCATCAATGAGATTAGTGAAATCACCAGCATCAAGAAGGAGGATGTCATCTCCACTCTGCAGTACCTCAATCTCATCAACTACTACAAGGGCCAGTACATCCTCACACTGTCAGAGGACATCGTGGATGGCCATGAGCGGGCCATGCTCAAGCGGCTCCTGCGGATCGACTCCAAGTGTCTGCACTTCACTCCCAAGGACTGGAGCAAGAGGGGGAAGTGGTGACCAGACACTGCCCACTGCAGTGCCAAGACGGCAGCAGGACTGGGGCTGATAGCCCACCCCGCCCCCACTGCAGCTCCCACAAAGCACTCTAAGGGAGATGGGGCTGAGGACAGCTCAAAAAGGAGAGGACAGGCCTGGCAGGGGCCCACTGGTGCCCAGCACCAAGGCGAGCTCCGGGCTCAGACCAACTCCAAGGTCAGCTGGCCACAGGCCCAGGCCTCCTCTGAAGCAGGGACCAGAGGGAGCCAGGCAGCTGTGTACAGTGAGAAGGGATCCGGATGGGGGAGCTCTGTACAGAGGGCTGGTGATTGTAAAAATTTCTTTTGTAAAGTAGAAGTTGGGGGTGGGGTGGGTGCTGGCTGCAAAAATTTCTGGCTTCTCTTACCCCTATTGCCCCCGGCAATAAATTGTTTCTATATGCCA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0341--Growth regulation
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0005667--C:transcription factor complex
GO:0016407--F:acetyltransferase activity
GO:0050681--F:androgen receptor binding
GO:0004402--F:histone acetyltransferase activity
GO:0046872--F:metal ion binding
GO:0070491--F:repressing transcription factor binding
GO:0003713--F:transcription coactivator activity
GO:0030521--P:androgen receptor signaling pathway
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0071392--P:cellular response to estradiol stimulus
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0000729--P:DNA double-strand break processing
GO:0006260--P:DNA replication
GO:0000731--P:DNA synthesis involved in DNA repair
GO:0006302--P:double-strand break repair
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0016573--P:histone acetylation
GO:0032703--P:negative regulation of interleukin-2 production
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1901985--P:positive regulation of protein acetylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0040008--P:regulation of growth
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0010212--P:response to ionizing radiation
GO:0000732--P:strand displacement
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
