WERAM Information

Tag Content
WERAM ID WERAM-Hos-0070
Ensembl Protein ID ENSP00000365019.3
Uniprot Accession Q9Y657; SPIN1_HUMAN; A8K0X6; B3KRQ4; Q7KZJ8; Q9GZT2; Q9H0N7
Genbank Protein ID NP_006708.2
Protein Name Spindlin-1
Genbank Nucleotide ID NM_006717.2
Gene Name Spindlin1;SPIN1;OCR
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000106723.16 ENST00000375859.3 ENSP00000365019.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3K4me3; H3R8me2a R 24589551
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 1.00e-37 130.4 53 261
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Domain Profile
  Me_Reader Tudor
          Tudor.txt   3 kvGlrVvakwssdG....yfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqyg 63 
                        +vG+r+++ w+ +G    ++++g+++   ++v++++++y+iky++ +++y+l+L+k++r+ ++++
  ENSP00000365019.3  53 IVGCRIQHGWK-EGngpvTQWKGTVL---DQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEV 113
                        59*********.7779*********9...*******************************99885 PP
          Tudor.txt   3 kvGlrVvakwssdG...yfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqy 62 
                        ++G+ V+++++ +    + ++g+++   +r+++++++++i+ye ++++y+++L+++++  +++
  ENSP00000365019.3 132 MIGKAVEHMFETEDgskDEWRGMVL---ARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLR 191
                        78********85446*********9...****************************9988776 PP
          Tudor.txt   2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekg 55 
                        s vG++V++  + dG    g+++   h+ve+++++y+ik++d+ ++y+++L+k+
  ENSP00000365019.3 212 SLVGKQVEYAKE-DGSKRTGMVI---HQVEAKPSVYFIKFDDDFHIYVYDLVKT 261
                        78**********.**********...*************************996 PP
Protein Sequence
(Fasta)		MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNIVGCRIQH 60
GWKEGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT 120
SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ 180
LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP 240
SVYFIKFDDD FHIYVYDLVK TS 262
Nucleotide Sequence
(Fasta)		TCCGCGGCGA GGGAGCGGGG GCGGGGAGGC GCCGTCTGGC TCAGGCTGGG GCCGGCGGGA 60
GCGCGAACGA GCGACGGCGG AACCCGTGGG CCTGTGGACT GCAGCCTCGG CGGTCAGCAG 120
AGTGCTTGTG ATTTCACGTA TTTTTGCTGA ACTCGTAAAA GAGACACTTG GATGGTGGAT 180
TAACCAGAAC ACTAACATTC TGTGAAAAGT TTCAAATTGG AGAATATTGA ATTTTCACCC 240
TAGTCCAGCA GCTCCGCTGC TCACTTAAAT ACAGATGAAT GAAGACCCCA TTCGGAAAGA 300
CACCTGGCCA GCGGTCCAGA GCTGATGCAG GCCATGCTGG AGTATCTGCC AACATGATGA 360
AGAAGAGGAC ATCCCACAAA AAACATCGGA GCAGTGTGGG TCCGAGCAAA CCTGTTTCCC 420
AGCCCCGGCG GAACATCGTA GGCTGCAGGA TTCAGCATGG GTGGAAAGAG GGGAATGGCC 480
CTGTTACCCA GTGGAAAGGA ACCGTTCTGG ACCAGGTGCC TGTAAATCCT TCTTTGTATC 540
TTATAAAATA CGATGGATTT GACTGTGTTT ATGGACTAGA ACTTAATAAA GATGAAAGAG 600
TTTCTGCGCT TGAAGTCCTC CCTGATAGAG TTGCGACATC TCGAATCAGC GATGCACACT 660
TGGCAGACAC AATGATTGGC AAAGCAGTGG AACATATGTT TGAGACAGAG GATGGTTCTA 720
AAGATGAGTG GAGGGGAATG GTCTTAGCAC GTGCACCTGT CATGAACACA TGGTTTTACA 780
TTACCTATGA GAAAGACCCT GTCTTGTACA TGTACCAACT CTTAGATGAT TACAAAGAAG 840
GCGACCTTCG CATTATGCCT GATTCCAATG ATTCACCTCC AGCAGAAAGG GAACCAGGAG 900
AAGTTGTGGA CAGCCTGGTA GGCAAACAAG TGGAATATGC CAAAGAAGAT GGCTCGAAAA 960
GGACTGGCAT GGTCATTCAT CAAGTAGAAG CCAAGCCCTC CGTCTATTTC ATCAAGTTTG 1020
ATGATGATTT CCATATTTAT GTCTACGATT TGGTGAAAAC ATCCTAGATG TCATCACAAA 1080
CTCTGCCAAA TTTGTGGAAC TATGAAATGT ATTATTTGTA GACATAAAGA CTTGATTGCT 1140
TTCCAGTTTA ATGAAAGCTT AAATGTCCCT GCGAACCCAC AATCTCTGCC AGCAGAACTG 1200
GTTTTGTTCT GAATAGTACA GATTGATGTG AACACAAAGC ATTTTGTGTA AGGAGAACCC 1260
CTTTCTTTTA AAAGAAGTCT GTCTATTTCG AGGGGAGTTA CAGGCAAGTT TGGTAAAAGT 1320
TAAGCTAGTA TCATAGTCAT TTAAAATTGT AATAGATCTT AACCATTTTC CCCCTCACCC 1380
TAACTCTCTT ATTCTGCCGC CACAATGCAA GCATAGTTTG ATGTTTTCGT TATTGCCTTT 1440
TTTGAGATGT ATGTATCTGT ATCTACCTAT ATCTATATGT GTGTATACAT ATATAATATA 1500
TACACACAGA TACAAGTGTA CACACACACA CCACACACCA CACACACCCC ACTGGCAGTC 1560
TTTGTGGATT AGGATGGGGG TGACATAATT TTCTTGAGTT TAACAGGAGT GCTTTACCCA 1620
AGTCAGTCAT GGATATGATA TCACTGCTCT TTATTTAAAA GTAAACTTTG GGCACAGGAA 1680
CCATATGGGA ACATTCAGCT TGTTTAAAAA AAAAAAATCA GAAGTTCAGA GCACCTTTTC 1740
AATCTGGAGC CCTTAAACCA TAAGTCCAAA TATGAATTAT TTGTGAACAG TTAATGACCC 1800
ATATTAGAAT TTTACAATCT GGTGAACAAT CTGGGTAAAA GGCTACCTTT AATTCTAAGC 1860
TTCATTTTTT TTTGGGGGGG GGTTACATTT TAATCATAAA TTCTTTTTTG CAAAGCCCAG 1920
GTTCTTGTTC CACACAGTGT AATGTAGGTG TATTTTGGAC AGCACATATG GTCCATTGTG 1980
TACAAGTCAG TAATCTGGAT TTCAGTACAT GGATTTAAAA GGCAACAATC CATCACTGGT 2040
TTGTGTGTTT TTGGTTAAGT TTCTGGAAGA ATACAATGCT TTTATATTGG AAGTATAAGT 2100
TTTGAGTGGC ATTGTTGCCT TCTAACAAGC TCTCTGGGAC TTTTAAAGTT TTATTACTAT 2160
TATTGCTAAT GTATGATTAT GGTCAGAGAC TTTCAACCCA CCCCTTCCTG CCTACCCCTG 2220
GCTTTTCCTC ACAAAGAATG TCTAGACAAA CAGCAGCTTA GTCTCCTGAC ACCTCTTGTG 2280
GGGTGCATGT TCCTGCTCCA GGTATGCTGT TCATGTGGAT TCATTCCATT CAGTGGCCCC 2340
TTGGGGTTTG CATGCCAGTG AAGCGTTACC ATAGAAGAGC CAGCCGTTTG TGTTCGCTTG 2400
GTAGGTGTAA GTAATAGCAG CCCTTAGCCA CGGAGTCTTT ATGTGGTTTA TTCCTGCAAG 2460
GTTGTTTTAA ACTGAAATAG AACTGCTAGT GTGATTGGTT GATCAGCAAA ACAGCTGCTC 2520
TCATTTTGTT TTGGAGGAAC CCTGGTGGTT TGACAGCCAG GAGAAAGGCC ATATGTGAAA 2580
CCAGTCTCTT GTGGAGATTG GAAATCCTCC CTGATATTTG GGCAGAGCCT AAACGTGCAT 2640
GCTTGTCACT CAAACACCAG AAGTTTGAAT CAGAGGTCTG AGTGACCTCT TTTGTGGCTG 2700
TTCTTGATGG TTTCCAGGCC TCGTTATGCA TGGTTTGCTT GATGCCCATT TTTTGTGCCT 2760
TGTGCTGTTG GATGGTAACG ACCACTCACC ATGTAAACAC AGTACCTCAG TTTTCTGTCC 2820
ACAGCTGCAG TCGCTCTGTC CCTCGTGCTT CACTGTGGGC AGCCAGGGAC AAGCTTCTGA 2880
AAGCAGTGTG ATACCCAAGT CATAGGTGCT TCTCGTATGT GAACAGGTGT CATTCTACAG 2940
ATCTGTTATG TGTTTTCCTG TTGACTCTTA AGAGTCCCTG CATGTAAATC TCAAAGCTGA 3000
GCCTGGCTCC CAGAGTCCAG ACTGACATTA CAGCGCAAGA GTTTGCAAGT GTGTCCAGCA 3060
TGCACCAACT GTGCAGAACT TGGCTCGGTA ACTTTGCGTG GAAAAATAAA GTACATTTTG 3120
AAGTATCTTG AGGGTTGGGT CAATTGAGAC ATTTCTAGCA TTACTTAATG ACTTGCATTG 3180
TGGTTTTTCT GCAAGCAACT TTAATGACTT TTTTTATACC ACATGGTCTC CCAGTTTCTA 3240
GATGAATGCA ACATGATGAT GGTGATGATG ACGATGAGTT TAATCATTGT TCATTTATTG 3300
CCTTTAGGGC TGAGGGAAAG GGAAGGTTTG TTTTTTTTTC TCCCCATTTT CCCCCATTCT 3360
GTCTTTCTTT TGGTGACTTA CACCACATGT AATGACGCTA TGACTAATTC TGCTCCCAAG 3420
CCCTTGTATC TTGGGCTTCA TTTTAGGCTC ATGTGTCAGA TCTGCATGCA TTGCTTGCAT 3480
TTTTCTGGTA TCTGAATGTT GGTTCCTTGT TCCAGGAATT CAACATTAAT TTCCAAAAGT 3540
ATCATGGGAC TTGTGACAAT ACAAGACATG AATCTATGTA TAAAATTTAT CGGCCTTTCT 3600
CATTTACCTG CTCTAGTATT ATTGTATTGT GTGTGCGTGC GTGTGTGATG TCAGGCTGCC 3660
ACGTAAAACT TCAGAGAAAA ATCTTAAAAG CAGACCATCC TTTTTTGCAT GCTCTATTCT 3720
AAGTAGAATG TTCAATGTAA CTGACTAAAA TTGCATGTTA AAGATATTTA GGTTTTTTTG 3780
TTTTCTTTAT TTTTATTTGT TTTCAGTTTC CTGTATATTT GCTTACTGTG CCGTTTTAGT 3840
GGTTTTAGGA TAAAAATGCA CTGGTGAAGC AAATGTAGTG CCAACAGAAG GTGATTTTCC 3900
AGTTGTAAAT GTCATGCAGC ATTTGAAGGG ACTGTGTTTT CTTAAAAAAA AATCACAGTT 3960
ACTTCTAAAC CAGATTTCAT TTCTTTTATT GTTTTATGTG CCAAACCACG AAGTGCATTG 4020
GGCTTCAATC TCTGAACACT GTAGACCCAT TAGAAGACTG TTCCGATTGT TACAAATTGT 4080
AGTGCCTGAA AACACTCTTA AGCTGATTGT CTTAACAAAA TGAAAGTTCT CCAAAGACAA 4140
AACAGAACAA TTATTATAAC AAAATAATTA TGGTTGAAAT GTCTGTGGTT CCTTGGAAAT 4200
GCTGCGCTCT TTGTGTTTTT CCATCATTAG TGCAGTTGGA ATGAATGTGT ATAGGTCAGA 4260
GGTCTTCGTG TTCACATTTT AAAATTAGGT AAATGACCTC ATCTTTCAAG CTTGAATTCA 4320
TTTTTAATTT TAATTTTATT TTATACAATG TGTAGACAGT TCCCTGTTCT CTGCATTTAG 4380
AAGTATACAC AATATAAATC TGTTAATTCT GTAAGTAATT TTTATAATTA TGATGTAACT 4440
CTATCTTATC CTTAAAACAT TTAAAATAAA CCCTTTATGT GCAA 4485
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0879--Wnt signaling pathway
--
Interpro

IPR003671--SPIN/Ssty
IPR029579--Spindlin-1/z
PROSITE
Pfam

PF02513--Spin-Ssty
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0035064--F:methylated histone binding
GO:0016568--P:chromatin modification
GO:0007276--P:gamete generation
GO:0051321--P:meiotic cell cycle
GO:0007275--P:multicellular organism development
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0009303--P:rRNA transcription
GO:0016055--P:Wnt signaling pathway
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0183 ENSPPYP00000021687.2 Pongo abelii 100 2e-147 518
WERAM-Paa-0201 ENSPANP00000019351.1 Papio anubis 100 2e-147 518
WERAM-Pat-0176 ENSPTRP00000040509.3 Pan troglodytes 100 2e-147 518
WERAM-Orc-0120 ENSOCUP00000010209.2 Oryctolagus cuniculus 100 2e-147 518
WERAM-Chs-0088 ENSCSAP00000003605.1 Chlorocebus sabaeus 100 2e-147 518
WERAM-Loa-0198 ENSLAFP00000020125.1 Loxodonta africana 100 3e-147 517
WERAM-Mum-0036 ENSMUSP00000093473.5 Mus musculus 99 4e-147 517
WERAM-Ict-0207 ENSSTOP00000021942.1 Ictidomys tridecemlineatus 100 4e-147 517
WERAM-Nol-0055 ENSNLEP00000006581.1 Nomascus leucogenys 100 4e-147 517
WERAM-Ect-0094 ENSETEP00000011128.1 Echinops telfairi 99 5e-147 517
WERAM-Caj-0186 ENSCJAP00000032147.2 Callithrix jacchus 100 5e-147 517
WERAM-Vip-0060 ENSVPAP00000005581.1 Vicugna pacos 99 1e-146 516
WERAM-Mup-0091 ENSMPUP00000008517.1 Mustela putorius furo 99 1e-146 516
WERAM-Caf-0026 ENSCAFP00000031883.2 Canis familiaris 99 1e-146 516
WERAM-Bot-0039 ENSBTAP00000003961.5 Bos taurus 99 1e-146 516
WERAM-Aim-0042 ENSAMEP00000003478.1 Ailuropoda melanoleuca 99 1e-146 516
WERAM-Ran-0068 ENSRNOP00000014787.5 Rattus norvegicus 99 1e-146 515
WERAM-Tut-0071 ENSTTRP00000005286.1 Tursiops truncatus 99 2e-146 515
WERAM-Ptv-0153 ENSPVAP00000012630.1 Pteropus vampyrus 99 4e-146 514
WERAM-Pes-0014 ENSPSIP00000003800.1 Pelodiscus sinensis 97 8e-145 509
WERAM-Fec-0080 ENSFCAP00000006674.3 Felis catus 96 1e-144 509
WERAM-Tag-0007 ENSTGUP00000000476.1 Taeniopygia guttata 97 2e-144 508
WERAM-Gaga-0136 ENSGALP00000024012.2 Gallus gallus 97 2e-144 508
WERAM-Fia-0153 ENSFALP00000012957.1 Ficedula albicollis 97 2e-144 508
WERAM-Anp-0123 ENSAPLP00000013743.1 Anas platyrhynchos 97 2e-144 508
WERAM-Sah-0068 ENSSHAP00000008345.1 Sarcophilus harrisii 97 3e-144 508
WERAM-Mod-0114 ENSMODP00000016746.2 Monodelphis domestica 97 7e-144 506
WERAM-Anc-0172 ENSACAP00000016243.1 Anolis carolinensis 96 1e-143 506
WERAM-Xet-0074 ENSXETP00000023772.2 Xenopus tropicalis 94 3e-142 501
WERAM-Lac-0098 ENSLACP00000012289.1 Latimeria chalumnae 95 1e-139 492
WERAM-Dan-0140 ENSDNOP00000025924.1 Dasypus novemcinctus 95 7e-138 486
WERAM-Chh-0051 ENSCHOP00000006189.1 Choloepus hoffmanni 92 4e-137 484
WERAM-Prc-0155 ENSPCAP00000014742.1 Procavia capensis 99 3e-135 478
WERAM-Asm-0209 ENSAMXP00000019889.1 Astyanax mexicanus 92 5e-135 477
WERAM-Dar-0125 ENSDARP00000076360.3 Danio rerio 90 7e-135 476
WERAM-Mim-0133 ENSMICP00000013220.1 Microcebus murinus 98 3e-132 468
WERAM-Mae-0063 ENSMEUP00000005813.1 Macropus eugenii 97 4e-132 467
WERAM-Otg-0030 ENSOGAP00000001938.2 Otolemur garnettii 100 4e-131 464
WERAM-Cap-0002 ENSCPOP00000000662.2 Cavia porcellus 100 1e-130 462
WERAM-Myl-0093 ENSMLUP00000007758.2 Myotis lucifugus 99 2e-130 461
WERAM-Gog-0088 ENSGGOP00000007450.2 Gorilla gorilla 100 5e-130 460
WERAM-Ova-0078 ENSOARP00000008227.1 Ovis aries 99 1e-129 459
WERAM-Mam-0172 ENSMMUP00000024457.2 Macaca mulatta 84 9e-126 446
WERAM-Tas-0022 ENSTSYP00000002664.1 Tarsius syrichta 83 9e-125 443
WERAM-Sus-0090 ENSSSCP00000013151.1 Sus scrofa 82 5e-124 440
WERAM-Leo-0094 ENSLOCP00000012515.1 Lepisosteus oculatus 94 2e-123 438
WERAM-Meg-0027 ENSMGAP00000002086.2 Meleagris gallopavo 94 4e-123 437
WERAM-Orn-0004 ENSONIP00000000718.1 Oreochromis niloticus 83 1e-122 436
WERAM-Xim-0189 ENSXMAP00000015073.1 Xiphophorus maculatus 83 2e-121 432
WERAM-Pof-0007 ENSPFOP00000000963.1 Poecilia formosa 83 2e-121 432
WERAM-Ten-0015 ENSTNIP00000004207.1 Tetraodon nigroviridis 83 3e-121 431
WERAM-Ocp-0116 ENSOPRP00000011480.1 Ochotona princeps 83 4e-121 431
WERAM-Tar-0135 ENSTRUP00000029489.1 Takifugu rubripes 82 3e-120 428
WERAM-Orla-0164 ENSORLP00000019105.1 Oryzias latipes 85 1e-119 426
WERAM-Eqc-0019 ENSECAP00000002384.1 Equus caballus 76 9e-114 406
WERAM-Ere-0026 ENSEEUP00000001958.1 Erinaceus europaeus 76 9e-113 403
WERAM-Gaa-0196 ENSGACP00000024164.1 Gasterosteus aculeatus 86 2e-106 382
WERAM-Tub-0036 ENSTBEP00000004285.1 Tupaia belangeri 74 3e-101 365
WERAM-Gam-0128 ENSGMOP00000013441.1 Gadus morhua 77 1e-89 326
Created Date 25-Jun-2016