WERAM Information

Tag Content
WERAM ID WERAM-Mum-0036
Ensembl Protein ID ENSMUSP00000093473.5
Uniprot Accession Q61142; SPIN1_MOUSE; Q3TLC3; Q3UT05; Q91VG8
Genbank Protein ID NP_001269957.1; NP_001269958.1; NP_001269959.1; NP_035592.1; NP_666155.1; XP_006516956.1; XP_006516957.1
Protein Name Spindlin-1
Genbank Nucleotide ID NM_001283028.1; NM_001283029.1; NM_001283030.1; NM_011462.3; NM_146043.4; XM_006516893.2; XM_006516894.2
Gene Name Spindlin1;Spin1Spin
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021395.10 ENSMUST00000095797.5 ENSMUSP00000093473.5
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3K4me3 K 21960006
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 6.50e-38 130.3 53 261
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (By similarity). Overexpression induces metaphase arrest and chromosomal instability (PubMed:18543248). Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (PubMed:23894536).
Domain Profile
  Me_Reader Tudor
             Tudor.txt   3 kvGlrVvakwssdG....yfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqyg 63 
                           +vG+r+++ w  +G    ++++g+++   ++v++++++y+iky++ +++y+l+L+k++r+ ++++
  ENSMUSP00000093473.5  53 IVGCRIQHGWR-EGngpvTQWKGTVL---DQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEV 113
                           59*********.7779*********9...*******************************99885 PP
             Tudor.txt   3 kvGlrVvakwssdG...yfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqy 62 
                           ++G+ V+++++ +    + ++g+++   +r+++++++++i+ye ++++y+++L+++++  +++
  ENSMUSP00000093473.5 132 MIGKAVEHMFETEDgskDEWRGMVL---ARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLR 191
                           78********85446*********9...****************************9988776 PP
             Tudor.txt   2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekg 55 
                           s vG++V++  + dG    g+++   h+ve+++++y+ik++d+ ++y+++L+k+
  ENSMUSP00000093473.5 212 SLVGKQVEYAKE-DGSKRTGMVI---HQVEAKPSVYFIKFDDDFHIYVYDLVKT 261
                           78**********.**********...*************************996 PP
Protein Sequence
(Fasta)		MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRTSV GPSKPVSQPR RNIVGCRIQH 60
GWREGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT 120
SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ 180
LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP 240
SVYFIKFDDD FHIYVYDLVK TS 262
Nucleotide Sequence
(Fasta)		GGCGGCCGCG GCGAGGAGCG GGGGTGGGGA GGCGCCGTCT GGCTCGGGCT GGGCCGGCGG 60
GGAGCACGAG CGAACCACGG CGGCCCCGTG GGCAGCCTCG GTGGCCGACA GAGTGCTTGG 120
GATCCCGTGT GTTTTTGCTG AACTTGTAAA GGAGACATCT GGATGGTGGA TTAACACGAA 180
CCTGTGGGCA GCCTCATAGC TGAGAACATT GGATTTTCAC CCTAGTCCAG CAGCTCTGCT 240
GCTCACATAG ATACAGATGA ATGAAGACCC CATTCGGGAA GACACCTGGC CAACGGTCCA 300
GAGCTGATGC AGGCCATGCT GGAGTATCTG CAAACATGAT GAAGAAGAGG ACATCTCACA 360
AAAAACATCG GACCAGTGTG GGACCAAGCA AGCCTGTGTC CCAACCCCGG CGGAACATCG 420
TAGGCTGCAG GATCCAGCAT GGATGGAGAG AGGGCAATGG CCCTGTTACC CAGTGGAAGG 480
GGACTGTCCT GGACCAGGTG CCTGTGAATC CTTCCCTGTA TCTTATAAAG TACGATGGAT 540
TTGACTGTGT TTATGGACTA GAACTTAATA AGGATGAAAG AGTTTCTGCA CTGGAAGTCC 600
TCCCTGATAG AGTTGCAACA TCTCGGATCA GCGATGCACA CTTAGCGGAC ACAATGATCG 660
GCAAAGCAGT GGAGCACATG TTTGAGACAG AGGACGGCTC TAAAGATGAG TGGAGGGGGA 720
TGGTCTTGGC ACGGGCGCCT GTCATGAACA CATGGTTTTA CATCACCTAT GAGAAAGACC 780
CTGTCTTGTA CATGTACCAG CTCCTCGATG ACTACAAAGA AGGCGACCTC CGCATCATGC 840
CTGATTCCAA TGATTCGCCT CCAGCAGAAA GGGAGCCAGG AGAAGTTGTG GACAGCCTGG 900
TAGGCAAGCA AGTGGAATAT GCCAAAGAAG ACGGCTCGAA AAGGACTGGC ATGGTCATCC 960
ACCAAGTAGA GGCCAAGCCC TCTGTCTATT TCATCAAGTT TGATGACGAT TTCCATATTT 1020
ACGTCTACGA TTTGGTGAAA ACATCCTAGA TGTCATCACA AACTTTGCCA AATTTGTGGA 1080
ACTATTAAAT GTATAATTTG TAGACATAAA GACTTGATTG CTTTCCAGTT TAATGAAAGC 1140
TTAGATGTCC CTGCGAACCC ACAATCTCCA CCAGCAGAGC TGGTGTTGTT CTGAATAGTG 1200
CAGACTGATT CGAACACAAG GCATCTGTGA GGGGAGTCCT CCCTCTTCAA AGCATCTGTG 1260
TGAGGGGGTC TTCCCTCTTA CAAGAAAGCT GTCTGTTGGG GGTTACAAGC AAGGTGGTAA 1320
ACGTTAAGCT AGTATCATAG TCATTTAAAC CTGGATAGAT TGTAACCATT TTCCCTTCAC 1380
TCTGACACTG TCTTATTCTG CTGCCACAAT GCAAGCATAG TTTGTTATTT TTGTTACTGC 1440
CTTTTTTGAG AGATTATGTA TCTATATAGC TACCTGTCTA GATCTGCATC TGTGTGCCTA 1500
TGTATATATT ATACACACAC AGAGGCACTC ACCGCTGGCT CTCCTTTCCT TGGGGATTGG 1560
GGTGGGGGTG ATAACGTTTT CTCCAGTTCA ACAGGAGTGC TTGACCCAAG TCAGTCATAT 1620
TTATAATATG CCTGCTCTTT GTTTAAAATT AAATTTGGGC ACAGGAAGCA CACAGAGACA 1680
TTTAGGTTGT TTAAAAAGTC AGAATTTCTG AGTACCATTT CAGTCTGGAG GCTTTTAGCT 1740
GAGTCCAGGT ATAAATTAGC CATAAACAGT CAATGACCCA CAGTAGTCTT TAGTAAACTG 1800
TTGAGAAATC TGGGTAAAAG GCTGCCTTCA ATTCTAAGCT TTGTTTTTTT GTGGTTTTTG 1860
TTATTATTTG TTTCTGTTGT TTACTCTTTA ATCGTAAGTA CTTTTAAACC ACGACCCAGG 1920
TCCTTGGTTC ACATGGAATA ATAAAGATGT GTTTTTAGAT GGCACATTGG TCCATTTGTA 1980
CACACCTGTC ATCGGGATCT TAGTACATGG ACTTAAAAGG CAACACTACA TCAATGGTTT 2040
GTATATGTGG TGAATTCCTG CAAGAACAGT GCATTTGTAT TAGAAATGTA AGTTTTAAGG 2100
ATGGCCTTGT TGCCTTCTAT CAAGTTCTCT GGGACTTTGT AATTTTGATT ACTACTATTG 2160
ATACATGGTT ATGGTCAGAA GGCCTCTTCT CCCTTCCTCC CTCACTCCCT CTCCTCCTAG 2220
CTTTCCCCAC AGAGAATGTT AGACCAGTAT GGCTTCTTGC CTTGATCCTG TTGTGGCAGT 2280
GTCTGTTCCT GCCCCAGGTG TGCTATTCAC GCAGGTTTAT TCCCTCCATG GCCTCCGGGC 2340
TTTGCATGTC TATGATGTGT GTGTCGCTGG GAAGGTCATG CTTGCCAGTT ATGGGTGGAT 2400
CGCAGCTCTT CGCCATCAAG TGCATTCAGG ATTATTCCTG GGAGGTTGCT TAAAGCTGAA 2460
ATAGAACTGA AATGCAGTTG GTAGACTAGC CAAACATCTG CTTGCTCTCA CTTTGTTTTG 2520
GAAGAACCAT GGTAGCTTGT CAGCTGGTAG AAAGATGGTT TGTAAAAACC AGTTTCTCAC 2580
GGAGGTTGAA CCTATCTGTG GCTGGACAGT CTTGGATACT GTCAAGCAAA CACCAGAGGC 2640
TTGGCCAAGT ATAGTTACAA TTACCTAGTT GGGGTTCTTC CTGATGCAAG AAATTTTTCA 2700
CTGTTCGAGG CACATGGTTA TTGGCTATCC ATTTAGTTTT CACAGAGGCT GACCACCTTA 2760
CACTGCTGGG TGGTCACAAC TGCTCACCAT GTGAACATAG TACCTCAGTT CTGTCCTTGG 2820
CTGCAATCGT TGTGTGCTCA GTGTTTTCTC ATAGGCACCA GGGACAGGCT TCTCAAGGCA 2880
GTATGATATA CCCTAGTCTT TGGTGCCTCT AGTATATGTG ACCAGGTGTC GTCCTGCATG 2940
TAAATCTCCG AGCTGAGTCT GACTCACAGC CCATGCTGTC ATCTGTGGCA CAAGTGGGTG 3000
TGAGTACGTC CTGCATGCAC TAACGGTGCA GAACATGGCA TGGTGACTAG AAAGTAAAAC 3060
TCCTTTTGAA GTGTCCCAAG GACTGGGTCA GTTAGAACCT GTCTGCCACT ATCTGATGAC 3120
TTACATTGTG GTTTTCTACA AGCCACCTCA GTTAACTTTG GTTCCCCGTG GACTCCCAGG 3180
CTGGAGGAGG AAAGCGTGAG GACGGGGATG ATTTTGATCA CGATTCCATT TATTGCCTTT 3240
ACATAAGGTT GAGGGAAGGG GAAGGTTTGG TTTGTTTGTC TTTTAATTGT TTTTTTTTTC 3300
TTTTTTTTTT TTTTAATTCC CCCACCCCAC CCTCTTTCTT TTGGTGGCTT CCACCACCCT 3360
TAATGGTGAC AGACTCCTGG GCCTGCCACC TTGGACTTCC CTTAGGCTCA CAGTTCAGAT 3420
CTGCATGCAT TGCTTGCATT GTTCTGGTAT CTGAATGTTG ATTCCTCATT TAGGAGTTCA 3480
GCATTAATTT CCAAAATTTT CATGGGGCTT GTGGCAACAC GGGCCGTGAA TCTGTGTATA 3540
AAATTTACTG GCCTTCTTCA CTTACCTGCT CTAGTATCGT ATCGTGTGTG CGTGCGTGTG 3600
TGACGTCAGG CTGCCACGTA AACTTCAGAG AAGAACCTTA AAGCAGACCA TCCATTTTTG 3660
CATGCTCTCT TCTAAGTAGA ATGTTCAATG TAACTAAAAC TAAAATTGCA TGTCAAAGAG 3720
ACCTAGGTTC TTTCTTTCTT TCTTTCTCTC TTTCTTTCAG TTTGCTTTTG GTTTCCTGTA 3780
TATTTGCTTA CTGTGCTGTT CTAGTGGTTG TAGGGTAAAG ACGAACTGGT GAAGCAGTCG 3840
TAGCGCCGAC CGAAGGTGAT TCCAGTTGTA TATGTCACGC AGCATTCGAA GGGACTGTGC 3900
ACGCTCTAAA GATCACAGTT GCTTCTAAGC CAGATTTCAT TTCTATTCTT GTTTTATGTG 3960
CCAAACCCCA AAGTGCATTG GGCCTGAATC TCTGAACACT GTAGACCCAT TAGAAGGAAG 4020
ATTGTTCTGA CCGTCACAAA TTGTAGTGCC TGAAAACACT TAACACTGAT TGTCTAAGAG 4080
ATGAAAGTCC TCCAAAGATG ACACAGGAAA AATACTACAA GTAATTGTGG TGGAAATGTC 4140
TGTGTTCCTT GGGAATGCTG CGCTCTCTGT AGTTTCCATC ATTGGTGCAG TTCGAACGAA 4200
TGAGTAGAGT TCAGAGGTCT TCGTGTTCAC ATTTAAAACT AGATAAATGA CCTCATTTTC 4260
TTGAGCTTGA ATTCATTTTT AATTTTAATT TTATTTTATA CAACGTGTAG ACGGTTCCCT 4320
GTTCTCTGCA TTTAGAAGTA TACACAGTAC AACTGTTAAT TCTGTAAGTA ATTTTTATAA 4380
TTATGATGTA ACTCTTATCC TTCCTTAAAA CATTAAAATA AACCCTTTAT GTGC 4435
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0469--Meiosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0879--Wnt signaling pathway
--
Interpro

IPR003671--SPIN/Ssty
IPR029579--Spindlin-1/z
PROSITE
Pfam

PF02513--Spin-Ssty
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0016568--P:chromatin modification
GO:0007143--P:female meiotic division
GO:0007276--P:gamete generation
GO:0007275--P:multicellular organism development
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0009303--P:rRNA transcription
GO:0016055--P:Wnt signaling pathway
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0068 ENSRNOP00000014787.5 Rattus norvegicus 100 2e-155 545
WERAM-Ict-0207 ENSSTOP00000021942.1 Ictidomys tridecemlineatus 100 2e-155 545
WERAM-Poa-0183 ENSPPYP00000021687.2 Pongo abelii 99 5e-155 543
WERAM-Paa-0201 ENSPANP00000019351.1 Papio anubis 99 5e-155 543
WERAM-Pat-0176 ENSPTRP00000040509.3 Pan troglodytes 99 5e-155 543
WERAM-Orc-0120 ENSOCUP00000010209.2 Oryctolagus cuniculus 99 5e-155 543
WERAM-Hos-0070 ENSP00000365019.3 Homo sapiens 99 5e-155 543
WERAM-Chs-0088 ENSCSAP00000003605.1 Chlorocebus sabaeus 99 5e-155 543
WERAM-Loa-0198 ENSLAFP00000020125.1 Loxodonta africana 99 5e-155 543
WERAM-Ect-0094 ENSETEP00000011128.1 Echinops telfairi 98 6e-155 543
WERAM-Nol-0055 ENSNLEP00000006581.1 Nomascus leucogenys 99 7e-155 543
WERAM-Caj-0186 ENSCJAP00000032147.2 Callithrix jacchus 99 1e-154 542
WERAM-Vip-0060 ENSVPAP00000005581.1 Vicugna pacos 98 2e-154 541
WERAM-Mup-0091 ENSMPUP00000008517.1 Mustela putorius furo 98 2e-154 541
WERAM-Caf-0026 ENSCAFP00000031883.2 Canis familiaris 98 2e-154 541
WERAM-Bot-0039 ENSBTAP00000003961.5 Bos taurus 98 2e-154 541
WERAM-Aim-0042 ENSAMEP00000003478.1 Ailuropoda melanoleuca 98 2e-154 541
WERAM-Tut-0071 ENSTTRP00000005286.1 Tursiops truncatus 98 3e-154 541
WERAM-Ptv-0153 ENSPVAP00000012630.1 Pteropus vampyrus 98 7e-154 540
WERAM-Pes-0014 ENSPSIP00000003800.1 Pelodiscus sinensis 97 5e-152 533
WERAM-Tag-0007 ENSTGUP00000000476.1 Taeniopygia guttata 96 1e-151 532
WERAM-Gaga-0136 ENSGALP00000024012.2 Gallus gallus 96 1e-151 532
WERAM-Fia-0153 ENSFALP00000012957.1 Ficedula albicollis 96 1e-151 532
WERAM-Anp-0123 ENSAPLP00000013743.1 Anas platyrhynchos 96 1e-151 532
WERAM-Sah-0068 ENSSHAP00000008345.1 Sarcophilus harrisii 96 2e-151 531
WERAM-Mod-0114 ENSMODP00000016746.2 Monodelphis domestica 96 3e-151 531
WERAM-Anc-0172 ENSACAP00000016243.1 Anolis carolinensis 95 2e-150 528
WERAM-Fec-0080 ENSFCAP00000006674.3 Felis catus 96 2e-149 525
WERAM-Xet-0074 ENSXETP00000023772.2 Xenopus tropicalis 94 5e-149 523
WERAM-Dan-0140 ENSDNOP00000025924.1 Dasypus novemcinctus 94 8e-146 513
WERAM-Prc-0155 ENSPCAP00000014742.1 Procavia capensis 98 4e-143 504
WERAM-Lac-0098 ENSLACP00000012289.1 Latimeria chalumnae 94 3e-141 498
WERAM-Chh-0051 ENSCHOP00000006189.1 Choloepus hoffmanni 91 2e-140 495
WERAM-Mae-0063 ENSMEUP00000005813.1 Macropus eugenii 96 2e-139 492
WERAM-Otg-0030 ENSOGAP00000001938.2 Otolemur garnettii 99 8e-139 489
WERAM-Mim-0133 ENSMICP00000013220.1 Microcebus murinus 97 1e-137 486
WERAM-Gog-0088 ENSGGOP00000007450.2 Gorilla gorilla 99 2e-137 485
WERAM-Ova-0078 ENSOARP00000008227.1 Ovis aries 98 4e-137 484
WERAM-Dar-0125 ENSDARP00000076360.3 Danio rerio 90 2e-136 481
WERAM-Asm-0209 ENSAMXP00000019889.1 Astyanax mexicanus 91 1e-135 479
WERAM-Cap-0002 ENSCPOP00000000662.2 Cavia porcellus 99 1e-134 475
WERAM-Myl-0093 ENSMLUP00000007758.2 Myotis lucifugus 97 2e-133 472
WERAM-Mam-0172 ENSMMUP00000024457.2 Macaca mulatta 83 4e-131 464
WERAM-Orn-0004 ENSONIP00000000718.1 Oreochromis niloticus 83 1e-128 456
WERAM-Sus-0090 ENSSSCP00000013151.1 Sus scrofa 81 3e-128 454
WERAM-Ten-0015 ENSTNIP00000004207.1 Tetraodon nigroviridis 83 1e-127 452
WERAM-Xim-0189 ENSXMAP00000015073.1 Xiphophorus maculatus 83 2e-127 451
WERAM-Pof-0007 ENSPFOP00000000963.1 Poecilia formosa 83 2e-127 451
WERAM-Tar-0135 ENSTRUP00000029489.1 Takifugu rubripes 82 6e-126 447
WERAM-Meg-0027 ENSMGAP00000002086.2 Meleagris gallopavo 92 9e-126 446
WERAM-Tas-0022 ENSTSYP00000002664.1 Tarsius syrichta 83 1e-125 446
WERAM-Leo-0094 ENSLOCP00000012515.1 Lepisosteus oculatus 94 6e-125 444
WERAM-Ocp-0116 ENSOPRP00000011480.1 Ochotona princeps 83 5e-122 434
WERAM-Orla-0164 ENSORLP00000019105.1 Oryzias latipes 84 8e-121 430
WERAM-Eqc-0019 ENSECAP00000002384.1 Equus caballus 76 8e-118 420
WERAM-Ere-0026 ENSEEUP00000001958.1 Erinaceus europaeus 76 5e-117 417
WERAM-Gaa-0196 ENSGACP00000024164.1 Gasterosteus aculeatus 83 5e-109 390
WERAM-Tub-0036 ENSTBEP00000004285.1 Tupaia belangeri 73 2e-104 375
WERAM-Gam-0128 ENSGMOP00000013441.1 Gadus morhua 73 2e-91 332
Created Date 25-Jun-2016