WERAM Information

Tag Content
WERAM ID WERAM-Hos-0162
Ensembl Protein ID ENSP00000364929.3
Uniprot Accession Q9UK53; ING1_HUMAN; O00532; O43658; Q53ZR3; Q5T9G8; Q5T9G9; Q5T9H0; Q5T9H1; Q9H007; Q9HD98; Q9HD99; Q9NS83; Q9P0U6; Q9UBC6; Q9UIJ1; Q9UIJ2; Q9UIJ3; Q9UIJ4; Q9UK52
Genbank Protein ID NP_001254657.1; NP_005528.4; NP_937860.1; NP_937861.1; NP_937862.1
Protein Name Inhibitor of growth protein 1
Genbank Nucleotide ID NM_001267728.1; NM_005537.5; NM_198217.2; NM_198218.2; NM_198219.2
Gene Name ING1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000153487.12 ENST00000375774.3 ENSP00000364929.3
ENSG00000153487.12 ENST00000333219.8 ENSP00000328436.7
ENSG00000153487.12 ENST00000338450.7 ENSP00000345202.7
ENSG00000153487.12 ENST00000375775.3 ENSP00000364930.3
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 18533182
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 2.00e-12 49.3 354 400
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Domain Profile
  Me_Reader PHD
            PHD.txt   2 tiClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCk 51 
                        t+Cl C+++++ge  m+ Cd+  C+ +wfH +Cv+l+  + p+g +wyCp+C+
  ENSP00000364929.3 354 TYCL-CNQVSYGE--MIGCDNdeCPiEWFHFSCVGLN--HKPKG-KWYCPKCR 400
                        89*9.*******6..*****99***************..*****.*******8 PP
Protein Sequence
(Fasta)		MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL 60
GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW 120
RVSPRPLSPL SPATFGRGFI AVAVIPGLWA RGRGCSSDRL PRPAGPARRQ FQAASLLTRG 180
WGRAWPWKQI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE 240
LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE 300
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ 360
VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY 420
NR 422
Nucleotide Sequence
(Fasta)		AGCGGAGGCG GGGAAGGCGC CCATCTGCGC TGCGCTCGGG GGGGCGCGGG CAGATCGCTG 60
GCTTGGAGAG GACTGTGGCA GGTGAGAGGA CCTGTGCGTC GTTCTCTGCA GACCTGGCCG 120
CCCCGGGTGT CAGAGAGAGG TGGCGAGTTC GTGTCCGCCG GGAATTGTTG GCTGTTGGGG 180
AAACTTTCCT GCGAGGTCAG TCAAGGCTTT GGGGGCTCTG TTTTGAATGT GGATCACCAC 240
TCGGAGTTTA CTAATGTTTA CAAGGCTGCG CAGTAGGGAA ACGGAAGAGT TGGGTGGGGG 300
CAAAAAAAAA AATTGACCGC TATCCCCGAA AGTACTAGAC GCCTCTGCCG GGAAGGCGCC 360
CCTGCGCGTT CTATCCGAGA CGTAGCTTCG CAGCGAATTT TATAGGAACT TCATTAGCAT 420
ATTATGGAAC GTCCCGCCTC AGCCCCCCAG TAGTTGGCTG TGATGTCCTT CGTGGAATGT 480
CCTTATCATT CCCCTGCGGA ACGATTGGTC GCTGAGGCGG ATGAAGGCGG GCCTAGCGCA 540
ATAACTGGTA TGGGTCTGTG TTTCCGCTGT CTTCTTTTTT CTTTTTCGGG GAGGAGCGGG 600
GTGGAGGGTG GACGAGTTGA TTTGAACGTC TTCGGGTCGC TCGGCCTCCA GCCTTGGATT 660
GGTTCTTCTC GCTGCTGGGG CGGGCCGTGC TCTTCCGCCC TGCGGTGTGG TTGGTTCTCC 720
TCCTGGCCTC CGCCCTCCAA ATCGGCGATT CCCATAGGCG GCGGCTCTCG GGGTGCGGGG 780
CGAGTCTCCC GCTGGCCTCC TCCCCATTGG CTGGAGGCCT GGCGGGTGTC GCCCCGGCCC 840
CTCTCCCCGC TCAGCCCGGC CACTTTCGGG CGCGGATTTA TAGCAGTAGC AGTGATCCCG 900
GGCCTGTGGG CTCGGGGCCG GGGCTGCAGT TCGGACCGCC TCCCGCGACC CGCGGGGCCG 960
GCTCGGAGAC AGTTTCAGGC CGCATCTCTG CTGACCCGAG GGTGGGGCCG CGCGTGGCCG 1020
TGGAAACAGA TCCTGAAGGA GCTAGACGAG TGCTACGAGC GCTTCAGTCG CGAGACAGAC 1080
GGGGCGCAGA AGCGGCGGAT GCTGCACTGT GTGCAGCGCG CGCTGATCCG CAGCCAGGAG 1140
CTGGGCGACG AGAAGATCCA GATCGTGAGC CAGATGGTGG AGCTGGTGGA GAACCGCACG 1200
CGGCAGGTGG ACAGCCACGT GGAGCTGTTC GAGGCGCAGC AGGAGCTGGG CGACACAGCG 1260
GGCAACAGCG GCAAGGCTGG CGCGGACAGG CCCAAAGGCG AGGCGGCAGC GCAGGCTGAC 1320
AAGCCCAACA GCAAGCGCTC ACGGCGGCAG CGCAACAACG AGAACCGTGA GAACGCGTCC 1380
AGCAACCACG ACCACGACGA CGGCGCCTCG GGCACACCCA AGGAGAAGAA GGCCAAGACC 1440
TCCAAGAAGA AGAAGCGCTC CAAGGCCAAG GCGGAGCGAG AGGCGTCCCC TGCCGACCTC 1500
CCCATCGACC CCAACGAACC CACGTACTGT CTGTGCAACC AGGTCTCCTA TGGGGAGATG 1560
ATCGGCTGCG ACAACGACGA GTGCCCCATC GAGTGGTTCC ACTTCTCGTG CGTGGGGCTC 1620
AATCATAAAC CCAAGGGCAA GTGGTACTGT CCCAAGTGCC GGGGGGAGAA CGAGAAGACC 1680
ATGGACAAAG CCCTGGAGAA ATCCAAAAAA GAGAGGGCTT ACAACAGGTA GTTTGTGGAC 1740
AGGCGCCTGG TGTGAGGAGG ACAAAATAAA CCGTGTATTT ATTACATTGC TGCCTTTGTT 1800
GAGGTGCAAG GAGTGTAAAA TGTATATTTT TAAAGAATGT TAGTAAAGGA ACCATTCCTT 1860
TCATAGGGAT GGCAGTGATT CTGTTTGCCT TTTGTTTTCA TTGGTACACG TGTAACAAGA 1920
AAGTGGTCTG TGGATCAGCA TTTTAGAAAC TACAAATATA GGTTTGATTC AACACTTAAG 1980
TCTCAGACTG ATTTCTTGCG GGAGGAGGGG GACTAAACTC AACCTAACAC ATTAAATGTG 2040
GAAGGAAAAT ATTTCATTTA GCTTTTTTAT TTTAATACAA GTAATATTAT TACTTTATGA 2100
ACAATTTTTT TTAATTGGCC ATGTCGCCAA AAATACAGCC TATAGTAAAT GTGTTTCTTG 2160
CTGCCATGAT GTATATCCAT ATAACAATTC AGTAACAAAG GTTTAAAGTT TGAAGATTAT 2220
TTTTTAAAAA GGTAAATGGT TAAATTTTAC ATGACAGATA TTTTATCTAT TGGCCTGTTC 2280
CCCAAATGGC CATTTTAAAA TGCTTGGGTA CACTTCTCTT AAGTGGTCTA GTCAAGGAAC 2340
CTCAAGTCAT GCTTTTGCTA TCACCAATCA TAGTGTACCC ATCTTTAATT TATATCAGGT 2400
GTATAAATGT ACATTTCCAA ATGAACTTGC ACTTGTTATA TTATAATTGG AAGTGCAGTC 2460
AGCAGATGCT GTTGTGAAGC TAATGTCACA ATTATGTGCA AAGGTGTGCT TCCTGCTGTA 2520
TGTGAGCTGT AAAAATGTTA CGTGAAGAAA TAAATGAAAC TTGGCCAGTT TGTTCCTCTA 2580
GTAGTATATT TAATTTTGAC ATAAGTAACT TTTAAAATTT GTCTTAAAAA TTTATACACC 2640
AGCAATTTAG ACAAAGCCTT AAGCAAATTT TGTATTATTG TTCTCACTTA TTATTAATAA 2700
TGAAGTAGAA GTTACTTAAT TGCCAGCAAA TAAATACGTG TCAAAAAAGA ATCTGTATTC 2760
AGACCCTGGG TCAGGAAATT ACTGCCCACT TGTCAAGTTC AGCCCACCAT CTGTTTGAAG 2820
ATTATATGAA GTTTAAATTC TAGTGTCCAT AAATAAAGTT TCAGCGGAAC 2871
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR028643--ING1
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0016568--P:chromatin modification
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0010941--P:regulation of cell death
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Paa-0110 ENSPANP00000005560.1 Papio anubis 93 0.0 638
WERAM-Dio-0088 ENSDORP00000008945.1 Dipodomys ordii 67 5e-112 401
WERAM-Ect-0093 ENSETEP00000011108.1 Echinops telfairi 66 8e-111 397
WERAM-Pat-0051 ENSPTRP00000010265.3 Pan troglodytes 99 3e-109 392
WERAM-Gog-0144 ENSGGOP00000011140.2 Gorilla gorilla 99 3e-109 392
WERAM-Nol-0080 ENSNLEP00000009727.1 Nomascus leucogenys 98 1e-108 390
WERAM-Poa-0054 ENSPPYP00000006275.2 Pongo abelii 98 1e-108 390
WERAM-Chs-0206 ENSCSAP00000013496.1 Chlorocebus sabaeus 98 3e-108 389
WERAM-Caj-0145 ENSCJAP00000026053.2 Callithrix jacchus 99 1e-107 387
WERAM-Ptv-0055 ENSPVAP00000005811.1 Pteropus vampyrus 69 3e-105 379
WERAM-Cap-0180 ENSCPOP00000019315.1 Cavia porcellus 74 6e-100 361
WERAM-Ict-0189 ENSSTOP00000019167.1 Ictidomys tridecemlineatus 90 3e-98 355
WERAM-Dan-0197 ENSDNOP00000033547.1 Dasypus novemcinctus 88 1e-97 354
WERAM-Aim-0196 ENSAMEP00000018018.1 Ailuropoda melanoleuca 88 2e-96 350
WERAM-Tag-0116 ENSTGUP00000009109.1 Taeniopygia guttata 88 4e-96 349
WERAM-Caf-0074 ENSCAFP00000009145.1 Canis familiaris 87 4e-96 348
WERAM-Mum-0179 ENSMUSP00000062593.4 Mus musculus 88 8e-96 348
WERAM-Pes-0156 ENSPSIP00000018616.1 Pelodiscus sinensis 87 9e-96 347
WERAM-Mod-0036 ENSMODP00000005573.2 Monodelphis domestica 87 1e-95 347
WERAM-Otg-0039 ENSOGAP00000002553.2 Otolemur garnettii 88 1e-95 347
WERAM-Mup-0121 ENSMPUP00000010546.1 Mustela putorius furo 88 2e-95 347
WERAM-Myl-0143 ENSMLUP00000011702.2 Myotis lucifugus 88 2e-95 347
WERAM-Anp-0057 ENSAPLP00000006316.1 Anas platyrhynchos 88 2e-95 346
WERAM-Mae-0127 ENSMEUP00000012763.1 Macropus eugenii 82 6e-95 345
WERAM-Tut-0127 ENSTTRP00000010355.1 Tursiops truncatus 87 7e-95 345
WERAM-Eqc-0018 ENSECAP00000002300.1 Equus caballus 88 7e-95 345
WERAM-Chh-0082 ENSCHOP00000008858.1 Choloepus hoffmanni 89 7e-95 344
WERAM-Fia-0063 ENSFALP00000004565.1 Ficedula albicollis 87 8e-95 344
WERAM-Sah-0069 ENSSHAP00000008395.1 Sarcophilus harrisii 87 2e-94 343
WERAM-Gaga-0156 ENSGALP00000027168.4 Gallus gallus 81 2e-94 343
WERAM-Prc-0119 ENSPCAP00000010535.1 Procavia capensis 88 3e-94 342
WERAM-Anc-0061 ENSACAP00000006030.2 Anolis carolinensis 86 4e-94 342
WERAM-Ora-0131 ENSOANP00000024605.3 Ornithorhynchus anatinus 86 3e-93 339
WERAM-Meg-0157 ENSMGAP00000016461.2 Meleagris gallopavo 87 1e-92 337
WERAM-Orc-0106 ENSOCUP00000008968.3 Oryctolagus cuniculus 87 2e-92 337
WERAM-Mam-0207 ENSMMUP00000019814.2 Macaca mulatta 99 2e-92 336
WERAM-Ova-0069 ENSOARP00000007525.1 Ovis aries 86 6e-92 335
WERAM-Bot-0195 ENSBTAP00000035217.4 Bos taurus 87 1e-91 333
WERAM-Lac-0063 ENSLACP00000008528.1 Latimeria chalumnae 83 2e-91 333
WERAM-Ran-0095 ENSRNOP00000019454.5 Rattus norvegicus 88 8e-91 331
WERAM-Xet-0056 ENSXETP00000018004.3 Xenopus tropicalis 80 1e-87 320
WERAM-Fec-0211 ENSFCAP00000024152.1 Felis catus 88 9e-87 318
WERAM-Sus-0156 ENSSSCP00000019265.1 Sus scrofa 84 6e-85 311
WERAM-Ocp-0050 ENSOPRP00000004396.1 Ochotona princeps 84 2e-83 306
WERAM-Loa-0220 ENSLAFP00000021507.1 Loxodonta africana 82 6e-83 305
WERAM-Asm-0081 ENSAMXP00000008390.1 Astyanax mexicanus 68 4e-71 265
WERAM-Leo-0081 ENSLOCP00000011043.1 Lepisosteus oculatus 72 9e-71 265
WERAM-Ten-0170 ENSTNIP00000002163.1 Tetraodon nigroviridis 64 1e-67 254
WERAM-Orla-0198 ENSORLP00000022617.2 Oryzias latipes 63 4e-67 252
WERAM-Dar-0050 ENSDARP00000118972.1 Danio rerio 56 6e-66 248
WERAM-Gaa-0028 ENSGACP00000004599.1 Gasterosteus aculeatus 58 5e-65 245
WERAM-Tar-0119 ENSTRUP00000025018.1 Takifugu rubripes 59 4e-64 242
WERAM-Vip-0056 ENSVPAP00000005332.1 Vicugna pacos 56 2e-56 217
WERAM-Orn-0189 ENSONIP00000019769.1 Oreochromis niloticus 53 3e-56 216
WERAM-Mim-0014 ENSMICP00000001205.1 Microcebus murinus 57 4e-56 216
WERAM-Pof-0169 ENSPFOP00000014200.1 Poecilia formosa 52 3e-55 213
WERAM-Soa-0115 ENSSARP00000010879.1 Sorex araneus 58 5e-55 212
WERAM-Tas-0017 ENSTSYP00000002061.1 Tarsius syrichta 58 5e-55 212
WERAM-Ere-0043 ENSEEUP00000003677.1 Erinaceus europaeus 58 7e-55 212
WERAM-Xim-0083 ENSXMAP00000007731.1 Xiphophorus maculatus 52 7e-55 212
WERAM-Gam-0075 ENSGMOP00000008031.1 Gadus morhua 52 1e-53 207
WERAM-Pem-0082 ENSPMAP00000008755.1 Petromyzon marinus 75 2e-30 130
WERAM-Cii-0033 ENSCINP00000012930.3 Ciona intestinalis 34 3e-29 127
WERAM-Drm-0046 FBpp0080103 Drosophila melanogaster 77 2e-27 120
WERAM-Bro-0124 Bo7g036450.1 Brassica oleracea 82 2e-26 117
WERAM-Brr-0075 Bra015016.1-P Brassica rapa 82 2e-26 117
WERAM-Arl-0064 fgenesh2_kg.3__ 2635__ AT3G24010.1 Arabidopsis lyrata 80 3e-26 117
WERAM-Tub-0041 ENSTBEP00000005072.1 Tupaia belangeri 74 3e-26 116
WERAM-Orbr-0038 OB03G13430.1 Oryza brachyantha 74 1e-25 114
WERAM-Amt-0044 ERN15806 Amborella trichopoda 33 2e-25 114
WERAM-Art-0077 AT3G24010.1 Arabidopsis thaliana 76 2e-25 114
WERAM-Org-0031 ORGLA03G0031600.1 Oryza glaberrima 35 3e-25 113
WERAM-Lep-0035 LPERR03G03140.1 Leersia perrieri 74 3e-25 113
WERAM-Orp-0029 OPUNC03G03150.1 Oryza punctata 70 3e-25 113
WERAM-Cis-0004 ENSCSAVP00000000651.1 Ciona savignyi 83 4e-25 113
WERAM-Brd-0037 BRADI1G75507.1 Brachypodium distachyon 78 5e-25 112
WERAM-Ors-0028 OS03T0143600-01 Oryza sativa 70 7e-25 112
WERAM-Orni-0030 ONIVA03G03130.1 Oryza nivara 70 8e-25 112
WERAM-Ori-0037 BGIOSGA011837-PA Oryza indica 70 8e-25 112
WERAM-Orm-0033 OMERI03G03370.1 Oryza meridionalis 70 1e-24 112
WERAM-Orgl-0033 OGLUM03G03290.1 Oryza glumaepatula 35 1e-24 111
WERAM-Thc-0053 EOY05425 Theobroma cacao 78 2e-24 111
WERAM-Orr-0030 ORUFI03G03130.1 Oryza rufipogon 70 2e-24 110
WERAM-Orb-0031 OBART03G03390.1 Oryza barthii 70 2e-24 110
WERAM-Prp-0084 EMJ28765 Prunus persica 76 3e-24 110
WERAM-Mua-0030 GSMUA_Achr1P03410_001 Musa acuminata 72 5e-24 109
WERAM-Met-0017 KEH41192 Medicago truncatula 76 6e-24 109
WERAM-Sem-0058 EFJ35540 Selaginella moellendorffii 76 6e-24 109
Created Date 25-Jun-2016