WERAM Information
Tag | Content | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
WERAM ID | WERAM-Hos-0216 | ||||||||||||
Ensembl Protein ID | ENSP00000328939.4 | ||||||||||||
Uniprot Accession | O14607; UTY_HUMAN; A8K9Z3; E1U199; E1U1A0; F5H4V7; F8W8R7; O14608 | ||||||||||||
Genbank Protein ID | NP_001245181.1; NP_001245183.1; NP_009056.3; NP_872600.1; NP_872601.1 | ||||||||||||
Protein Name | Histone demethylase UTY | ||||||||||||
Genbank Nucleotide ID | NM_001258252.1; NM_001258254.1; NM_007125.4; NM_182659.1; NM_182660.1 | ||||||||||||
Gene Name | KDM6C;UTY | ||||||||||||
Ensembl Information | |||||||||||||
Details |
|
||||||||||||
Status | Reviewed | ||||||||||||
Classification |
|
||||||||||||
Organism | Homo sapiens | ||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||
Functional Description (View) |
Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. | ||||||||||||
Domain Profile | HDM UTX_UTY UTX.txt 1 kwkkqlkelsklpafvrvisaanllshvghtilgmntvqlymkvpgsrtpghqennnlcsvninigpgdcewfavpeeywgklsdlcekn 90 |
||||||||||||
Protein Sequence (Fasta) | MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 60 EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 120 ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 180 KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 240 TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 300 FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 360 SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL 420 TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS 480 SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI 540 LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL 600 SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG 660 IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL 720 IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST 780 EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS 840 TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF 900 PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD 960 PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLREENEK RTQHKDHSDN ESTSSENSGR 1020 RRKGPFKTIK FGTNIDLSDN KKWKLQLHEL TKLPAFARVV SAGNLLTHVG HTILGMNTVQ 1080 LYMKVPGSRT PGHQENNNFC SVNINIGPGD CEWFVVPEDY WGVLNDFCEK NNLNFLMSSW 1140 WPNLEDLYEA NVPVYRFIQR PGDLVWINAG TVHWVQAVGW CNNIAWNVGP LTACQYKLAV 1200 ERYEWNKLKS VKSPVPMVHL SWNMARNIKV SDPKLFEMIK YCLLKILKQY QTLREALVAA 1260 GKEVIWHGRT NDEPAHYCSI CEVEVFNLLF VTNESNTQKT YIVHCHDCAR KTSKSLENFV 1320 VLEQYKMEDL IQVYDQFTLA LSLSSSS 1347 |
||||||||||||
Nucleotide Sequence (Fasta) | TTTGCTCATC GTTTGTTGTT TAGATAATAT CATGAACTGA TAAATGCAGT TGCCACGTTG 60 ATTCCCTAGG GCCTGGCTTA CCGACTGAGG TCATAAGATA TTATGCCTTC TCTTTAGACT 120 TGGTCAGTGG AGAGGAAATG GGCAAAGAAC CAGCCTATGG AGGTGACAAG GCCTTAGGGC 180 CAAAAGTCTT GAGGGTGAAG GTTTAGGGCC TGCGCAGCTT CCCTGCCATG CCCCGCAAGG 240 TCTCGCATTC GCAAGGCTTG TGACAGTGGG AGCCTCATTA CGGACTCTCC TAAAGTCCAT 300 GGTGTCCTCT TTTCGCATTT GCGCCCCGTG GGTGATGCCC GATGCCGCCC TTCCCATCGC 360 TCTCTTCCCC TTCAAGCGTA TCGCAACTGC AAAAACACCC AGCACAGACA CTCCATTTTC 420 TATCTTAATG CATTTAACTA GCACAACCTA CAGGTTGTTC CATCCCAGAG ACTACCCTTT 480 TCTCCATAGA CGTGACCATC AACCAACCAG CGGTCAGAAT CAGTCAGCCT CTGTCATGTT 540 CCTAGGTCCT TGGCGAACTG GCTGGGCGGG GTCCCAGCAG CCTAGGAGTA CAGTGGAGCA 600 ATGCCTGACG TAAGTCAACA AAGATCACGT GAGACGAATC AGTCGCCTAG ATTGGCTACA 660 ACTAAGTGGT TGGGAGCGGG GAGGTCGCGG CGGCTGCGTG GGGTTCGCCC GTGACACAAT 720 TACAACTTTG TGCTGGTGCT GGCAAAGTTT GTGATTTTAA GAAATTCTGC TGTGCTCTCC 780 AGCACTGCGA GCTTCTGCCT TCCCTGTAGT TTCCCAGATG TGATCCAGGT AGCCGAGTTC 840 CGCTGCCCGT GCTTCGGTAG CTTAAGTCTT TGCCTCAGCT TTTTTCCTTG CAGCCGCTGA 900 GGAGGCGATA AAATTGGCGT CACAGTCTCA AGCAGCGATT GAAGGCGTCT TTTCAACTAC 960 TCGATTAAGG TTGGGTATCG TCGTGGGACT TGGAAATTTG TTGTTTCCAT GAAATCCTGC 1020 GCAGTGTCGC TCACTACCGC CGCTGTTGCC TTCGGTGATG AGGCAAAGAA AATGGCGGAA 1080 GGAAAAGCGA GCCGCGAGAG TGAAGAGGAG TCTGTTAGCC TGACAGTCGA GGAAAGGGAG 1140 GCGCTTGGTG GCATGGACAG CCGTCTCTTC GGGTTCGTGA GGCTTCATGA AGATGGCGCC 1200 AGAACGAAGA CCCTACTAGG CAAGGCTGTT CGCTGCTACG AATCTTTAAT CTTAAAAGCT 1260 GAAGGAAAAG TGGAGTCTGA CTTCTTTTGC CAATTAGGTC ACTTCAACCT CTTGTTGGAA 1320 GATTATTCAA AAGCATTATC TGCATATCAG AGATATTACA GTTTACAGGC TGACTACTGG 1380 AAGAATGCTG CGTTTTTATA TGGCCTTGGT TTGGTCTACT TCTACTACAA TGCATTTCAT 1440 TGGGCAATTA AAGCATTTCA AGATGTCCTT TATGTTGACC CCAGCTTTTG TCGAGCCAAG 1500 GAAATTCATT TACGACTTGG GCTCATGTTC AAAGTGAACA CAGACTACAA GTCTAGTTTA 1560 AAGCATTTTC AGTTAGCCTT GATTGACTGT AATCCATGTA CTTTGTCCAA TGCTGAAATT 1620 CAATTTCATA TTGCCCATTT GTATGAAACC CAGAGGAAGT ATCATTCTGC AAAGGAGGCA 1680 TATGAACAAC TTTTGCAGAC AGAAAACCTT CCTGCACAAG TAAAAGCAAC TGTATTGCAA 1740 CAGTTAGGTT GGATGCATCA TAATATGGAT CTAGTAGGAG ACAAAGCCAC AAAGGAAAGC 1800 TATGCTATTC AGTATCTCCA AAAGTCTTTG GAGGCAGATC CTAATTCTGG CCAATCGTGG 1860 TATTTTCTTG GAAGGTGTTA TTCAAGTATT GGGAAAGTTC AGGATGCCTT TATATCTTAC 1920 AGGCAATCTA TTGATAAATC AGAAGCAAGT GCAGATACAT GGTGTTCAAT AGGTGTGTTG 1980 TATCAGCAGC AAAATCAGCC TATGGATGCT TTACAGGCAT ATATTTGTGC TGTACAATTG 2040 GACCATGGGC ATGCCGCAGC CTGGATGGAC CTAGGTACTC TCTATGAATC CTGCAATCAA 2100 CCTCAAGATG CCATTAAATG CTACCTAAAT GCAGCTAGAA GCAAACGTTG TAGTAATACC 2160 TCTACGCTTG CTGCAAGAAT TAAATTTCTA CAGAATGGTT CTGATAACTG GAATGGTGGC 2220 CAGAGTCTTT CACATCATCC AGTACAGCAA GTTTATTCGT TGTGTTTGAC ACCACAGAAA 2280 TTACAGCACT TGGAACAACT GCGAGCAAAT AGAGATAATT TAAATCCAGC ACAGAAGCAT 2340 CAGCTGGAAC AGTTAGAAAG TCAGTTTGTC TTAATGCAGC AAATGAGACA CAAAGAAGTT 2400 GCTCAGGTAC GAACTACTGG AATTCATAAC GGGGCCATAA CTGATTCATC ACTGCCTACA 2460 AACTCTGTCT CTAATCGACA ACCACATGGT GCTCTGACCA GAGTATCTAG CGTCTCTCAG 2520 CCTGGAGTTC GCCCTGCTTG TGTTGAAAAA CTTTTGTCCA GTGGAGCTTT TTCTGCAGGC 2580 TGTATTCCTT GTGGCACATC AAAAATTCTA GGAAGTACAG ACACTATCTT GCTAGGCAGT 2640 AATTGTATAG CAGGAAGTGA AAGTAATGGA AATGTGCCTT ACCTGCAGCA AAATACACAC 2700 ACTCTACCTC ATAATCATAC AGACCTGAAC AGCAGCACAG AAGAGCCATG GAGAAAACAG 2760 CTATCTAACT CCGCTCAGGG GCTTCATAAA AGTCAGAGTT CATGTTTGTC AGGACCTAAT 2820 GAAGAACAAC CTCTGTTTTC CACTGGGTCA GCCCAGTATC ACCAGGCAAC TAGCACTGGT 2880 ATTAAGAAGG CGAATGAACA TCTCACTCTG CCTAGTAATT CAGTACCACA GGGGGATGCT 2940 GACAGTCACC TCTCCTGTCA TACTGCTACC TCAGGTGGAC AACAAGGCAT TATGTTTACC 3000 AAAGAGAGCA AGCCTTCAAA AAATAGATCC TTGGTGCCTG AAACAAGCAG GCATACTGGA 3060 GACACATCTA ATGGCTGTGC TGATGTCAAG GGACTTTCTA ATCATGTTCA TCAGTTGATA 3120 GCAGATGCTG TTTCCAGTCC TAACCATGGA GATTCACCAA ATTTATTAAT TGCAGACAAT 3180 CCTCAGCTCT CTGCTTTGTT GATTGGAAAA GCCAATGGCA ATGTGGGTAC TGGAACCTGT 3240 GACAAAGTGA ATAATATTCA CCCAGCTGTT CATACAAAGA CTGATCATTC TGTTGCCTCT 3300 TCACCCTCTT CAGCCATTTC CACAGCAACA CCTTCTCCTA AATCCACTGA GCAGAGAAGC 3360 ATAAACAGTG TTACCAGCCT TAACAGTCCT CACAGTGGAT TACACACAGT CAATGGAGAG 3420 GGGCTGGGGA AGTCACAGAG CTCTACAAAA GTAGACCTGC CTTTAGCTAG CCACAGATCT 3480 ACTTCTCAGA TCTTACCATC AATGTCAGTG TCTATATGCC CCAGTTCAAC AGAAGTTCTG 3540 AAAGCATGCA GGAATCCAGG TAAAAATGGC TTGTCTAATA GCTGCATTTT GTTAGATAAA 3600 TGTCCACCTC CAAGACCACC AACTTCACCA TACCCACCCT TGCCAAAGGA CAAGTTGAAT 3660 CCACCCACAC CTAGTATTTA CTTGGAAAAT AAACGTGATG CTTTCTTTCC TCCATTACAT 3720 CAATTTTGTA CAAATCCAAA AAACCCTGTT ACAGTAATAC GTGGCCTTGC TGGAGCTCTT 3780 AAATTAGATC TTGGACTTTT CTCTACCAAA ACTTTGGTAG AAGCTAACAA TGAACATATG 3840 GTAGAAGTGA GGACACAGTT GCTGCAACCA GCAGATGAAA ACTGGGATCC CACTGGAACA 3900 AAGAAAATCT GGCGTTGTGA AAGCAATAGA TCTCATACTA CAATTGCCAA ATACGCACAA 3960 TACCAGGCTT CCTCCTTCCA GGAATCATTG AGAGAAGAAA ATGAGAAAAG AACACAACAC 4020 AAAGATCATT CAGATAACGA ATCCACATCT TCAGAGAATT CTGGAAGGAG AAGGAAAGGA 4080 CCTTTTAAAA CCATAAAATT TGGGACCAAC ATTGACCTCT CTGATAACAA AAAGTGGAAG 4140 TTGCAGTTAC ATGAACTGAC TAAACTTCCT GCTTTTGCGC GTGTGGTGTC AGCAGGAAAT 4200 CTTCTAACCC ATGTTGGGCA TACCATTCTG GGCATGAATA CAGTACAACT GTATATGAAA 4260 GTTCCAGGGA GTCGGACACC AGGTCACCAA GAAAATAACA ACTTCTGCTC TGTTAACATA 4320 AATATTGGTC CAGGAGATTG TGAATGGTTT GTTGTACCTG AAGATTATTG GGGTGTTCTG 4380 AATGACTTCT GTGAAAAAAA TAATTTGAAT TTTTTAATGA GTTCTTGGTG GCCCAACCTT 4440 GAAGATCTTT ATGAAGCAAA TGTCCCTGTG TATAGATTTA TTCAGCGACC TGGAGATTTG 4500 GTCTGGATAA ATGCAGGCAC TGTGCATTGG GTTCAAGCTG TTGGCTGGTG CAATAACATT 4560 GCCTGGAATG TTGGTCCACT TACAGCCTGC CAGTATAAAT TGGCAGTGGA ACGGTATGAA 4620 TGGAACAAAT TGAAAAGTGT GAAGTCACCA GTACCCATGG TGCATCTTTC CTGGAATATG 4680 GCACGAAATA TCAAAGTCTC AGATCCAAAG CTTTTTGAAA TGATTAAGTA TTGTCTTTTG 4740 AAAATTCTGA AGCAATATCA GACATTGAGA GAAGCTCTTG TTGCAGCAGG AAAAGAGGTT 4800 ATATGGCATG GGCGGACAAA TGATGAACCA GCTCATTACT GTAGCATTTG TGAGGTGGAG 4860 GTTTTTAATC TGCTTTTTGT CACTAATGAA AGCAATACTC AAAAAACCTA CATAGTACAT 4920 TGCCATGATT GTGCACGAAA AACAAGCAAA AGTTTGGAAA ATTTTGTGGT GCTCGAACAG 4980 TACAAAATGG AGGACCTAAT CCAAGTTTAT GATCAATTTA CACTAGCTCT TTCATTATCA 5040 TCCTCATCTT GATATAGTTC CATGAATATT AAATGAGATT ATTTCTGCTC TTCAGGAAAT 5100 TTCTGCACCA CTGGTTTTGT AGCTGTTTCA TAAAACTGTT GACTAAAAGC TATGTCTATG 5160 CAACCTTCCA AGAATAGTAT GTCAAGCAAC TGGACACAGT GCTGCCTCTG CTTCAGGACT 5220 TAACATGCTG ATCCAGCTGT ACTTCAGAAA AATAATATTA ATCATATGTT TTGTGTACGT 5280 ATGACAAACT GTCAAAGTGA CACAGAATAC TGATTTGAAG ATAGCCTTTT TTATGTTTCT 5340 CTATTTCTGG GCTGATGAAT TAATATTCAT TTGTATTTTA ACCCTGCAGA ATTTTCCTTA 5400 GTTAAAAACA CTTTCCTAGC TGGTCATTTC TTCATAAGAT AGCAAATTTA AATCTCTCCT 5460 CGATCAGCTT TTAAAAAATG TGTACTATTA TCTGAGGAAG TTTTTTACTG CTTTATGTTT 5520 TTGTGTGTTT TGAGGCCATG ATGATTACAT TTGTGGTTCC AAAATAATTT TTTTAAATAT 5580 TAATAGCCCA TATACAAAGA TAATGGATTG CACATAGACA AAGAAATAAA CTTCAGATTT 5640 GTGATTTTTG TTTCTAAACT TGATACAGAT TTACACTATT TATAAATACG TATTTATTGC 5700 CTGAAAATAT TTGTGAATGG AATGTTGTTT TTTTCCAGAC GTAACTGCCA TTAAATACTA 5760 AGGAGTTCTG TAGTTTTAAA CACTACTCCT ATTACATTTT ATATGTGTAG ATAAAACTGC 5820 TTAGTATTAT ACAGAAATTT TTATTAAAAT TGTTAAATGT TTAAAGGGTT TCCCAATGTT 5880 TGAGTTTAAA AAAGACTTTC TGAAAAAATC CACTTTTTGT TCATTTTCAA ACCTAATGAT 5940 TATATGTATT TTATATGTGT GTGTATGTGT ACACACATGT ATAATATATA CAGAAACCTC 6000 GATATATAAT TGTATAGATT TTAAAAGTTT TATTTTTTAC ATCTATGGTA GTTTTTGAGG 6060 TGCCTATTAT AAAGTATTAC GGAAGTTTGC TGTTTTTAAA GTAAATGTCT TTTAGTGTGA 6120 TTTATTAAGT TGTAGTCACC ATAGTGATAG CCCATAAATA ATTGCTGGAA AATTGTATTT 6180 TATAACAGTA GAAAACATAT AGTCAGTGAA GTAAATATTT TAAAGGAAAC ATTATATAGA 6240 TTTGATAAAT GTTGTTTATA ATTAAGAGTT TCTTATGGAA AAGAGATTCA GAATGATAAC 6300 CTCTTTTAGA GAACAAATAA GTGACTTATT TTTTTAAAGC TAGATGACTT TGAAATGCTA 6360 TACTGTCCTG CTTGTACAAC ATGGTTTGGG GTGAAGGGGA GGAAAGTATT AAAAAATCTA 6420 TATCGCTAGT AAATTGTAAT AAGTTCTATT AAAACTTGTA TTTCATATGA AAAATTTGCT 6480 AATTTAATAT TAACTCATTT GATAATAATA CTTGTCTTTT CTACCTCTC |
||||||||||||
Sequence Source | Ensembl | ||||||||||||
Keyword | KW-0002--3D-structure |
||||||||||||
Interpro | IPR003347--JmjC_dom |
||||||||||||
PROSITE | |||||||||||||
Pfam | |||||||||||||
Gene Ontology | GO:0005654--C:nucleoplasm |
||||||||||||
Orthology | |||||||||||||
Created Date | 25-Jun-2016 |