WERAM Information

Tag Content
WERAM ID WERAM-Hos-0014
Ensembl Protein ID ENSP00000322579.3
Uniprot Accession Q9BUL5; PHF23_HUMAN; A1DZ74; B3KVH8; B4DLK6; D3DTN4; Q8IZK0; Q96HG7; Q9H5X0
Genbank Protein ID NP_001271446.1; NP_001271447.1; NP_077273.2
Protein Name PHD finger protein 23
Genbank Nucleotide ID NM_001284517.1; NM_001284518.1; NM_024297.2
Gene Name PHF23
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000040633.12 ENST00000320316.7 ENSP00000322579.3
ENSG00000040633.12 ENST00000454255.6 ENSP00000414607.2
ENSG00000040633.12 ENST00000576955.5 ENSP00000458953.1
ENSG00000040633.12 ENST00000571362.5 ENSP00000460738.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 24535671
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 1.30e-09 40.4 341 386
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
Domain Profile
  Me_Reader PHD
            PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
                        +C+ C+k+ +g++ m++C+ C +w+Hl+C k++++++p+   +yC++Cke
  ENSP00000322579.3 341 TCY-CRKPFAGRP-MIECSLCGTWIHLSCAKIKKTNVPDF--FYCQKCKE 386
                        699.*******98.************************99..******96 PP
Protein Sequence
(Fasta)		MLEAMAEPSP EDPPPTLKPE TQPPEKRRRT IEDFNKFCSF VLAYAGYIPP SKEESDWPAS 60
GSSSPLRGES AADSDGWDSA PSDLRTIQTF VKKAKSSKRR AAQAGPTQPG PPRSTFSRLQ 120
APDSATLLEK MKLKDSLFDL DGPKVASPLS PTSLTHTSRP PAALTPVPLS QGDLSHPPRK 180
KDRKNRKLGP GAGAGFGVLR RPRPTPGDGE KRSRIKKSKK RKLKKAERGD RLPPPGPPQA 240
PPSDTDSEEE EEEEEEEEEE EMATVVGGEA PVPVLPTPPE APRPPATVHP EGVPPADSES 300
KEVGSTETSQ DGDASSSEGE MRVMDEDIMV ESGDDSWDLI TCYCRKPFAG RPMIECSLCG 360
TWIHLSCAKI KKTNVPDFFY CQKCKELRPE ARRLGGPPKS GEP 403
Nucleotide Sequence
(Fasta)		AGGAGGGAGC AGGCGGCCGG CGGCGCGGGG GGAGGGGGCC CGGTCCGGGA GTGCGGGAGG 60
CAGTGGTAGA GGGAGGTGGC GGCAGCGGCT AGCGGACTCG AGTCTCAACC GGGCTGAGGC 120
GGACACTTCT GTGGAGCGAA GCAGTGGGAG CATCGAGCAC TAGAGGCGGC ACCGGGATCC 180
CCGGCTCCGG GGAGGGGGGC GCCGGACCGG GAGGAGGGGA GGGGGCGATG CTGGAAGCCA 240
TGGCGGAGCC CAGTCCCGAA GATCCACCTC CGACCCTTAA GCCAGAGACT CAGCCACCAG 300
AGAAACGGCG GAGAACAATT GAGGATTTCA ACAAATTCTG CAGTTTTGTT TTGGCATATG 360
CTGGTTACAT TCCCCCTAGC AAAGAGGAAA GTGACTGGCC AGCCTCTGGC TCCAGCTCTC 420
CATTGCGAGG AGAGAGTGCG GCCGACAGTG ATGGCTGGGA CTCGGCCCCC TCAGATCTTC 480
GAACCATCCA GACTTTTGTT AAGAAAGCAA AGTCATCCAA GAGAAGGGCA GCTCAAGCAG 540
GTCCCACCCA GCCAGGACCC CCAAGGTCCA CTTTCTCTCG TCTGCAGGCC CCCGACAGTG 600
CTACCTTGCT TGAGAAGATG AAGCTCAAGG ACTCTCTCTT TGATCTGGAT GGGCCCAAAG 660
TGGCATCTCC TTTGTCCCCC ACATCCCTGA CACATACCTC CCGGCCCCCT GCTGCTCTTA 720
CCCCCGTGCC CCTTTCCCAG GGGGACCTCT CCCATCCTCC TCGAAAGAAG GACCGAAAGA 780
ACCGAAAGTT GGGGCCAGGA GCTGGGGCTG GCTTTGGGGT GCTTCGGAGG CCTCGGCCAA 840
CTCCTGGGGA TGGGGAAAAG AGATCTCGAA TCAAGAAGAG CAAGAAGCGG AAGTTAAAAA 900
AGGCAGAACG GGGGGATAGA CTCCCACCTC CTGGGCCTCC CCAGGCACCC CCCAGTGATA 960
CAGACTCTGA AGAGGAGGAG GAAGAGGAGG AAGAGGAAGA AGAAGAAGAG ATGGCAACAG 1020
TGGTAGGGGG TGAAGCCCCA GTCCCTGTGC TGCCAACACC CCCTGAGGCT CCTAGGCCCC 1080
CTGCCACAGT GCACCCTGAA GGAGTCCCTC CTGCTGACAG TGAAAGCAAG GAGGTGGGCA 1140
GCACTGAAAC AAGCCAAGAT GGAGATGCCA GCTCCAGTGA AGGCGAGATG CGGGTCATGG 1200
ACGAGGACAT CATGGTAGAA TCAGGTGATG ACTCATGGGA TCTGATCACA TGTTACTGTC 1260
GAAAGCCCTT TGCAGGGCGG CCCATGATTG AGTGCAGCCT GTGTGGGACG TGGATCCACC 1320
TCTCCTGTGC TAAGATTAAG AAGACCAACG TCCCCGACTT CTTTTATTGC CAGAAATGCA 1380
AGGAACTGAG GCCAGAGGCC CGGCGGTTAG GGGGGCCTCC CAAATCTGGA GAGCCCTGAT 1440
GGCACCAACT TTAGCCTGGA ACTTCCAAAT GACAACATGA TTTGGGAACT GAGCCTCAGG 1500
GTCCTCAGCC TATCCCCTGG AGCTTGGATA CTGTCTGCAC TTCAAGGCAG GAATTCTCAA 1560
GGGAGACTTG TTTGAAAATG AGTGTCTCAC TTTCCCACCC TATCCTTCCT CCCCACTCTG 1620
TGGACTTGAA ATTGAATCCA TTACGGTTGG GGATGGGAGG CTGTCTGTGT CCCGACACAT 1680
AATCTCTGTC TCTTGGACCT GCCACCATCA CTTTCTGGGT CAGGATTGGA ATTGGGATGG 1740
AATGGGACAG TTGTCTATAA AACTCTAGTG TAAATATTAG CACTCCCCTC CCTCATCTTT 1800
TCTTCTATTT CACTCCCCAT TTATTTTCTT CTACACCGGT TGTATTTTTA ATTTTGGACT 1860
TCCCCTATTG GGCATGGCAG CTCAAAGGTG GAGTACTAGA GCCTGGCCAA GTGAGGAAGG 1920
AAAGCAGAAA GGTGACGATT CTCACTCACC TCTTTTGTTT TTAATAATAT CGGCCGCTGT 1980
TTGTACAGAC AGCCTGCGTG TTGTAAATAA AGCAGAGTGG GCTCTTTTGT GTTTATA 2038
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE
Pfam

PF00628--PHD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:1902902--P:negative regulation of autophagosome assembly
GO:1901097--P:negative regulation of autophagosome maturation
GO:0031398--P:positive regulation of protein ubiquitination
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0068 ENSPTRP00000014782.5 Pan troglodytes 100 1e-157 553
WERAM-Paa-0196 ENSPANP00000019606.1 Papio anubis 100 1e-157 553
WERAM-Chs-0146 ENSCSAP00000008107.1 Chlorocebus sabaeus 100 1e-157 553
WERAM-Gog-0064 ENSGGOP00000005695.2 Gorilla gorilla 100 6e-152 534
WERAM-Mam-0087 ENSMMUP00000013822.2 Macaca mulatta 99 7e-152 534
WERAM-Otg-0205 ENSOGAP00000019215.1 Otolemur garnettii 96 7e-151 531
WERAM-Bot-0137 ENSBTAP00000019811.5 Bos taurus 92 1e-149 526
WERAM-Mup-0119 ENSMPUP00000010401.1 Mustela putorius furo 96 3e-147 518
WERAM-Fec-0170 ENSFCAP00000020857.1 Felis catus 95 2e-145 512
WERAM-Ova-0119 ENSOARP00000011777.1 Ovis aries 94 5e-145 511
WERAM-Aim-0188 ENSAMEP00000017447.1 Ailuropoda melanoleuca 95 1e-144 509
WERAM-Caf-0166 ENSCAFP00000023711.4 Canis familiaris 95 3e-144 509
WERAM-Orc-0066 ENSOCUP00000006044.2 Oryctolagus cuniculus 92 6e-144 507
WERAM-Ict-0167 ENSSTOP00000021607.1 Ictidomys tridecemlineatus 96 1e-142 503
WERAM-Mum-0027 ENSMUSP00000018716.3 Mus musculus 94 2e-139 492
WERAM-Sus-0137 ENSSSCP00000019003.2 Sus scrofa 95 6e-139 491
WERAM-Tut-0113 ENSTTRP00000009255.1 Tursiops truncatus 96 3e-138 489
WERAM-Dio-0048 ENSDORP00000004887.1 Dipodomys ordii 94 2e-137 486
WERAM-Loa-0179 ENSLAFP00000017147.2 Loxodonta africana 95 6e-137 484
WERAM-Ect-0034 ENSETEP00000003159.1 Echinops telfairi 92 2e-132 469
WERAM-Ocp-0123 ENSOPRP00000012523.1 Ochotona princeps 80 2e-120 429
WERAM-Sah-0085 ENSSHAP00000009538.1 Sarcophilus harrisii 81 9e-119 424
WERAM-Cap-0141 ENSCPOP00000016640.1 Cavia porcellus 94 2e-118 422
WERAM-Mae-0118 ENSMEUP00000011637.1 Macropus eugenii 82 4e-116 415
WERAM-Ran-0115 ENSRNOP00000024079.4 Rattus norvegicus 90 5e-90 328
WERAM-Soa-0005 ENSSARP00000000405.1 Sorex araneus 94 3e-67 253
WERAM-Caj-0173 ENSCJAP00000030678.2 Callithrix jacchus 96 7e-64 241
WERAM-Pes-0107 ENSPSIP00000013145.1 Pelodiscus sinensis 82 5e-43 172
WERAM-Orla-0058 ENSORLP00000007723.2 Oryzias latipes 62 2e-38 157
WERAM-Pof-0074 ENSPFOP00000006739.1 Poecilia formosa 76 2e-35 147
WERAM-Xim-0197 ENSXMAP00000015829.1 Xiphophorus maculatus 76 2e-35 147
WERAM-Orn-0221 ENSONIP00000023859.1 Oreochromis niloticus 76 1e-34 145
WERAM-Ten-0121 ENSTNIP00000013041.1 Tetraodon nigroviridis 74 1e-34 144
WERAM-Gaa-0208 ENSGACP00000025644.1 Gasterosteus aculeatus 74 1e-34 144
WERAM-Leo-0150 ENSLOCP00000017823.1 Lepisosteus oculatus 70 7e-34 142
WERAM-Asm-0119 ENSAMXP00000012156.1 Astyanax mexicanus 72 7e-34 142
WERAM-Gam-0077 ENSGMOP00000008386.1 Gadus morhua 73 4e-33 139
WERAM-Dar-0079 ENSDARP00000107356.2 Danio rerio 70 6e-33 139
WERAM-Tar-0129 ENSTRUP00000028438.1 Takifugu rubripes 67 3e-31 133
WERAM-Lac-0153 ENSLACP00000017918.1 Latimeria chalumnae 70 3e-27 120
WERAM-Prc-0134 ENSPCAP00000012250.1 Procavia capensis 71 5e-27 119
WERAM-Mod-0052 ENSMODP00000007352.1 Monodelphis domestica 71 7e-27 119
WERAM-Tub-0120 ENSTBEP00000013288.1 Tupaia belangeri 71 8e-27 119
WERAM-Eqc-0061 ENSECAP00000007783.1 Equus caballus 71 1e-26 118
WERAM-Poa-0015 ENSPPYP00000002246.1 Pongo abelii 71 1e-26 118
WERAM-Mim-0144 ENSMICP00000014885.1 Microcebus murinus 71 1e-26 118
WERAM-Ora-0109 ENSOANP00000020536.1 Ornithorhynchus anatinus 71 1e-26 118
WERAM-Ptv-0147 ENSPVAP00000012281.1 Pteropus vampyrus 71 1e-26 118
WERAM-Ere-0040 ENSEEUP00000003023.1 Erinaceus europaeus 71 1e-26 118
WERAM-Dan-0176 ENSDNOP00000027263.1 Dasypus novemcinctus 71 1e-26 117
WERAM-Vip-0065 ENSVPAP00000005888.1 Vicugna pacos 71 3e-26 117
WERAM-Xet-0076 ENSXETP00000024365.3 Xenopus tropicalis 67 5e-26 116
WERAM-Myl-0012 ENSMLUP00000000964.2 Myotis lucifugus 76 7e-26 115
WERAM-Fia-0120 ENSFALP00000010247.1 Ficedula albicollis 68 4e-25 113
WERAM-Anp-0150 ENSAPLP00000015580.1 Anas platyrhynchos 68 4e-25 113
WERAM-Tag-0039 ENSTGUP00000002655.1 Taeniopygia guttata 68 5e-25 112
WERAM-Gaga-0174 ENSGALP00000041130.1 Gallus gallus 68 8e-25 112
WERAM-Meg-0010 ENSMGAP00000000678.1 Meleagris gallopavo 68 8e-25 112
WERAM-Anc-0186 ENSACAP00000022041.1 Anolis carolinensis 55 1e-24 111
WERAM-Nol-0089 ENSNLEP00000010509.2 Nomascus leucogenys 67 8e-19 92.4
Created Date 25-Jun-2016