WERAM Information

Tag Content
WERAM ID WERAM-Mum-0027
Ensembl Protein ID ENSMUSP00000018716.3
Uniprot Accession Q8BSN5; PHF23_MOUSE; Q3TCH1; Q8BT31; Q8CDY2; Q8CIA4; Q8CIU8; Q8CIU9; Q9CWC8
Genbank Protein ID NP_001278054.1; NP_001278055.1; NP_001278056.1; NP_084340.2; XP_006534565.2; XP_006537281.2
Protein Name PHD finger protein 23
Genbank Nucleotide ID NM_001291125.1; NM_001291126.1; NM_001291127.1; NM_030064.4; XM_006534502.2; XM_006537218.2
Gene Name PHF23
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000018572.10 ENSMUST00000018716.9 ENSMUSP00000018716.3
ENSMUSG00000018572.10 ENSMUST00000101526.8 ENSMUSP00000099064.2
ENSMUSG00000018572.10 ENSMUST00000133485.7 ENSMUSP00000117373.1
ENSMUSG00000018572.10 ENSMUST00000135814.1 ENSMUSP00000120665.1
ENSMUSG00000018572.10 ENSMUST00000153684.7 ENSMUSP00000121780.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me3 K 23201125
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 7.20e-10 40.4 339 384
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria.
Domain Profile
  Me_Reader PHD
               PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
                           +C+ C+k+ +g++ m++C+ C +w+Hl+C k++++++p+   +yC++Cke
  ENSMUSP00000018716.3 339 TCY-CRKPFAGRP-MIECSLCGTWIHLSCAKIKKTNVPDF--FYCQKCKE 384
                           699.*******98.************************99..******96 PP
Protein Sequence
(Fasta)		MLEAMAEPSP EDPPPTLKPE TQPPEKRRRT IEDFNKFCSF VLAYAGYIPP SKEESDWPAS 60
GSSSPLRGES AADSDGWDSA PSDLRTIQTF VKKAKSSKRR AVQSGPTQPG PPRSTFSRLQ 120
APDSATLLEK MKLKDSLFDL DGPKVASPLS PTSLTHTSRP PAALAPVPLS QGDLSQPRKK 180
DRKNRKLGPG GGAGFGVLRR PRPAPGDGEK RSRIKKSKKR KLKKADRGDR LPPPGPPRAP 240
PSDTDSEEEE EEEEEEDDEE EMTVGGGVPA PVLPTPPEAP RPPVTVHSEG APPTDSEGKD 300
VGSTETSQDG DASSSEGEMR VMDEDIMVES GDDSWDLITC YCRKPFAGRP MIECSLCGTW 360
IHLSCAKIKK TNVPDFFYCQ KCKELRPEAR RLGGLPKSGE P 401
Nucleotide Sequence
(Fasta)		GAGGGAGGAG AGAGGAGGAG GAGGAGGAGG GAGCAGGCGG CCGGCGGTGC GGGGGGAGGG 60
GGCCCGGTCC GGGAGTGCGG GAGGCAGTGG TGGAGGGAGG TGGCGGTAGC GGAGTGGAGT 120
CTCAACCGCG CCAAGCGGAC ACTTCGGTGG AGCGAGGCGG TAGAAACACG GAGCACTCAA 180
GGCAGCACCG GGAATCCCGG CTTCGAGGAG GGGGTCGCCG GACCGGGTGG AGGGGAGGGG 240
GCGATGCTGG AAGCCATGGC GGAGCCCAGT CCCGAAGATC CGCCTCCGAC TCTTAAACCA 300
GAGACTCAGC CACCGGAGAA AAGGCGGAGA ACCATTGAGG ATTTTAACAA ATTCTGCAGT 360
TTTGTCTTGG CCTATGCTGG TTACATCCCC CCTAGCAAAG AGGAAAGCGA TTGGCCAGCC 420
TCTGGCTCTA GCTCTCCATT GCGAGGTGAG AGTGCAGCAG ACAGTGATGG CTGGGACTCG 480
GCCCCGTCGG ACCTTCGAAC TATCCAGACT TTTGTTAAGA AAGCAAAGTC ATCAAAGAGA 540
AGGGCAGTTC AATCAGGTCC TACCCAGCCA GGACCCCCAA GGTCCACTTT TTCTCGTCTG 600
CAGGCTCCTG ACAGTGCTAC TCTGCTTGAG AAGATGAAGC TCAAGGACTC TCTTTTTGAT 660
CTGGATGGGC CCAAAGTGGC ATCTCCACTC TCTCCCACAT CATTGACGCA TACTTCCCGG 720
CCCCCCGCTG CTCTCGCCCC AGTGCCGCTG TCCCAGGGGG ACCTCTCCCA GCCTCGAAAG 780
AAGGACCGAA AGAATAGAAA GTTGGGACCA GGAGGTGGGG CTGGCTTTGG GGTGCTTCGG 840
AGACCTCGAC CAGCTCCTGG GGATGGGGAA AAGCGGTCTC GAATCAAGAA GAGCAAGAAG 900
CGGAAGTTGA AAAAGGCAGA TCGGGGAGAT AGACTCCCAC CTCCTGGCCC TCCTAGGGCT 960
CCTCCCAGTG ATACAGACTC TGAAGAGGAG GAGGAAGAGG AAGAAGAGGA AGATGATGAG 1020
GAAGAGATGA CAGTGGGGGG TGGAGTCCCA GCCCCTGTGC TCCCAACACC CCCTGAGGCC 1080
CCCAGGCCCC CTGTTACAGT GCACTCTGAA GGTGCTCCCC CTACTGACAG TGAAGGCAAA 1140
GATGTGGGCA GCACAGAAAC AAGCCAAGAT GGAGATGCTA GCTCCAGTGA AGGCGAGATG 1200
CGGGTCATGG ATGAGGACAT CATGGTAGAA TCAGGTGACG ACTCCTGGGA TCTGATCACG 1260
TGTTACTGCA GAAAGCCCTT TGCGGGGCGG CCCATGATTG AGTGCAGCCT CTGTGGGACG 1320
TGGATCCACC TCTCCTGTGC TAAGATTAAG AAGACCAACG TTCCCGACTT CTTTTATTGC 1380
CAGAAATGCA AGGAACTTCG GCCAGAGGCC CGGCGGTTAG GGGGTCTCCC CAAATCTGGA 1440
GAACCCTGAC ATCACTAAGG CTGGAACTTG TGACATTACT TGGGAACTGA GCCTCAGGGT 1500
CCCCAGCCTT CCCTTGGAGT GAGGAGGCTG TCCCCACTTG AGGGCCACAA TTCCCAAGGG 1560
AGACGTATTT GGAAATGAGT GTCTTCTACT CTGTCCTTCC TGCTCCATGG ACTTGAAGTT 1620
GACCCCATTA CAGTTGGGTC GGGGAGGCTG GATCTGTAGA CAGAATCTCT GTCCAGTCAA 1680
CCCTGTACCC TTTTCACTTG CAGGTCCAGG GCTCAAACTG GGATGTAATG GGATAGTTGT 1740
CTATAAAACT GTAGTGTAAA TACAGCACTC CCCTCATGTT TCTTCTCTCT CCCGTTTACT 1800
TTCTTTTACA CCGGATGTAT TTTTAATTTG GGGCTCCCCC ATTTGAGCGA GGTTGCTCAG 1860
AGGTGGAGTA CCAAAGCCTG TGGAGTGAGG AAGGAAAGAA AAAGGTGTCA ATTAGCACTC 1920
GCCTCGTTTT TAATACTGTT GGCCGGCTGC TCAGACAGAC GGCCTGCGTG TTGTAAATAA 1980
AGCAGAGTGG GCTCTTGTGT TTTACA 2007
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE
Pfam

PF00628--PHD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:1902902--P:negative regulation of autophagosome assembly
GO:1901097--P:negative regulation of autophagosome maturation
GO:0031398--P:positive regulation of protein ubiquitination
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ict-0167 ENSSTOP00000021607.1 Ictidomys tridecemlineatus 94 2e-151 532
WERAM-Orc-0066 ENSOCUP00000006044.2 Oryctolagus cuniculus 91 2e-149 525
WERAM-Otg-0205 ENSOGAP00000019215.1 Otolemur garnettii 94 4e-149 525
WERAM-Ova-0119 ENSOARP00000011777.1 Ovis aries 92 8e-149 523
WERAM-Mup-0119 ENSMPUP00000010401.1 Mustela putorius furo 95 1e-148 523
WERAM-Aim-0188 ENSAMEP00000017447.1 Ailuropoda melanoleuca 94 2e-148 522
WERAM-Caf-0166 ENSCAFP00000023711.4 Canis familiaris 94 5e-148 521
WERAM-Bot-0137 ENSBTAP00000019811.5 Bos taurus 91 7e-148 520
WERAM-Fec-0170 ENSFCAP00000020857.1 Felis catus 92 8e-148 520
WERAM-Paa-0196 ENSPANP00000019606.1 Papio anubis 94 2e-147 519
WERAM-Chs-0146 ENSCSAP00000008107.1 Chlorocebus sabaeus 94 2e-147 519
WERAM-Hos-0014 ENSP00000322579.3 Homo sapiens 94 7e-147 517
WERAM-Pat-0068 ENSPTRP00000014782.5 Pan troglodytes 94 2e-146 516
WERAM-Mam-0087 ENSMMUP00000013822.2 Macaca mulatta 94 7e-142 501
WERAM-Gog-0064 ENSGGOP00000005695.2 Gorilla gorilla 93 2e-141 499
WERAM-Dio-0048 ENSDORP00000004887.1 Dipodomys ordii 91 4e-141 498
WERAM-Sus-0137 ENSSSCP00000019003.2 Sus scrofa 93 2e-140 496
WERAM-Tut-0113 ENSTTRP00000009255.1 Tursiops truncatus 93 4e-139 491
WERAM-Cap-0141 ENSCPOP00000016640.1 Cavia porcellus 92 5e-127 451
WERAM-Ran-0115 ENSRNOP00000024079.4 Rattus norvegicus 94 5e-89 325
WERAM-Ocp-0123 ENSOPRP00000012523.1 Ochotona princeps 92 7e-80 295
WERAM-Ect-0034 ENSETEP00000003159.1 Echinops telfairi 96 3e-78 289
WERAM-Soa-0005 ENSSARP00000000405.1 Sorex araneus 94 2e-75 280
WERAM-Loa-0179 ENSLAFP00000017147.2 Loxodonta africana 95 3e-74 276
WERAM-Sah-0085 ENSSHAP00000009538.1 Sarcophilus harrisii 83 6e-65 245
WERAM-Mae-0118 ENSMEUP00000011637.1 Macropus eugenii 82 2e-61 234
WERAM-Caj-0173 ENSCJAP00000030678.2 Callithrix jacchus 95 2e-61 233
WERAM-Pes-0107 ENSPSIP00000013145.1 Pelodiscus sinensis 82 2e-43 173
WERAM-Orla-0058 ENSORLP00000007723.2 Oryzias latipes 63 7e-40 162
WERAM-Gaa-0208 ENSGACP00000025644.1 Gasterosteus aculeatus 69 8e-36 148
WERAM-Pof-0074 ENSPFOP00000006739.1 Poecilia formosa 76 1e-35 147
WERAM-Xim-0197 ENSXMAP00000015829.1 Xiphophorus maculatus 76 1e-35 147
WERAM-Ten-0121 ENSTNIP00000013041.1 Tetraodon nigroviridis 74 6e-35 145
WERAM-Orn-0221 ENSONIP00000023859.1 Oreochromis niloticus 76 7e-35 145
WERAM-Leo-0150 ENSLOCP00000017823.1 Lepisosteus oculatus 70 4e-34 142
WERAM-Asm-0119 ENSAMXP00000012156.1 Astyanax mexicanus 72 5e-34 142
WERAM-Gam-0077 ENSGMOP00000008386.1 Gadus morhua 73 3e-33 140
WERAM-Dar-0079 ENSDARP00000107356.2 Danio rerio 70 4e-33 139
WERAM-Tar-0129 ENSTRUP00000028438.1 Takifugu rubripes 75 3e-31 133
WERAM-Lac-0153 ENSLACP00000017918.1 Latimeria chalumnae 70 3e-27 120
WERAM-Prc-0134 ENSPCAP00000012250.1 Procavia capensis 71 5e-27 119
WERAM-Mod-0052 ENSMODP00000007352.1 Monodelphis domestica 71 6e-27 119
WERAM-Tub-0120 ENSTBEP00000013288.1 Tupaia belangeri 71 7e-27 119
WERAM-Eqc-0061 ENSECAP00000007783.1 Equus caballus 71 9e-27 118
WERAM-Mim-0144 ENSMICP00000014885.1 Microcebus murinus 71 1e-26 118
WERAM-Poa-0015 ENSPPYP00000002246.1 Pongo abelii 71 1e-26 118
WERAM-Ora-0109 ENSOANP00000020536.1 Ornithorhynchus anatinus 71 1e-26 118
WERAM-Ptv-0147 ENSPVAP00000012281.1 Pteropus vampyrus 71 1e-26 118
WERAM-Dan-0176 ENSDNOP00000027263.1 Dasypus novemcinctus 71 1e-26 118
WERAM-Ere-0040 ENSEEUP00000003023.1 Erinaceus europaeus 71 1e-26 118
WERAM-Vip-0065 ENSVPAP00000005888.1 Vicugna pacos 71 2e-26 117
WERAM-Xet-0076 ENSXETP00000024365.3 Xenopus tropicalis 67 4e-26 116
WERAM-Myl-0012 ENSMLUP00000000964.2 Myotis lucifugus 76 6e-26 115
WERAM-Fia-0120 ENSFALP00000010247.1 Ficedula albicollis 68 4e-25 113
WERAM-Anp-0150 ENSAPLP00000015580.1 Anas platyrhynchos 68 4e-25 113
WERAM-Tag-0039 ENSTGUP00000002655.1 Taeniopygia guttata 68 4e-25 113
WERAM-Gaga-0174 ENSGALP00000041130.1 Gallus gallus 68 7e-25 112
WERAM-Meg-0010 ENSMGAP00000000678.1 Meleagris gallopavo 68 8e-25 112
WERAM-Anc-0186 ENSACAP00000022041.1 Anolis carolinensis 57 7e-24 108
WERAM-Nol-0089 ENSNLEP00000010509.2 Nomascus leucogenys 67 8e-19 92.4
WERAM-Scp-0015 SPAC343.11c.1:pep Schizosaccharomyces pombe 39 6e-06 49.7
Created Date 25-Jun-2016