WERAM Information

Tag Content
WERAM ID WERAM-Hos-0029
Ensembl Protein ID ENSP00000320566.5
Uniprot Accession Q9NXR8; ING3_HUMAN; A8K790; O60394; Q567P3; Q6GMT3; Q7Z762; Q969G0; Q96DT4; Q9HC99; Q9P081
Genbank Protein ID NP_061944.2; NP_938008.1
Protein Name Inhibitor of growth protein 3
Genbank Nucleotide ID NM_019071.2; NM_198267.1
Gene Name ING3;HSPC301
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000071243.15 ENST00000315870.9 ENSP00000320566.5
ENSG00000071243.15 ENST00000431467.1 ENSP00000388506.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader PHD PHD-type H3K4me2/3 K 24463511
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader PHD 4.10e-12 48.4 361 407
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
Domain Profile
  Me_Reader PHD
            PHD.txt   2 tiClvCgkddegekemvqCde..Cd.dwfHlkCvklplsslpegkswyCpsCk 51 
                         +C+ C+++++ge  mv Cd+  C+ +wfH+ Cv+l+  ++p+g +wyCp+C+
  ENSP00000320566.5 361 RYCI-CNQVSYGE--MVGCDNqdCPiEWFHYGCVGLT--EAPKG-KWYCPQCT 407
                        69*9.*******6..**********************..*****.*******8 PP
Protein Sequence
(Fasta)		MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE 60
QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE 120
RRSLELDTPS QPVNNHHAHS HTPVEKRKYN PTSHHTTTDH IPEKKFKSEA LLSTLTSDAS 180
KENTLGCRNN NSTASSNNAY NVNSSQPLGS YNIGSLSSGT GAGAITMAAA QAVQATAQMK 240
EGRRTSSLKA SYEAFKNNDF QLGKEFSMAR ETVGYSSSSA LMTTLTQNAS SSAADSRSGR 300
KSKNNNKSSS QQSSSSSSSS SLSSCSSSST VVQEISQQTT VVPESDSNSQ VDWTYDPNEP 360
RYCICNQVSY GEMVGCDNQD CPIEWFHYGC VGLTEAPKGK WYCPQCTAAM KRRGSRHK 418
Nucleotide Sequence
(Fasta)		TTTTTTTTTT TTTCTTTTTT TTTTTTTGCC GGAGTCGAGC GGGTGCTGCT AGCGGAGGCG 60
CCATATTGGA GGGGACAAAA CTCCGGCGAC AGCGAGTGAC ACAAATAAAC CCCTGGACCC 120
CCTTGTTCCC TCAGCTCTAA GGGCCGCGAT GTTGTACCTA GAAGACTATC TGGAAATGAT 180
TGAGCAGCTT CCTATGGATC TGCGGGACCG CTTCACGGAA ATGCGCGAGA TGGACCTGCA 240
GGTGCAGAAT GCAATGGATC AACTAGAACA AAGAGTCAGT GAATTCTTTA TGAATGCAAA 300
GAAAAATAAA CCTGAGTGGA GGGAAGAGCA AATGGCATCC ATCAAAAAAG ACTACTATAA 360
AGCTTTGGAA GATGCAGATG AGAAGGTTCA GTTGGCAAAC CAGATATATG ACTTGGTAGA 420
TCGACACTTG AGAAAGCTGG ATCAGGAACT GGCTAAGTTT AAAATGGAGC TGGAAGCTGA 480
TAATGCTGGA ATTACAGAAA TATTAGAGAG GCGATCTTTG GAATTAGACA CTCCTTCACA 540
GCCAGTGAAC AATCACCATG CTCATTCACA TACTCCAGTG GAAAAAAGGA AATATAATCC 600
AACTTCTCAC CATACGACAA CAGATCATAT TCCTGAAAAG AAATTTAAAT CTGAAGCTCT 660
TCTATCCACC CTTACGTCAG ATGCCTCTAA GGAAAATACA CTAGGTTGTC GAAATAATAA 720
TTCCACAGCC TCTTCTAACA ATGCCTACAA TGTGAATTCC TCCCAACCTC TGGGATCCTA 780
TAACATTGGC TCGTTATCTT CAGGAACTGG TGCAGGGGCA ATTACCATGG CAGCTGCTCA 840
AGCAGTTCAG GCTACAGCTC AGATGAAGGA GGGACGAAGA ACATCAAGTT TAAAAGCCAG 900
TTATGAAGCA TTTAAGAATA ATGACTTTCA GTTGGGAAAA GAATTTTCAA TGGCCAGGGA 960
AACAGTTGGC TATTCATCAT CTTCGGCACT TATGACAACA TTAACACAGA ATGCCAGTTC 1020
ATCAGCAGCC GACTCACGGA GTGGTCGAAA GAGCAAAAAC AACAACAAGT CTTCAAGCCA 1080
GCAGTCATCA TCTTCCTCCT CCTCTTCTTC CTTATCATCG TGTTCTTCAT CATCAACTGT 1140
TGTACAAGAA ATCTCTCAAC AAACAACTGT AGTGCCAGAA TCTGATTCAA ATAGTCAGGT 1200
TGATTGGACT TACGACCCAA ATGAACCTCG ATACTGCATT TGTAATCAGG TATCTTATGG 1260
TGAGATGGTG GGATGTGATA ACCAAGATTG CCCTATAGAA TGGTTCCATT ATGGCTGCGT 1320
TGGATTGACA GAGGCACCAA AAGGCAAATG GTACTGTCCA CAGTGCACTG CTGCAATGAA 1380
GAGAAGAGGC AGCAGACACA AATAAAGGTG GTCCTTTTGT TTGATGAAGA AATAAACTTC 1440
AGCTGAAGAT TTTATATAGG ACTTTAAAAA GAAGAGAAGA GAAAGAAGAA ACAATGCATT 1500
TCCAGGCAAC CACTTAAAGG ATTTACATAG ACAATCCTAT AAGATCTTGA ACTTGAATTT 1560
TATGGGTTGT ATTTTAATAA TGTAAGTAAA TTATTTATGC ACTCCTGGTG TGCTATGAAT 1620
ATTATTCCAG TTAGCCTTGG ATTATTTCAG TGGCCAACAT ATGCAGACAT TTGTACTCCT 1680
CAACCATTTT CTCAAAGTAA TGGGCATTCT ATGATTTAGA CTTCAAGGAA TTCCAATGAT 1740
GAAGATTTTA AGGAAAGTAT TTTATATTCA ACAGGTATAT TCTGCTGCAT GTACTGTACT 1800
CCAGAGCTGT TATGTAACAC TGTATATAAA TGGTTGCAAA AAAAAAAAAA AGTCAGTGCT 1860
TCTAAAAAGA ATTTAAGATA ATGGTTTTTA AAATGCCTTT ATAATAAGCT TTGTTTCTTT 1920
GTGAAACTAA TTCAGCAGGC TGAAGGAAAT GGTTCATGTG ATAATGTGGG CTGGTATCCT 1980
CTAGAGTACC TGGGTACATA AACAGAAACT CCTGTAGGTA AAAAGTAATT TGTGCCATTA 2040
GTCTTTCTAT GTTTCTGCAT CCAGATAGAG TGCAGTTCAT GAGGGAGGGG GCGGGGGACT 2100
GAAGGGGAAA GGGCGTTAAA GTGATACATT TTTATACCAA ATGTGTTTAT TTTTTTGTGC 2160
AAGTAATCCT TAAAATTGCA ATTGTATTAG GTGTTAAAAT AAAGTTTTTA AAAAATTACT 2220
TGTATTTATA CTTTACATAC TTAATAATGA AAATTTCTGA ATTCCAATTA ACTTTCAACT 2280
TTCATAATCT AAAAAGAATC AGAGACCCAG GACACAGAAT ACTGTGTAAT CTGTGATGTC 2340
TTTAATGATG TTTAGAGTTT GTGATATAAG AATACAGGAA AGACATTTTT AATGTAAATT 2400
TGAAATGCCA ATGTATTTTT TTAAGAACAT CATCTGGCTT TTCCTTCAGT CTAAAAGACA 2460
TGAAAGAAGT GTAAGTATAG CAGTTAAAAC GAAAATAATG GTTATGGGTG TTTTGACTGG 2520
AGGCAATGTA GCCAAATAGA GTAAAGAGAC CCCCCTGGTC GGGAGCTCCA AATTGAGCTA 2580
TTTTTGATTC TACCACTTAC TGATATGACA GTTAATTCAA ATTTTGTATC ACTCTGGGCC 2640
TTACTACACC AGGGTGATGC TGACTGCAGA ATAGATCTTA TTCTAAGGTG CTATTTAAAT 2700
TATAAATTTG CATAGTGGAG GTTTTATTTA AAGTATAATA TTGAGTCTGG TCGATAGAAA 2760
AATCCTTAAC TTTTAAGATA CTTAATATAT CATATATATT TTATATTGAA ACTTACTGGG 2820
TCCATCAGAT TTCTGCTTTA ATTAAACCAC TTATGAGCTT CTTAGAACTT ATTCAGATAA 2880
CAGTGTAAAA TCTATGCAGT GCTACCCAAA GGGTGTGAGG TAGATAGGGG ATTTCAAAGA 2940
TCTCTTCCAC CTTTGAGATC CCATGATTCT GAGCTGCCAC AGTCTGATTA TACAACTCTA 3000
CCAGCTCCCT AAACAAGTTA GGTTCATTTG TGAGTACTCA TCATTTCATA ATATCATGAT 3060
TATCACGATT TCATGATACT CAATATTTTG AGATTTTATA ACCCTTTAAG AAGTGATAAA 3120
TAATGTAGTA TTCAATTCGT TTATCAAAGT ATATTGCCTG GAAATGCTCA CATGTATCAT 3180
TTACATCCTC TATATATTAT GACTATTCCA AACTCATTCA TTTTATAGAA ATGGTCAAAG 3240
GAAAAAGCCT TATGTACAGC CTTATTTGAA GAGAAAGTTC TTTGTCTGAG TCAGGAACAT 3300
CCTGTTATCC AGCTGCTACA TCCCCTTTCA GTGTGAATTC CACTCCTTAC CAAATCACTT 3360
AGAAAACACT TTGACAAGTT TTAAACTCAA ACACTGAATA TTTTATGAAG CATGTGTAAA 3420
GAAAGAAACC AAAATTTGGT GCAGGTATTT AGTAATGGGT AGAACCTGTT AATATCTGAG 3480
TCATATATAA TGGGGCCAAA CATGGAACTA CCTCATCAAC CCCCCAAAAA TGTGGCCAAC 3540
TATTAATATT CTTTGTGACA TTTACACCAA GGGGCATAGT AAGTATTTTT GGTATTATAA 3600
AATACACATT CAAAATCTCT GTTGTACAAA ACTCATGTAA CAGTTGGGAC AAAATATCCA 3660
AATGTGGGTT CACAGTTCAC AGGTGGTGAA AATTGAGGCC TTACTGCTAT GGAGTGTATA 3720
TCAAAATGTT CATGGTGACA CATTTGAAGC AATAAATGGC TTAATTAAAT GCCAAAA 3778
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0043065--P:positive regulation of apoptotic process
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0165 ENSPPYP00000020124.2 Pongo abelii 100 0.0 692
WERAM-Pat-0164 ENSPTRP00000033606.4 Pan troglodytes 100 0.0 692
WERAM-Nol-0127 ENSNLEP00000014397.1 Nomascus leucogenys 100 0.0 692
WERAM-Paa-0124 ENSPANP00000004010.1 Papio anubis 100 0.0 692
WERAM-Chs-0132 ENSCSAP00000006990.1 Chlorocebus sabaeus 100 0.0 692
WERAM-Mup-0077 ENSMPUP00000006997.1 Mustela putorius furo 99 0.0 687
WERAM-Caf-0038 ENSCAFP00000005192.3 Canis familiaris 99 0.0 687
WERAM-Ict-0046 ENSSTOP00000003622.2 Ictidomys tridecemlineatus 99 0.0 686
WERAM-Eqc-0045 ENSECAP00000006448.1 Equus caballus 99 0.0 686
WERAM-Bot-0150 ENSBTAP00000021725.5 Bos taurus 98 0.0 685
WERAM-Myl-0177 ENSMLUP00000014873.2 Myotis lucifugus 99 0.0 684
WERAM-Aim-0073 ENSAMEP00000006322.1 Ailuropoda melanoleuca 99 0.0 684
WERAM-Orc-0015 ENSOCUP00000001622.3 Oryctolagus cuniculus 99 0.0 684
WERAM-Dan-0010 ENSDNOP00000001153.3 Dasypus novemcinctus 99 0.0 684
WERAM-Sus-0124 ENSSSCP00000017603.2 Sus scrofa 98 0.0 682
WERAM-Fec-0200 ENSFCAP00000020713.1 Felis catus 98 0.0 681
WERAM-Otg-0055 ENSOGAP00000003761.2 Otolemur garnettii 99 0.0 679
WERAM-Caj-0180 ENSCJAP00000031565.1 Callithrix jacchus 98 0.0 679
WERAM-Ova-0192 ENSOARP00000019466.1 Ovis aries 98 0.0 679
WERAM-Tut-0185 ENSTTRP00000015382.1 Tursiops truncatus 93 0.0 678
WERAM-Loa-0213 ENSLAFP00000019667.1 Loxodonta africana 98 0.0 677
WERAM-Ptv-0107 ENSPVAP00000009534.1 Pteropus vampyrus 98 0.0 677
WERAM-Ran-0034 ENSRNOP00000007476.4 Rattus norvegicus 94 0.0 677
WERAM-Soa-0122 ENSSARP00000011714.1 Sorex araneus 97 0.0 674
WERAM-Mum-0100 ENSMUSP00000031680.3 Mus musculus 95 0.0 674
WERAM-Cap-0197 ENSCPOP00000018334.1 Cavia porcellus 98 0.0 669
WERAM-Chh-0044 ENSCHOP00000005027.1 Choloepus hoffmanni 97 0.0 661
WERAM-Sah-0147 ENSSHAP00000015324.1 Sarcophilus harrisii 94 0.0 660
WERAM-Prc-0118 ENSPCAP00000010407.1 Procavia capensis 92 0.0 658
WERAM-Pes-0054 ENSPSIP00000007361.1 Pelodiscus sinensis 91 0.0 631
WERAM-Lac-0111 ENSLACP00000013747.2 Latimeria chalumnae 86 3e-180 628
WERAM-Anc-0074 ENSACAP00000006929.2 Anolis carolinensis 89 4e-178 621
WERAM-Leo-0165 ENSLOCP00000019441.1 Lepisosteus oculatus 86 2e-170 596
WERAM-Ten-0032 ENSTNIP00000006039.1 Tetraodon nigroviridis 78 6e-168 587
WERAM-Tar-0017 ENSTRUP00000003694.1 Takifugu rubripes 81 9e-168 587
WERAM-Orn-0086 ENSONIP00000009520.1 Oreochromis niloticus 82 9e-168 587
WERAM-Xim-0108 ENSXMAP00000009576.1 Xiphophorus maculatus 83 2e-163 572
WERAM-Anp-0009 ENSAPLP00000001673.1 Anas platyrhynchos 88 9e-163 570
WERAM-Pof-0248 ENSPFOP00000029114.1 Poecilia formosa 83 1e-162 570
WERAM-Ora-0058 ENSOANP00000008990.3 Ornithorhynchus anatinus 91 7e-162 567
WERAM-Ect-0116 ENSETEP00000013115.1 Echinops telfairi 89 1e-161 566
WERAM-Tag-0065 ENSTGUP00000004796.1 Taeniopygia guttata 91 2e-161 566
WERAM-Asm-0105 ENSAMXP00000010482.1 Astyanax mexicanus 81 2e-161 566
WERAM-Gam-0190 ENSGMOP00000018296.1 Gadus morhua 80 4e-161 565
WERAM-Gaa-0006 ENSGACP00000000841.2 Gasterosteus aculeatus 80 5e-159 558
WERAM-Fia-0124 ENSFALP00000010408.1 Ficedula albicollis 91 1e-157 553
WERAM-Meg-0093 ENSMGAP00000008949.1 Meleagris gallopavo 91 2e-157 552
WERAM-Gaga-0094 ENSGALP00000014665.4 Gallus gallus 91 8e-157 550
WERAM-Dar-0072 ENSDARP00000031200.5 Danio rerio 76 2e-156 549
WERAM-Xet-0148 ENSXETP00000049164.2 Xenopus tropicalis 75 2e-151 533
WERAM-Mae-0124 ENSMEUP00000012568.1 Macropus eugenii 81 4e-150 528
WERAM-Gog-0044 ENSGGOP00000004268.2 Gorilla gorilla 100 2e-113 406
WERAM-Tas-0001 ENSTSYP00000000124.1 Tarsius syrichta 87 1e-93 340
WERAM-Ocp-0149 ENSOPRP00000015445.1 Ochotona princeps 76 5e-77 285
WERAM-Cis-0005 ENSCSAVP00000000824.1 Ciona savignyi 58 3e-52 202
WERAM-Cii-0019 ENSCINP00000007229.3 Ciona intestinalis 59 5e-51 199
WERAM-Pem-0004 ENSPMAP00000000234.1 Petromyzon marinus 80 2e-42 170
WERAM-Drm-0038 FBpp0074385 Drosophila melanogaster 63 7e-42 169
WERAM-Arl-0064 fgenesh2_kg.3__ 2635__ AT3G24010.1 Arabidopsis lyrata 67 6e-28 122
WERAM-Art-0077 AT3G24010.1 Arabidopsis thaliana 65 2e-27 120
WERAM-Brd-0037 BRADI1G75507.1 Brachypodium distachyon 60 2e-26 117
WERAM-Thc-0053 EOY05425 Theobroma cacao 69 2e-26 117
WERAM-Lep-0035 LPERR03G03140.1 Leersia perrieri 59 3e-26 117
WERAM-Brr-0075 Bra015016.1-P Brassica rapa 67 3e-26 116
WERAM-Bro-0124 Bo7g036450.1 Brassica oleracea 67 3e-26 116
WERAM-Orbr-0038 OB03G13430.1 Oryza brachyantha 60 3e-26 116
WERAM-Orla-0129 ENSORLP00000015380.1 Oryzias latipes 74 4e-26 116
WERAM-Glm-0258 GLYMA20G19970.1 Glycine max 57 8e-26 115
WERAM-Orp-0029 OPUNC03G03150.1 Oryza punctata 59 9e-26 115
WERAM-Mod-0036 ENSMODP00000005573.2 Monodelphis domestica 72 1e-25 115
WERAM-Met-0017 KEH41192 Medicago truncatula 71 1e-25 114
WERAM-Prp-0084 EMJ28765 Prunus persica 65 2e-25 114
WERAM-Orr-0030 ORUFI03G03130.1 Oryza rufipogon 58 2e-25 114
WERAM-Orb-0031 OBART03G03390.1 Oryza barthii 58 2e-25 114
WERAM-Tra-0133 Traes_4AL_78F1233CC.2 Triticum aestivum 57 2e-25 114
WERAM-Ors-0028 OS03T0143600-01 Oryza sativa 56 2e-25 114
WERAM-Mam-0207 ENSMMUP00000019814.2 Macaca mulatta 72 2e-25 114
WERAM-Mim-0014 ENSMICP00000001205.1 Microcebus murinus 72 2e-25 114
WERAM-Vip-0056 ENSVPAP00000005332.1 Vicugna pacos 72 3e-25 113
WERAM-Dio-0155 ENSDORP00000014378.1 Dipodomys ordii 72 4e-25 113
WERAM-Orm-0033 OMERI03G03370.1 Oryza meridionalis 58 4e-25 113
WERAM-Orni-0030 ONIVA03G03130.1 Oryza nivara 58 4e-25 113
WERAM-Ori-0037 BGIOSGA011837-PA Oryza indica 58 4e-25 113
WERAM-Org-0031 ORGLA03G0031600.1 Oryza glaberrima 58 4e-25 113
WERAM-Sot-0036 PGSC0003DMT400030294 Solanum tuberosum 63 4e-25 113
WERAM-Sol-0119 Solyc09g091190.2.1 Solanum lycopersicum 63 4e-25 113
WERAM-Hov-0088 MLOC_66032.4 Hordeum vulgare 60 4e-25 113
WERAM-Ere-0043 ENSEEUP00000003677.1 Erinaceus europaeus 72 5e-25 113
WERAM-Tru-0022 TRIUR3_10173-P1 Triticum urartu 57 5e-25 112
WERAM-Orgl-0033 OGLUM03G03290.1 Oryza glumaepatula 60 6e-25 112
WERAM-Tub-0041 ENSTBEP00000005072.1 Tupaia belangeri 63 6e-25 112
WERAM-Sob-0014 Sb01g047350.1 Sorghum bicolor 64 9e-25 112
Created Date 25-Jun-2016