| Tag |
Content |
| WERAM ID |
WERAM-Hos-0145 |
| Ensembl Protein ID |
ENSP00000271640.5 |
| Uniprot Accession |
Q15047; SETB1_HUMAN; A6NEW2; Q5SZD8; Q5SZD9; Q5SZE0; Q5SZE7; Q96GM9
|
| Genbank Protein ID |
NP_001138887.1; NP_001230420.1; NP_036564.3
|
| Protein Name |
Histone-lysine N-methyltransferase SETDB1 |
| Genbank Nucleotide ID |
NM_001145415.1; NM_001243491.1; NM_012432.3
|
| Gene Name |
SETDB1;ESET;KG1T;KMT1E;TDRD21;H3-K9-HMTase4 |
| Ensembl Information |
|
| Details |
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SUV39 |
9.90e-76 |
255.1 |
803 |
1266 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306).
|
| Domain Profile |
HMT SUV39
SUV39.txt 1 vrLqvfktenkGwGvrclddiakgsFvciyaGeiltddeaekegleegdeyladldskesvenlkegyesdvplssdss........... 79
vrLq+fkt+nkGwG+rclddiakgsFvciyaG+iltdd+a+kegle+gdey+a+ld++esven+kegyesd+p+ssdss
ENSP00000271640.5 803 VRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSgvdlkdqedgn 892
79**************************************************************************************** PP
SUV39.txt 80 .......................................................................................... 79
ENSP00000271640.5 893 sgtedpeesnddssddnfckdedfstssvwrsyatrrqtrgqkenglsettskdshppdlgpphipvppsipvggcnppsseetpknkva 982
****************************************************************************************** PP
SUV39.txt 80 .......................................................................................... 79
ENSP00000271640.5 983 swlscnsvseggfadsdshssfktneggegraggsrmeaekastsglgikdegdikqakkedtddrnkmsvvtessrnygynpspvkpeg 1072
****************************************************************************************** PP
SUV39.txt 80 .......................................................................................... 79
ENSP00000271640.5 1073 lrrppsktsmhqsrrlmasaqsnpddvltlssstesegesgtsrkptagqtsatavdsddiqtissgsegddfedkknmtgpmkrqvavk 1162
****************************************************************************************** PP
SUV39.txt 80 .................................ntrqekdkeeseyiidakkegnvgrflnHscspNlfvqnvfvdthdlrfprvafFas 136
ntrq++d+ees+yiidak egn+gr+lnHscspNlfvqnvfvdthdlrfp+vafFas
ENSP00000271640.5 1163 strgfalksthgiaikstnmasvdkgesapvrkNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFAS 1252
****************************************************************************************** PP
SUV39.txt 137 krikagtELtwdYg 150
kri+agtELtwdY+
ENSP00000271640.5 1253 KRIRAGTELTWDYN 1266
*************7 PP
|
Protein Sequence
(Fasta) | MSSLPGCIGL DAATATVESE EIAELQQAVV EELGISMEEL RHFIDEELEK MDCVQQRKKQ 60
LAELETWVIQ KESEVAHVDQ LFDDASRAVT NCESLVKDFY SKLGLQYRDS SSEDESSRPT 120
EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 180
HKGTLSQMSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS 240
LLSGNHIAYD YHPPADKLYV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 300
YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYVTAY PNRPMVLLKS GQLIKTEWEG 360
TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASALE KKQGQLRTRP 420
NMGAVRSKGP VVQYTQDLTG TGTQFKPVEP PQPTAPPAPP FPPAPPLSPQ AGDSDLESQL 480
AQSRKQVAKK STSFRPGSVG SGHSSPTSPA LSENVSGGKP GINQTYRSPL GSTASAPAPS 540
ALPAPPAPPV FHGMLERAPA EPSYRAPMEK LFYLPHVCSY TCLSRVRPMR NEQYRGKNPL 600
LVPLLYDFRR MTARRRVNRK MGFHVIYKTP CGLCLRTMQE IERYLFETGC DFLFLEMFCL 660
DPYVLVDRKF QPYKPFYYIL DITYGKEDVP LSCVNEIDTT PPPQVAYSKE RIPGKGVFIN 720
TGPEFLVGCD CKDGCRDKSK CACHQLTIQA TACTPGGQIN PNSGYQYKRL EECLPTGVYE 780
CNKRCKCDPN MCTNRLVQHG LQVRLQLFKT QNKGWGIRCL DDIAKGSFVC IYAGKILTDD 840
FADKEGLEMG DEYFANLDHI ESVENFKEGY ESDAPCSSDS SGVDLKDQED GNSGTEDPEE 900
SNDDSSDDNF CKDEDFSTSS VWRSYATRRQ TRGQKENGLS ETTSKDSHPP DLGPPHIPVP 960
PSIPVGGCNP PSSEETPKNK VASWLSCNSV SEGGFADSDS HSSFKTNEGG EGRAGGSRME 1020
AEKASTSGLG IKDEGDIKQA KKEDTDDRNK MSVVTESSRN YGYNPSPVKP EGLRRPPSKT 1080
SMHQSRRLMA SAQSNPDDVL TLSSSTESEG ESGTSRKPTA GQTSATAVDS DDIQTISSGS 1140
EGDDFEDKKN MTGPMKRQVA VKSTRGFALK STHGIAIKST NMASVDKGES APVRKNTRQF 1200
YDGEESCYII DAKLEGNLGR YLNHSCSPNL FVQNVFVDTH DLRFPWVAFF ASKRIRAGTE 1260
LTWDYNYEVG SVEGKELLCC CGAIECRGRL L 1291Protein Fasta Sequence
>ENSP00000271640.5|SETDB1;ESET;KG1T;KMT1E;TDRD21;H3-K9-HMTase4|Homo sapiens
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL |
Nucleotide Sequence
(Fasta) | GGCACTAAAG GTTTGCTTCC GGGCGTTTCT TTTGCTTCCC CTTCCCTCTT TCACGCTTCC 60
TCCCCTCCCC CTCCTCCCTT ATCCCTTCGC TTTCGCTCTT TTCCGTCGAG GCCGACCCCT 120
GAGTTGTGAG TCTGGGGTCT GGTTGGTGAA AAAGAGCCCT TGAAGCTGGA AGACGGGAGA 180
GGACAAAAGC ATGTCTTCCC TTCCTGGGTG CATTGGTTTG GATGCAGCAA CAGCTACAGT 240
GGAGTCTGAA GAGATTGCAG AGCTGCAACA GGCAGTGGTT GAGGAACTGG GTATCTCTAT 300
GGAGGAACTT CGGCATTTCA TCGATGAGGA ACTGGAGAAG ATGGATTGTG TACAGCAACG 360
CAAGAAGCAG CTAGCAGAGT TAGAGACATG GGTAATACAG AAAGAATCTG AGGTGGCTCA 420
CGTTGACCAA CTCTTTGATG ATGCATCCAG GGCAGTGACT AATTGTGAGT CTTTGGTGAA 480
GGACTTCTAC TCCAAGCTGG GACTACAATA CCGGGACAGT AGCTCTGAGG ACGAATCTTC 540
CCGGCCTACA GAAATAATTG AGATTCCTGA TGAAGATGAT GATGTCCTCA GTATTGATTC 600
AGGTGATGCT GGGAGCAGAA CTCCAAAAGA CCAGAAGCTC CGTGAAGCTA TGGCTGCCTT 660
AAGAAAGTCA GCTCAAGATG TTCAGAAGTT CATGGATGCT GTCAACAAGA AGAGCAGTTC 720
CCAGGATCTG CATAAAGGAA CCTTGAGTCA GATGTCTGGA GAACTAAGCA AAGATGGTGA 780
CCTGATAGTC AGCATGCGAA TTCTGGGCAA GAAGAGAACT AAGACTTGGC ACAAAGGCAC 840
CCTTATTGCC ATCCAGACAG TTGGGCCAGG GAAGAAATAC AAGGTGAAAT TTGACAACAA 900
AGGAAAGAGT CTACTGTCGG GGAACCATAT TGCCTATGAT TACCACCCTC CTGCTGACAA 960
GCTGTATGTG GGCAGTCGGG TGGTCGCCAA ATACAAAGAT GGGAATCAGG TCTGGCTCTA 1020
TGCTGGCATT GTAGCTGAGA CACCAAACGT CAAAAACAAG CTCAGGTTTC TCATTTTCTT 1080
TGATGATGGC TATGCTTCCT ATGTCACACA GTCGGAACTG TATCCCATTT GCCGGCCACT 1140
GAAAAAGACT TGGGAGGACA TAGAAGACAT CTCCTGCCGT GACTTCATAG AGGAGTATGT 1200
CACTGCCTAC CCCAACCGCC CCATGGTACT GCTCAAGAGT GGCCAGCTTA TCAAGACTGA 1260
GTGGGAAGGC ACGTGGTGGA AGTCCCGAGT TGAGGAGGTG GATGGCAGCC TAGTCAGGAT 1320
CCTCTTCCTG GATGACAAAA GATGTGAGTG GATCTATCGA GGCTCTACAC GGCTGGAGCC 1380
CATGTTCAGC ATGAAAACAT CCTCAGCCTC TGCACTGGAG AAGAAGCAAG GACAGCTCAG 1440
GACACGTCCA AATATGGGTG CTGTGAGGAG CAAAGGCCCT GTTGTCCAGT ACACACAGGA 1500
TCTGACCGGT ACTGGAACCC AGTTCAAGCC AGTGGAACCC CCACAGCCTA CAGCTCCACC 1560
TGCCCCACCT TTCCCACCTG CTCCACCTCT ATCCCCCCAA GCAGGTGACA GTGACTTGGA 1620
AAGCCAGCTT GCCCAGTCAC GGAAGCAGGT AGCCAAAAAG AGCACGTCCT TTCGACCAGG 1680
ATCTGTGGGC TCTGGTCATT CCTCCCCTAC ATCTCCTGCA CTCAGTGAAA ATGTCTCTGG 1740
TGGGAAACCT GGGATCAACC AGACATATAG ATCACCTTTA GGCTCCACAG CCTCTGCCCC 1800
AGCACCCTCA GCACTCCCGG CCCCTCCAGC ACCCCCAGTC TTCCATGGCA TGCTGGAGCG 1860
GGCCCCAGCA GAGCCCTCCT ACCGTGCTCC CATGGAGAAG CTTTTCTACT TACCTCATGT 1920
CTGCAGCTAT ACCTGTCTGT CTCGAGTCAG ACCTATGAGG AATGAGCAGT ACCGGGGCAA 1980
GAACCCTCTG CTGGTCCCGT TACTATATGA CTTCCGGCGG ATGACAGCCC GGCGTCGAGT 2040
TAACCGCAAG ATGGGCTTTC ATGTTATCTA TAAGACACCT TGTGGTCTCT GCCTTCGGAC 2100
AATGCAGGAG ATAGAACGCT ACCTTTTCGA GACTGGCTGT GACTTCCTCT TCCTGGAGAT 2160
GTTCTGTTTG GATCCATATG TTCTTGTGGA CCGAAAGTTT CAGCCCTATA AGCCTTTTTA 2220
CTATATTTTG GACATCACTT ATGGGAAGGA AGATGTTCCC CTATCCTGTG TCAATGAGAT 2280
TGACACAACC CCTCCACCCC AGGTGGCCTA CAGCAAGGAA CGTATCCCGG GCAAGGGTGT 2340
TTTCATTAAC ACAGGCCCTG AATTTCTGGT TGGCTGTGAC TGCAAGGATG GGTGTCGGGA 2400
CAAGTCCAAG TGTGCCTGCC ATCAACTAAC TATCCAGGCT ACAGCCTGTA CCCCAGGAGG 2460
CCAAATCAAC CCTAACTCTG GCTACCAGTA CAAGAGACTA GAAGAGTGTC TACCCACAGG 2520
GGTATATGAG TGTAACAAAC GCTGCAAATG TGACCCAAAC ATGTGCACAA ACCGGTTGGT 2580
GCAACATGGA CTACAAGTTC GGCTACAGCT ATTCAAGACA CAGAACAAGG GCTGGGGTAT 2640
CCGCTGCTTG GATGACATTG CCAAAGGCTC TTTTGTTTGT ATTTATGCAG GCAAAATCCT 2700
GACAGATGAC TTTGCAGACA AGGAGGGTCT GGAAATGGGT GATGAGTACT TTGCAAATCT 2760
GGACCATATC GAGAGCGTGG AGAACTTCAA AGAAGGATAT GAGAGTGATG CCCCCTGTTC 2820
CTCTGACAGC AGTGGTGTAG ACTTGAAGGA CCAGGAAGAT GGCAACAGCG GTACAGAGGA 2880
CCCTGAAGAG TCCAATGATG ATAGCTCAGA TGATAACTTC TGTAAGGATG AGGACTTCAG 2940
CACCAGTTCA GTGTGGCGGA GCTATGCTAC CCGGAGGCAG ACCCGGGGCC AGAAAGAGAA 3000
CGGACTCTCT GAGACAACTT CCAAGGACTC CCACCCCCCA GATCTTGGAC CCCCACATAT 3060
TCCTGTTCCT CCCTCAATCC CTGTAGGTGG CTGCAATCCA CCTTCCTCCG AAGAGACACC 3120
CAAGAACAAG GTGGCCTCAT GGTTGAGCTG CAATAGTGTC AGTGAAGGTG GTTTTGCTGA 3180
CTCTGATAGC CATTCATCCT TCAAGACTAA TGAAGGTGGG GAGGGCCGGG CTGGGGGAAG 3240
CCGAATGGAG GCTGAGAAGG CCTCCACCTC AGGACTAGGC ATCAAGGATG AGGGAGACAT 3300
CAAACAGGCC AAGAAAGAGG ACACTGACGA CCGAAACAAG ATGTCAGTAG TTACTGAAAG 3360
CTCTCGAAAT TACGGTTACA ATCCTTCTCC TGTGAAGCCT GAAGGACTTC GCCGCCCACC 3420
TAGTAAGACT AGTATGCATC AAAGCCGAAG ACTCATGGCT TCTGCTCAGT CCAACCCTGA 3480
TGATGTCCTG ACACTGTCCA GCAGCACAGA AAGTGAGGGG GAAAGTGGGA CCAGCCGAAA 3540
GCCCACTGCT GGTCAGACTT CGGCTACAGC GGTTGACAGT GATGATATCC AGACCATATC 3600
CTCTGGCTCT GAAGGGGATG ACTTTGAGGA CAAGAAGAAC ATGACTGGTC CAATGAAGCG 3660
TCAAGTGGCA GTAAAATCAA CCCGAGGCTT TGCTCTTAAA TCAACCCATG GGATTGCAAT 3720
TAAATCAACC AACATGGCCT CTGTGGACAA GGGGGAGAGC GCACCTGTTC GTAAGAACAC 3780
ACGCCAATTC TATGATGGCG AGGAGTCTTG CTACATCATT GATGCCAAGC TTGAAGGCAA 3840
CCTGGGCCGC TACCTCAACC ACAGTTGCAG CCCCAACCTG TTTGTCCAGA ATGTCTTCGT 3900
GGATACCCAT GATCTTCGCT TCCCCTGGGT GGCCTTCTTT GCCAGCAAAA GAATCCGGGC 3960
TGGGACAGAA CTTACTTGGG ACTACAACTA CGAGGTGGGC AGTGTGGAAG GCAAGGAGCT 4020
ACTCTGTTGC TGTGGGGCCA TTGAATGCAG AGGACGTCTT CTTTAGAGGA CAGCCTTCTT 4080
CCCAACCCTT CTTGAACTGT CGTTTCCTCA GGAACTGGGT CTTCCTGATT GTTGAACCCT 4140
GACCCGAAGT CTCTGGGCTA GCTACTCCCC CCAGCTCCTA GTTGATAGAA ATGGGGGTTC 4200
TGGACCAGAT GATCCCTTCC AATGTGGTGC TAGCAGGCAG GATCCCTTCT CCACCTCCAA 4260
AGGCCCTAAA GGGTGGGGAG AGATCACCAC TCTAACCTCG GCCTGACATC CCTCCCATCC 4320
CATATTTGTC CAAGTGTTCC TGCTTCTAAC AGACTTTGTT CTTAGAATGG AGCCTGTGTA 4380
TCTACTATCT CCAGTTTGTA TTATTTCTTG AAAGTCTTTT AACAATATGA TAAAACT
4438Nucleotide Fasta Sequence
>ENSP00000271640.5|SUV39|Homo sapiens
GGCACTAAAGGTTTGCTTCCGGGCGTTTCTTTTGCTTCCCCTTCCCTCTTTCACGCTTCCTCCCCTCCCCCTCCTCCCTTATCCCTTCGCTTTCGCTCTTTTCCGTCGAGGCCGACCCCTGAGTTGTGAGTCTGGGGTCTGGTTGGTGAAAAAGAGCCCTTGAAGCTGGAAGACGGGAGAGGACAAAAGCATGTCTTCCCTTCCTGGGTGCATTGGTTTGGATGCAGCAACAGCTACAGTGGAGTCTGAAGAGATTGCAGAGCTGCAACAGGCAGTGGTTGAGGAACTGGGTATCTCTATGGAGGAACTTCGGCATTTCATCGATGAGGAACTGGAGAAGATGGATTGTGTACAGCAACGCAAGAAGCAGCTAGCAGAGTTAGAGACATGGGTAATACAGAAAGAATCTGAGGTGGCTCACGTTGACCAACTCTTTGATGATGCATCCAGGGCAGTGACTAATTGTGAGTCTTTGGTGAAGGACTTCTACTCCAAGCTGGGACTACAATACCGGGACAGTAGCTCTGAGGACGAATCTTCCCGGCCTACAGAAATAATTGAGATTCCTGATGAAGATGATGATGTCCTCAGTATTGATTCAGGTGATGCTGGGAGCAGAACTCCAAAAGACCAGAAGCTCCGTGAAGCTATGGCTGCCTTAAGAAAGTCAGCTCAAGATGTTCAGAAGTTCATGGATGCTGTCAACAAGAAGAGCAGTTCCCAGGATCTGCATAAAGGAACCTTGAGTCAGATGTCTGGAGAACTAAGCAAAGATGGTGACCTGATAGTCAGCATGCGAATTCTGGGCAAGAAGAGAACTAAGACTTGGCACAAAGGCACCCTTATTGCCATCCAGACAGTTGGGCCAGGGAAGAAATACAAGGTGAAATTTGACAACAAAGGAAAGAGTCTACTGTCGGGGAACCATATTGCCTATGATTACCACCCTCCTGCTGACAAGCTGTATGTGGGCAGTCGGGTGGTCGCCAAATACAAAGATGGGAATCAGGTCTGGCTCTATGCTGGCATTGTAGCTGAGACACCAAACGTCAAAAACAAGCTCAGGTTTCTCATTTTCTTTGATGATGGCTATGCTTCCTATGTCACACAGTCGGAACTGTATCCCATTTGCCGGCCACTGAAAAAGACTTGGGAGGACATAGAAGACATCTCCTGCCGTGACTTCATAGAGGAGTATGTCACTGCCTACCCCAACCGCCCCATGGTACTGCTCAAGAGTGGCCAGCTTATCAAGACTGAGTGGGAAGGCACGTGGTGGAAGTCCCGAGTTGAGGAGGTGGATGGCAGCCTAGTCAGGATCCTCTTCCTGGATGACAAAAGATGTGAGTGGATCTATCGAGGCTCTACACGGCTGGAGCCCATGTTCAGCATGAAAACATCCTCAGCCTCTGCACTGGAGAAGAAGCAAGGACAGCTCAGGACACGTCCAAATATGGGTGCTGTGAGGAGCAAAGGCCCTGTTGTCCAGTACACACAGGATCTGACCGGTACTGGAACCCAGTTCAAGCCAGTGGAACCCCCACAGCCTACAGCTCCACCTGCCCCACCTTTCCCACCTGCTCCACCTCTATCCCCCCAAGCAGGTGACAGTGACTTGGAAAGCCAGCTTGCCCAGTCACGGAAGCAGGTAGCCAAAAAGAGCACGTCCTTTCGACCAGGATCTGTGGGCTCTGGTCATTCCTCCCCTACATCTCCTGCACTCAGTGAAAATGTCTCTGGTGGGAAACCTGGGATCAACCAGACATATAGATCACCTTTAGGCTCCACAGCCTCTGCCCCAGCACCCTCAGCACTCCCGGCCCCTCCAGCACCCCCAGTCTTCCATGGCATGCTGGAGCGGGCCCCAGCAGAGCCCTCCTACCGTGCTCCCATGGAGAAGCTTTTCTACTTACCTCATGTCTGCAGCTATACCTGTCTGTCTCGAGTCAGACCTATGAGGAATGAGCAGTACCGGGGCAAGAACCCTCTGCTGGTCCCGTTACTATATGACTTCCGGCGGATGACAGCCCGGCGTCGAGTTAACCGCAAGATGGGCTTTCATGTTATCTATAAGACACCTTGTGGTCTCTGCCTTCGGACAATGCAGGAGATAGAACGCTACCTTTTCGAGACTGGCTGTGACTTCCTCTTCCTGGAGATGTTCTGTTTGGATCCATATGTTCTTGTGGACCGAAAGTTTCAGCCCTATAAGCCTTTTTACTATATTTTGGACATCACTTATGGGAAGGAAGATGTTCCCCTATCCTGTGTCAATGAGATTGACACAACCCCTCCACCCCAGGTGGCCTACAGCAAGGAACGTATCCCGGGCAAGGGTGTTTTCATTAACACAGGCCCTGAATTTCTGGTTGGCTGTGACTGCAAGGATGGGTGTCGGGACAAGTCCAAGTGTGCCTGCCATCAACTAACTATCCAGGCTACAGCCTGTACCCCAGGAGGCCAAATCAACCCTAACTCTGGCTACCAGTACAAGAGACTAGAAGAGTGTCTACCCACAGGGGTATATGAGTGTAACAAACGCTGCAAATGTGACCCAAACATGTGCACAAACCGGTTGGTGCAACATGGACTACAAGTTCGGCTACAGCTATTCAAGACACAGAACAAGGGCTGGGGTATCCGCTGCTTGGATGACATTGCCAAAGGCTCTTTTGTTTGTATTTATGCAGGCAAAATCCTGACAGATGACTTTGCAGACAAGGAGGGTCTGGAAATGGGTGATGAGTACTTTGCAAATCTGGACCATATCGAGAGCGTGGAGAACTTCAAAGAAGGATATGAGAGTGATGCCCCCTGTTCCTCTGACAGCAGTGGTGTAGACTTGAAGGACCAGGAAGATGGCAACAGCGGTACAGAGGACCCTGAAGAGTCCAATGATGATAGCTCAGATGATAACTTCTGTAAGGATGAGGACTTCAGCACCAGTTCAGTGTGGCGGAGCTATGCTACCCGGAGGCAGACCCGGGGCCAGAAAGAGAACGGACTCTCTGAGACAACTTCCAAGGACTCCCACCCCCCAGATCTTGGACCCCCACATATTCCTGTTCCTCCCTCAATCCCTGTAGGTGGCTGCAATCCACCTTCCTCCGAAGAGACACCCAAGAACAAGGTGGCCTCATGGTTGAGCTGCAATAGTGTCAGTGAAGGTGGTTTTGCTGACTCTGATAGCCATTCATCCTTCAAGACTAATGAAGGTGGGGAGGGCCGGGCTGGGGGAAGCCGAATGGAGGCTGAGAAGGCCTCCACCTCAGGACTAGGCATCAAGGATGAGGGAGACATCAAACAGGCCAAGAAAGAGGACACTGACGACCGAAACAAGATGTCAGTAGTTACTGAAAGCTCTCGAAATTACGGTTACAATCCTTCTCCTGTGAAGCCTGAAGGACTTCGCCGCCCACCTAGTAAGACTAGTATGCATCAAAGCCGAAGACTCATGGCTTCTGCTCAGTCCAACCCTGATGATGTCCTGACACTGTCCAGCAGCACAGAAAGTGAGGGGGAAAGTGGGACCAGCCGAAAGCCCACTGCTGGTCAGACTTCGGCTACAGCGGTTGACAGTGATGATATCCAGACCATATCCTCTGGCTCTGAAGGGGATGACTTTGAGGACAAGAAGAACATGACTGGTCCAATGAAGCGTCAAGTGGCAGTAAAATCAACCCGAGGCTTTGCTCTTAAATCAACCCATGGGATTGCAATTAAATCAACCAACATGGCCTCTGTGGACAAGGGGGAGAGCGCACCTGTTCGTAAGAACACACGCCAATTCTATGATGGCGAGGAGTCTTGCTACATCATTGATGCCAAGCTTGAAGGCAACCTGGGCCGCTACCTCAACCACAGTTGCAGCCCCAACCTGTTTGTCCAGAATGTCTTCGTGGATACCCATGATCTTCGCTTCCCCTGGGTGGCCTTCTTTGCCAGCAAAAGAATCCGGGCTGGGACAGAACTTACTTGGGACTACAACTACGAGGTGGGCAGTGTGGAAGGCAAGGAGCTACTCTGTTGCTGTGGGGCCATTGAATGCAGAGGACGTCTTCTTTAGAGGACAGCCTTCTTCCCAACCCTTCTTGAACTGTCGTTTCCTCAGGAACTGGGTCTTCCTGATTGTTGAACCCTGACCCGAAGTCTCTGGGCTAGCTACTCCCCCCAGCTCCTAGTTGATAGAAATGGGGGTTCTGGACCAGATGATCCCTTCCAATGTGGTGCTAGCAGGCAGGATCCCTTCTCCACCTCCAAAGGCCCTAAAGGGTGGGGAGAGATCACCACTCTAACCTCGGCCTGACATCCCTCCCATCCCATATTTGTCCAAGTGTTCCTGCTTCTAACAGACTTTGTTCTTAGAATGGAGCCTGTGTATCTACTATCTCCAGTTTGTATTATTTCTTGAAAGTCTTTTAACAATATGATAAAACT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
--
|
| Interpro |
IPR016177--DNA-bd_dom
IPR025796--Hist-Lys_N-MeTrfase_SETDB1
IPR001739--Methyl_CpG_DNA-bd
IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR001214--SET_dom
IPR002999--Tudor
|
| PROSITE |
PS50982--MBD
PS50868--POST_SET
PS50867--PRE_SET
PS51573--SAM_MT43_SUVAR39_1
PS50280--SET
|
| Pfam |
PF01429--MBD
PF05033--Pre-SET
PF00856--SET
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:1990841--F:promoter-specific chromatin binding
GO:0008270--F:zinc ion binding
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0007265--P:Ras protein signal transduction
GO:0045471--P:response to ethanol
GO:0033273--P:response to vitamin
GO:0006351--P:transcription, DNA-templated
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| Orthology |
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| Created Date |
25-Jun-2016 |
