| Tag |
Content |
| WERAM ID |
WERAM-Mum-0023 |
| Ensembl Protein ID |
ENSMUSP00000102789.3 |
| Uniprot Accession |
O88974; SETB1_MOUSE; Q6AXH8; Q78N64; Q78N65; Q80U84; Q8BTV6; Q8CIX7; Q922K1
|
| Genbank Protein ID |
|
| Protein Name |
Histone-lysine N-methyltransferase SETDB1 |
| Genbank Nucleotide ID |
|
| Gene Name |
SETDB1;ESET |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
SUV39 |
SET |
H3K9; H3K27 |
K |
26279314; 22991445
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
SUV39 |
1.10e-75 |
254.2 |
262 |
1282 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (By similarity). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity). |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (By similarity). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity).
|
| Domain Profile |
HMT SUV39
SUV39.txt 15 vrclddiakgsFvciyaGeiltddeaek 42
r + + + g+ v yaG + ++ ++++
ENSMUSP00000102789.3 262 SRVVAKYKDGNQVWLYAGIVAETPNVKN 289
578889999*********9999888765 PP
SUV39.txt 1 vrLqvfktenkGwGvrclddiakgsFvciyaGeiltddeaekegleegdeyladldskesvenlkegyesdvplssdss........ 79
vrLq+fkt+nkGwG+rclddiakgsFvciyaG+iltdd+a+kegle+gdey+a+ld++esven+kegyesdvp+ssdss
ENSMUSP00000102789.3 820 VRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDVPTSSDSSgvdmkdqe 906
79************************************************************************************* PP
SUV39.txt 80 ....................................................................................... 79
ENSMUSP00000102789.3 907 dgnsgsedpeesnddssddnfckdedfstssvwrsyatrrqtrgqkenelsemtskdsrppdlgpphvpipssvsvggcnppsseet 993
*************************************************************************************** PP
SUV39.txt 80 ....................................................................................... 79
ENSMUSP00000102789.3 994 pknkvaswlscnsvseggfadsdsrssfktseggdgragggrgeaerastsglsfkdegdnkqpkkedpenrnkmpvvtegsqnhgh 1080
*************************************************************************************** PP
SUV39.txt 80 ....................................................................................... 79
ENSMUSP00000102789.3 1081 nppmkseglrrsaskmsvlqsqrvvtstqsnpddiltlssstesegesgtsrkptaghtsatavdsddiqtissgsdgddfedkknl 1167
*************************************************************************************** PP
SUV39.txt 80 ............................................ntrqekdkeeseyiidakkegnvgrflnHscspNlfvqnvfvd 122
ntrq++d+ees+yiidak egn+gr+lnHscspNlfvqnvfvd
ENSMUSP00000102789.3 1168 sgptkrqvavkstrgfalksthgiaikstnmasvdkgesapvrkNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVD 1254
*************************************************************************************** PP
SUV39.txt 123 thdlrfprvafFaskrikagtELtwdYg 150
thdlrfp+vafFaskri+agtELtwdY+
ENSMUSP00000102789.3 1255 THDLRFPWVAFFASKRIRAGTELTWDYN 1282
***************************7 PP
|
Protein Sequence
(Fasta) | MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK MDCIQQRKKQ 60
LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY SKLGLQYHDS SSEDEASRPT 120
EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 180
HKGTLGQVSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS 240
LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 300
YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 360
TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASAME KKQGGQLRTR 420
PNMGAVRSKG PVVQYTQDLT GTGIQFKPME PLQPIAPPAP LPIPPLSPQA ADTDLESQLA 480
QSRKQVAKKS TSFRPGSVGS GHSSPTSSTL SENVSAGKLG INQTYRSPLA SVTSTPASAA 540
PPVPPVPPGP PTPPGPPAPP GPLAPPAFHG MLERAPAEPS YRAPMEKLFY LPHVCSYTCL 600
SRIRPMRNEQ YRGKNPLLVP LLYDFRRMTA RRRVNRKMGF HVIYKTPCGL CLRTMQEIER 660
YLFETGCDFL FLEMFCLDPY VLVDRKFQPF KPFYYILDIT YGKEDVPLSC VNEIDTTPPP 720
QVAYSKERIP GKGVFINTGP EFLVGCDCKD GCRDKSKCAC HQLTIQATAC TPGGQVNPNS 780
GYQYKRLEEC LPTGVYECNK RCNCDPNMCT NRLVQHGLQV RLQLFKTQNK GWGIRCLDDI 840
AKGSFVCIYA GKILTDDFAD KEGLEMGDEY FANLDHIESV ENFKEGYESD VPTSSDSSGV 900
DMKDQEDGNS GSEDPEESND DSSDDNFCKD EDFSTSSVWR SYATRRQTRG QKENELSEMT 960
SKDSRPPDLG PPHVPIPSSV SVGGCNPPSS EETPKNKVAS WLSCNSVSEG GFADSDSRSS 1020
FKTSEGGDGR AGGGRGEAER ASTSGLSFKD EGDNKQPKKE DPENRNKMPV VTEGSQNHGH 1080
NPPMKSEGLR RSASKMSVLQ SQRVVTSTQS NPDDILTLSS STESEGESGT SRKPTAGHTS 1140
ATAVDSDDIQ TISSGSDGDD FEDKKNLSGP TKRQVAVKST RGFALKSTHG IAIKSTNMAS 1200
VDKGESAPVR KNTRQFYDGE ESCYIIDAKL EGNLGRYLNH SCSPNLFVQN VFVDTHDLRF 1260
PWVAFFASKR IRAGTELTWD YNYEVGSVEG KELLCCCGAI ECRGRLL 1307Protein Fasta Sequence
>ENSMUSP00000102789.3|SETDB1;ESET|Mus musculus
MSSLPGCMSLAAAPAAADSAEIAELQQAVVEELGISMEELRQYIDEELEKMDCIQQRKKQLAELETWVLQKESEVAYVDRLFDDASREVTNCESLVKDFYSKLGLQYHDSSSEDEASRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDLHKGTLGQVSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGLGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLFVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDSSCRDFIEEYITAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASAMEKKQGGQLRTRPNMGAVRSKGPVVQYTQDLTGTGIQFKPMEPLQPIAPPAPLPIPPLSPQAADTDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSSTLSENVSAGKLGINQTYRSPLASVTSTPASAAPPVPPVPPGPPTPPGPPAPPGPLAPPAFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRIRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPFKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQVNPNSGYQYKRLEECLPTGVYECNKRCNCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDVPTSSDSSGVDMKDQEDGNSGSEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENELSEMTSKDSRPPDLGPPHVPIPSSVSVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSRSSFKTSEGGDGRAGGGRGEAERASTSGLSFKDEGDNKQPKKEDPENRNKMPVVTEGSQNHGHNPPMKSEGLRRSASKMSVLQSQRVVTSTQSNPDDILTLSSSTESEGESGTSRKPTAGHTSATAVDSDDIQTISSGSDGDDFEDKKNLSGPTKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL |
Nucleotide Sequence
(Fasta) | CAAGGCGGAG CCCTGGAGTA AAACCTGGGG TCGGGGTTGT GAGACGCGGC CCTTGCGGTC 60
GGGCGCCAGA GTTGTGGGGA GGACGGACTG AGGGCCAAAG CATGTCCTCC CTCCCTGGGT 120
GCATGAGTTT GGCTGCAGCG CCAGCTGCAG CTGACTCTGC AGAGATTGCT GAGCTGCAGC 180
AGGCGGTGGT TGAAGAGCTG GGTATCTCTA TGGAGGAACT TCGTCAGTAC ATTGATGAGG 240
AACTGGAAAA GATGGACTGC ATACAGCAGC GCAAGAAGCA GCTCGCAGAG CTGGAGACGT 300
GGGTACTACA GAAAGAGTCT GAAGTGGCTT ATGTTGATCG GCTGTTTGAT GATGCATCCA 360
GGGAAGTGAC TAACTGTGAG TCTTTGGTGA AGGATTTCTA CTCTAAGCTG GGACTACAGT 420
ATCATGACAG TAGCTCTGAG GATGAAGCTT CCCGGCCCAC AGAGATCATT GAGATTCCTG 480
ATGAAGATGA TGATGTCCTC AGTATTGATT CAGGTGATGC TGGGAGCAGA ACTCCAAAAG 540
ACCAGAAGCT TCGTGAAGCT ATGGCTGCCT TAAGAAAATC AGCTCAAGAT GTCCAGAAGT 600
TCATGGATGC TGTCAACAAG AAAAGCAGTT CTCAAGATCT ACATAAAGGA ACCTTGGGTC 660
AGGTGTCTGG AGAACTGAGC AAAGATGGGG ACCTGATAGT CAGCATGCGG ATTCTGGGCA 720
AGAAGAGGAC TAAGACATGG CACAAAGGCA CCCTTATTGC CATCCAGACT GTTGGGCTAG 780
GAAAAAAATA CAAAGTGAAA TTTGACAACA AAGGAAAGAG TCTGCTATCT GGGAACCATA 840
TTGCCTATGA TTACCACCCT CCCGCTGACA AGCTGTTTGT GGGCAGTCGA GTGGTGGCCA 900
AGTACAAAGA TGGAAATCAG GTCTGGCTTT ATGCTGGCAT TGTAGCTGAG ACCCCTAACG 960
TCAAGAACAA GCTCAGATTT TTAATTTTTT TTGATGATGG CTATGCTTCC TATGTCACTC 1020
AGTCAGAGCT TTATCCCATT TGCCGACCAC TAAAAAAGAC TTGGGAGGAC ATAGAAGATA 1080
GCTCCTGCCG AGACTTCATA GAGGAATATA TCACTGCCTA TCCAAACCGC CCAATGGTAC 1140
TTCTCAAGAG TGGGCAGCTT ATCAAGACTG AGTGGGAAGG CACATGGTGG AAGTCTCGAG 1200
TTGAAGAGGT GGATGGCAGC CTAGTCAGGA TCCTCTTTCT GGATGACAAA AGATGTGAGT 1260
GGATATATCG AGGCTCTACA CGCCTGGAAC CTATGTTTAG TATGAAGACA TCCTCAGCCT 1320
CTGCAATGGA GAAGAAGCAA GGGGGGCAAC TCAGAACCCG TCCTAATATG GGTGCTGTGA 1380
GGAGCAAAGG TCCTGTTGTT CAGTATACAC AGGATCTAAC TGGTACTGGA ATCCAGTTTA 1440
AGCCCATGGA GCCCCTACAG CCTATAGCTC CACCGGCCCC ACTTCCTATA CCTCCTCTTT 1500
CCCCCCAAGC AGCTGACACT GACTTAGAAA GCCAACTTGC ACAATCACGG AAACAAGTAG 1560
CCAAGAAGAG CACATCATTC CGACCAGGAT CTGTGGGCTC CGGCCATTCC TCCCCTACTT 1620
CATCCACACT CAGTGAAAAT GTGTCTGCTG GGAAACTTGG GATAAACCAG ACATATCGGT 1680
CACCTTTGGC CTCAGTAACA TCTACCCCAG CATCTGCAGC CCCTCCAGTC CCTCCAGTCC 1740
CACCAGGGCC TCCAACCCCT CCAGGGCCTC CAGCTCCTCC AGGGCCTCTA GCTCCTCCAG 1800
CCTTCCATGG CATGTTAGAG CGGGCACCAG CTGAGCCCTC CTACCGAGCC CCCATGGAGA 1860
AGCTTTTCTA TTTACCTCAT GTCTGCAGTT ACACTTGTTT GTCCCGGATC AGACCCATGA 1920
GAAACGAACA GTATCGGGGC AAGAACCCTC TATTAGTTCC ACTTCTGTAT GACTTCCGGA 1980
GGATGACAGC ACGGCGCAGA GTTAACCGCA AAATGGGCTT TCATGTAATC TATAAGACAC 2040
CCTGTGGTCT CTGCCTTCGG ACGATGCAGG AGATAGAGCG CTACCTTTTT GAGACTGGCT 2100
GTGACTTTCT GTTCCTGGAG ATGTTCTGTT TGGATCCATA TGTTCTTGTT GACAGAAAGT 2160
TTCAACCCTT TAAGCCTTTT TACTATATTT TGGACATCAC CTATGGCAAG GAAGATGTTC 2220
CCCTGTCCTG TGTTAATGAG ATTGACACAA CTCCCCCACC CCAGGTGGCC TACAGCAAGG 2280
AACGCATTCC TGGCAAGGGT GTTTTCATTA ACACAGGCCC TGAATTTCTG GTTGGCTGTG 2340
ACTGCAAGGA TGGGTGTCGG GATAAATCCA AATGTGCCTG CCACCAGCTA ACTATCCAGG 2400
CCACAGCCTG TACCCCAGGG GGCCAAGTCA ACCCTAACTC TGGCTACCAG TATAAAAGAC 2460
TAGAAGAGTG TCTGCCCACA GGGGTTTATG AGTGTAACAA ACGCTGCAAT TGTGACCCAA 2520
ACATGTGCAC AAATCGGTTG GTGCAGCATG GTCTGCAGGT TCGACTACAG CTGTTTAAGA 2580
CACAGAACAA GGGCTGGGGT ATCCGCTGCT TGGATGATAT TGCCAAAGGC TCTTTTGTCT 2640
GCATTTATGC AGGCAAAATC CTGACAGATG ACTTTGCAGA CAAAGAAGGC CTGGAGATGG 2700
GTGATGAGTA CTTTGCAAAT CTGGACCACA TTGAAAGTGT GGAGAACTTC AAGGAAGGAT 2760
ATGAGAGTGA TGTCCCCACT TCCTCTGACA GCAGTGGGGT AGATATGAAG GACCAGGAAG 2820
ATGGCAACAG CGGTTCAGAG GACCCTGAAG AATCCAATGA TGACAGCTCT GATGATAACT 2880
TCTGTAAGGA TGAGGACTTC AGCACCAGTT CAGTGTGGCG TAGCTATGCT ACCCGGAGGC 2940
AGACTCGGGG TCAAAAGGAG AATGAATTGT CTGAGATGAC TTCCAAGGAC TCCCGCCCCC 3000
CAGACCTCGG GCCTCCACAT GTTCCTATCC CTTCCTCAGT ATCTGTAGGG GGCTGCAATC 3060
CACCTTCCTC TGAAGAGACA CCCAAGAACA AGGTGGCCTC GTGGTTGAGT TGCAATAGTG 3120
TCAGTGAAGG TGGATTTGCT GACTCTGACA GCCGTTCTTC CTTCAAGACT AGTGAAGGTG 3180
GAGATGGCCG TGCTGGGGGA GGCCGGGGAG AGGCTGAAAG GGCCTCTACC TCAGGATTGA 3240
GCTTCAAGGA TGAAGGAGAC AATAAGCAGC CTAAAAAAGA GGACCCTGAG AACCGAAACA 3300
AGATGCCAGT AGTTACTGAA GGCTCTCAGA ATCATGGACA TAATCCTCCC ATGAAGTCTG 3360
AAGGGCTTCG CCGATCAGCT AGTAAAATGT CTGTGCTCCA GAGCCAGCGA GTTGTGACTT 3420
CTACTCAGTC AAACCCTGAT GACATCCTGA CACTGTCCAG CAGCACAGAG AGTGAGGGGG 3480
AAAGTGGAAC CAGCCGAAAG CCCACTGCTG GTCACACTTC AGCCACAGCT GTTGATAGTG 3540
ATGACATCCA GACCATCTCT TCTGGCTCTG ACGGTGATGA CTTTGAGGAC AAGAAGAACT 3600
TGTCAGGACC AACAAAGCGC CAGGTGGCAG TAAAATCAAC CCGAGGCTTT GCTCTTAAAT 3660
CAACCCATGG TATTGCCATT AAATCAACCA ACATGGCTTC CGTGGACAAG GGGGAGAGTG 3720
CACCAGTTCG TAAGAACACA CGCCAGTTCT ATGATGGTGA AGAGTCTTGC TACATCATTG 3780
ATGCCAAACT TGAAGGCAAC CTAGGCCGCT ACCTCAATCA CAGTTGCAGC CCCAACCTGT 3840
TTGTCCAGAA TGTGTTTGTG GATACCCATG ATCTTCGCTT CCCTTGGGTG GCCTTCTTTG 3900
CCAGCAAGAG AATCCGGGCT GGAACAGAAC TCACTTGGGA CTACAACTAC GAAGTGGGCA 3960
GTGTGGAAGG CAAGGAGCTG CTGTGCTGCT GTGGGGCCAT TGAATGCAGA GGGAGACTTC 4020
TTTAGAGGAA GACTTCCTCA CTTTGAGAAC GCTTGAACTA TCCTTTTCCC CAGGAACTGG 4080
GTCTTCCTGA CTGTTGAACT CTGACCCCAA GTCTCTGATC TAGCTTCTTC CCAGCTCCTA 4140
GTAGATAGAG ATGGGGATTC TCAATCAGGA CTTTCCCAGC GTGGTGCTAG CAGGCACTAG 4200
GGTGGGTAGA CATGACCACT CTAGCATCAG CCTGAGGTCC TTCTCATCTT GTATGCATTC 4260
ATGATTCACA TGGGCTGTGT ATCTGCCATC CCTGATTTGT ATGGTTTCTT GAAAGTCTTC 4320
TAACAAGATG GTAAAGTAGA GATTGTGGTT TGTCTTATCT CCTGCCTTGA TCTTCCATGT 4380
CATTTCCCAG TGGGCAACTA TCATTAGTTT ATACCTCGAT TTTATTTGCC CTGTGTAATT 4440
TTTAACTAAA AATGTTACAT AACCACAAGG GAGGCCTAAG AAAAAAACTA ACCCTTTCTC 4500
AAGTCTTAAT AGTCTGACAC AGTCATGTTT TATTTAACCT TTAATATACT TTAATTAAAA 4560
AAAATTAACA GTA
4574Nucleotide Fasta Sequence
>ENSMUSP00000102789.3|SUV39|Mus musculus
CAAGGCGGAGCCCTGGAGTAAAACCTGGGGTCGGGGTTGTGAGACGCGGCCCTTGCGGTCGGGCGCCAGAGTTGTGGGGAGGACGGACTGAGGGCCAAAGCATGTCCTCCCTCCCTGGGTGCATGAGTTTGGCTGCAGCGCCAGCTGCAGCTGACTCTGCAGAGATTGCTGAGCTGCAGCAGGCGGTGGTTGAAGAGCTGGGTATCTCTATGGAGGAACTTCGTCAGTACATTGATGAGGAACTGGAAAAGATGGACTGCATACAGCAGCGCAAGAAGCAGCTCGCAGAGCTGGAGACGTGGGTACTACAGAAAGAGTCTGAAGTGGCTTATGTTGATCGGCTGTTTGATGATGCATCCAGGGAAGTGACTAACTGTGAGTCTTTGGTGAAGGATTTCTACTCTAAGCTGGGACTACAGTATCATGACAGTAGCTCTGAGGATGAAGCTTCCCGGCCCACAGAGATCATTGAGATTCCTGATGAAGATGATGATGTCCTCAGTATTGATTCAGGTGATGCTGGGAGCAGAACTCCAAAAGACCAGAAGCTTCGTGAAGCTATGGCTGCCTTAAGAAAATCAGCTCAAGATGTCCAGAAGTTCATGGATGCTGTCAACAAGAAAAGCAGTTCTCAAGATCTACATAAAGGAACCTTGGGTCAGGTGTCTGGAGAACTGAGCAAAGATGGGGACCTGATAGTCAGCATGCGGATTCTGGGCAAGAAGAGGACTAAGACATGGCACAAAGGCACCCTTATTGCCATCCAGACTGTTGGGCTAGGAAAAAAATACAAAGTGAAATTTGACAACAAAGGAAAGAGTCTGCTATCTGGGAACCATATTGCCTATGATTACCACCCTCCCGCTGACAAGCTGTTTGTGGGCAGTCGAGTGGTGGCCAAGTACAAAGATGGAAATCAGGTCTGGCTTTATGCTGGCATTGTAGCTGAGACCCCTAACGTCAAGAACAAGCTCAGATTTTTAATTTTTTTTGATGATGGCTATGCTTCCTATGTCACTCAGTCAGAGCTTTATCCCATTTGCCGACCACTAAAAAAGACTTGGGAGGACATAGAAGATAGCTCCTGCCGAGACTTCATAGAGGAATATATCACTGCCTATCCAAACCGCCCAATGGTACTTCTCAAGAGTGGGCAGCTTATCAAGACTGAGTGGGAAGGCACATGGTGGAAGTCTCGAGTTGAAGAGGTGGATGGCAGCCTAGTCAGGATCCTCTTTCTGGATGACAAAAGATGTGAGTGGATATATCGAGGCTCTACACGCCTGGAACCTATGTTTAGTATGAAGACATCCTCAGCCTCTGCAATGGAGAAGAAGCAAGGGGGGCAACTCAGAACCCGTCCTAATATGGGTGCTGTGAGGAGCAAAGGTCCTGTTGTTCAGTATACACAGGATCTAACTGGTACTGGAATCCAGTTTAAGCCCATGGAGCCCCTACAGCCTATAGCTCCACCGGCCCCACTTCCTATACCTCCTCTTTCCCCCCAAGCAGCTGACACTGACTTAGAAAGCCAACTTGCACAATCACGGAAACAAGTAGCCAAGAAGAGCACATCATTCCGACCAGGATCTGTGGGCTCCGGCCATTCCTCCCCTACTTCATCCACACTCAGTGAAAATGTGTCTGCTGGGAAACTTGGGATAAACCAGACATATCGGTCACCTTTGGCCTCAGTAACATCTACCCCAGCATCTGCAGCCCCTCCAGTCCCTCCAGTCCCACCAGGGCCTCCAACCCCTCCAGGGCCTCCAGCTCCTCCAGGGCCTCTAGCTCCTCCAGCCTTCCATGGCATGTTAGAGCGGGCACCAGCTGAGCCCTCCTACCGAGCCCCCATGGAGAAGCTTTTCTATTTACCTCATGTCTGCAGTTACACTTGTTTGTCCCGGATCAGACCCATGAGAAACGAACAGTATCGGGGCAAGAACCCTCTATTAGTTCCACTTCTGTATGACTTCCGGAGGATGACAGCACGGCGCAGAGTTAACCGCAAAATGGGCTTTCATGTAATCTATAAGACACCCTGTGGTCTCTGCCTTCGGACGATGCAGGAGATAGAGCGCTACCTTTTTGAGACTGGCTGTGACTTTCTGTTCCTGGAGATGTTCTGTTTGGATCCATATGTTCTTGTTGACAGAAAGTTTCAACCCTTTAAGCCTTTTTACTATATTTTGGACATCACCTATGGCAAGGAAGATGTTCCCCTGTCCTGTGTTAATGAGATTGACACAACTCCCCCACCCCAGGTGGCCTACAGCAAGGAACGCATTCCTGGCAAGGGTGTTTTCATTAACACAGGCCCTGAATTTCTGGTTGGCTGTGACTGCAAGGATGGGTGTCGGGATAAATCCAAATGTGCCTGCCACCAGCTAACTATCCAGGCCACAGCCTGTACCCCAGGGGGCCAAGTCAACCCTAACTCTGGCTACCAGTATAAAAGACTAGAAGAGTGTCTGCCCACAGGGGTTTATGAGTGTAACAAACGCTGCAATTGTGACCCAAACATGTGCACAAATCGGTTGGTGCAGCATGGTCTGCAGGTTCGACTACAGCTGTTTAAGACACAGAACAAGGGCTGGGGTATCCGCTGCTTGGATGATATTGCCAAAGGCTCTTTTGTCTGCATTTATGCAGGCAAAATCCTGACAGATGACTTTGCAGACAAAGAAGGCCTGGAGATGGGTGATGAGTACTTTGCAAATCTGGACCACATTGAAAGTGTGGAGAACTTCAAGGAAGGATATGAGAGTGATGTCCCCACTTCCTCTGACAGCAGTGGGGTAGATATGAAGGACCAGGAAGATGGCAACAGCGGTTCAGAGGACCCTGAAGAATCCAATGATGACAGCTCTGATGATAACTTCTGTAAGGATGAGGACTTCAGCACCAGTTCAGTGTGGCGTAGCTATGCTACCCGGAGGCAGACTCGGGGTCAAAAGGAGAATGAATTGTCTGAGATGACTTCCAAGGACTCCCGCCCCCCAGACCTCGGGCCTCCACATGTTCCTATCCCTTCCTCAGTATCTGTAGGGGGCTGCAATCCACCTTCCTCTGAAGAGACACCCAAGAACAAGGTGGCCTCGTGGTTGAGTTGCAATAGTGTCAGTGAAGGTGGATTTGCTGACTCTGACAGCCGTTCTTCCTTCAAGACTAGTGAAGGTGGAGATGGCCGTGCTGGGGGAGGCCGGGGAGAGGCTGAAAGGGCCTCTACCTCAGGATTGAGCTTCAAGGATGAAGGAGACAATAAGCAGCCTAAAAAAGAGGACCCTGAGAACCGAAACAAGATGCCAGTAGTTACTGAAGGCTCTCAGAATCATGGACATAATCCTCCCATGAAGTCTGAAGGGCTTCGCCGATCAGCTAGTAAAATGTCTGTGCTCCAGAGCCAGCGAGTTGTGACTTCTACTCAGTCAAACCCTGATGACATCCTGACACTGTCCAGCAGCACAGAGAGTGAGGGGGAAAGTGGAACCAGCCGAAAGCCCACTGCTGGTCACACTTCAGCCACAGCTGTTGATAGTGATGACATCCAGACCATCTCTTCTGGCTCTGACGGTGATGACTTTGAGGACAAGAAGAACTTGTCAGGACCAACAAAGCGCCAGGTGGCAGTAAAATCAACCCGAGGCTTTGCTCTTAAATCAACCCATGGTATTGCCATTAAATCAACCAACATGGCTTCCGTGGACAAGGGGGAGAGTGCACCAGTTCGTAAGAACACACGCCAGTTCTATGATGGTGAAGAGTCTTGCTACATCATTGATGCCAAACTTGAAGGCAACCTAGGCCGCTACCTCAATCACAGTTGCAGCCCCAACCTGTTTGTCCAGAATGTGTTTGTGGATACCCATGATCTTCGCTTCCCTTGGGTGGCCTTCTTTGCCAGCAAGAGAATCCGGGCTGGAACAGAACTCACTTGGGACTACAACTACGAAGTGGGCAGTGTGGAAGGCAAGGAGCTGCTGTGCTGCTGTGGGGCCATTGAATGCAGAGGGAGACTTCTTTAGAGGAAGACTTCCTCACTTTGAGAACGCTTGAACTATCCTTTTCCCCAGGAACTGGGTCTTCCTGACTGTTGAACTCTGACCCCAAGTCTCTGATCTAGCTTCTTCCCAGCTCCTAGTAGATAGAGATGGGGATTCTCAATCAGGACTTTCCCAGCGTGGTGCTAGCAGGCACTAGGGTGGGTAGACATGACCACTCTAGCATCAGCCTGAGGTCCTTCTCATCTTGTATGCATTCATGATTCACATGGGCTGTGTATCTGCCATCCCTGATTTGTATGGTTTCTTGAAAGTCTTCTAACAAGATGGTAAAGTAGAGATTGTGGTTTGTCTTATCTCCTGCCTTGATCTTCCATGTCATTTCCCAGTGGGCAACTATCATTAGTTTATACCTCGATTTTATTTGCCCTGTGTAATTTTTAACTAAAAATGTTACATAACCACAAGGGAGGCCTAAGAAAAAAACTAACCCTTTCTCAAGTCTTAATAGTCTGACACAGTCATGTTTTATTTAACCTTTAATATACTTTAATTAAAAAAAATTAACAGTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
--
|
| Interpro |
IPR016177--DNA-bd_dom
IPR025796--Hist-Lys_N-MeTrfase_SETDB1
IPR001739--Methyl_CpG_DNA-bd
IPR003616--Post-SET_dom
IPR007728--Pre-SET_dom
IPR001214--SET_dom
IPR002999--Tudor
|
| PROSITE |
PS50982--MBD
PS50868--POST_SET
PS50867--PRE_SET
PS51573--SAM_MT43_SUVAR39_1
PS50280--SET
|
| Pfam |
PF01429--MBD
PF05033--Pre-SET
PF00856--SET
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:1990841--F:promoter-specific chromatin binding
GO:0008270--F:zinc ion binding
GO:0060348--P:bone development
GO:0036124--P:histone H3-K9 trimethylation
GO:0001833--P:inner cell mass cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0007265--P:Ras protein signal transduction
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
