| Tag |
Content |
| WERAM ID |
WERAM-Hos-0031 |
| Ensembl Protein ID |
ENSP00000263360.6 |
| Uniprot Accession |
O75530; EED_HUMAN; A8K7V5; O00149; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7
|
| Genbank Protein ID |
NP_001294936.1; NP_003788.2
|
| Protein Name |
Polycomb protein EED |
| Genbank Nucleotide ID |
NM_001308007.1; NM_003797.4
|
| Gene Name |
EED |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
WD40 |
WD1-7 |
H3K9; H3K27 |
K |
25365549; 25381642
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
WD40 |
2.80e-152 |
509.1 |
91 |
439 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
|
| Domain Profile |
Me_Reader WD40
WD40.txt 1 dhekelsavkfepaseegaslvaatvgseavtvydcqtqgeikllqky..kghdeefysvawtadsnkrhslLasAgdrglirlldveagqc 90
dh+++l++v+f+++s+eg++lv+atvgs++vt+y+c++qgei+llq+y +++de+fy++awt+dsn++h+lLa+Ag+rg+ir+++++++qc
ENSP00000263360.6 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYvdADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQC 182
8***********************************************9999**************************************** PP
WD40.txt 91 ikvlvgHknaiaelkFsPkdenlllsaSfdkrvrlWdiktdklkkif...eahsdevldvdydlrgslivScgmdgslkiWdvrskrrvcev 179
ik++vgH+nai+elkF+P+d+nllls+S+d+++rlW+i+td+l++if e+h+devl++dydl g++i+Scgmd+slk+W+++skr+++++
ENSP00000263360.6 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274
******************************************************************************************** PP
WD40.txt 180 klvddenpeksnrr....................VdcvrfsngdlilsgsldntivlW.......dirkikqsevavvvLkrfeyskteiyy 244
k+++d+np+k+nr+ Vdcvr+ +gdlils+s++n+iv+W di+kik+se++v++L+rf+ys+++i+y
ENSP00000263360.6 275 KESYDYNPNKTNRPfisqkihfpdfstrdihrnyVDCVRW-LGDLILSKSCENAIVCWkpgkmedDIDKIKPSESNVTILGRFDYSQCDIWY 365
****************************************.*************************************************** PP
WD40.txt 245 islsfsvdn.kkilvsgdedgkvyvwdlsveaalkakelllklgkvtakimqtsvspnesiiiltaltddnivkiWdr 321
+ +fs+d+ +k+l++g+++gk+yvwdl+ve+++kak+++l+++k++a+i+qts+s+++si+i a++dd+++++Wdr
ENSP00000263360.6 366 M--RFSMDFwQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILI--AVCDDASIWRWDR 439
*..************************************************************..************8 PP
|
Protein Sequence
(Fasta) | MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 60
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 120
VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM 180
QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL 240
SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS 300
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ 360
CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR 420
DSSILIAVCD DASIWRWDRL R 441Protein Fasta Sequence
>ENSP00000263360.6|EED|Homo sapiens
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR |
Nucleotide Sequence
(Fasta) | ATTCGCCAGA TGGGGGAAGC CAGGGGGAAG CAGGTTACTG TTTTTGCATT TCTATCTTCA 60
AGGAAGAATT AGGTTATGAA TAGTTCCGTG AATAGTCAGG AAGCGCTGTC CTCCAAGTTC 120
AAGATTAAGG AAACGTGGCA TGCACAGCTA AAGCAAGAGG TGACGTCTTG TATCTTCCCC 180
CGTTTCCTGG GACATTGGTG GTGTAGCCCA TTCCACAGAC TTTCGCTCCC TAGCAGCGGG 240
TCGGAGATCG AAGGAACGGG CCAATTGCGG CTGAAACGTC TTTGGAAGGA GGAAGGGGGT 300
GAGGGAGCAT CCCTTTGAGT TTCGCCTCTT CTCGAGGCGG TGGTGGGAAG GGAGACATAC 360
TTAATACTGC CCTCTTAATC CAACGGACCT TACATCGTGT AGACTGCCGG GAGGGCGGCG 420
GGAAAAGGGC AAGACGGGAG TTGGGGAAGG GAAGGAGCCA GGAAGCCGCG CGGGAGGGCG 480
CGCGCGCGCG CCCCTTTTTC AGCAGTGTGG CGGGGTCGCA CGCACGCCCG CCTCGGCGGC 540
TGGGCGCGAT TTGCGACAGT GGGGGGGGCG GTGGAGGTGG CGGCGGCAGC GGCAACTTTG 600
CGGCAAGCTC GGGCCGGGCT TGCTTGACGG CGGTGTGGCG GAGGCCCCGC CCCAGGCGGC 660
AGGAACCTGG AGGGAGGCGG AGGAATATGT CCGAGAGGGA AGTGTCGACT GCGCCGGCGG 720
GAACAGACAT GCCTGCGGCC AAGAAGCAGA AGCTGAGCAG TGACGAGAAC AGCAATCCAG 780
ACCTCTCTGG AGACGAGAAT GATGACGCTG TCAGTATAGA AAGTGGTACA AACACTGAAC 840
GCCCTGATAC ACCTACAAAC ACGCCAAATG CACCTGGAAG GAAAAGTTGG GGAAAGGGAA 900
AATGGAAGTC AAAGAAATGC AAATATTCTT TCAAATGTGT AAATAGTCTC AAGGAAGATC 960
ATAACCAACC ATTGTTTGGA GTTCAGTTTA ACTGGCACAG TAAAGAAGGA GATCCATTAG 1020
TGTTTGCAAC TGTAGGAAGC AACAGAGTTA CCTTGTATGA ATGTCATTCA CAAGGAGAAA 1080
TCCGGTTGTT GCAATCTTAC GTGGATGCTG ATGCTGATGA AAACTTTTAC ACTTGTGCAT 1140
GGACCTATGA TAGCAATACG AGCCATCCTC TGCTGGCTGT AGCTGGATCT AGAGGCATAA 1200
TTAGGATAAT AAATCCTATA ACAATGCAGT GTATAAAGCA CTATGTTGGC CATGGAAATG 1260
CTATCAATGA GCTGAAATTC CATCCAAGAG ATCCAAATCT TCTCCTGTCA GTAAGTAAAG 1320
ATCATGCTTT ACGATTATGG AATATCCAGA CGGACACTCT GGTGGCAATA TTTGGAGGCG 1380
TAGAAGGGCA CAGAGATGAA GTTCTAAGTG CTGATTATGA TCTTTTGGGT GAAAAAATAA 1440
TGTCCTGTGG TATGGATCAT TCTCTTAAAC TTTGGAGGAT CAATTCAAAG AGAATGATGA 1500
ATGCAATTAA GGAATCTTAT GATTATAATC CAAATAAAAC TAACAGGCCA TTTATTTCTC 1560
AGAAAATCCA TTTTCCTGAT TTTTCTACCA GAGACATACA TAGGAATTAT GTTGATTGTG 1620
TGCGATGGTT AGGCGATTTG ATACTTTCTA AGTCTTGTGA AAATGCCATT GTGTGCTGGA 1680
AACCTGGCAA GATGGAAGAT GATATAGATA AAATTAAACC CAGTGAATCT AATGTGACTA 1740
TTCTTGGGCG ATTTGATTAC AGCCAGTGTG ACATTTGGTA CATGAGGTTT TCTATGGATT 1800
TCTGGCAAAA GATGCTTGCA TTGGGCAATC AAGTTGGCAA ACTTTATGTT TGGGATTTAG 1860
AAGTAGAAGA TCCTCATAAA GCCAAATGTA CAACACTGAC TCATCATAAA TGTGGTGCTG 1920
CTATTCGACA AACCAGTTTT AGCAGGGATA GCAGCATTCT TATAGCTGTT TGTGATGATG 1980
CCAGTATTTG GCGCTGGGAT CGACTTCGAT AAAATACTTT TGCCTAATCA AAATTAGAGT 2040
GTGTTTGTTG TCTGTGTAAA ATAGAATTAA TGTATCTTGC TAGTAAGGGC ACGTAGAGCA 2100
TTTAGAGTTG TCTTTCAGCA TTCAATCAGG CTGAGCTGAA TGTAGTGATG TTTACATTGT 2160
TTACATTCTT TGTACTGTCT TCCTGCTCAG ACTCTACTGC TTTTAATAAA AATTTATTTT 2220
TGT
2224Nucleotide Fasta Sequence
>ENSP00000263360.6|WD40|Homo sapiens
ATTCGCCAGATGGGGGAAGCCAGGGGGAAGCAGGTTACTGTTTTTGCATTTCTATCTTCAAGGAAGAATTAGGTTATGAATAGTTCCGTGAATAGTCAGGAAGCGCTGTCCTCCAAGTTCAAGATTAAGGAAACGTGGCATGCACAGCTAAAGCAAGAGGTGACGTCTTGTATCTTCCCCCGTTTCCTGGGACATTGGTGGTGTAGCCCATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGGCTGAAACGTCTTTGGAAGGAGGAAGGGGGTGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATACTTAATACTGCCCTCTTAATCCAACGGACCTTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGGGAAGGAGCCAGGAAGCCGCGCGGGAGGGCGCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGCTGGGCGCGATTTGCGACAGTGGGGGGGGCGGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATGATGACGCTGTCAGTATAGAAAGTGGTACAAACACTGAACGCCCTGATACACCTACAAACACGCCAAATGCACCTGGAAGGAAAAGTTGGGGAAAGGGAAAATGGAAGTCAAAGAAATGCAAATATTCTTTCAAATGTGTAAATAGTCTCAAGGAAGATCATAACCAACCATTGTTTGGAGTTCAGTTTAACTGGCACAGTAAAGAAGGAGATCCATTAGTGTTTGCAACTGTAGGAAGCAACAGAGTTACCTTGTATGAATGTCATTCACAAGGAGAAATCCGGTTGTTGCAATCTTACGTGGATGCTGATGCTGATGAAAACTTTTACACTTGTGCATGGACCTATGATAGCAATACGAGCCATCCTCTGCTGGCTGTAGCTGGATCTAGAGGCATAATTAGGATAATAAATCCTATAACAATGCAGTGTATAAAGCACTATGTTGGCCATGGAAATGCTATCAATGAGCTGAAATTCCATCCAAGAGATCCAAATCTTCTCCTGTCAGTAAGTAAAGATCATGCTTTACGATTATGGAATATCCAGACGGACACTCTGGTGGCAATATTTGGAGGCGTAGAAGGGCACAGAGATGAAGTTCTAAGTGCTGATTATGATCTTTTGGGTGAAAAAATAATGTCCTGTGGTATGGATCATTCTCTTAAACTTTGGAGGATCAATTCAAAGAGAATGATGAATGCAATTAAGGAATCTTATGATTATAATCCAAATAAAACTAACAGGCCATTTATTTCTCAGAAAATCCATTTTCCTGATTTTTCTACCAGAGACATACATAGGAATTATGTTGATTGTGTGCGATGGTTAGGCGATTTGATACTTTCTAAGTCTTGTGAAAATGCCATTGTGTGCTGGAAACCTGGCAAGATGGAAGATGATATAGATAAAATTAAACCCAGTGAATCTAATGTGACTATTCTTGGGCGATTTGATTACAGCCAGTGTGACATTTGGTACATGAGGTTTTCTATGGATTTCTGGCAAAAGATGCTTGCATTGGGCAATCAAGTTGGCAAACTTTATGTTTGGGATTTAGAAGTAGAAGATCCTCATAAAGCCAAATGTACAACACTGACTCATCATAAATGTGGTGCTGCTATTCGACAAACCAGTTTTAGCAGGGATAGCAGCATTCTTATAGCTGTTTGTGATGATGCCAGTATTTGGCGCTGGGATCGACTTCGATAAAATACTTTTGCCTAATCAAAATTAGAGTGTGTTTGTTGTCTGTGTAAAATAGAATTAATGTATCTTGCTAGTAAGGGCACGTAGAGCATTTAGAGTTGTCTTTCAGCATTCAATCAGGCTGAGCTGAATGTAGTGATGTTTACATTGTTTACATTCTTTGTACTGTCTTCCTGCTCAGACTCTACTGCTTTTAATAAAAATTTATTTTTGT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
--
|
| Interpro |
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF00400--WD40
|
| Gene Ontology |
GO:0035098--C:ESC/E(Z) complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045120--C:pronucleus
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0042054--F:histone methyltransferase activity
GO:0042802--F:identical protein binding
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0021510--P:spinal cord development
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
