WERAM Information

Tag Content
WERAM ID WERAM-Hos-0124
Ensembl Protein ID ENSP00000255613.3
Uniprot Accession Q86Y97; KMT5C_HUMAN; Q8WZ10; Q9BRZ6
Genbank Protein ID NP_116090.2; XP_005259395.1; XP_006723505.1; XP_011525717.1
Protein Name Histone-lysine N-methyltransferase KMT5C
Genbank Nucleotide ID NM_032701.3; XM_005259338.2; XM_006723442.2; XM_011527415.1
Gene Name SUV420H2;KMT5C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000133247.13 ENST00000255613.7 ENSP00000255613.3
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SUV4-20 SET H4K20 K 25537518; 26807165; 20889125; 20951770
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SUV4-20 7.90e-61 205.6 110 218
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
Domain Profile
  HMT SUV4-20
        SUV4-20.txt   2 eckrysleeqkgakivstkewkkndkiellvgviaelseadedallragendfsvmystrkrcaqlwlgpaayinhdcrpnckfvstgrdta 93 
                        +c+rys +e++gakivst++wkkn+k+ellvg+iael+eade+ llragendfs+mystrkr+aqlwlgpaa+inhdc+pnckfv++++++a
  ENSP00000255613.3 110 PCTRYS-METNGAKIVSTRAWKKNEKLELLVGCIAELREADEG-LLRAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPADGNAA 199
                        8*****.9**********************************9.************************************************ PP
        SUV4-20.txt  94 cvkvlrdiepgdeitcfyg 112
                        cvkvlrdiepgde+tcfyg
  ENSP00000255613.3 200 CVKVLRDIEPGDEVTCFYG 218
                        ******************9 PP
Protein Sequence
(Fasta)		MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS ALETFLRQRD 60
LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF LPESGFTILP CTRYSMETNG 120
AKIVSTRAWK KNEKLELLVG CIAELREADE GLLRAGENDF SIMYSTRKRS AQLWLGPAAF 180
INHDCKPNCK FVPADGNAAC VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG 240
AFRTRPREPA LPPRPLDKYQ LRETKRRLQQ GLDSGSRQGL LGPRACVHPS PLRRDPFCAA 300
CQPLRLPACS ARPDTSPLWL QWLPQPQPRV RPRKRRRPRP RRAPVLSTHH AARVSLHRWG 360
GCGPHCRLRG EALVALGQPP HARWAPQQDW HWARRYGLPY VVRVDLRRLA PAPPATPAPA 420
GTPGPILIPK QALAFAPFSP PKRLRLVVSH GSIDLDVGGE EL 462
Nucleotide Sequence
(Fasta)		GAGCAGATGG GAGGTGCGGC GACAGTGTTT GACGAGAGCC GAAGGAGGCT GTGGGAGGTG 60
TTGGCGGCGG CGGCGCGGGC GCCTGAGGAG GAGGAGGAGA AGCGGATGAG ATCGTGGGGC 120
TCACCAGCGT CCCCCATGGC TTCTGAGTAG CGTGGGAGTG GAGTCAGCAC CAAGCCAGGC 180
TCCCCGCGCC TGCCTTGCCC TCACCTGCTC CTGCTCTCTG CCAGAGGCAG CATGGTCCGC 240
AGGGCACCAT GGGGCCCGAC AGAGTGACAG CACGAGAACT GTGCGAGAAC GACGACCTGG 300
CCACCAGCCT CGTCCTGGAC CCCTACCTCG GTTTCCGCAC CCATAAGATG AACGTCAGCC 360
CTGTGCCCCC CCTGCGGCGA CAGCAGCACC TGCGCTCAGC GCTGGAAACT TTCCTGAGGC 420
AGCGGGACCT GGAGGCTGCG TACCGGGCCC TGACGCTGGG AGGCTGGACG GCCCGCTACT 480
TCCAGAGCCG GGGCCCGCGG CAGGAGGCTG CCCTCAAGAC CCACGTCTAT CGCTACCTCC 540
GTGCCTTCCT GCCGGAAAGT GGCTTTACCA TCCTGCCCTG CACGCGCTAC TCCATGGAGA 600
CCAACGGGGC CAAGATCGTG TCCACTCGTG CTTGGAAAAA GAATGAGAAG CTGGAGCTGC 660
TGGTGGGCTG CATTGCAGAG CTGCGGGAGG CAGATGAGGG GCTGCTGAGG GCCGGTGAGA 720
ATGACTTCAG CATCATGTAC TCAACCCGCA AGCGGAGTGC TCAGCTGTGG CTGGGCCCAG 780
CCGCCTTCAT CAACCATGAC TGCAAACCCA ACTGCAAGTT TGTGCCTGCA GATGGGAACG 840
CAGCCTGCGT GAAGGTGCTC CGGGACATTG AGCCTGGGGA CGAGGTGACA TGCTTCTACG 900
GCGAGGGCTT CTTCGGCGAG AAGAATGAGC ACTGTGAATG CCACACCTGT GAGAGGAAAG 960
GTGAAGGAGC TTTCCGAACC AGGCCTAGGG AGCCCGCGTT GCCACCACGG CCCCTGGACA 1020
AGTACCAGCT GCGTGAGACC AAGCGGCGGC TGCAGCAAGG CCTGGACAGT GGCAGCCGAC 1080
AGGGCCTGCT GGGCCCTCGG GCCTGCGTGC ACCCATCCCC GCTGCGCCGG GACCCATTCT 1140
GCGCCGCCTG CCAGCCCCTG CGCCTGCCAG CCTGCAGCGC CCGCCCAGAC ACCTCACCCC 1200
TCTGGCTCCA GTGGCTGCCT CAGCCCCAGC CCCGAGTGCG GCCCCGGAAG CGCCGACGCC 1260
CCCGGCCCCG GAGGGCCCCA GTGCTCTCCA CCCACCACGC TGCCCGCGTC TCCCTGCACC 1320
GATGGGGAGG CTGTGGCCCC CACTGCCGCC TGCGAGGAGA GGCCCTGGTG GCCCTGGGCC 1380
AGCCCCCCCA CGCCCGCTGG GCCCCTCAGC AGGACTGGCA CTGGGCCCGG CGCTATGGGC 1440
TGCCTTACGT GGTGCGTGTG GACCTTCGTC GCCTGGCCCC AGCCCCACCA GCTACCCCAG 1500
CCCCTGCTGG GACCCCAGGC CCCATCCTGA TCCCGAAGCA GGCCCTCGCC TTCGCCCCCT 1560
TCTCCCCACC CAAGCGCCTA CGGCTGGTGG TCAGCCACGG CTCCATCGAC CTGGATGTCG 1620
GCGGTGAAGA GCTGTGACAG GCCGGACGGG GAGGCCCAGC AGGGAGAGAG GGTCTCTCTC 1680
CTAGCTGCTA CCCAGGACCT CCAGAAGGAG CCCTTGGACC TCTGGGAGGG AGCTGACCCT 1740
TGACTCCAGC ATAGCTCTGA CCCTGGAATG GGGTTGGTTT GGACACCCCC AGGGATCTGA 1800
GCCCTGACCC TTTGTGACTG CTGACCCCTG AGCCACCCCC ACTCCCACAG GGAGCCCCGG 1860
CCATTTGCTG CCCTCCCCAC CCCTGCCCCA GCCTCAGGAC TGCAGGAGCC ATCCGCCCCC 1920
CTCAGCCCCT TCCTCCCCAG GGAGCAAAGC CATAAGGGGC AGGGGCCACC CCACGGCATC 1980
TCCCCAGAAG TACAGGCCTC AGGAGGAGGT GGAACTGATG TAGGGGGTGG CACTCCCCAG 2040
AGACTGCCCT CACGAGGGGA CTGGGTTCGC TCTCAGCTCT GCAGCTGTCT GCGGTGGGGG 2100
GAAGGTTGGG GGGTGTCTGG AGGCATGTTC CCCTCACCAC CCCCCGTGGG TCTCAGGGAG 2160
GCCGGGTGTG ACCTCATCTT TCTCATGGTG CTATCCTGGT GCTATTGGGG TGGGGAGCTC 2220
CCTCCCCTCC CCCACACCAG AAAGGGGTAT GTTGGGGGCT TGGAAGCACT TGAACTTTTT 2280
ATTTTATTAA AACCTTGTTA TAAGCAGC 2309
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
Interpro

IPR025790--Hist-Lys_N-MTase_Suvar4-20
IPR001214--SET_dom
PROSITE

PS51570--SAM_MT43_SUVAR420_2
PS50280--SET
Pfam

PF00856--SET
Gene Ontology

GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005721--C:pericentric heterochromatin
GO:0042799--F:histone methyltransferase activity (H4-K20 specific)
GO:0034773--P:histone H4-K20 trimethylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Gog-0066 ENSGGOP00000005728.2 Gorilla gorilla 99 0.0 810
WERAM-Poa-0088 ENSPPYP00000011671.2 Pongo abelii 99 0.0 802
WERAM-Pat-0092 ENSPTRP00000019781.4 Pan troglodytes 98 0.0 790
WERAM-Mam-0023 ENSMMUP00000004094.2 Macaca mulatta 97 0.0 787
WERAM-Paa-0076 ENSPANP00000009661.1 Papio anubis 97 0.0 785
WERAM-Chs-0019 ENSCSAP00000016286.1 Chlorocebus sabaeus 96 0.0 781
WERAM-Otg-0050 ENSOGAP00000003483.2 Otolemur garnettii 91 0.0 736
WERAM-Aim-0049 ENSAMEP00000003925.1 Ailuropoda melanoleuca 90 0.0 731
WERAM-Caf-0033 ENSCAFP00000003774.4 Canis familiaris 86 0.0 717
WERAM-Eqc-0100 ENSECAP00000011505.1 Equus caballus 86 0.0 714
WERAM-Ict-0011 ENSSTOP00000000609.2 Ictidomys tridecemlineatus 87 0.0 714
WERAM-Dan-0194 ENSDNOP00000032334.1 Dasypus novemcinctus 87 0.0 712
WERAM-Tut-0009 ENSTTRP00000000539.1 Tursiops truncatus 87 0.0 710
WERAM-Ptv-0073 ENSPVAP00000006892.1 Pteropus vampyrus 87 0.0 698
WERAM-Bot-0129 ENSBTAP00000018728.4 Bos taurus 84 0.0 697
WERAM-Mup-0082 ENSMPUP00000007507.1 Mustela putorius furo 86 0.0 696
WERAM-Prc-0132 ENSPCAP00000011674.1 Procavia capensis 81 0.0 682
WERAM-Cap-0111 ENSCPOP00000008175.2 Cavia porcellus 80 0.0 662
WERAM-Ran-0113 ENSRNOP00000023744.5 Rattus norvegicus 81 0.0 654
WERAM-Mum-0208 ENSMUSP00000096452.2 Mus musculus 80 0.0 647
WERAM-Dio-0127 ENSDORP00000012039.1 Dipodomys ordii 78 2e-178 622
WERAM-Fec-0193 ENSFCAP00000018823.1 Felis catus 87 5e-154 541
WERAM-Mae-0103 ENSMEUP00000010117.1 Macropus eugenii 73 2e-152 536
WERAM-Ova-0009 ENSOARP00000001530.1 Ovis aries 65 1e-135 480
WERAM-Ect-0106 ENSETEP00000011903.1 Echinops telfairi 94 6e-129 458
WERAM-Pem-0039 ENSPMAP00000004993.1 Petromyzon marinus 62 1e-95 347
WERAM-Pes-0137 ENSPSIP00000016261.1 Pelodiscus sinensis 62 1e-95 347
WERAM-Meg-0099 ENSMGAP00000009510.1 Meleagris gallopavo 62 2e-95 347
WERAM-Fia-0155 ENSFALP00000013275.1 Ficedula albicollis 62 2e-95 346
WERAM-Gaga-0132 ENSGALP00000022853.4 Gallus gallus 62 2e-95 346
WERAM-Ten-0031 ENSTNIP00000006027.1 Tetraodon nigroviridis 56 2e-94 343
WERAM-Nol-0066 ENSNLEP00000007961.2 Nomascus leucogenys 62 2e-94 343
WERAM-Orn-0183 ENSONIP00000018952.1 Oreochromis niloticus 60 3e-94 342
WERAM-Myl-0090 ENSMLUP00000007496.2 Myotis lucifugus 62 4e-94 342
WERAM-Anp-0068 ENSAPLP00000008382.1 Anas platyrhynchos 62 6e-94 342
WERAM-Sus-0178 ENSSSCP00000023262.1 Sus scrofa 62 7e-94 342
WERAM-Pof-0184 ENSPFOP00000015576.1 Poecilia formosa 61 8e-94 341
WERAM-Lac-0183 ENSLACP00000021105.1 Latimeria chalumnae 58 1e-93 340
WERAM-Leo-0015 ENSLOCP00000003102.1 Lepisosteus oculatus 59 2e-93 340
WERAM-Tar-0133 ENSTRUP00000028898.1 Takifugu rubripes 58 4e-93 339
WERAM-Tag-0124 ENSTGUP00000010243.1 Taeniopygia guttata 57 7e-93 338
WERAM-Loa-0072 ENSLAFP00000005452.3 Loxodonta africana 58 1e-92 337
WERAM-Xet-0066 ENSXETP00000022104.3 Xenopus tropicalis 60 1e-92 337
WERAM-Asm-0222 ENSAMXP00000021268.1 Astyanax mexicanus 61 2e-92 337
WERAM-Mod-0194 ENSMODP00000026655.4 Monodelphis domestica 58 2e-92 337
WERAM-Tas-0034 ENSTSYP00000003476.1 Tarsius syrichta 58 3e-92 336
WERAM-Orc-0023 ENSOCUP00000002410.3 Oryctolagus cuniculus 57 4e-92 336
WERAM-Ocp-0084 ENSOPRP00000007619.1 Ochotona princeps 58 4e-92 335
WERAM-Gaa-0184 ENSGACP00000023105.2 Gasterosteus aculeatus 59 5e-92 335
WERAM-Caj-0163 ENSCJAP00000028971.2 Callithrix jacchus 57 9e-92 334
WERAM-Dar-0091 ENSDARP00000060190.3 Danio rerio 61 9e-92 334
WERAM-Anc-0156 ENSACAP00000014471.3 Anolis carolinensis 57 5e-91 332
WERAM-Xim-0165 ENSXMAP00000013465.1 Xiphophorus maculatus 57 6e-91 332
WERAM-Sah-0067 ENSSHAP00000008159.1 Sarcophilus harrisii 56 6e-91 332
WERAM-Orla-0008 ENSORLP00000000741.2 Oryzias latipes 55 2e-90 330
WERAM-Vip-0088 ENSVPAP00000008125.1 Vicugna pacos 57 4e-90 329
WERAM-Mim-0147 ENSMICP00000015214.1 Microcebus murinus 73 6e-88 322
WERAM-Gam-0070 ENSGMOP00000006748.1 Gadus morhua 57 2e-86 317
WERAM-Soa-0014 ENSSARP00000001556.1 Sorex araneus 59 4e-86 316
WERAM-Cis-0010 ENSCSAVP00000001617.1 Ciona savignyi 57 1e-82 304
WERAM-Drm-0024 FBpp0070146 Drosophila melanogaster 54 7e-70 262
WERAM-Ere-0118 ENSEEUP00000012535.1 Erinaceus europaeus 49 2e-64 243
WERAM-Cii-0003 ENSCINP00000001120.3 Ciona intestinalis 58 8e-63 238
WERAM-Cae-0051 C32D5.5 Caenorhabditis elegans 45 2e-53 207
WERAM-Tub-0071 ENSTBEP00000008881.1 Tupaia belangeri 48 1e-52 204
WERAM-Chh-0089 ENSCHOP00000010005.1 Choloepus hoffmanni 64 2e-32 137
WERAM-Ora-0140 ENSOANP00000030528.1 Ornithorhynchus anatinus 72 2e-31 134
WERAM-Ved-0035 EGY19263 Verticillium dahliae 31 8e-30 129
WERAM-Asc-0031 CADACLAP00007456 Aspergillus clavatus 31 1e-29 128
WERAM-Mao-0023 MGG_07393T0 Magnaporthe oryzae 37 4e-29 126
WERAM-Trv-0026 EHK15263 Trichoderma virens 31 7e-29 125
WERAM-Asfu-0019 CADAFUAP00004791 Aspergillus fumigatus 32 1e-28 125
WERAM-Fuo-0013 FOXG_02431P0 Fusarium oxysporum 29 6e-28 122
WERAM-Pyt-0038 EFQ86274 Pyrenophora teres 30 7e-28 122
WERAM-Phn-0027 SNOT_13760 Phaeosphaeria nodorum 31 1e-27 121
WERAM-Pytr-0029 EDU42362 Pyrenophora triticirepentis 30 3e-27 120
WERAM-Aso-0021 CADAORAP00005449 Aspergillus oryzae 29 3e-27 120
WERAM-Asf-0014 CADAFLAP00005976 Aspergillus flavus 29 3e-27 120
WERAM-Lem-0035 CBX97497 Leptosphaeria maculans 31 4e-27 120
WERAM-Asni-0030 CADANGAP00009644 Aspergillus niger 28 6e-27 119
WERAM-Lab-0053 EDR08823 Laccaria bicolor 33 6e-27 119
WERAM-Ast-0007 CADATEAP00004009 Aspergillus terreus 30 8e-27 119
WERAM-Nec-0025 EFNCRP00000004675 Neurospora crassa 28 9e-27 119
WERAM-Trr-0019 EGR45730 Trichoderma reesei 29 9e-27 119
WERAM-Map-0031 MAPG_09251T0 Magnaporthe poae 29 2e-26 117
WERAM-Gag-0038 GGTG_12747T0 Gaeumannomyces graminis 36 7e-26 115
WERAM-Asn-0027 CADANIAP00006863 Aspergillus nidulans 30 2e-25 114
WERAM-Chg-0017 EAQ91584 Chaetomium globosum 29 8e-25 112
WERAM-Yal-0021 CAG79838 Yarrowia lipolytica 34 1e-23 108
WERAM-Coi-0004 EAS35489 Coccidioides immitis 27 2e-23 107
WERAM-Tum-0007 CAZ83332 Tuber melanosporum 38 4e-23 106
WERAM-Scp-0046 SPCC4B3.12.1:pep Schizosaccharomyces pombe 37 1e-22 105
WERAM-Zyt-0032 Mycgr3P85175 Zymoseptoria tritici 28 5e-22 103
WERAM-Scj-0007 EEB06106 Schizosaccharomyces japonicus 32 5e-21 99.8
WERAM-Miv-0008 MVLG_00947T0 Microbotryum violaceum 29 2e-20 98.2
WERAM-Usm-0002 UM00543P0 Ustilago maydis 48 2e-18 91.3
WERAM-Spr-0012 CBQ67956 Sporisorium reilianum 48 2e-18 91.3
WERAM-Pug-0035 EFP91874 Puccinia graminis 31 7e-13 72.8
WERAM-Put-0024 PTTG_08954P0 Puccinia triticina 30 1e-12 72.0
WERAM-Mel-0024 EGG06895 Melampsora laricipopulina 36 1e-12 72.0
WERAM-Crn-0014 AAW42294 Cryptococcus neoformans 35 6e-07 52.8
Created Date 25-Jun-2016