| Tag |
Content |
| WERAM ID |
WERAM-Hos-0072 |
| Ensembl Protein ID |
ENSP00000225603.4 |
| Uniprot Accession |
P83916; CBX1_HUMAN; P23197
|
| Genbank Protein ID |
NP_001120700.1; NP_006798.1
|
| Protein Name |
Chromobox protein homolog 1 |
| Genbank Nucleotide ID |
NM_001127228.1; NM_006807.4
|
| Gene Name |
Cbx1 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Me_Reader |
DCD |
Chromo1 |
H3K9me3 |
K |
22514736
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
DCD |
1.70e-36 |
111.1 |
23 |
78 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. |
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
|
| Domain Profile |
Me_Reader DCD
Chromo-2.txt 3 verIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61
ve++++ kG+++yL+kWk+ +we++ en ++p l+ +f ++++ ++ +
ENSP00000225603.4 23 VEKVLDRR-VVKGKVEYLLKWKGFSDEDNTWEPE--ENLDCPDLIAEFLQSQKTAHETD 78
77888877.689***********98888899986..79*************99999865 PP
Chromo-2.txt 2 mverIinhsvdkkGelhyLikWkdlpYdeaswesatvenkkypqlvqsfyeeresmrgee 61
++erIi+++ d++Gel++L+kWk++ dea++++a+++n k+pq+v+sfyeer+++++++
ENSP00000225603.4 118 EPERIIGAT-DSSGELMFLMKWKNS--DEADLVPAKEANVKCPQVVISFYEERLTWHSYP 174
79*******.***************..******************************986 PP
|
Protein Sequence
(Fasta) | MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN TWEPEENLDC 60
PDLIAEFLQS QKTAHETDKS EGGKRKADSD SEDKGEESKP KKKKEESEKP RGFARGLEPE 120
RIIGATDSSG ELMFLMKWKN SDEADLVPAK EANVKCPQVV ISFYEERLTW HSYPSEDDDK 180
KDDKN 185Protein Fasta Sequence
>ENSP00000225603.4|Cbx1|Homo sapiens
MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN |
Nucleotide Sequence
(Fasta) | GAGGCCCATG GTGCCGTGCG GCGGGTCGTT GCGCCTGCGC GGTGCGAGCG GCGGGCAGCG 60
CAGACTGCGA GGCTCTTTTG TTCGGCTGAG GGGAGGGCCG TTGGCCGGGG CCTGCGGTAC 120
GCCGCTTCAG TGAGGGACGC CACTGCGGCC ACCCGGCTTG CTGCCTTCCT GGGCGCCACT 180
CCCCCAGGCG ACCCGACGCG ACGCGCCAGC AGCGCAGCAC CGATTCCTCT CGGGCTCTTG 240
GGCGCTGCTC TGAGCAGCGT CACCCTTTAC ACCAGAAAGC TGGCGGGCAC TATGGGGAAA 300
AAACAAAACA AGAAGAAAGT GGAGGAGGTG CTAGAAGAGG AGGAAGAGGA ATATGTGGTG 360
GAAAAAGTTC TCGACCGTCG AGTGGTAAAG GGCAAAGTGG AGTACCTCCT AAAGTGGAAG 420
GGATTCTCAG ATGAGGACAA CACATGGGAG CCAGAAGAGA ACCTGGATTG CCCCGACCTC 480
ATTGCTGAGT TTCTGCAGTC ACAGAAAACA GCACATGAGA CAGATAAATC AGAGGGAGGC 540
AAGCGCAAAG CTGATTCTGA TTCTGAAGAT AAGGGAGAGG AGAGCAAACC AAAGAAGAAG 600
AAAGAAGAGT CAGAAAAGCC ACGAGGCTTT GCTCGAGGTT TGGAGCCGGA GCGGATTATT 660
GGAGCTACAG ACTCCAGTGG AGAGCTCATG TTCCTGATGA AATGGAAAAA CTCTGATGAG 720
GCTGACCTGG TCCCTGCCAA GGAAGCCAAT GTCAAGTGCC CACAGGTTGT CATATCCTTC 780
TATGAGGAAA GGCTGACGTG GCATTCCTAC CCCTCGGAGG ATGATGACAA AAAAGATGAC 840
AAGAACTAAC GCTCCTGAGT ACCAGCCCCT GTCACATCTG ACTGTGGGTT TCAAGTGGGA 900
AGGGAAGGAG TTCTACTTGT CTTGACACCA TAGAGGTGGC TTGAGAAGAT GTCCTTTGAA 960
GAGCCAGTAT AGTTTCTGTG CCCTGCAGCA GCCCAAGTGC TTTAAAGCCG TTTCAAGCTG 1020
TATAGTTTGC ACACCCATCC CAGTGGAGGG GAAAGGGGAT AAGTGTTTCA AGGCAACCTT 1080
TTCTGCACTT TGCTGCGAAA AGCAAAGGGC CTTCTATGAA GGACAAAACT TGCAGAATTG 1140
GGTGTGTGGG AGAGCAAAAA AATACTGTAG ATCTTCAAAG AGCATCTCCA CAACCCACAG 1200
CCTTCTTCCC AATAGTGTTA ACTCTGCATT TTTACAGCGT AGCATGTGTG TAGTTTTTGG 1260
CTATTACTGG TGTATTATTT GGGGGAGGGA GGGATGGGGA GGGGAGAAAG GGAGATGGGT 1320
AGCATCATTT TGATTAACAT TTGGGGCCTG ATAGGGGAAA TGGTGAAGCA ATGGAAAAGA 1380
ACAGACAACT AATGATTTGC TTCTATGTCC AGAATATTTT ACCTTTAAAA AAATGTCATT 1440
GGCACCATAA ATAAGGACTG TGAGAGACTG TTTAAAAGCT GTGAAAGTCT GAAACCTATA 1500
AGCCAAGGTG TTCCCTGCCT AAACTTATTG CTGTTCCCAC AAAGGACTAA GCCTGTTCAT 1560
AAGTTACCAA AGTTGCCATT TTGGAGATGG AAATTGACGA GGAGGGAAGG TCTTTTATTG 1620
GAGAGTATAC AGTACAAGCA GATCATTCTG CCTTAGAGGT GCTAATTCCC GAAATTAGAA 1680
GACCCTTTCT TTTCCAGTAA CGAAGTTATA AATATCAGCT TGTTCATCCA AGCCACTGGC 1740
TGAGGTGTTA GGAAGAGGAA GAGGGTGGTA GAGGAGGTAA GACAGTAGGG AAAGACAAGG 1800
GCCCATGCTC TTAGTGGGGA AAACTCTTGG AGCCGTTTAC TTTGAGCTTT GAACACTGAA 1860
ACCATTGTTG GCAGGGTTCA GTCACTGACA GCACAAGTTT CACTGAATTG ATCCAAGAGT 1920
TTAGTGATTT CAAAAGCCTT GGTCTCAGGA GAAGATTAAA CTTTCATATT GGGCAGTGGT 1980
TCACTTTAAA ACACACACAT ACACACACAA AACAATTTTT TAAGAAATCC TAATAAGTAA 2040
CATACCCAAA ATGCTCTGTC TTGAGTCATG AGAACCATCA GTTCTTGATA TTGTCTAGAC 2100
TTGCATCTAG AGCTACGTTG TAAAATTCTT TTAGGCATGT GTTAGATTTC TGTGTAAACT 2160
TTGTTTAAAT GTAAACTTCA TACTACATTG TCAGTTTTTG TCTTAATAAA ACTATAGATT 2220
TATAATCCCT GA
2233Nucleotide Fasta Sequence
>ENSP00000225603.4|DCD|Homo sapiens
GAGGCCCATGGTGCCGTGCGGCGGGTCGTTGCGCCTGCGCGGTGCGAGCGGCGGGCAGCGCAGACTGCGAGGCTCTTTTGTTCGGCTGAGGGGAGGGCCGTTGGCCGGGGCCTGCGGTACGCCGCTTCAGTGAGGGACGCCACTGCGGCCACCCGGCTTGCTGCCTTCCTGGGCGCCACTCCCCCAGGCGACCCGACGCGACGCGCCAGCAGCGCAGCACCGATTCCTCTCGGGCTCTTGGGCGCTGCTCTGAGCAGCGTCACCCTTTACACCAGAAAGCTGGCGGGCACTATGGGGAAAAAACAAAACAAGAAGAAAGTGGAGGAGGTGCTAGAAGAGGAGGAAGAGGAATATGTGGTGGAAAAAGTTCTCGACCGTCGAGTGGTAAAGGGCAAAGTGGAGTACCTCCTAAAGTGGAAGGGATTCTCAGATGAGGACAACACATGGGAGCCAGAAGAGAACCTGGATTGCCCCGACCTCATTGCTGAGTTTCTGCAGTCACAGAAAACAGCACATGAGACAGATAAATCAGAGGGAGGCAAGCGCAAAGCTGATTCTGATTCTGAAGATAAGGGAGAGGAGAGCAAACCAAAGAAGAAGAAAGAAGAGTCAGAAAAGCCACGAGGCTTTGCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAGGCTGACCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCTCGGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGAAGGGAAGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCAGCCCAAGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTTTTCTGCACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAGATCTTCAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGGCTATTACTGGTGTATTATTTGGGGGAGGGAGGGATGGGGAGGGGAGAAAGGGAGATGGGTAGCATCATTTTGATTAACATTTGGGGCCTGATAGGGGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATTGGCACCATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTGCTGTTCCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTGGAGAGTATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATAAATATCAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGGGCCCATGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACAGCACAAGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGTTCACTTTAAAACACACACATACACACACAAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATGAGAACCATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACTTTGTTTAAATGTAAACTTCATACTACATTGTCAGTTTTTGTCTTAATAAAACTATAGATTTATAATCCCTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
--
|
| Interpro |
IPR000953--Chromo/shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR008251--Chromo_shadow_dom
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
|
| PROSITE |
PS00598--CHROMO_1
PS50013--CHROMO_2
|
| Pfam |
PF00385--Chromo
PF01393--Chromo_shadow
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0010369--C:chromocenter
GO:0000775--C:chromosome, centromeric region
GO:0001939--C:female pronucleus
GO:0001940--C:male pronucleus
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005721--C:pericentric heterochromatin
GO:0005819--C:spindle
GO:0003682--F:chromatin binding
GO:0019899--F:enzyme binding
GO:1990226--F:histone methyltransferase binding
GO:0045892--P:negative regulation of transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
