WERAM Information

Tag Content
WERAM ID WERAM-Mum-0177
Ensembl Protein ID ENSMUSP00000116313.2
Uniprot Accession E9Q5F9; SETD2_MOUSE; Q69ZC0; Q6PCY9; Q8K0F3
Genbank Protein ID NP_001074809.2
Protein Name Histone-lysine N-methyltransferase SETD2
Genbank Nucleotide ID NM_001081340.2
Gene Name SETD2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000044791.16 ENSMUST00000153838.7 ENSMUSP00000116313.2
ENSMUSG00000044791.16 ENSMUST00000198823.1 ENSMUSP00000142553.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SET2 SET H3K36 K 18157086
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SET2 1.10e-52 178.6 1525 1641
HMT SET1 1.10e-29 104.4 1526 1641
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis.
Domain Profile
  HMT SET2
              SET2.txt    2 kveliktekkGyGlrakeeikkdefileYvGevidekeakkRlkeyeeekvkdfYlleldkdeviDatkkGnlaRfinhsCePncet 88  
                            +ve+i tekkG+Glra++++++++f+leY+Gev+d+ke+k+R+key+++k+ ++Y+++l++de+iDat+kGn++Rf+nhsCePncet
  ENSMUSP00000116313.2 1525 DVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCET 1611
                            699************************************************************************************ PP
              SET2.txt   89 qkwtvegelrvglfakkkikkgeeltfdYn 118 
                            qkwtv+g+lrvg+f++k +++g+eltfdY+
  ENSMUSP00000116313.2 1612 QKWTVNGQLRVGFFTTKLVPSGSELTFDYQ 1641
                            *****************************7 PP
  HMT SET1
              SET1.txt    3 levakskikglglvakkeiekeelviEYvGevirsevadkrekeyekkeig.vylfrldedaevvvdatkkgniarfinhscepNce 88  
                            +ev   ++kg+gl+a+k++  +++v EY+Gev+ +++ + r key +++ +  y+++l++d   ++dat+kgn +rf+nhscepNce
  ENSMUSP00000116313.2 1526 VEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIhYYFMALKND--EIIDATQKGNCSRFMNHSCEPNCE 1610
                            77888899***********************************998776664888899999..9*********************** PP
              SET1.txt   89 akvvavdgekkiviyakraIekgeeltydYk 119 
                            ++  +v+g+ +++ + ++ ++ g elt+dY+
  ENSMUSP00000116313.2 1611 TQKWTVNGQLRVGFFTTKLVPSGSELTFDYQ 1641
                            ******************************6 PP
Protein Sequence
(Fasta)		MKPLPSQQPP PKMGDFYDPE HPTPEEEENE AKIENVQKTG FIKGPVFKGV ASSRFLPKGT 60
KTKVNLEEQG RQKVSFSFSF TKKTLQNRFL TALSNEKQSD SPNSPAPPLQ VDSNPKVKMD 120
AGDTFPATEE SSPPKSRVEL GRIHFKKHLL HVTSRPQLAA STTAASPLPP TTQLPAVLAE 180
SMIDSPPSSP PPPPPPPQAS SPSPPAQISE PVALPQPPAT ALMTSPPGPL PGDVAVRAQK 240
ESPVKSGPEV LEVDTKQDIV SNSLEEHTVQ TLKEQADHLL QKEDSHIGKE EEVSDGSKIS 300
LSSKKASSKK KSSQFEGTFL GSESDEDSVR TSSSQRSHDL KSSTSIDKER DFKKSSAPSK 360
SEDLGKSSRS KTERDDRYCS YSKLERDTRY VSSRCRSERD RRRSRSRSRS DRASRTSLSY 420
SRSERSHYYD SERRYHRSSP YRERTRYSRP YTDNRARESS DSEDEYKKTY PRRTSAHSYR 480
DLRTSSSYSK FDRDCKTETS YLEMERRGKY TSKLERESKR TSEHETIKRC CSPPNELGFR 540
RGSSYSKHDN STSRYKSALS KSISKNDKFK NSFCCTELNE ENKQSHSFSL QTPCSKGSEL 600
RTINKISERE KTGSPTPSNQ LNDSPTFKKL DESPVLKPEF IGHDGRESIK ELELSKVKND 660
QLRNFCSIEL NVNGSPETEA DVATFCTSKT DAISMTSDDS VTGSEVSPLI KACMLSSNGF 720
QNVGRCRERD SDDTCRQHNT SKSPFREMEP LLSPHHDKLM SLPVKTIDYP KTLIKEPVDK 780
RHSCCKTKDS DIYCSPNENP EAENAEPSAM TISSHSFVNV HLESKTVICD NREPTDRHSE 840
NTCDEYKQSI GSTSSASHNH FDGLYEPIGS SGISSLQSPP SGIRCEENTS PTLDAVESKK 900
GIDFLKYARK ETDVGSALPD SGKGFSWENR HNNVLSGQSL QEAQEEGNSI LHERRGRPEI 960
PLDEEQRGHT HISDDSEVVF PYDLNLTMED SDGITYTLKC DSSGNAPEIV STVHEDYSGS 1020
SASSSDESDS EDTESDDSSI PRNRLQSVVV VPKNSTLPME ETSPCSSRSS QSYKHYSDRW 1080
EDGLETRRHA YEEEYESKGC SQTEKYFLHK GTERSAESCY SQFGRKADNH LPDIAHAQSD 1140
GVDSTSQTDS RSDHLGHLNP EDTLRAKTSR PQELPVYSDD FEDLPNKSRQ QMIFSNRPDS 1200
SRLGKTELSF SSSCDISRMD GLHSSEELRN LGWDFSQQER PTTTYQQPDS SYGTCGTHKY 1260
QQSTEHYGGT HNYWQGNGYW DPRSAGRPPG TGLAYDRIQG QVPDSLTDDR EEEEHWDQRS 1320
GSHFSSPSNK FFFHQKDKGS VQAPEISSNS IKDALVMNER KDFSKNFEKN DIKERGPPKK 1380
RRQELESDSE SDGELQARKK VRVEMEQGES SVPQHSELMG PSCAMDDFRD PQRWKEFAKL 1440
GKMPCYFDLI EENVYLTERK KNKSHRDIKR MQCECTPLSK DERAQGEVAC GEDCLNRLLM 1500
IECSSRCPNG DYCSNRRFQR KQHADVEVIL TEKKGWGLRA AKDLPSNTFV LEYCGEVLDH 1560
KEFKARVKEY ARNKNIHYYF MALKNDEIID ATQKGNCSRF MNHSCEPNCE TQKWTVNGQL 1620
RVGFFTTKLV PSGSELTFDY QFQRYGKEAQ KCFCGSANCR GYLGGENRVS IRAAGGKMKK 1680
ERSRKKDSVD GELEALMENG EGLSDKNQVL SLSRLMVRIE TLEQKLTCLK LIQNTHSQSC 1740
LKSFLERHGL SLLWIWMAEL GDGRESNQKL QEEIIKTLEH LPIPTKNMLE ESKVLPIIQR 1800
WSQTKTAVPQ LSEGDGYSSE NTSRAHTPLN TPDPSAKPST EMDTDTPKKL IFRRLKIISE 1860
NSMDSAVSDV TSELECKDGK EDLDQLETVT VEEDEELQSQ QLLPQQLCES KVESEATIEV 1920
SKLPTSEPEA DTETEPKDSN GTKLEETIAE ETPSQDEEEG VSDVESERSQ EPPDKTVDIS 1980
DLATKLLDSW KDLKEVYRIP KKSQTEKEST VAERGRDAAA FRDQTAPKTP NRSRERDPDK 2040
QSQNKEKRKR RGSLSPPSSA YERGTKRPDD RYDTPTSKKK VRIKDRNKLS TEERRKLFEQ 2100
EVAQREAQKQ QQQMQNLGMT SPLPFDSLGY NASHHPFAGY PPGYPMQAYV DPSNPNAGKV 2160
LLPTPSMDPV CSPAPYDHAQ PLVGHSTESL AAPPSVPVVP HVAASVEVSS SQYVAQNESV 2220
VHQDSNVPVM PVQAPGPVQG QNYNVWESNQ QSVSVQQQYS PAQSQTTIYY QGQTCSTVYS 2280
VTSPYSQTTP PIVQSYAQPS LQYIQGQQIF TAHPQGVVVQ PTAAVTSIVA PGQPQSLQPP 2340
EMVVTNNLLD LPPPSPPKPK TIVLPPNWKT ARDPEGKIYY YHVITRQTQW DPPTWESPGD 2400
DASLEHEAEM DLGTPTYDEN PMKTSKKPKT AEADTSSELA KKSKEVFRKE MSQFIVQCLN 2460
PYRKPDCKVG RITTTEDFKH LARKLTHGVM NKELKYCKNP EDLECNENVK HKTKEYIKKY 2520
MQKFGAVYKP KEDTELE 2537
Nucleotide Sequence
(Fasta)		CGGCCGCCTC CCCTCCGGTC CCCTCCCCCG CATCGGCCTG CCGCGGGGAG GGGGCTAGCG 60
TCGCCGCCTC CAGCCGCTCC TCATGAAGCC GCTGCCGTCG CAGCAGCCGC CACCGAAGAT 120
GGGGGATTTC TACGATCCCG AGCACCCGAC CCCTGAAGAA GAAGAAAATG AGGCAAAGAT 180
TGAAAATGTG CAGAAAACAG GTTTCATCAA AGGACCAGTG TTCAAAGGTG TTGCTTCAAG 240
TCGATTTTTG CCCAAAGGCA CGAAGACAAA AGTTAATTTG GAGGAACAGG GACGGCAAAA 300
GGTGTCATTC AGCTTCAGTT TTACAAAGAA AACTTTACAG AATAGATTTC TCACTGCGCT 360
TAGCAATGAA AAGCAAAGTG ATTCTCCAAA CTCCCCAGCT CCCCCTCTTC AAGTAGACTC 420
AAACCCTAAA GTTAAAATGG ACGCTGGAGA TACTTTTCCT GCTACAGAAG AATCTTCGCC 480
ACCAAAATCG AGAGTGGAAT TGGGCAGAAT TCATTTTAAG AAACATTTGC TTCATGTGAC 540
ATCTAGGCCA CAGCTGGCTG CAAGTACAAC AGCAGCATCT CCCCTTCCTC CTACAACACA 600
GTTACCAGCA GTCTTAGCAG AGTCGATGAT AGACTCACCA CCTTCATCTC CACCCCCACC 660
TCCTCCACCT CCCCAGGCCT CATCACCCTC ACCACCAGCA CAGATATCAG AGCCAGTGGC 720
CTTGCCGCAA CCCCCAGCAA CAGCACTAAT GACATCACCA CCAGGACCTT TACCAGGAGA 780
CGTAGCCGTG AGAGCTCAGA AAGAATCACC AGTTAAAAGT GGACCCGAAG TTTTAGAGGT 840
GGATACAAAG CAAGATATTG TATCTAATAG TTTGGAAGAA CACACAGTTC AAACTTTGAA 900
GGAACAAGCA GATCATCTCC TGCAAAAAGA AGATTCCCAT ATTGGGAAGG AAGAAGAGGT 960
TTCAGATGGC TCTAAGATAA GCCTCAGTTC TAAAAAAGCA AGTTCTAAGA AGAAATCTTC 1020
ACAATTTGAA GGCACATTTC TTGGTTCAGA GTCTGATGAA GATTCTGTAC GGACTTCTTC 1080
CAGTCAAAGA TCACATGATT TAAAATCTTC AACAAGCATT GACAAGGAAA GAGATTTTAA 1140
GAAGAGCTCA GCACCTTCAA AAAGTGAGGA TTTGGGGAAA TCATCAAGAT CGAAAACAGA 1200
GAGAGATGAT AGATATTGTA GCTACTCAAA ACTTGAACGA GATACTCGGT ATGTATCTTC 1260
CCGATGTCGG TCCGAAAGAG ATCGAAGGCG AAGCCGATCT CGTTCTAGAT CTGACAGAGC 1320
CTCTAGAACT AGTTTGTCTT ATTCTCGCTC AGAAAGATCT CATTATTATG ATTCTGAACG 1380
GCGCTACCAT AGGAGTTCCC CTTATCGTGA GAGGACACGC TATTCTCGGC CATATACTGA 1440
TAACAGGGCA CGGGAGAGCT CAGACTCTGA AGATGAGTAT AAGAAGACAT ACCCACGGCG 1500
TACCTCAGCC CATTCCTACA GAGACCTAAG GACATCATCA TCTTACTCTA AATTTGATCG 1560
GGACTGTAAA ACTGAGACCT CTTACTTAGA GATGGAGAGA AGAGGAAAGT ATACTTCAAA 1620
ACTAGAAAGA GAATCCAAAC GGACTTCAGA GCATGAAACC ATAAAAAGAT GTTGTTCTCC 1680
CCCAAATGAA CTGGGATTCC GACGGGGGTC ATCATATTCC AAGCATGATA ACAGTACTTC 1740
CCGTTATAAA TCTGCCCTTT CAAAATCTAT ATCCAAGAAT GATAAATTTA AAAATTCTTT 1800
CTGTTGTACA GAATTAAATG AGGAAAACAA ACAATCTCAT TCGTTTAGTT TGCAGACTCC 1860
TTGTTCAAAA GGTAGTGAAT TAAGAACAAT TAATAAGATT TCTGAAAGAG AAAAGACTGG 1920
GTCTCCAACT CCATCAAATC AATTAAACGA TTCACCTACT TTTAAAAAGC TAGATGAATC 1980
TCCTGTTCTT AAGCCTGAAT TTATAGGACA CGATGGCCGT GAAAGTATTA AAGAATTGGA 2040
GTTATCAAAA GTGAAAAATG ATCAATTAAG AAATTTTTGT TCCATTGAAT TAAATGTAAA 2100
CGGATCTCCA GAGACAGAAG CTGATGTGGC AACATTTTGT ACTTCTAAGA CAGATGCTAT 2160
ATCAATGACT TCTGATGATA GTGTGACTGG ATCAGAGGTA TCCCCTTTGA TCAAGGCTTG 2220
CATGCTTTCA TCAAATGGAT TTCAGAATGT TGGTAGATGC AGAGAAAGGG ACTCAGATGA 2280
TACTTGTAGG CAGCATAATA CGTCAAAAAG TCCATTTAGG GAAATGGAAC CTTTGTTGTC 2340
ACCACACCAT GATAAACTCA TGTCTTTGCC AGTTAAGACT ATAGATTATC CCAAAACATT 2400
AATTAAAGAA CCAGTTGATA AGAGACATTC TTGCTGCAAA ACCAAAGATT CAGATATATA 2460
CTGTTCTCCA AATGAAAACC CTGAAGCTGA GAACGCTGAA CCTTCAGCTA TGACGATTTC 2520
TTCACATAGC TTTGTGAATG TGCATTTGGA ATCCAAGACA GTTATATGTG ATAATAGGGA 2580
GCCGACAGAC CGGCACTCAG AGAATACATG TGATGAATAT AAGCAGAGCA TTGGTAGCAC 2640
TAGTTCAGCT TCTCATAACC ATTTTGATGG TTTGTATGAG CCTATAGGGA GTTCAGGTAT 2700
TTCATCTCTC CAGAGTCCTC CGTCAGGAAT AAGATGTGAA GAAAACACAT CTCCAACTCT 2760
AGATGCAGTG GAGAGTAAAA AAGGCATAGA TTTTTTAAAG TATGCACGGA AAGAAACAGA 2820
TGTTGGTAGT GCCCTTCCTG ATTCAGGAAA AGGATTTTCT TGGGAAAACA GGCATAATAA 2880
TGTGTTATCT GGGCAGTCTT TGCAAGAGGC TCAAGAAGAA GGGAATTCCA TATTGCATGA 2940
GAGAAGAGGA AGACCAGAAA TCCCCTTAGA TGAGGAACAA AGAGGCCATA CACATATTTC 3000
TGATGATTCA GAAGTGGTAT TTCCTTATGA TTTGAACTTG ACCATGGAAG ACAGTGATGG 3060
TATAACCTAC ACCTTAAAAT GTGATAGTAG TGGAAATGCT CCAGAGATTG TATCTACTGT 3120
CCATGAAGAC TATTCTGGAT CTTCTGCAAG TTCAAGCGAT GAAAGTGATT CTGAAGATAC 3180
AGAGTCTGAT GATAGCAGTA TTCCAAGAAA CCGACTCCAG TCTGTTGTGG TTGTGCCAAA 3240
GAATTCTACT TTGCCCATGG AAGAGACAAG TCCCTGTTCT TCTCGGAGCA GTCAGAGCTA 3300
CAAACATTAT TCTGACCGCT GGGAAGATGG ATTAGAGACC AGGAGACATG CATATGAGGA 3360
AGAGTATGAG AGTAAAGGCT GTTCTCAAAC TGAAAAATAC TTCCTTCATA AAGGAACAGA 3420
GAGAAGTGCA GAAAGTTGTT ATTCACAGTT TGGCAGGAAA GCAGATAATC ACCTGCCTGA 3480
CATTGCTCAT GCTCAGAGTG ACGGGGTTGA TAGTACAAGT CAGACAGACT CGAGATCTGA 3540
CCATCTAGGT CACCTGAATC CAGAGGACAC ATTAAGAGCC AAAACATCTA GGCCACAAGA 3600
GCTACCAGTT TATTCTGACG ATTTTGAAGA TCTCCCAAAT AAGTCTCGGC AGCAGATGAT 3660
TTTCTCTAAT CGGCCAGATA GTAGTAGACT AGGAAAAACA GAGCTGAGTT TTTCTTCCTC 3720
TTGTGACATT TCCCGAATGG ATGGCTTGCA CTCATCAGAA GAGCTCAGAA ACCTAGGGTG 3780
GGACTTTTCC CAACAGGAAA GGCCCACCAC CACATACCAG CAGCCTGACA GCAGCTATGG 3840
AACCTGTGGT ACACATAAGT ATCAACAAAG TACTGAACAC TATGGTGGGA CCCATAATTA 3900
CTGGCAAGGC AATGGCTATT GGGATCCAAG ATCAGCAGGT AGACCTCCAG GAACTGGGCT 3960
TGCTTATGAT CGAATCCAAG GGCAAGTACC AGATTCTCTA ACAGACGATC GTGAAGAAGA 4020
GGAACATTGG GATCAACGAA GTGGATCACA TTTTTCAAGC CCGTCCAATA AATTTTTCTT 4080
CCATCAGAAG GACAAGGGAT CAGTGCAAGC ACCGGAAATA AGCAGCAATT CAATTAAAGA 4140
CGCTTTAGTT ATGAACGAAA GGAAAGATTT TTCGAAAAAC TTTGAAAAAA ATGATATAAA 4200
AGAGAGAGGG CCTCCTAAAA AACGAAGGCA AGAGTTGGAG AGTGATTCTG AAAGTGATGG 4260
TGAACTACAG GCTAGAAAGA AAGTTAGAGT GGAGATGGAG CAGGGAGAAT CATCTGTGCC 4320
CCAGCACTCA GAACTGATGG GGCCTTCGTG TGCTATGGAT GACTTCAGGG ACCCACAGCG 4380
GTGGAAAGAA TTTGCCAAGC TGGGGAAGAT GCCATGTTAC TTTGATCTTA TTGAAGAAAA 4440
TGTTTATTTA ACAGAAAGGA AGAAGAACAA ATCCCACCGG GATATTAAGC GAATGCAGTG 4500
TGAGTGTACA CCTCTTTCTA AGGATGAAAG AGCTCAAGGT GAAGTAGCAT GTGGAGAAGA 4560
TTGCCTTAAT CGTCTCCTCA TGATTGAATG TTCCTCTCGA TGTCCAAATG GAGATTACTG 4620
TTCAAACAGA CGGTTTCAGA GAAAACAGCA TGCAGATGTA GAAGTCATAC TTACAGAAAA 4680
GAAAGGCTGG GGCTTAAGGG CTGCTAAGGA TCTTCCTTCG AACACCTTTG TCCTGGAATA 4740
CTGTGGAGAG GTACTTGATC ATAAAGAGTT TAAAGCTCGG GTGAAAGAAT ATGCACGGAA 4800
CAAAAACATC CACTACTACT TCATGGCCCT GAAAAATGAC GAGATAATAG ATGCCACTCA 4860
AAAAGGGAAT TGCTCTCGTT TCATGAATCA TAGCTGTGAA CCAAACTGTG AAACCCAGAA 4920
ATGGACTGTG AATGGACAGC TGAGGGTTGG ATTTTTTACC ACCAAACTAG TTCCTTCAGG 4980
CTCAGAATTA ACTTTTGACT ACCAGTTCCA AAGATATGGC AAAGAAGCTC AGAAGTGTTT 5040
CTGTGGGTCA GCCAACTGCC GGGGCTACTT GGGAGGAGAA AACAGAGTCA GTATCAGAGC 5100
TGCAGGAGGG AAGATGAAAA AGGAACGCTC TCGAAAGAAG GATTCAGTGG ATGGAGAACT 5160
TGAAGCACTG ATGGAAAATG GTGAAGGCCT CTCTGATAAG AACCAGGTTC TTAGTTTATC 5220
CCGGCTCATG GTTAGAATTG AAACTTTGGA ACAGAAACTT ACCTGTCTTA AGCTCATTCA 5280
GAACACACAC TCACAGTCCT GCCTCAAGTC ATTTCTGGAA CGTCATGGGT TGTCACTGTT 5340
GTGGATCTGG ATGGCAGAGC TTGGCGACGG CCGGGAAAGT AACCAGAAGC TTCAGGAAGA 5400
GATTATAAAG ACTTTGGAGC ATTTGCCCAT TCCTACTAAA AATATGTTGG AAGAAAGCAA 5460
AGTACTTCCA ATTATTCAGC GCTGGTCTCA AACTAAGACT GCTGTTCCTC AGTTAAGTGA 5520
AGGAGACGGG TATTCTAGTG AGAATACATC ACGTGCTCAC ACACCGCTTA ATACACCGGA 5580
CCCTTCTGCC AAGCCGAGCA CGGAAATGGA TACAGATACT CCCAAGAAAC TCATATTCCG 5640
CAGACTGAAG ATTATAAGTG AAAATAGCAT GGACAGTGCA GTCTCGGACG TCACTAGTGA 5700
GCTAGAATGC AAGGATGGCA AAGAGGACCT TGATCAGTTA GAGACTGTCA CTGTGGAAGA 5760
GGATGAAGAG CTGCAGTCCC AGCAGCTCCT CCCACAGCAG CTGTGCGAGT CCAAAGTTGA 5820
GAGTGAAGCC ACTATTGAAG TCAGTAAGTT ACCCACATCT GAACCGGAGG CAGACACGGA 5880
GACAGAGCCC AAAGACAGCA ATGGCACAAA ACTAGAAGAA ACTATTGCTG AGGAAACACC 5940
ATCCCAAGAT GAAGAAGAGG GAGTGTCTGA TGTTGAAAGT GAGAGAAGCC AGGAGCCACC 6000
AGATAAAACA GTGGATATAA GTGATTTGGC TACCAAGTTA CTAGACAGTT GGAAAGATCT 6060
AAAGGAGGTG TATCGGATTC CAAAGAAAAG TCAAACTGAA AAGGAGAGCA CAGTAGCTGA 6120
ACGAGGAAGA GATGCTGCTG CCTTCAGAGA TCAAACAGCT CCAAAGACTC CTAACAGGTC 6180
TAGAGAGAGA GACCCAGACA AGCAGTCTCA AAATAAAGAG AAAAGGAAAC GACGGGGCTC 6240
TCTGTCACCA CCCTCTTCTG CATATGAGCG GGGAACAAAA AGGCCAGATG ACAGATATGA 6300
TACACCAACT TCTAAAAAGA AAGTACGAAT TAAAGACCGA AACAAACTTT CTACAGAGGA 6360
GCGCAGGAAG TTGTTTGAAC AAGAGGTGGC ACAGAGGGAA GCTCAGAAGC AACAGCAACA 6420
GATGCAGAAC TTGGGGATGA CATCACCACT CCCCTTTGAC TCTCTGGGAT ATAATGCCTC 6480
TCATCACCCC TTTGCTGGGT ACCCACCAGG TTACCCCATG CAAGCCTATG TGGATCCCAG 6540
CAACCCTAAT GCTGGAAAGG TGCTTCTGCC CACACCTAGC ATGGACCCTG TGTGCTCCCC 6600
TGCTCCTTAT GATCACGCTC AGCCCTTGGT AGGACATTCT ACAGAATCCC TTGCTGCTCC 6660
CCCATCTGTG CCAGTGGTGC CGCATGTGGC AGCCTCTGTG GAAGTTTCCA GTTCTCAGTA 6720
TGTAGCTCAG AATGAAAGTG TTGTACACCA AGACTCCAAT GTTCCTGTAA TGCCAGTACA 6780
AGCTCCAGGC CCAGTCCAAG GACAGAATTA CAATGTCTGG GAGTCAAACC AACAGTCTGT 6840
CAGTGTACAA CAGCAGTATT CTCCTGCACA ATCTCAAACA ACCATATATT ATCAAGGACA 6900
GACATGTTCA ACTGTCTATA GTGTGACCTC GCCTTATTCA CAGACAACTC CTCCAATTGT 6960
GCAGAGTTAT GCCCAGCCAA GTCTTCAGTA TATCCAGGGA CAGCAGATTT TCACAGCTCA 7020
CCCACAAGGA GTGGTGGTAC AGCCAACTGC AGCCGTGACT TCAATAGTTG CACCAGGGCA 7080
GCCTCAGTCC TTACAGCCAC CTGAAATGGT TGTAACAAAT AATCTACTGG ACCTGCCACC 7140
ACCCTCCCCT CCAAAACCAA AAACGATTGT TTTACCTCCC AACTGGAAGA CAGCCCGAGA 7200
CCCTGAGGGG AAGATCTACT ACTACCACGT GATCACAAGA CAGACTCAGT GGGATCCTCC 7260
TACTTGGGAA AGCCCAGGAG ATGATGCCAG CCTTGAGCAT GAAGCTGAAA TGGACCTGGG 7320
AACCCCAACC TATGATGAAA ACCCCATGAA GACATCAAAA AAGCCCAAGA CAGCAGAAGC 7380
AGACACCTCC AGTGAGCTGG CAAAGAAAAG CAAAGAAGTA TTCAGAAAAG AGATGTCTCA 7440
GTTCATTGTC CAGTGCCTGA ATCCTTACCG GAAACCTGAC TGCAAGGTGG GCAGGATCAC 7500
CACCACTGAA GATTTCAAGC ACCTCGCCCG AAAGCTGACT CATGGAGTTA TGAATAAGGA 7560
GCTGAAGTAC TGTAAGAACC CCGAGGACCT GGAGTGCAAT GAGAATGTGA AACACAAAAC 7620
CAAGGAGTAC ATCAAGAAGT ACATGCAGAA GTTTGGGGCT GTTTACAAAC CTAAAGAGGA 7680
CACTGAACTA GAGTGACCTC AGGCCAGAGT GGAGTATGAG CGGAAAGGAT GAATCCTGTG 7740
GCTTCTGCCC TACCCCACGG CCAAGGCTGT GCTACTGATG TGATGACCCA CCATCCTGAG 7800
CAGTTCAAAC CTGCAGGTGT CAGCTGTAAG CTGCAAAAGT GAGCTCTGTC TCCAAATGAC 7860
CCCTAGTTGT GAGCTGTTGG TGTAACAGTT ACAGGCCATC AGAGGCAGTA GCCTAGGGAA 7920
GACCTTGGCC ACACGACCCC ATTCTCAAAT CTGGGTCTCC CCCTTGGCGG TGCTGTCAGC 7980
GCACAGACCC ATGCGCACCT CCCCCAGATC CTTTACCCTG ACAATATGTA TTATATTTTA 8040
ATGTATATGT GAAGATATTG AAAATAATTT GTTTTTCCTG GTTTTTGTTC TGTTTTTGTT 8100
TGCTGTTAGC ATCTATGTGC TGGAATCAAG GAAAGACTTT GTGAGGATAG TATAAATTCT 8160
CCTGCAAGGT TGGATTTGTT ATCATGTAAA TATCCCAACG CAGGCTGCCT TGTGGTTTGG 8220
CCGCCTTGTG CTATGTTGAT AAGATTGATT TACTGCTTCA GATCACTTTA CTTTATCCAA 8280
TTTTTACTGA ACTTTTTATG TAAAAAATAA AATCAATTAA AGAACTTGGA ATGTGTGCTC 8340
CCTCAAAATT 8351
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
--
Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR013257--SRI
IPR001202--WW_dom
PROSITE

PS51215--AWS
PS50868--POST_SET
PS50280--SET
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00856--SET
PF08236--SRI
PF00397--WW
Gene Ontology

GO:0005694--C:chromosome
GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0001525--P:angiogenesis
GO:0035441--P:cell migration involved in vasculogenesis
GO:0060977--P:coronary vasculature morphogenesis
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0048568--P:embryonic organ development
GO:0060669--P:embryonic placenta morphogenesis
GO:0030900--P:forebrain development
GO:0097676--P:histone H3-K36 dimethylation
GO:0010452--P:histone H3-K36 methylation
GO:0097198--P:histone H3-K36 trimethylation
GO:0048332--P:mesoderm morphogenesis
GO:0006298--P:mismatch repair
GO:0001763--P:morphogenesis of a branching structure
GO:0001843--P:neural tube closure
GO:0034728--P:nucleosome organization
GO:0018023--P:peptidyl-lysine trimethylation
GO:0060039--P:pericardium development
GO:0010468--P:regulation of gene expression
GO:0010793--P:regulation of mRNA export from nucleus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0048864--P:stem cell development
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0001570--P:vasculogenesis
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0141 ENSRNOP00000028408.5 Rattus norvegicus 94 0.0 3905
WERAM-Caf-0145 ENSCAFP00000019740.3 Canis familiaris 85 0.0 3789
WERAM-Chs-0194 ENSCSAP00000012204.1 Chlorocebus sabaeus 84 0.0 3750
WERAM-Eqc-0058 ENSECAP00000007791.1 Equus caballus 84 0.0 3747
WERAM-Gog-0197 ENSGGOP00000025052.2 Gorilla gorilla 84 0.0 3742
WERAM-Fec-0157 ENSFCAP00000015869.2 Felis catus 84 0.0 3742
WERAM-Ict-0161 ENSSTOP00000016952.1 Ictidomys tridecemlineatus 86 0.0 3741
WERAM-Poa-0125 ENSPPYP00000015574.2 Pongo abelii 85 0.0 3740
WERAM-Aim-0141 ENSAMEP00000013463.1 Ailuropoda melanoleuca 84 0.0 3737
WERAM-Hos-0212 ENSP00000386759.3 Homo sapiens 85 0.0 3736
WERAM-Paa-0066 ENSPANP00000003313.1 Papio anubis 84 0.0 3727
WERAM-Pat-0126 ENSPTRP00000025629.4 Pan troglodytes 84 0.0 3714
WERAM-Mup-0172 ENSMPUP00000014934.1 Mustela putorius furo 83 0.0 3680
WERAM-Bot-0037 ENSBTAP00000003838.5 Bos taurus 82 0.0 3633
WERAM-Nol-0062 ENSNLEP00000007605.1 Nomascus leucogenys 83 0.0 3621
WERAM-Ova-0043 ENSOARP00000005431.1 Ovis aries 82 0.0 3615
WERAM-Mam-0194 ENSMMUP00000027793.2 Macaca mulatta 85 0.0 3501
WERAM-Dan-0009 ENSDNOP00000001031.3 Dasypus novemcinctus 82 0.0 3444
WERAM-Myl-0114 ENSMLUP00000009203.2 Myotis lucifugus 79 0.0 3221
WERAM-Cap-0096 ENSCPOP00000007389.2 Cavia porcellus 84 0.0 3122
WERAM-Tut-0177 ENSTTRP00000015037.1 Tursiops truncatus 83 0.0 3063
WERAM-Mod-0123 ENSMODP00000017559.3 Monodelphis domestica 71 0.0 2980
WERAM-Sah-0117 ENSSHAP00000012598.1 Sarcophilus harrisii 71 0.0 2966
WERAM-Loa-0040 ENSLAFP00000002747.3 Loxodonta africana 82 0.0 2868
WERAM-Pes-0163 ENSPSIP00000019522.1 Pelodiscus sinensis 64 0.0 2640
WERAM-Fia-0033 ENSFALP00000002007.1 Ficedula albicollis 61 0.0 2441
WERAM-Orc-0024 ENSOCUP00000002465.3 Oryctolagus cuniculus 89 0.0 2435
WERAM-Gaga-0059 ENSGALP00000008825.4 Gallus gallus 62 0.0 2418
WERAM-Vip-0107 ENSVPAP00000009702.1 Vicugna pacos 85 0.0 2371
WERAM-Tag-0003 ENSTGUP00000000172.1 Taeniopygia guttata 60 0.0 2349
WERAM-Tas-0101 ENSTSYP00000010617.1 Tarsius syrichta 81 0.0 2292
WERAM-Ptv-0035 ENSPVAP00000003990.1 Pteropus vampyrus 80 0.0 2105
WERAM-Anc-0016 ENSACAP00000002203.3 Anolis carolinensis 72 0.0 1932
WERAM-Anp-0041 ENSAPLP00000004480.1 Anas platyrhynchos 68 0.0 1873
WERAM-Ocp-0056 ENSOPRP00000004800.1 Ochotona princeps 78 0.0 1863
WERAM-Caj-0020 ENSCJAP00000004202.1 Callithrix jacchus 80 0.0 1784
WERAM-Dio-0143 ENSDORP00000013341.1 Dipodomys ordii 72 0.0 1675
WERAM-Lac-0058 ENSLACP00000008064.1 Latimeria chalumnae 63 0.0 1674
WERAM-Mim-0156 ENSMICP00000016078.1 Microcebus murinus 93 0.0 1658
WERAM-Prc-0063 ENSPCAP00000005892.1 Procavia capensis 74 0.0 1638
WERAM-Tub-0124 ENSTBEP00000013685.1 Tupaia belangeri 84 0.0 1617
WERAM-Asm-0171 ENSAMXP00000016940.1 Astyanax mexicanus 53 0.0 1288
WERAM-Meg-0030 ENSMGAP00000002517.2 Meleagris gallopavo 73 0.0 1285
WERAM-Orn-0031 ENSONIP00000003854.1 Oreochromis niloticus 52 0.0 1271
WERAM-Tar-0164 ENSTRUP00000035102.1 Takifugu rubripes 56 0.0 1251
WERAM-Soa-0060 ENSSARP00000006011.1 Sorex araneus 84 0.0 1070
WERAM-Pof-0017 ENSPFOP00000001631.1 Poecilia formosa 54 0.0 920
WERAM-Xim-0177 ENSXMAP00000014226.1 Xiphophorus maculatus 54 0.0 902
WERAM-Leo-0048 ENSLOCP00000006757.1 Lepisosteus oculatus 55 0.0 855
WERAM-Dar-0144 ENSDARP00000114457.1 Danio rerio 52 0.0 783
WERAM-Orla-0081 ENSORLP00000010328.1 Oryzias latipes 67 0.0 771
WERAM-Cii-0057 ENSCINP00000025949.2 Ciona intestinalis 62 1e-81 303
WERAM-Drm-0037 FBpp0290774 Drosophila melanogaster 52 4e-72 272
WERAM-Cis-0029 ENSCSAVP00000005982.1 Ciona savignyi 63 1e-70 267
WERAM-Php-0067 PP1S28_356V6.1 Physcomitrella patens 48 2e-61 236
WERAM-Art-0032 AT1G77300.1 Arabidopsis thaliana 46 4e-61 235
WERAM-Bro-0120 Bo6g121240.1 Brassica oleracea 47 7e-61 234
WERAM-Brr-0078 Bra015678.1-P Brassica rapa 47 8e-61 234
WERAM-Arl-0052 fgenesh2_kg.2__ 2024__ AT1G77300.1 Arabidopsis lyrata 47 1e-60 233
WERAM-Crn-0030 AAW44778 Cryptococcus neoformans 36 3e-60 233
WERAM-Tum-0015 CAZ82931 Tuber melanosporum 37 5e-60 232
WERAM-Zyt-0011 Mycgr3P20674 Zymoseptoria tritici 35 1e-59 231
WERAM-Nec-0001 EFNCRP00000000016 Neurospora crassa 34 2e-59 229
WERAM-Sem-0083 EFJ16223 Selaginella moellendorffii 47 2e-59 229
WERAM-Amt-0022 ERN08747 Amborella trichopoda 47 3e-59 229
WERAM-Chg-0015 EAQ91281 Chaetomium globosum 36 3e-59 229
WERAM-Prp-0004 EMJ23127 Prunus persica 47 8e-59 228
WERAM-Put-0020 PTTG_08628P0 Puccinia triticina 36 1e-58 227
WERAM-Fuo-0030 FOXG_09334P0 Fusarium oxysporum 34 3e-58 226
WERAM-Mel-0032 EGG05344 Melampsora laricipopulina 35 3e-58 226
WERAM-Chr-0033 EDP02327 Chlamydomonas reinhardtii 44 3e-58 226
WERAM-Sol-0077 Solyc06g059960.2.1 Solanum lycopersicum 45 6e-58 225
WERAM-Trr-0038 EGR45981 Trichoderma reesei 35 7e-58 224
WERAM-Glm-0044 GLYMA04G42405.1 Glycine max 46 9e-58 224
WERAM-Pyt-0041 EFQ85104 Pyrenophora teres 36 1e-57 224
WERAM-Pug-0021 EFP82907 Puccinia graminis 36 1e-57 224
WERAM-Lem-0034 CBX96970 Leptosphaeria maculans 36 1e-57 223
WERAM-Asc-0008 CADACLAP00001395 Aspergillus clavatus 33 2e-57 223
WERAM-Pytr-0017 EDU46790 Pyrenophora triticirepentis 35 3e-57 223
WERAM-Asni-0036 CADANGAP00013329 Aspergillus niger 34 4e-57 222
WERAM-Miv-0037 MVLG_05378T0 Microbotryum violaceum 34 8e-57 221
WERAM-Asf-0029 CADAFLAP00010840 Aspergillus flavus 34 8e-57 221
WERAM-Mao-0006 MGG_01661T0 Magnaporthe oryzae 34 1e-56 221
WERAM-Usm-0014 UM02500P0 Ustilago maydis 34 1e-56 220
WERAM-Coi-0027 EAS30731 Coccidioides immitis 36 3e-56 219
WERAM-Orp-0022 OPUNC02G18200.1 Oryza punctata 45 3e-56 219
WERAM-Trv-0033 EHK18776 Trichoderma virens 35 4e-56 219
WERAM-Viv-0111 VIT_18s0001g01700.t01 Vitis vinifera 44 4e-56 219
WERAM-Sob-0071 Sb04g022620.1 Sorghum bicolor 45 5e-56 218
WERAM-Asfu-0029 CADAFUAP00006520 Aspergillus fumigatus 34 5e-56 218
WERAM-Orgl-0024 OGLUM02G20630.1 Oryza glumaepatula 45 6e-56 218
WERAM-Orni-0022 ONIVA02G22370.1 Oryza nivara 45 6e-56 218
WERAM-Ved-0022 EGY14913 Verticillium dahliae 34 7e-56 218
WERAM-Orr-0022 ORUFI02G21420.1 Oryza rufipogon 45 7e-56 218
WERAM-Thc-0097 EOY16446 Theobroma cacao 44 8e-56 218
WERAM-Aso-0020 CADAORAP00004002 Aspergillus oryzae 36 9e-56 218
WERAM-Sei-0057 Si016071m Setaria italica 45 1e-55 217
WERAM-Met-0069 KEH35350 Medicago truncatula 44 1e-55 217
WERAM-Spr-0007 CBQ71244 Sporisorium reilianum 34 2e-55 217
WERAM-Asn-0025 CADANIAP00006232 Aspergillus nidulans 36 2e-55 216
WERAM-Ors-0021 OS02T0554000-01 Oryza sativa 45 2e-55 216
WERAM-Org-0023 ORGLA02G0174000.1 Oryza glaberrima 46 3e-55 216
WERAM-Tra-0077 Traes_2BS_D44A3B19F.1 Triticum aestivum 44 3e-55 216
WERAM-Yal-0019 CAG79692 Yarrowia lipolytica 36 3e-55 216
WERAM-Phn-0008 SNOT_01198 Phaeosphaeria nodorum 35 4e-55 216
WERAM-Scj-0019 EEB07769 Schizosaccharomyces japonicus 33 4e-55 215
WERAM-Zem-0120 GRMZM2G352431_P01 Zea mays 44 5e-55 215
WERAM-Mua-0138 GSMUA_Achr9P08570_001 Musa acuminata 45 7e-55 214
WERAM-Map-0019 MAPG_06439T0 Magnaporthe poae 34 7e-55 214
WERAM-Brd-0085 BRADI3G45727.1 Brachypodium distachyon 44 9e-55 214
WERAM-Hov-0052 MLOC_53863.1 Hordeum vulgare 44 1e-54 214
WERAM-Lab-0050 EDR09647 Laccaria bicolor 42 1e-54 214
WERAM-Lep-0028 LPERR02G16340.1 Leersia perrieri 45 4e-54 212
WERAM-Scp-0013 SPAC29B12.02c.1:pep Schizosaccharomyces pombe 35 4e-54 212
WERAM-Scs-0026 EDO04606 Sclerotinia sclerotiorum 33 8e-54 211
WERAM-Orbr-0026 OB02G27880.1 Oryza brachyantha 44 9e-54 211
WERAM-Pot-0026 POPTR_0002s07930.1 Populus trichocarpa 45 2e-53 210
WERAM-Gag-0009 GGTG_01904T0 Gaeumannomyces graminis 33 2e-53 209
WERAM-Asg-0016 AAS52557 Ashbya gossypii 34 3e-53 209
WERAM-Orm-0025 OMERI02G20080.1 Oryza meridionalis 42 4e-53 209
WERAM-Cag-0005 CAG58098 Candida glabrata 36 4e-52 206
WERAM-Caa-0013 KGT70398 Candida albicans 46 2e-51 203
WERAM-Ori-0052 BGIOSGA016424-PA Oryza indica 43 2e-51 203
WERAM-Osl-0018 ABP00208 Ostreococcus lucimarinus 47 2e-50 200
WERAM-Xet-0165 ENSXETP00000005100.3 Xenopus tropicalis 48 2e-50 200
WERAM-Aet-0014 EMT20452 Aegilops tauschii 39 2e-50 200
WERAM-Sac-0023 YJL168C Saccharomyces cerevisiae 43 3e-50 199
WERAM-Kop-0006 CAY68124 Komagataella pastoris 47 1e-49 197
WERAM-Kll-0003 CAH02882 Kluyveromyces lactis 34 3e-49 196
WERAM-Sus-0116 ENSSSCP00000016766.2 Sus scrofa 41 9e-49 194
WERAM-Otg-0155 ENSOGAP00000013154.2 Otolemur garnettii 41 1e-48 194
WERAM-Gam-0039 ENSGMOP00000004113.1 Gadus morhua 48 2e-48 193
WERAM-Ora-0032 ENSOANP00000005155.1 Ornithorhynchus anatinus 42 2e-48 193
WERAM-Gaa-0041 ENSGACP00000006025.1 Gasterosteus aculeatus 48 6e-48 191
Created Date 25-Jun-2016