| Tag |
Content |
| WERAM ID |
WERAM-Mum-0065 |
| Ensembl Protein ID |
ENSMUSP00000109271.2 |
| Uniprot Accession |
Q8CHK4; KAT5_MOUSE; A1L394; Q8CGZ3; Q8CGZ4; Q8VIH0
|
| Genbank Protein ID |
NP_001186176.1; NP_001186177.1; NP_848752.1
|
| Protein Name |
Histone acetyltransferase KAT5 |
| Genbank Nucleotide ID |
NM_001199247.1; NM_001199248.1; NM_178637.2
|
| Gene Name |
KAT5;Htatip;Tip60 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
MYST |
MYST-type HAT |
H2AK5; H4K16 |
K |
26550034; 23927873
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
MYST |
3.80e-127 |
424.7 |
228 |
504 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. |
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity.
|
| Domain Profile |
HAT MYST
MYST.txt 2 kvkniekielgkyeiktwysspfpeelkklkklyicefclkytkskeslkrhlkkCklrkpPgneiyrkdklsvfevdGkkqklycqnl 90
++knie+ielg++++k+wy+sp+p+el++l++ly+cefclky +s ++l+rhl+kC+lr+pPgneiyrk+++s+fe+dG+k+k+y+qnl
ENSMUSP00000109271.2 228 RMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNL 316
789************************************************************************************** PP
MYST.txt 91 CllaklfldhktlyydvepflFYvltetdekgahlvGyFskekesaekynlaCilvlPpyqrkGyGklLiefsYelsrkegkigsPekP 179
Cllak+fldhktlyyd++pflFYv+te d kg+h+vGyFskekes+e+yn+aCil+lPpyqr+GyGklLiefsYels++egk+g+PekP
ENSMUSP00000109271.2 317 CLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKP 405
***************************************************************************************** PP
MYST.txt 180 LsdlgllsYrsyWkevllell....kekeekkkitikelskatgiaveDivstleslnlikekkgqyillksekiveellklakskkkk 264
LsdlgllsYrsyW++++le+l +e+ e+ +iti+e+s+ t+i++eD++stl+ lnli+++kgqyil+ se+iv+ +++++ k+
ENSMUSP00000109271.2 406 LSDLGLLSYRSYWSQTILEILmglkSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAML--KRL 492
*********************88877777888***********************************************88887..99* PP
MYST.txt 265 lkvdeeklkwkp 276
l++d+++l+++p
ENSMUSP00000109271.2 493 LRIDSKCLHFTP 504
*********987 PP
|
Protein Sequence
(Fasta) | MAEVGEIIEG CRLPVLRRNQ DNEDEWPLAE ILSVKDISGR KLFYVHYIDF NKRLDEWVTH 60
ERLDLKKIQF PKKEAKTPTK NGLPGSRPGS PEREVPASAQ ASGKTLPIPV QITLRFNLPK 120
EREAIPGGEP DQPLSSSSCL QPNHRSTKRK VEVVSPATPV PSETAPASVF PQNGSARRAV 180
AAQPGRKRKS NCLGTDEDSQ DSSDGIPSAP RMTGSLVSDR SHDDIVTRMK NIECIELGRH 240
RLKPWYFSPY PQELTTLPVL YLCEFCLKYG RSLKCLQRHL TKCDLRHPPG NEIYRKGTIS 300
FFEIDGRKNK SYSQNLCLLA KCFLDHKTLY YDTDPFLFYV MTEYDCKGFH IVGYFSKEKE 360
STEDYNVACI LTLPPYQRRG YGKLLIEFSY ELSKVEGKTG TPEKPLSDLG LLSYRSYWSQ 420
TILEILMGLK SESGERPQIT INEISEITSI KKEDVISTLQ YLNLINYYKG QYILTLSEDI 480
VDGHERAMLK RLLRIDSKCL HFTPKDWSKR GKW 513Protein Fasta Sequence
>ENSMUSP00000109271.2|KAT5;Htatip;Tip60|Mus musculus
MAEVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGSARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW |
Nucleotide Sequence
(Fasta) | AGCGCACTCA GCTCCGGAAG TGACGTCTCC CAGAGGGGCC GGAAGTGGCA GTGGAGGGAG 60
GGAAGATGGC GGAGGTGGGG GAGATAATCG AGGGCTGCCG CCTGCCCGTG CTGCGGCGCA 120
ACCAGGACAA CGAAGATGAG TGGCCCCTGG CTGAGATCCT GAGCGTGAAG GACATCAGTG 180
GCCGAAAGCT TTTCTATGTC CATTACATTG ACTTCAACAA ACGTCTGGAT GAATGGGTGA 240
CTCACGAGCG GCTGGACTTA AAGAAGATCC AATTTCCCAA GAAAGAGGCC AAGACACCTA 300
CCAAGAACGG ACTTCCTGGG TCCCGCCCCG GCTCTCCCGA AAGAGAGGTG CCGGCCTCCG 360
CCCAGGCCAG CGGGAAGACC TTGCCAATCC CGGTCCAGAT CACACTCCGC TTCAACCTGC 420
CCAAGGAGCG GGAGGCCATC CCAGGTGGCG AGCCTGACCA GCCGCTCTCC TCCAGCTCCT 480
GCCTGCAACC CAACCACCGC TCAACGAAAC GGAAGGTGGA GGTGGTTTCA CCAGCAACCC 540
CAGTGCCCAG CGAGACAGCC CCAGCCTCGG TTTTCCCTCA GAATGGGTCA GCCCGTAGGG 600
CAGTGGCAGC CCAGCCTGGA CGGAAGCGGA AATCTAATTG CTTGGGCACT GATGAGGATT 660
CTCAGGACAG CTCAGATGGA ATACCGTCAG CACCACGAAT GACTGGCAGT CTGGTGTCTG 720
ACCGGAGCCA CGACGACATT GTCACCCGGA TGAAGAACAT TGAGTGTATT GAGCTTGGCC 780
GGCACCGCCT CAAGCCGTGG TACTTCTCCC CGTACCCACA AGAGCTTACC ACGCTACCCG 840
TCCTCTACCT GTGCGAATTT TGCCTCAAAT ATGGCCGTAG CCTCAAGTGT CTGCAACGCC 900
ACTTGACCAA ATGTGATCTT CGGCACCCTC CAGGCAATGA AATTTACCGC AAGGGCACCA 960
TCTCCTTTTT TGAGATTGAT GGACGGAAAA ACAAGAGTTA CTCACAAAAC CTGTGTCTTC 1020
TGGCCAAGTG TTTCCTGGAC CACAAAACAC TGTACTATGA CACTGACCCC TTCCTCTTCT 1080
ACGTAATGAC GGAGTATGAC TGCAAAGGTT TCCACATCGT GGGCTACTTC TCCAAGGAAA 1140
AGGAATCCAC AGAAGATTAC AATGTGGCCT GCATCTTGAC TCTGCCTCCC TACCAGCGCC 1200
GGGGCTATGG CAAGCTGCTT ATTGAGTTCA GCTATGAACT CTCGAAAGTA GAAGGGAAGA 1260
CCGGAACTCC TGAGAAACCC CTGTCAGATC TTGGCCTCCT ATCCTACCGA AGTTACTGGT 1320
CCCAAACCAT CTTGGAGATC CTGATGGGGC TGAAGTCGGA GAGCGGGGAG AGGCCACAGA 1380
TCACCATCAA TGAGATCAGT GAAATCACTA GTATCAAGAA AGAAGATGTC ATCTCCACAC 1440
TGCAGTATCT CAACCTCATC AATTACTACA AGGGCCAGTA TATCCTAACT CTGTCAGAAG 1500
ACATCGTGGA TGGGCATGAG CGGGCTATGC TCAAGCGGCT CCTTCGGATT GACTCCAAGT 1560
GTCTGCACTT CACTCCCAAA GACTGGAGCA AGAGAGGAAA GTGGTGACAC ACACTACCCA 1620
TTGCCATACC ACGAGAGCTG GCCGAACCAT GGCTAGCACC CTGTCTTGTC CCATTTGAGC 1680
TTCGAAGAGG CACGCAAAGT GAGACAGGCC GAAGAACAGA CCCAAGAGGA GAAGAGGCCT 1740
AGGAGGGGCC CACTAGTGGC CAGTGCCAAG GCAAGCTCAG GTCTAGGCCA ACTCCGAGGA 1800
TAACTGGCTT ACTGGCCCAG GTCCGCTCTG AACACGTGGA CCAAAGGGAT CCAGGCAGCT 1860
GTGTACATTA AGATGGGTGG GGAGCATTCT GTACAGGACC GGTGATTGTA AAAATTTCTT 1920
TTATAAAGGA GGAGCTGGAG GGTGGGGTGG GCGCTGGTTG CAAAGTTCTG GCCCCTCTTG 1980
CCCCCAGAAA TAAATTGTTT ATATAGGC
2009Nucleotide Fasta Sequence
>ENSMUSP00000109271.2|MYST|Mus musculus
AGCGCACTCAGCTCCGGAAGTGACGTCTCCCAGAGGGGCCGGAAGTGGCAGTGGAGGGAGGGAAGATGGCGGAGGTGGGGGAGATAATCGAGGGCTGCCGCCTGCCCGTGCTGCGGCGCAACCAGGACAACGAAGATGAGTGGCCCCTGGCTGAGATCCTGAGCGTGAAGGACATCAGTGGCCGAAAGCTTTTCTATGTCCATTACATTGACTTCAACAAACGTCTGGATGAATGGGTGACTCACGAGCGGCTGGACTTAAAGAAGATCCAATTTCCCAAGAAAGAGGCCAAGACACCTACCAAGAACGGACTTCCTGGGTCCCGCCCCGGCTCTCCCGAAAGAGAGGTGCCGGCCTCCGCCCAGGCCAGCGGGAAGACCTTGCCAATCCCGGTCCAGATCACACTCCGCTTCAACCTGCCCAAGGAGCGGGAGGCCATCCCAGGTGGCGAGCCTGACCAGCCGCTCTCCTCCAGCTCCTGCCTGCAACCCAACCACCGCTCAACGAAACGGAAGGTGGAGGTGGTTTCACCAGCAACCCCAGTGCCCAGCGAGACAGCCCCAGCCTCGGTTTTCCCTCAGAATGGGTCAGCCCGTAGGGCAGTGGCAGCCCAGCCTGGACGGAAGCGGAAATCTAATTGCTTGGGCACTGATGAGGATTCTCAGGACAGCTCAGATGGAATACCGTCAGCACCACGAATGACTGGCAGTCTGGTGTCTGACCGGAGCCACGACGACATTGTCACCCGGATGAAGAACATTGAGTGTATTGAGCTTGGCCGGCACCGCCTCAAGCCGTGGTACTTCTCCCCGTACCCACAAGAGCTTACCACGCTACCCGTCCTCTACCTGTGCGAATTTTGCCTCAAATATGGCCGTAGCCTCAAGTGTCTGCAACGCCACTTGACCAAATGTGATCTTCGGCACCCTCCAGGCAATGAAATTTACCGCAAGGGCACCATCTCCTTTTTTGAGATTGATGGACGGAAAAACAAGAGTTACTCACAAAACCTGTGTCTTCTGGCCAAGTGTTTCCTGGACCACAAAACACTGTACTATGACACTGACCCCTTCCTCTTCTACGTAATGACGGAGTATGACTGCAAAGGTTTCCACATCGTGGGCTACTTCTCCAAGGAAAAGGAATCCACAGAAGATTACAATGTGGCCTGCATCTTGACTCTGCCTCCCTACCAGCGCCGGGGCTATGGCAAGCTGCTTATTGAGTTCAGCTATGAACTCTCGAAAGTAGAAGGGAAGACCGGAACTCCTGAGAAACCCCTGTCAGATCTTGGCCTCCTATCCTACCGAAGTTACTGGTCCCAAACCATCTTGGAGATCCTGATGGGGCTGAAGTCGGAGAGCGGGGAGAGGCCACAGATCACCATCAATGAGATCAGTGAAATCACTAGTATCAAGAAAGAAGATGTCATCTCCACACTGCAGTATCTCAACCTCATCAATTACTACAAGGGCCAGTATATCCTAACTCTGTCAGAAGACATCGTGGATGGGCATGAGCGGGCTATGCTCAAGCGGCTCCTTCGGATTGACTCCAAGTGTCTGCACTTCACTCCCAAAGACTGGAGCAAGAGAGGAAAGTGGTGACACACACTACCCATTGCCATACCACGAGAGCTGGCCGAACCATGGCTAGCACCCTGTCTTGTCCCATTTGAGCTTCGAAGAGGCACGCAAAGTGAGACAGGCCGAAGAACAGACCCAAGAGGAGAAGAGGCCTAGGAGGGGCCCACTAGTGGCCAGTGCCAAGGCAAGCTCAGGTCTAGGCCAACTCCGAGGATAACTGGCTTACTGGCCCAGGTCCGCTCTGAACACGTGGACCAAAGGGATCCAGGCAGCTGTGTACATTAAGATGGGTGGGGAGCATTCTGTACAGGACCGGTGATTGTAAAAATTTCTTTTATAAAGGAGGAGCTGGAGGGTGGGGTGGGCGCTGGTTGCAAAGTTCTGGCCCCTCTTGCCCCCAGAAATAAATTGTTTATATAGGC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0005667--C:transcription factor complex
GO:0004402--F:histone acetyltransferase activity
GO:0046872--F:metal ion binding
GO:0070491--F:repressing transcription factor binding
GO:0003713--F:transcription coactivator activity
GO:0071392--P:cellular response to estradiol stimulus
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006302--P:double-strand break repair
GO:0016573--P:histone acetylation
GO:0032703--P:negative regulation of interleukin-2 production
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1901985--P:positive regulation of protein acetylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010212--P:response to ionizing radiation
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
