WERAM Information
Tag | Content | ||||||||||||
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WERAM ID | WERAM-Mum-0026 | ||||||||||||
Ensembl Protein ID | ENSMUSP00000091620.4 | ||||||||||||
Uniprot Accession | Q5NCY0; KDM6B_MOUSE; Q3UWY9; Q4VC26; Q6ZQD3 | ||||||||||||
Genbank Protein ID | NP_001017426.1; XP_006532961.1; XP_011247221.1; XP_011247222.1; XP_011247223.1; XP_011247224.1; XP_011247225.1 | ||||||||||||
Protein Name | Lysine-specific demethylase 6B | ||||||||||||
Genbank Nucleotide ID | NM_001017426.1; XM_006532898.1; XM_011248919.1; XM_011248920.1; XM_011248921.1; XM_011248922.1; XM_011248923.1 | ||||||||||||
Gene Name | KDM6B;JMJD3 | ||||||||||||
Ensembl Information |
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Details |
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Status | Reviewed | ||||||||||||
Classification |
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Organism | Mus musculus | ||||||||||||
NCBI Taxa ID | 10090 | ||||||||||||
Functional Description (View) |
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. | ||||||||||||
Domain Profile | HDM UTX_UTY UTX.txt 1 kwkkqlkelsklpafvrvisaanllshvghtilgmntvqlymkvpgsrtpghqennnlcsvninigpgdcewfavpeeywgklsdlc 87 |
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Protein Sequence (Fasta) | MHRAVDPPGA RSAREAFALG GLSCAGAWSS CPPHPPPRSS WLPGGRCSAS VGQPPLSAPL 60 PPSHGSSSGH PNKPYYAPGT PTPRPLHGKL ESLHGCVQAL LREPAQPGLW EQLGQLYESE 120 HDSEEAVCCY HRALRYGGSF AELGPRIGRL QQAQLWNFHA GSCQHRAKVL PPLEQVWNLL 180 HLEHKRNYGA KRGGPPVKRS AEPPVVQPMP PAALSGPSGE EGLSPGGKRR RGCSSEQAGL 240 PPGLPLPPPP PPPPPPPPPP PPPPPPLPGL AISPPFQLTK PGLWNTLHGD AWGPERKGSA 300 PPERQEQRHS MPHSYPYPAP AYSAHPPSHR LVPNTPLGPG PRPPGAESHG CLPATRPPGS 360 DLRESRVQRS RMDSSVSPAA STACVPYAPS RPPGLPGTSS SSSSSSSSNN TGLRGVEPSP 420 GIPGADHYQN PALEISPHQA RLGPSAHSSR KPFLTAPAAT PHLSLPPGTP SSPPPPCPRL 480 LRPPPPPAWM KGSACRAARE DGEILGELFF GAEGPPRPPP PPLPHRDGFL GPPNPRFSVG 540 TQDSHNPPIP PTTTSSSSSS NSHSSSPTGP VPFPPPSYLA RSIDPLPRPS SPTLSPQDPP 600 LPPLTLALPP APPSSCHQNT SGSFRRSESP RPRVSFPKTP EVGQGPPPGP VSKAPQPVPP 660 GVGELPARGP RLFDFPPTPL EDQFEEPAEF KILPDGLANI MKMLDESIRK EEEQQQQQEA 720 GVAPPPPLKE PFASLQPPFP SDTAPATTTA APTTATTTTT TTTTTTQEEE KKPPPALPPP 780 PPLAKFPPPP QPQPPPPPPA SPASLLKSLA SVLEGQKYCY RGTGAAVSTR PGSVPATQYS 840 PSPASGATAP PPTSVAPSAQ GSPKPSVSSS SQFSTSGGPW AREHRAGEEP APGPVTPAQL 900 PPPLPLPPAR SESEVLEEIS RACETLVERV GRSAINPVDT ADPVDSGTEP QPPPAQAKEE 960 SGGVAVAAAG PGSGKRRQKE HRRHRRACRD SVGRRPREGR AKAKAKAPKE KSRRVLGNLD 1020 LQSEEIQGRE KARPDVGGVS KVKTPTAPAP PPAPAPAAQP TPPSAPVPGK KTREEAPGPP 1080 GVSRADMLKL RSLSEGPPKE LKIRLIKVES GDKETFIASE VEERRLRMAD LTISHCAADV 1140 MRASKNAKVK GKFRESYLSP AQSVKPKINT EEKLPREKLN PPTPSIYLES KRDAFSPVLL 1200 QFCTDPRNPI TVIRGLAGSL RLNLGLFSTK TLVEASGEHT VEVRTQVQQP SDENWDLTGT 1260 RQIWPCESSR SHTTIAKYAQ YQASSFQESL QEERESEDEE SEEPDSTTGT SPSSAPDPKN 1320 HHIIKFGTNI DLSDAKRWKP QLQELLKLPA FMRVTSTGNM LSHVGHTILG MNTVQLYMKV 1380 PGSRTPGHQE NNNFCSVNIN IGPGDCEWFA VHEHYWETIS AFCDRHGVDY LTGSWWPILD 1440 DLYASNIPVY RFVQRPGDLV WINAGTVHWV QATGWCNNIA WNVGPLTAYQ YQLALERYEW 1500 NEVKNVKSIV PMIHVSWNVA RTVKISDPDL FKMIKFCLLQ SMKHCQVQRE SLVRAGKKIA 1560 YQGRVKDEPA YYCNECDVEV FNILFVTSEN GSRNTYLVHC EGCARRRSAG LQGVVVLEQY 1620 RTEELAQAYD AFTLAPASTS R 1641 |
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Nucleotide Sequence (Fasta) | AGGTTCCCCC AGGCACCATG TCAGCCTCAT AGCAGGACCC ACCCCACGAC TTCTGCTGTA 60 GCCCATAGGA CCCACCCCAC TTCTGCTGTA ACCCACTGCT GGAGTGCTTG TTCCATGAGA 120 CAGTCCACTT CCAACTCCAT CTGGCTGTTA CTGAGGCGGA GACAAGGGTG ATGATTGGCT 180 TTCTGTGGAT AGAGAAGTCT TGTGATTGGC TAAATTTCTG AAGCTCTTGA AGCTGTGAGA 240 GGACGCTCCC ACGGAGGCTG GAATTGGTTG CAGAAGGCCA GAGACTGTCA CCTGGAAACA 300 GTGGGCACTA TTGTTAAGGG CAGTTGGAGC TGGACCATCG TGCCAGAGAG CTGGGGCAGG 360 GGGCCGTGCC CCATCTCCAG GGCTCCTGGG GCCACTGCTG ACCTGGCTGG ATGCATCGGG 420 CAGTGGACCC TCCAGGGGCC CGCTCTGCAC GGGAAGCCTT TGCCCTTGGG GGCTTGAGCT 480 GTGCTGGGGC TTGGAGCTCC TGCCCACCCC ATCCTCCTCC CCGAAGCTCA TGGCTGCCCG 540 GAGGCAGATG CTCTGCCAGC GTTGGGCAGC CCCCACTCTC AGCTCCTTTA CCCCCATCTC 600 ATGGCAGTAG CTCCGGGCAC CCTAACAAAC CCTATTATGC TCCTGGGACA CCCACCCCAA 660 GACCCCTTCA CGGGAAGTTG GAATCCCTAC ATGGCTGTGT CCAGGCATTG CTCCGGGAGC 720 CAGCGCAGCC AGGGTTGTGG GAACAGCTTG GACAGTTGTA TGAATCAGAG CACGACAGTG 780 AGGAAGCCGT ATGCTGCTAC CATAGGGCCC TTCGCTATGG AGGAAGCTTC GCCGAGCTGG 840 GACCCCGGAT TGGCCGCTTG CAGCAGGCCC AGCTCTGGAA CTTTCATGCC GGTTCCTGTC 900 AGCACAGAGC CAAGGTCCTG CCTCCCCTGG AGCAAGTCTG GAATTTGCTG CACCTTGAGC 960 ACAAACGGAA CTATGGGGCT AAGCGAGGGG GCCCTCCAGT GAAGAGATCT GCTGAACCCC 1020 CCGTGGTCCA GCCTATGCCT CCTGCAGCCC TCTCAGGCCC CTCAGGAGAG GAGGGCCTTA 1080 GCCCTGGAGG CAAGCGCAGG AGAGGCTGCA GCTCTGAACA GGCTGGCCTT CCCCCAGGTC 1140 TGCCACTCCC TCCACCACCC CCACCCCCAC CGCCTCCACC ACCACCACCA CCCCCTCCAC 1200 CACCACCGCT GCCTGGCCTG GCTATTAGCC CCCCATTTCA GCTGACTAAG CCAGGGCTGT 1260 GGAATACCCT GCATGGAGAT GCTTGGGGCC CCGAGCGCAA GGGTTCAGCG CCGCCAGAGC 1320 GCCAGGAGCA GCGGCACTCG ATGCCTCATT CATATCCATA CCCAGCTCCC GCCTACTCCG 1380 CTCATCCGCC CAGCCATCGG CTGGTCCCCA ACACACCCCT TGGTCCAGGT CCCCGACCCC 1440 CAGGAGCAGA GAGCCATGGC TGCCTGCCTG CCACCCGTCC CCCCGGAAGT GACCTTAGAG 1500 AGAGCAGAGT TCAGAGGTCG CGGATGGACT CCAGCGTTTC ACCAGCAGCA TCTACCGCCT 1560 GCGTGCCTTA CGCCCCTTCC CGGCCCCCTG GCCTCCCCGG CACCAGCAGC AGCAGCAGCA 1620 GCAGCAGTAG CAGTAACAAC ACTGGTCTTC GGGGTGTGGA GCCAAGCCCA GGCATTCCTG 1680 GCGCTGACCA TTACCAAAAC CCTGCGCTGG AGATATCCCC TCACCAGGCC CGCCTGGGTC 1740 CCTCCGCACA CAGCAGTCGG AAACCATTTT TGACGGCCCC TGCTGCCACG CCCCACTTAT 1800 CCCTACCCCC TGGGACCCCA TCATCCCCTC CACCCCCATG TCCTCGCCTC TTGCGCCCTC 1860 CACCGCCCCC TGCTTGGATG AAGGGCTCAG CCTGCCGTGC AGCCCGAGAG GATGGAGAGA 1920 TCTTAGGGGA GCTCTTCTTT GGTGCTGAGG GACCTCCCCG TCCTCCTCCC CCACCCCTTC 1980 CCCACCGTGA TGGCTTCTTG GGGCCTCCAA ACCCCCGCTT TTCTGTGGGC ACTCAGGATT 2040 CGCATAACCC TCCCATTCCC CCAACCACCA CCAGCAGCAG CAGCAGCAGC AACAGCCACA 2100 GCAGTAGTCC TACTGGGCCG GTGCCCTTTC CACCACCCTC CTATCTGGCC AGAAGTATAG 2160 ACCCCCTCCC CAGGCCATCC AGCCCAACCT TGAGCCCCCA GGACCCACCT CTTCCACCAC 2220 TGACTCTTGC CCTGCCTCCA GCCCCTCCCT CCTCCTGCCA CCAAAATACC TCAGGAAGCT 2280 TCAGGCGCTC GGAGAGCCCC CGGCCCAGGG TCTCCTTCCC AAAGACCCCC GAGGTGGGGC 2340 AGGGGCCACC CCCAGGCCCT GTGAGTAAAG CCCCCCAGCC TGTGCCACCT GGGGTTGGAG 2400 AGCTGCCTGC CCGAGGCCCG AGGCTCTTTG ATTTCCCACC CACTCCGCTG GAGGACCAGT 2460 TTGAAGAGCC AGCCGAATTC AAGATCCTAC CTGATGGGCT GGCAAACATC ATGAAGATGC 2520 TGGATGAATC CATTCGGAAG GAGGAGGAGC AGCAGCAGCA GCAGGAGGCA GGCGTGGCTC 2580 CCCCACCCCC ACTCAAAGAG CCCTTTGCAT CTCTACAGCC TCCATTTCCC AGTGACACAG 2640 CCCCAGCCAC CACCACTGCT GCCCCCACCA CCGCCACCAC CACCACAACC ACCACCACCA 2700 CCACCACCCA AGAAGAGGAG AAGAAGCCAC CACCAGCCCT ACCACCACCA CCGCCTCTAG 2760 CCAAGTTTCC TCCACCTCCC CAGCCACAGC CCCCACCACC TCCACCAGCC AGCCCAGCCA 2820 GCCTGCTCAA ATCGTTGGCC TCTGTTCTTG AGGGACAAAA GTACTGTTAC CGGGGGACTG 2880 GAGCAGCCGT CTCAACCAGG CCCGGGTCCG TGCCCGCCAC TCAGTATTCC CCTAGTCCTG 2940 CATCAGGTGC TACCGCCCCA CCACCCACTT CAGTGGCCCC TAGTGCCCAG GGCTCCCCCA 3000 AGCCCTCGGT TTCCTCGTCA TCTCAGTTCT CTACCTCAGG CGGGCCTTGG GCCCGGGAGC 3060 ACAGGGCGGG TGAAGAGCCA GCACCAGGCC CCGTGACCCC TGCCCAGTTG CCCCCACCTC 3120 TGCCGCTGCC CCCTGCTCGT TCTGAGTCTG AGGTGCTAGA AGAAATCAGT CGGGCTTGTG 3180 AGACCCTTGT AGAGCGGGTG GGCCGGAGTG CCATCAACCC AGTGGACACG GCAGACCCAG 3240 TGGACAGTGG GACTGAGCCA CAGCCGCCGC CTGCGCAGGC CAAGGAGGAG AGTGGGGGGG 3300 TGGCGGTAGC AGCAGCAGGT CCAGGTAGTG GCAAGCGTCG TCAAAAGGAG CATCGGCGGC 3360 ACAGGCGGGC CTGTAGGGAC AGTGTGGGTC GACGACCCCG CGAGGGGAGG GCCAAGGCCA 3420 AGGCCAAGGC TCCCAAAGAA AAAAGCCGAA GGGTGCTGGG GAACCTCGAC TTGCAGAGTG 3480 AGGAGATCCA GGGCCGGGAG AAGGCCCGGC CCGATGTCGG TGGGGTTTCC AAAGTCAAGA 3540 CACCCACAGC TCCAGCACCC CCGCCTGCTC CTGCACCCGC TGCTCAGCCA ACACCCCCAT 3600 CAGCTCCTGT CCCTGGGAAG AAGACTCGTG AGGAGGCTCC GGGGCCTCCA GGTGTGAGCC 3660 GGGCAGATAT GCTGAAGCTC CGGTCACTTA GTGAGGGGCC TCCCAAGGAG CTGAAGATCA 3720 GGCTCATCAA GGTGGAAAGT GGGGACAAGG AGACCTTTAT CGCCTCTGAG GTGGAAGAGC 3780 GGCGGCTGCG CATGGCAGAC CTCACCATCA GCCACTGTGC CGCCGATGTC ATGCGTGCCA 3840 GCAAGAATGC CAAGGTGAAA GGGAAATTCC GAGAGTCCTA CCTGTCCCCT GCCCAGTCTG 3900 TGAAACCCAA GATCAACACT GAGGAGAAGC TGCCCCGGGA AAAACTCAAC CCCCCTACCC 3960 CCAGCATCTA TTTGGAGAGC AAACGAGATG CCTTCTCGCC GGTCCTGCTA CAGTTCTGTA 4020 CAGACCCCCG GAACCCCATC ACCGTCATCA GGGGCCTGGC TGGTTCACTT CGGCTCAACT 4080 TAGGCCTTTT CTCCACCAAG ACTCTGGTGG AGGCGAGCGG TGAACATACG GTGGAGGTCC 4140 GTACCCAAGT ACAGCAGCCC TCAGACGAGA ACTGGGACCT GACAGGTACC AGACAAATCT 4200 GGCCCTGTGA GAGCTCCCGT TCCCACACCA CCATCGCTAA ATACGCACAG TACCAGGCCT 4260 CGTCCTTCCA GGAGTCACTG CAGGAGGAGA GGGAGAGTGA GGATGAGGAA TCCGAGGAAC 4320 CAGACAGCAC TACAGGAACC TCTCCCAGCA GTGCACCGGA CCCCAAGAAC CATCACATCA 4380 TCAAGTTTGG CACTAACATC GACCTGTCTG ATGCCAAGAG GTGGAAGCCA CAGCTACAGG 4440 AGCTGCTGAA ACTGCCCGCC TTCATGCGGG TAACATCCAC AGGCAACATG CTCAGCCACG 4500 TGGGCCACAC CATCCTGGGC ATGAACACCG TGCAGCTATA CATGAAGGTC CCTGGCAGCC 4560 GAACGCCAGG CCACCAAGAG AATAACAATT TCTGCTCAGT CAACATCAAC ATTGGCCCTG 4620 GGGACTGCGA GTGGTTCGCG GTACATGAGC ACTATTGGGA GACCATCAGC GCCTTCTGCG 4680 ACCGGCATGG TGTGGACTAC TTGACTGGTT CCTGGTGGCC AATCTTGGAT GACCTCTATG 4740 CGTCCAATAT TCCTGTTTAC CGCTTCGTGC AGCGCCCTGG AGACCTTGTG TGGATTAATG 4800 CAGGGACTGT ACATTGGGTG CAGGCTACCG GCTGGTGCAA CAACATTGCC TGGAACGTGG 4860 GGCCCCTCAC CGCCTATCAG TACCAGCTGG CCCTGGAGCG ATATGAGTGG AACGAGGTGA 4920 AGAACGTCAA GTCCATTGTG CCCATGATTC ATGTGTCCTG GAACGTCGCT CGAACGGTCA 4980 AGATCAGCGA TCCTGACTTG TTCAAGATGA TCAAGTTCTG CCTCCTGCAG TCAATGAAGC 5040 ACTGTCAGGT ACAGCGGGAG AGCCTGGTGC GGGCAGGGAA GAAGATCGCT TACCAAGGCC 5100 GTGTCAAAGA CGAGCCTGCC TACTACTGCA ACGAATGCGA CGTGGAGGTG TTCAACATCC 5160 TGTTCGTTAC AAGTGAGAAT GGCAGCCGAA ACACGTACCT GGTGCACTGC GAGGGCTGTG 5220 CGCGCCGTCG CAGCGCGGGC CTACAGGGCG TGGTGGTGCT AGAGCAGTAC CGCACGGAGG 5280 AGCTGGCGCA GGCCTACGAT GCCTTCACAC TGGCTCCCGC CAGCACGTCT CGATGAGGCC 5340 GGACGCCCCG CTCGCCCGCC CACGCTGGGC GCGGCGGGGC CACCAGCACA CGCCTGGGCT 5400 GGACCTAGGT CCCGCCTCTG GCCGGGAAGG GGGTCGGGCC CAGCCCTTCC ACCCTATTGG 5460 CAGCTCCCCT CACTTAATTT ATTAAGAAAA AAAAAATGTT TTTTTTTTAA CAAATACGAG 5520 GAAAAAAAAA GGAAAAAAAA TGGGAGACGG GGAGGGGGCT GGCAGCCTCT CGCCCACCAG 5580 CGCCTCCCCT CACCGACTTT GGCCTTTCTA GCAACAGACA CAAGGACCAG GCTCCGGCGG 5640 CGGCGGGGGT CACATACGGG TTCCCTCAAG CCTGCCCGCC GCGCGCCCGC CCGCCGCCCG 5700 CCGGCGCAGA CGTTCGCGGC TCGTTGTGTA CATAGACGTT CGGCAGCCGA GGTTTTTAAT 5760 GAGATTCTCT CTATGGGCTT TACCCCTACC CCTGGACCTC CTTTTTTTTT TTTTTTTTTT 5820 TTTTTTTTTT ACTTCCAATG CTAGCTGTGA TCCCTGTATA TGTCTCTTGT TTATTCACTT 5880 GGTTATGATT CGTATTTTTG TTCTTTTTGT TTTTTGGTTT TTAATTTATA ACAGTCCCAC 5940 TCACCTCTAT TTATTCATTT TTTTTTTCTC TTTTTTTGGG AAAACCCGAC CTCTTACATC 6000 CCCAAGCCAT CCCTCCTGCC TCTTTGGGAG GCCCACTCCT GGGCCTTCCC TGCGCCCCAG 6060 TATGTCCGGG CTTGGCCCGT CTGTCTCCGC CCGCCCGCGG CTCCAGCCGG GCTCTCATGG 6120 TGCTCAAACC TGCTCCCCTC CCCTACGTCC TGCACTTTCT TGGACCAGTA CCCCCACTCC 6180 CGACCCAACC CCGACCCCAC CTGAGGGTGA GCGACTCCTG TACTGTAGGG GAAGAAGTGG 6240 GAACTGAAAT GGTATTTTGT AAAAAAAATA AATAAATAAA ATAAAAAGTT TTAAAGAACT 6300 ATGAGGAAAA GAAACCCTGT CCTCCCCAGC CTCGGCCATT TTAAAAACAT TGGACACACA 6360 CACACACACA CACACACACA CCTTTTTTAA GGCGTGAAAC ATCCCAGGGC AGGGCCTCTC 6420 TGGGGCAGGG ACACCCTGGG GTGATTTTCT CTGGGGCTTT ATTTTCATTT TCTTAGTTCG 6480 GTTTTTTTCC CCCCCGCTGG GGCTGCGGAG GGGTGGGGGG GTTTACAGTC CCGCCCCCTC 6540 GCACTGCACT GTCTCTCTGC CCCAGGGGCA GAGGGGGGCT TCCCATTCCT ACCCTATTTT 6600 CGGTGATTTT TGTGTGAGAA TATTATTAAA AATAAAAGCA GGAAAAAAAA AAAA 6655 |
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Sequence Source | Ensembl | ||||||||||||
Keyword | KW-0002--3D-structure |
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Interpro | IPR003347--JmjC_dom |
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PROSITE | PS51184--JMJC |
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Pfam | PF02373--JmjC |
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Gene Ontology | GO:0005634--C:nucleus |
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Orthology | |||||||||||||
Created Date | 25-Jun-2016 |