Tag |
Content |
WERAM ID |
WERAM-Mum-0056 |
Ensembl Protein ID |
ENSMUSP00000073402.5 |
Uniprot Accession |
Q9Z1B8; PHF1_MOUSE; O54808 |
Genbank Protein ID |
NP_033369.2 |
Protein Name |
PHD finger protein 1 |
Genbank Nucleotide ID |
NM_009343.3 |
Gene Name |
PHF1;Plc1;Tctex-3;Tctex3 |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
Me_Reader |
PHD |
PHD1,2 |
H3K36me3 |
K |
26745824 |
Me_Reader |
Tudor |
Tudor |
H3K36me3 |
K |
26745824 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
Me_Reader |
PHD |
6.40e-14 |
53.3 |
89 |
238 |
Me_Reader |
Tudor |
2.80e-13 |
51.4 |
31 |
85 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. |
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18086877). According to other reports, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
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Domain Profile |
Me_Reader PHD
PHD.txt 3 iClvCg..kddegekemvqCdeCddwfHlkCvklplsslp.eg..kswyCpsCk 51 +C+vC+ ++ g++ +v C++C++++H++C+ + ++p eg +sw+C++C+ ENSMUSP00000073402.5 89 LCCVCRseTVVPGNR-LVSCEKCRHAYHQDCHVPR-APAPgEGegASWVCRQCV 140 5778*6445566666.****************999.77776667799******7 PP PHD.txt 2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg...kswyCpsCk 51 +C+ Cg ++e + +m+qC +C +wfH C+++ ++l +g ++ C C+ ENSMUSP00000073402.5 187 SYCY-CGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGdrfYEFECCVCR 238 69*9.*766555567*******************88888995555666*9998 PP
Me_Reader Tudor
Tudor.txt 2 skvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnrlreqyg 63 +++G++V+a+w+ dG+ Y g+i ++v+s++e++++++ed++++ + L+k+++++++ g ENSMUSP00000073402.5 31 LWEGQDVLARWT-DGLLYLGTI----KKVDSAREVCLVQFEDDSQFLV--LWKDISPAALPG 85 689*********.*********....********************77..9****9998765 PP
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Protein Sequence (Fasta) | MAQLPRLSRL GAPSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV 60 CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV 120 PRAPAPGEGE GASWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH 180 LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG 240 PEKVRRLQLR WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE 300 RSSQLLSALN SHKDRFISGR EIKKRKCLFG LHARTPPPVE LLTGDGAPTS FPSGQGPGGG 360 VSRPLGKRWR SEPEPLRRRQ KGKVEELGPP TAAHSRHGSR EQRALQASVS PPPPSPNQSY 420 EGSSGYNFRP TDARCLPSSP IRMFASFHPS ASTAGTSGDS EPPDRSPLGL HIGFPTDTPK 480 SSPHSVTASS SSVPALTPGF SRHSPPSPLC RSLSPGTGGG VRGGVSYLSR GDPVRVLARR 540 VRPDGSVQYL VEWGGGGIF 559Protein Fasta Sequence
>ENSMUSP00000073402.5|PHF1;Plc1;Tctex-3;Tctex3|Mus musculus MAQLPRLSRLGAPSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGASWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSQLLSALNSHKDRFISGREIKKRKCLFGLHARTPPPVELLTGDGAPTSFPSGQGPGGGVSRPLGKRWRSEPEPLRRRQKGKVEELGPPTAAHSRHGSREQRALQASVSPPPPSPNQSYEGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSEPPDRSPLGLHIGFPTDTPKSSPHSVTASSSSVPALTPGFSRHSPPSPLCRSLSPGTGGGVRGGVSYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF
|
Nucleotide Sequence (Fasta) | AGAAGGTTAT TTCCTGCTGA CCCAGAGCAA GCCTCCCATC CGAAAAAGGG GCTGCAGGGA 60 TTTCCTCGAC CTCCGCGACC GGCCGCGCCC CCAACAGCGC AGCGCCCTCC GGGCCCGCTG 120 GAGGTGAGGG AGGTGCTGCC TGCCCGTCCC TCTGTCGTCT CCTCCCCCTG GTGCTCCCCA 180 CCCTCCACTC TCCTCCCTCC TTCTGTCGAC TCCTCCTGCC GCTGCTGCTG CTTTGGCTGC 240 TGCGTCATAC GCCCCAGAGC CGCCAGGACG GAGGGGCTGG GCCCGGGGAC CCCCTGGCCT 300 CCGCCTGCAC GCCCCCCGGC GCTCACACTC AGTCTTCCCG CACCGGAGAC TCATCCAGGT 360 CTCTTGAGTC TGACCCTACC TGGCTTCCAG CTGCCCCGGC TGTCACCGGC CCCCCCAGGA 420 TGCAATGGCG CAGCTCCCCC GGCTGAGCCG TTTGGGTGCC CCCTCTCTCT GGGATCCAGC 480 TTCCCCTGCT CCCACCTCAG GCCCCAGACC TCGGCTTTGG GAAGGCCAAG ATGTGCTGGC 540 CAGATGGACT GATGGGCTGC TGTACTTGGG TACCATCAAA AAGGTGGACA GTGCTCGAGA 600 GGTGTGTCTG GTCCAGTTTG AGGACGATTC CCAGTTTCTG GTTCTATGGA AGGATATCAG 660 CCCAGCTGCC CTCCCTGGGG AGGAGCTGCT CTGTTGTGTG TGTCGCTCTG AGACCGTGGT 720 ACCTGGGAAC CGGCTGGTCA GCTGTGAGAA GTGTCGCCAT GCTTATCACC AGGACTGTCA 780 CGTTCCCAGG GCCCCGGCCC CTGGAGAAGG AGAGGGCGCA TCCTGGGTAT GCCGCCAGTG 840 TGTCTTTGCA ATCGCCACTA AGAGGGGAGG CGCACTGAAG AAAGGTCCCT ATGCCCGGGC 900 CATGCTGGGC ATGAAGCTCT CCCTGCCATA CGGATTAAAA GGGCTGGACT GGGATGCTGG 960 ACATTTGAGC AACAGACAGC AGAGCTACTG CTACTGTGGA GGCCCTGGAG AGTGGAACCT 1020 GAAAATGCTG CAGTGCCGGA GCTGCCTCCA GTGGTTCCAT GAGGCCTGCA CCCAGTGTCT 1080 GAGCAAGCCC CTCCTCTACG GAGACAGATT CTATGAATTT GAGTGCTGTG TGTGCCGGGG 1140 CGGCCCTGAG AAGGTCCGGA GGTTACAGCT TCGCTGGGTG GATGTGGCCC ATCTTGTCCT 1200 CTACCACCTC AGCGTTTGCT GTAAGAAGAA ATATTTTGAT TTTGACCGAG AGATCCTCCC 1260 CTTCACCTCT GAGAATTGGG ACAGTCTGCT CCTGGGGGAG CTCTCAGATA CTCCCAAGGG 1320 AGAGCGCTCT TCCCAGCTCC TTTCTGCTCT TAACAGCCAC AAGGACCGTT TCATTTCAGG 1380 GAGGGAGATT AAAAAGCGAA AATGTCTTTT TGGTCTCCAT GCTCGGACCC CTCCTCCTGT 1440 GGAGCTTCTC ACTGGAGATG GAGCCCCCAC CAGCTTCCCT TCAGGGCAGG GCCCTGGGGG 1500 AGGGGTCTCA CGTCCCCTGG GGAAACGATG GAGGTCGGAG CCAGAACCCT TAAGGAGGAG 1560 GCAGAAGGGG AAAGTGGAGG AACTGGGGCC ACCCACGGCA GCACACAGTC GGCATGGGTC 1620 CCGGGAGCAG AGGGCCCTGC AGGCCTCGGT GTCTCCACCA CCCCCCAGCC CTAACCAGAG 1680 CTATGAGGGC AGCAGCGGCT ACAACTTCCG GCCCACAGAC GCCCGCTGTC TGCCCAGCAG 1740 CCCTATCCGG ATGTTCGCCT CCTTCCACCC TTCTGCCAGC ACTGCAGGGA CCTCTGGGGA 1800 CAGTGAACCC CCAGATAGGT CACCTCTGGG ACTTCACATT GGCTTCCCCA CAGACACCCC 1860 TAAAAGTTCA CCCCACTCAG TGACGGCCTC ATCTTCCTCG GTCCCAGCCC TGACCCCAGG 1920 CTTTTCCAGA CATTCACCCC CTTCTCCCTT GTGCCGTAGT CTGTCTCCGG GGACTGGGGG 1980 AGGAGTCCGA GGTGGGGTTA GCTACCTGTC CCGAGGGGAC CCTGTGAGGG TCCTTGCTCG 2040 AAGAGTGCGG CCTGACGGCT CTGTGCAGTA CCTAGTTGAG TGGGGAGGGG GGGGCATCTT 2100 CTGACAGCCT GCTTCTGCTC CCCTCCCCAT TCACACACTG GCACTTTCAT GCCCTGACCT 2160 CTGACCTCAC CTACAGCTGG GATGTACCTG GAGAGATGGG GAGTGGTTCT CCCTCCTGCC 2220 CAGGCTGGAA TCCAGGGGAG TGAAGAGGTC CTCTTCTCTG CCCCTTCATG ACTCCTAATG 2280 CCCCCCCTCA TTTCCTTTGA TGTTATTTTG TTACAGCTTT TGAGATAATT TTTTAAGACT 2340 ATTTAACCCC TGGGATTAGA GATTGGGGGG GGGGGTTTGG GTGGTCCAGG ATTCCAGACT 2400 GTATGACTGT AATAAAGATA AATAAACCT
Nucleotide Fasta Sequence
>ENSMUSP00000073402.5|Tudor|Mus musculus AGAAGGTTATTTCCTGCTGACCCAGAGCAAGCCTCCCATCCGAAAAAGGGGCTGCAGGGATTTCCTCGACCTCCGCGACCGGCCGCGCCCCCAACAGCGCAGCGCCCTCCGGGCCCGCTGGAGGTGAGGGAGGTGCTGCCTGCCCGTCCCTCTGTCGTCTCCTCCCCCTGGTGCTCCCCACCCTCCACTCTCCTCCCTCCTTCTGTCGACTCCTCCTGCCGCTGCTGCTGCTTTGGCTGCTGCGTCATACGCCCCAGAGCCGCCAGGACGGAGGGGCTGGGCCCGGGGACCCCCTGGCCTCCGCCTGCACGCCCCCCGGCGCTCACACTCAGTCTTCCCGCACCGGAGACTCATCCAGGTCTCTTGAGTCTGACCCTACCTGGCTTCCAGCTGCCCCGGCTGTCACCGGCCCCCCCAGGATGCAATGGCGCAGCTCCCCCGGCTGAGCCGTTTGGGTGCCCCCTCTCTCTGGGATCCAGCTTCCCCTGCTCCCACCTCAGGCCCCAGACCTCGGCTTTGGGAAGGCCAAGATGTGCTGGCCAGATGGACTGATGGGCTGCTGTACTTGGGTACCATCAAAAAGGTGGACAGTGCTCGAGAGGTGTGTCTGGTCCAGTTTGAGGACGATTCCCAGTTTCTGGTTCTATGGAAGGATATCAGCCCAGCTGCCCTCCCTGGGGAGGAGCTGCTCTGTTGTGTGTGTCGCTCTGAGACCGTGGTACCTGGGAACCGGCTGGTCAGCTGTGAGAAGTGTCGCCATGCTTATCACCAGGACTGTCACGTTCCCAGGGCCCCGGCCCCTGGAGAAGGAGAGGGCGCATCCTGGGTATGCCGCCAGTGTGTCTTTGCAATCGCCACTAAGAGGGGAGGCGCACTGAAGAAAGGTCCCTATGCCCGGGCCATGCTGGGCATGAAGCTCTCCCTGCCATACGGATTAAAAGGGCTGGACTGGGATGCTGGACATTTGAGCAACAGACAGCAGAGCTACTGCTACTGTGGAGGCCCTGGAGAGTGGAACCTGAAAATGCTGCAGTGCCGGAGCTGCCTCCAGTGGTTCCATGAGGCCTGCACCCAGTGTCTGAGCAAGCCCCTCCTCTACGGAGACAGATTCTATGAATTTGAGTGCTGTGTGTGCCGGGGCGGCCCTGAGAAGGTCCGGAGGTTACAGCTTCGCTGGGTGGATGTGGCCCATCTTGTCCTCTACCACCTCAGCGTTTGCTGTAAGAAGAAATATTTTGATTTTGACCGAGAGATCCTCCCCTTCACCTCTGAGAATTGGGACAGTCTGCTCCTGGGGGAGCTCTCAGATACTCCCAAGGGAGAGCGCTCTTCCCAGCTCCTTTCTGCTCTTAACAGCCACAAGGACCGTTTCATTTCAGGGAGGGAGATTAAAAAGCGAAAATGTCTTTTTGGTCTCCATGCTCGGACCCCTCCTCCTGTGGAGCTTCTCACTGGAGATGGAGCCCCCACCAGCTTCCCTTCAGGGCAGGGCCCTGGGGGAGGGGTCTCACGTCCCCTGGGGAAACGATGGAGGTCGGAGCCAGAACCCTTAAGGAGGAGGCAGAAGGGGAAAGTGGAGGAACTGGGGCCACCCACGGCAGCACACAGTCGGCATGGGTCCCGGGAGCAGAGGGCCCTGCAGGCCTCGGTGTCTCCACCACCCCCCAGCCCTAACCAGAGCTATGAGGGCAGCAGCGGCTACAACTTCCGGCCCACAGACGCCCGCTGTCTGCCCAGCAGCCCTATCCGGATGTTCGCCTCCTTCCACCCTTCTGCCAGCACTGCAGGGACCTCTGGGGACAGTGAACCCCCAGATAGGTCACCTCTGGGACTTCACATTGGCTTCCCCACAGACACCCCTAAAAGTTCACCCCACTCAGTGACGGCCTCATCTTCCTCGGTCCCAGCCCTGACCCCAGGCTTTTCCAGACATTCACCCCCTTCTCCCTTGTGCCGTAGTCTGTCTCCGGGGACTGGGGGAGGAGTCCGAGGTGGGGTTAGCTACCTGTCCCGAGGGGACCCTGTGAGGGTCCTTGCTCGAAGAGTGCGGCCTGACGGCTCTGTGCAGTACCTAGTTGAGTGGGGAGGGGGGGGCATCTTCTGACAGCCTGCTTCTGCTCCCCTCCCCATTCACACACTGGCACTTTCATGCCCTGACCTCTGACCTCACCTACAGCTGGGATGTACCTGGAGAGATGGGGAGTGGTTCTCCCTCCTGCCCAGGCTGGAATCCAGGGGAGTGAAGAGGTCCTCTTCTCTGCCCCTTCATGACTCCTAATGCCCCCCCTCATTTCCTTTGATGTTATTTTGTTACAGCTTTTGAGATAATTTTTTAAGACTATTTAACCCCTGGGATTAGAGATTGGGGGGGGGGGTTTGGGTGGTCCAGGATTCCAGACTGTATGACTGTAATAAAGATAAATAAACCT
|
Sequence Source |
Ensembl |
Keyword |
KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0206--Cytoskeleton KW-0227--DNA damage KW-0479--Metal-binding KW-0539--Nucleus KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc KW-0863--Zinc-finger --
|
Interpro |
IPR025894--Mtf2_C_dom IPR031202--PHF1 IPR002999--Tudor IPR019786--Zinc_finger_PHD-type_CS IPR011011--Znf_FYVE_PHD IPR001965--Znf_PHD IPR019787--Znf_PHD-finger IPR013083--Znf_RING/FYVE/PHD
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PROSITE |
PS01359--ZF_PHD_1 PS50016--ZF_PHD_2
|
Pfam |
PF14061--Mtf2_C PF00628--PHD
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0035098--C:ESC/E(Z) complex GO:0005815--C:microtubule organizing center GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0035861--C:site of double-strand break GO:0035064--F:methylated histone binding GO:0008270--F:zinc ion binding GO:0006974--P:cellular response to DNA damage stimulus GO:0016568--P:chromatin modification GO:0061086--P:negative regulation of histone H3-K27 methylation GO:0061087--P:positive regulation of histone H3-K27 methylation GO:0006355--P:regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |