Tag |
Content |
WERAM ID |
WERAM-Mum-0148 |
Ensembl Protein ID |
ENSMUSP00000045862.6 |
Uniprot Accession |
O70546; KDM6A_MOUSE; A2AID2; Q6DI80; Q7TSG4 |
Genbank Protein ID |
NP_001297373.1; NP_033509.1 |
Protein Name |
Lysine-specific demethylase 6A |
Genbank Nucleotide ID |
NM_001310444.1; NM_009483.2 |
Gene Name |
KDM6A;UTX |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDM |
UTX_UTY |
Jmjc |
H3K27me3 |
K |
26999603; 23658530 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
UTX_UTY |
5.10e-104 |
346.4 |
786 |
1258 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). |
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity).
|
Domain Profile |
HDM UTX_UTY
UTX.txt 59 csvninigpgdcew 72 n n+gpg c+ ENSMUSP00000045862.6 786 GKANNNVGPGTCDK 799 56799*******85 PP UTX.txt 1 kwkkqlkelsklpafvrvisaanllshvghtilgmntvqlymkvpgsrtpghqennnlcsvninigpgdcewfavpeeywgklsdlc 87 kwk ql+el+klpafvrv+sa+nllshvghtilgmntvqlymkvpgsrtpghqennn+csvninigpgdcewf+vpe ywg+l+d+c ENSMUSP00000045862.6 1095 KWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFC 1181 8************************************************************************************** PP UTX.txt 88 eknnvdyltgswwpvledlyeanipvyrfiqkpgdlvyvnagtvhwvqaigwcnniawnvgpltakqyklaleryey 164 eknn+++l+gswwp+ledlyean+pvyrfiq+pgdlv++nagtvhwvqaigwcnniawnvgplta+qykla+erye+ ENSMUSP00000045862.6 1182 EKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEW 1258 ****************************************************************************9 PP
|
Protein Sequence (Fasta) | MKSCGVSLAT AAAAAAAAAF GDEEKKMAAG KASGESEEAS PSLTAEEREA LGGLDSRLFG 60 FVRFHEDGAR MKALLGKAVR CYESLILKAE GKVESDFFCQ LGHFNLLLED YPKALSAYQR 120 YYSLQSDYWK NAAFLYGLGL VYFHYNAFQW AIKAFQEVLY VDPSFCRAKE IHLRLGLMFK 180 VNTDYESSLK HFQLALVDCN PCTLSNAEIQ FHIAHLYETQ RKYHSAKEAY EQLLQTENLS 240 AQVKATILQQ LGWMHHTVDL LGDKATKESY AIQYLQKSLE ADPNSGQSWY FLGRCYSSIG 300 KVQDAFISYR QSIDKSEASA DTWCSIGVLY QQQNQPMDAL QAYICAVQLD HGHAAAWMDL 360 GTLYESCNQP QDAIKCYLNA TRSKNCSNTS GLAARIKYLQ AQLCNLPQGS LQNKTKLLPS 420 IEEAWSLPIP AELTSRQGAM NTAQQNTSDN WSGGNAPPPV EQQTHSWCLT PQKLQHLEQL 480 RANRNNLNPA QKLMLEQLES QFVLMQQHQM RQTGVAQVRP TGILNGPTVD SSLPTNSVSG 540 QQPQLPLTRM PSVSQPGVHT ACPRQTLANG PFSAGHVPCS TSRTLGSTDT VLIGNNHVTG 600 SGSNGNVPYL QRNAPTLPHN RTNLTSSTEE PWKNQLSNST QGLHKGPSSH LAGPNGERPL 660 SSTGPSQHLQ AAGSGIQNQN GHPTLPSNSV TQGAALNHLS SHTATSGGQQ GITLTKESKP 720 SGNTLTVPET SRQTGETPNS TASVEGLPNH VHQVMADAVC SPSHGDSKSP GLLSSDNPQL 780 SALLMGKANN NVGPGTCDKV NNIHPTVHTK TDNSVASSPS SAISTATPSP KSTEQTTTNS 840 VTSLNSPHSG LHTINGEGME ESQSPIKTDL LLVSHRPSPQ IIPSMSVSIY PSSAEVLKAC 900 RNLGKNGLSN SSILLDKCPP PRPPSSPYPP LPKDKLNPPT PSIYLENKRD AFFPPLHQFC 960 TNPNNPVTVI RGLAGALKLD LGLFSTKTLV EANNEHMVEV RTQLLQPADE NWDPTGTKKI 1020 WHCESNRSHT TIAKYAQYQA SSFQESLREE NEKRSHHKDH SDSESTSSDN SGKRRKGPFK 1080 TIKFGTNIDL SDDKKWKLQL HELTKLPAFV RVVSAGNLLS HVGHTILGMN TVQLYMKVPG 1140 SRTPGHQENN NFCSVNINIG PGDCEWFVVP EGYWGVLNDF CEKNNLNFLM GSWWPNLEDL 1200 YEANVPVYRF IQRPGDLVWI NAGTVHWVQA IGWCNNIAWN VGPLTACQYK LAVERYEWNK 1260 LQNVKSIVPM VHLSWNMARN IKVSDPKLFE MIKYCLLRTL KQCQTLREAL IAAGKEIIWH 1320 GRTKEEPAHY CSICEVEVFD LLFVTNESNS RKTYIVHCQD CARKTSGNLE NFVVLEQYKM 1380 EDLMQVYDQF TLAPPLPSAS S 1401Protein Fasta Sequence
>ENSMUSP00000045862.6|KDM6A;UTX|Mus musculus MKSCGVSLATAAAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARMKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATILQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKNCSNTSGLAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGNAPPPVEQQTHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRQTGVAQVRPTGILNGPTVDSSLPTNSVSGQQPQLPLTRMPSVSQPGVHTACPRQTLANGPFSAGHVPCSTSRTLGSTDTVLIGNNHVTGSGSNGNVPYLQRNAPTLPHNRTNLTSSTEEPWKNQLSNSTQGLHKGPSSHLAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNTLTVPETSRQTGETPNSTASVEGLPNHVHQVMADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGPGTCDKVNNIHPTVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPIKTDLLLVSHRPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGKRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQNVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS
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Nucleotide Sequence (Fasta) | GGCTGCGCCG AGCGGGCTGT GAGGGGGGGG TCACGGCAGC GGCGTGGGGT TCGCTGTGTG 60 ACACAATTAC AACAACTTTG TGCTGGTGCC GGGGAAGTTT GTGTCTCCTA CGAATCCCCC 120 CCAGAGCTCC CGCTCCTCGC GCGCTCCGGC CATTCCCGCC GACCCTGCCT GTGGCTGCCC 180 CCTTCCCATC CCCGCGATGT GACCCTACAG CCGAGCCGTC GCCGCTCCGG ACCCAGTGGT 240 TCCACAGCCT CTGCTGCCTC TGCCTTCACC TCTACCGCGT TAGGATTTTT CGCTGCCGCC 300 TCTCGCGGCA GAGGAGGAGG CAGAAATAAA GTTGGTGTGC CGGTCTTGTG CGGAGATTGG 360 AGGCGTCCTT GCGGGCTCCG GCCCGGAGAG GGGGGGTGTC GGCGTTGGAG TTGTGAATTC 420 GCTGCGTTTC CATGAAATCC TGCGGAGTGT CGCTCGCTAC CGCCGCCGCC GCCGCCGCCG 480 CCGCCGCTTT CGGTGATGAG GAAAAGAAAA TGGCGGCGGG AAAAGCGAGC GGCGAGAGCG 540 AGGAGGCGTC CCCCAGCCTG ACAGCGGAGG AGAGGGAGGC GCTCGGCGGA CTGGACAGCC 600 GCCTTTTCGG GTTCGTGAGG TTTCATGAAG ATGGCGCCAG GATGAAGGCC CTGCTGGGCA 660 AGGCTGTTCG CTGCTACGAA TCTCTAATCT TAAAAGCTGA AGGGAAAGTG GAGTCTGATT 720 TCTTTTGTCA ATTAGGTCAC TTCAACCTCT TATTGGAAGA TTATCCAAAA GCATTATCTG 780 CATACCAGAG GTACTACAGT TTACAGTCTG ATTACTGGAA GAATGCTGCC TTTTTATATG 840 GTCTTGGTTT GGTCTACTTC CATTACAATG CATTTCAGTG GGCTATTAAA GCATTTCAGG 900 AGGTGCTTTA TGTCGATCCC AGCTTTTGTC GAGCCAAGGA AATTCATTTA CGACTTGGGC 960 TTATGTTCAA AGTGAACACA GACTATGAGT CTAGTTTAAA GCATTTTCAG TTAGCTTTGG 1020 TTGACTGTAA TCCCTGCACT TTGTCCAATG CTGAAATTCA GTTTCACATT GCCCACTTAT 1080 ATGAAACCCA GAGGAAGTAT CATTCTGCAA AAGAAGCTTA TGAGCAACTT TTGCAGACAG 1140 AAAACCTTTC TGCACAAGTA AAAGCAACTA TTTTACAACA ATTAGGTTGG ATGCATCACA 1200 CTGTGGATCT CCTGGGAGAT AAGGCCACCA AGGAAAGTTA TGCTATTCAG TATCTCCAGA 1260 AGTCCTTGGA AGCAGATCCA AATTCTGGCC AGTCCTGGTA TTTCCTTGGA AGGTGCTATT 1320 CAAGTATTGG GAAAGTTCAG GATGCCTTTA TATCTTACAG GCAATCTATT GATAAATCAG 1380 AAGCAAGTGC AGATACATGG TGTTCAATAG GTGTGCTCTA TCAACAGCAA AATCAGCCTA 1440 TGGATGCTTT GCAAGCTTAT ATTTGTGCTG TACAATTGGA CCACGGTCAT GCTGCAGCCT 1500 GGATGGATCT AGGCACTCTC TATGAATCCT GCAACCAACC TCAGGATGCT ATTAAATGCT 1560 ATTTAAATGC AACTAGAAGC AAAAATTGTA GTAATACCTC TGGACTTGCA GCACGAATTA 1620 AGTATTTACA GGCTCAGTTG TGTAACCTTC CACAAGGTAG TCTACAGAAT AAAACTAAAT 1680 TACTTCCTAG TATTGAGGAG GCATGGAGCC TACCAATCCC CGCAGAGCTT ACCTCCAGGC 1740 AGGGTGCCAT GAACACAGCA CAGCAGAATA CTTCTGATAA TTGGAGTGGT GGCAATGCAC 1800 CACCTCCAGT AGAACAACAA ACTCATTCAT GGTGTTTGAC ACCACAGAAA TTACAGCACT 1860 TGGAACAGCT CCGAGCAAAC AGAAATAATT TAAATCCAGC ACAGAAACTA ATGCTGGAAC 1920 AGCTGGAAAG TCAGTTTGTC TTAATGCAGC AACACCAAAT GAGACAAACA GGAGTTGCAC 1980 AGGTACGGCC TACTGGAATT CTTAATGGGC CAACAGTTGA CTCATCACTG CCTACAAACT 2040 CAGTTTCTGG CCAGCAGCCA CAGCTTCCTC TGACCAGAAT GCCTAGTGTC TCTCAGCCTG 2100 GAGTCCACAC TGCCTGTCCT AGGCAGACTT TGGCCAATGG ACCCTTTTCT GCAGGCCATG 2160 TTCCCTGTAG CACATCAAGA ACACTGGGAA GTACAGACAC TGTTTTGATA GGCAATAATC 2220 ATGTAACAGG AAGTGGAAGT AATGGAAACG TGCCTTACCT GCAGCGAAAC GCACCCACTC 2280 TACCTCATAA CCGCACAAAC CTGACCAGCA GCACAGAGGA GCCGTGGAAA AACCAACTAT 2340 CTAACTCCAC TCAGGGGCTT CACAAAGGTC CGAGTTCACA TTTGGCAGGT CCTAATGGTG 2400 AACGACCTCT ATCTTCCACT GGGCCTTCCC AGCATCTCCA GGCAGCTGGC TCTGGTATTC 2460 AGAATCAGAA TGGACATCCC ACCCTGCCTA GCAATTCAGT AACACAGGGG GCTGCTCTCA 2520 ATCACCTCTC CTCTCACACT GCTACCTCAG GTGGACAACA AGGCATTACC TTAACCAAAG 2580 AGAGCAAGCC TTCAGGAAAC ACATTGACGG TGCCTGAAAC AAGCAGGCAA ACTGGAGAGA 2640 CACCTAACAG CACTGCCAGT GTTGAGGGAC TTCCTAATCA TGTCCATCAG GTGATGGCAG 2700 ATGCTGTTTG CAGTCCTAGC CATGGAGATT CTAAGTCACC AGGTTTACTA AGTTCAGACA 2760 ATCCTCAGCT CTCTGCCTTG TTGATGGGAA AAGCTAATAA CAATGTGGGT CCTGGAACCT 2820 GTGACAAAGT CAATAACATC CACCCAACTG TCCATACAAA GACTGATAAT TCTGTTGCCT 2880 CTTCACCATC TTCAGCCATT TCCACAGCAA CACCTTCTCC TAAGTCCACT GAACAGACAA 2940 CCACAAACAG TGTTACCAGC CTTAACAGCC CTCACAGTGG GCTGCACACA ATTAATGGAG 3000 AAGGAATGGA AGAATCTCAG AGCCCCATTA AAACAGATCT GCTTCTAGTT AGCCACAGAC 3060 CTAGTCCTCA GATCATACCA TCAATGTCTG TGTCCATATA TCCCAGCTCA GCAGAAGTTC 3120 TGAAAGCTTG CAGGAATCTA GGTAAAAACG GCCTGTCTAA TAGTAGCATT CTGTTGGATA 3180 AATGTCCGCC TCCAAGACCA CCATCCTCAC CATACCCTCC CTTGCCAAAG GACAAGTTGA 3240 ATCCACCTAC ACCTAGTATT TATTTGGAAA ATAAACGTGA TGCTTTCTTT CCTCCATTAC 3300 ATCAATTTTG TACAAACCCA AACAACCCTG TTACAGTAAT ACGTGGCCTT GCTGGAGCTC 3360 TTAAATTAGA CTTGGGACTT TTCTCTACTA AAACTTTGGT GGAAGCTAAC AATGAACATA 3420 TGGTAGAAGT GAGGACACAG TTGTTACAAC CAGCAGATGA AAATTGGGAC CCTACTGGAA 3480 CCAAGAAAAT CTGGCACTGT GAAAGTAATA GATCTCATAC TACAATTGCT AAATATGCTC 3540 AGTACCAGGC CTCCTCATTC CAAGAATCAT TGAGAGAAGA AAATGAGAAA AGAAGTCACC 3600 ATAAAGACCA CTCAGACAGT GAATCTACAT CATCAGATAA TTCTGGGAAA AGAAGAAAAG 3660 GACCCTTTAA AACCATTAAG TTTGGGACCA ACATTGACCT GTCTGATGAC AAAAAGTGGA 3720 AGTTACAGCT ACATGAGCTG ACTAAACTTC CTGCCTTCGT GAGAGTTGTA TCTGCAGGAA 3780 ATCTTTTAAG CCACGTTGGT CATACTATAC TGGGCATGAA CACAGTTCAA CTATACATGA 3840 AAGTTCCAGG AAGCAGAACA CCAGGTCATC AAGAAAATAA CAACTTCTGT TCAGTTAATA 3900 TAAATATTGG CCCAGGTGAC TGTGAATGGT TTGTTGTTCC TGAAGGCTAC TGGGGTGTTT 3960 TGAATGACTT CTGTGAAAAA AATAATTTGA ATTTCTTAAT GGGTTCTTGG TGGCCCAACC 4020 TTGAAGATCT ATATGAAGCA AATGTTCCAG TGTATAGGTT TATTCAGCGA CCTGGAGATC 4080 TGGTCTGGAT AAATGCTGGC ACTGTTCATT GGGTTCAAGC TATTGGCTGG TGCAACAATA 4140 TTGCTTGGAA TGTTGGTCCA CTTACAGCCT GTCAGTATAA GTTAGCAGTG GAACGTTATG 4200 AATGGAACAA GTTGCAAAAT GTAAAGTCAA TAGTACCCAT GGTTCATCTT TCCTGGAATA 4260 TGGCACGAAA TATCAAGGTT TCAGATCCAA AGCTTTTTGA AATGATTAAG TATTGTCTTC 4320 TGAGAACGCT GAAGCAATGT CAGACATTGA GGGAAGCTCT AATTGCTGCA GGAAAAGAGA 4380 TCATATGGCA CGGGCGGACA AAAGAAGAAC CAGCTCATTA TTGTAGTATT TGTGAGGTGG 4440 AGGTTTTTGA TCTGCTTTTT GTCACTAATG AGAGTAATTC TCGAAAAACC TACATAGTAC 4500 ATTGCCAAGA TTGTGCACGA AAAACAAGTG GGAATCTGGA AAATTTTGTG GTGCTAGAAC 4560 AGTACAAAAT GGAGGATCTG ATGCAAGTCT ATGACCAATT TACATTAGCT CCTCCATTAC 4620 CATCCGCCTC ATCTTGATAT TGTTCCATGG ACATTAAACA TGAGACCTTT TCTGCTATTC 4680 AGAAAGTAAC CCAGTTCTGC ACCACTGCTA TTTGTAGCTA TCTCGTAAGG CTGCTGGCTG 4740 AAAACTGTGT CTATGCAACC TTCCAAGTGT GGAGTGTCAA CCAACTGGAC GGGAGAGTAC 4800 TGCTCCTATG CCAGGACTCT CGTAAAGCTA ATTAGCTGAA CTTCAGAGAA AAAAAAAAGA 4860 ATAATAATTA CCACGTTTTG TATATATCTG ACAAAACTGG CAACATCATA AAGACTACTG 4920 ACTTGAAGAC AACCTCTTTT ATATTTCTCG ATTTCTGGGC TAATGAATTT GTTTTCACCT 4980 ATCTTTTCCC TTTCAGAATT TTATTCGGGG GGGAAAATAA CTAGCCTAGC TGGTCATTTC 5040 TTTGTAAGGT AGTTAGCAAT ATTTAGTCTT TCTTTGGTCA CCTTTTTTTT TTTAATGTGA 5100 AAAGTTAAGT AAGAAACTTT TTTTACTGCT TTTATGAATT TCTGTCTTGT TTTGAAACTA 5160 TGATCGTTAT AATTTTGGTT CCCAAATAAA ACATTTAAAA AAAATAATTA ACAGCAACGT 5220 CACAAAGATA ATGGATTGCA CATAGACTAA GAAATAAACT TCAGAATTGT GATTTTTTTT 5280 GTTTCTAATC TTGATGTAAA TTTACACTAT TTATAAATAC ATATTTATTG CCTGAAAATA 5340 TTTGTGAATG GAATGCTGTT ATTTTTTCCA GATTTACCTG CCATTGAAAT TTTAAGGAGT 5400 TCTGTAATTT CAAACACTAC TCCTATTACA TTTTCTATGT GTAAATAAAA CTGCTTAGCC 5460 TTGTACAGAA ACTTTTATTA AAATTGTTTA ATGTTTAAAG AGTTTTCTAT TGTTTGAGTT 5520 TTAAAAAGAA TTTATGTACA GTGCCCAATT TTTGTTCACT TTTCAAATCT GATTATATAT 5580 ATTTTATATA TACTTATGTC TGTATATATA ATATATATAG AAATCTAGAT ATATGTATAA 5640 AGATTTAGAA TTTGAATTTT TCTTGTTTTA AGTTTCACAT CTATGGTAGA TTTTTGAGGT 5700 GTCTACTGTA AAGTATTGCT CACAAAAAGT ATGATTATTT TTAAAGAAAT ATATATGGTA 5760 TGTATCTTCA AGACCTAAAA TGTCAGACTG GTTTATTGTT AAATTGCAAC TACTGCAATT 5820 ACAGACAAAA AAAATCTGCC AAATGTAGTA TAATAGAAAA CATAGTGATT GAACTTAAAA 5880 CTTTAAAGGG AGTTTTAATA CAGGCTTTTC AAATCCTA
5919Nucleotide Fasta Sequence
>ENSMUSP00000045862.6|UTX_UTY|Mus musculus GGCTGCGCCGAGCGGGCTGTGAGGGGGGGGTCACGGCAGCGGCGTGGGGTTCGCTGTGTGACACAATTACAACAACTTTGTGCTGGTGCCGGGGAAGTTTGTGTCTCCTACGAATCCCCCCCAGAGCTCCCGCTCCTCGCGCGCTCCGGCCATTCCCGCCGACCCTGCCTGTGGCTGCCCCCTTCCCATCCCCGCGATGTGACCCTACAGCCGAGCCGTCGCCGCTCCGGACCCAGTGGTTCCACAGCCTCTGCTGCCTCTGCCTTCACCTCTACCGCGTTAGGATTTTTCGCTGCCGCCTCTCGCGGCAGAGGAGGAGGCAGAAATAAAGTTGGTGTGCCGGTCTTGTGCGGAGATTGGAGGCGTCCTTGCGGGCTCCGGCCCGGAGAGGGGGGGTGTCGGCGTTGGAGTTGTGAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCCGCCGCCGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCGGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTTTTCGGGTTCGTGAGGTTTCATGAAGATGGCGCCAGGATGAAGGCCCTGCTGGGCAAGGCTGTTCGCTGCTACGAATCTCTAATCTTAAAAGCTGAAGGGAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTACAGTTTACAGTCTGATTACTGGAAGAATGCTGCCTTTTTATATGGTCTTGGTTTGGTCTACTTCCATTACAATGCATTTCAGTGGGCTATTAAAGCATTTCAGGAGGTGCTTTATGTCGATCCCAGCTTTTGTCGAGCCAAGGAAATTCATTTACGACTTGGGCTTATGTTCAAAGTGAACACAGACTATGAGTCTAGTTTAAAGCATTTTCAGTTAGCTTTGGTTGACTGTAATCCCTGCACTTTGTCCAATGCTGAAATTCAGTTTCACATTGCCCACTTATATGAAACCCAGAGGAAGTATCATTCTGCAAAAGAAGCTTATGAGCAACTTTTGCAGACAGAAAACCTTTCTGCACAAGTAAAAGCAACTATTTTACAACAATTAGGTTGGATGCATCACACTGTGGATCTCCTGGGAGATAAGGCCACCAAGGAAAGTTATGCTATTCAGTATCTCCAGAAGTCCTTGGAAGCAGATCCAAATTCTGGCCAGTCCTGGTATTTCCTTGGAAGGTGCTATTCAAGTATTGGGAAAGTTCAGGATGCCTTTATATCTTACAGGCAATCTATTGATAAATCAGAAGCAAGTGCAGATACATGGTGTTCAATAGGTGTGCTCTATCAACAGCAAAATCAGCCTATGGATGCTTTGCAAGCTTATATTTGTGCTGTACAATTGGACCACGGTCATGCTGCAGCCTGGATGGATCTAGGCACTCTCTATGAATCCTGCAACCAACCTCAGGATGCTATTAAATGCTATTTAAATGCAACTAGAAGCAAAAATTGTAGTAATACCTCTGGACTTGCAGCACGAATTAAGTATTTACAGGCTCAGTTGTGTAACCTTCCACAAGGTAGTCTACAGAATAAAACTAAATTACTTCCTAGTATTGAGGAGGCATGGAGCCTACCAATCCCCGCAGAGCTTACCTCCAGGCAGGGTGCCATGAACACAGCACAGCAGAATACTTCTGATAATTGGAGTGGTGGCAATGCACCACCTCCAGTAGAACAACAAACTCATTCATGGTGTTTGACACCACAGAAATTACAGCACTTGGAACAGCTCCGAGCAAACAGAAATAATTTAAATCCAGCACAGAAACTAATGCTGGAACAGCTGGAAAGTCAGTTTGTCTTAATGCAGCAACACCAAATGAGACAAACAGGAGTTGCACAGGTACGGCCTACTGGAATTCTTAATGGGCCAACAGTTGACTCATCACTGCCTACAAACTCAGTTTCTGGCCAGCAGCCACAGCTTCCTCTGACCAGAATGCCTAGTGTCTCTCAGCCTGGAGTCCACACTGCCTGTCCTAGGCAGACTTTGGCCAATGGACCCTTTTCTGCAGGCCATGTTCCCTGTAGCACATCAAGAACACTGGGAAGTACAGACACTGTTTTGATAGGCAATAATCATGTAACAGGAAGTGGAAGTAATGGAAACGTGCCTTACCTGCAGCGAAACGCACCCACTCTACCTCATAACCGCACAAACCTGACCAGCAGCACAGAGGAGCCGTGGAAAAACCAACTATCTAACTCCACTCAGGGGCTTCACAAAGGTCCGAGTTCACATTTGGCAGGTCCTAATGGTGAACGACCTCTATCTTCCACTGGGCCTTCCCAGCATCTCCAGGCAGCTGGCTCTGGTATTCAGAATCAGAATGGACATCCCACCCTGCCTAGCAATTCAGTAACACAGGGGGCTGCTCTCAATCACCTCTCCTCTCACACTGCTACCTCAGGTGGACAACAAGGCATTACCTTAACCAAAGAGAGCAAGCCTTCAGGAAACACATTGACGGTGCCTGAAACAAGCAGGCAAACTGGAGAGACACCTAACAGCACTGCCAGTGTTGAGGGACTTCCTAATCATGTCCATCAGGTGATGGCAGATGCTGTTTGCAGTCCTAGCCATGGAGATTCTAAGTCACCAGGTTTACTAAGTTCAGACAATCCTCAGCTCTCTGCCTTGTTGATGGGAAAAGCTAATAACAATGTGGGTCCTGGAACCTGTGACAAAGTCAATAACATCCACCCAACTGTCCATACAAAGACTGATAATTCTGTTGCCTCTTCACCATCTTCAGCCATTTCCACAGCAACACCTTCTCCTAAGTCCACTGAACAGACAACCACAAACAGTGTTACCAGCCTTAACAGCCCTCACAGTGGGCTGCACACAATTAATGGAGAAGGAATGGAAGAATCTCAGAGCCCCATTAAAACAGATCTGCTTCTAGTTAGCCACAGACCTAGTCCTCAGATCATACCATCAATGTCTGTGTCCATATATCCCAGCTCAGCAGAAGTTCTGAAAGCTTGCAGGAATCTAGGTAAAAACGGCCTGTCTAATAGTAGCATTCTGTTGGATAAATGTCCGCCTCCAAGACCACCATCCTCACCATACCCTCCCTTGCCAAAGGACAAGTTGAATCCACCTACACCTAGTATTTATTTGGAAAATAAACGTGATGCTTTCTTTCCTCCATTACATCAATTTTGTACAAACCCAAACAACCCTGTTACAGTAATACGTGGCCTTGCTGGAGCTCTTAAATTAGACTTGGGACTTTTCTCTACTAAAACTTTGGTGGAAGCTAACAATGAACATATGGTAGAAGTGAGGACACAGTTGTTACAACCAGCAGATGAAAATTGGGACCCTACTGGAACCAAGAAAATCTGGCACTGTGAAAGTAATAGATCTCATACTACAATTGCTAAATATGCTCAGTACCAGGCCTCCTCATTCCAAGAATCATTGAGAGAAGAAAATGAGAAAAGAAGTCACCATAAAGACCACTCAGACAGTGAATCTACATCATCAGATAATTCTGGGAAAAGAAGAAAAGGACCCTTTAAAACCATTAAGTTTGGGACCAACATTGACCTGTCTGATGACAAAAAGTGGAAGTTACAGCTACATGAGCTGACTAAACTTCCTGCCTTCGTGAGAGTTGTATCTGCAGGAAATCTTTTAAGCCACGTTGGTCATACTATACTGGGCATGAACACAGTTCAACTATACATGAAAGTTCCAGGAAGCAGAACACCAGGTCATCAAGAAAATAACAACTTCTGTTCAGTTAATATAAATATTGGCCCAGGTGACTGTGAATGGTTTGTTGTTCCTGAAGGCTACTGGGGTGTTTTGAATGACTTCTGTGAAAAAAATAATTTGAATTTCTTAATGGGTTCTTGGTGGCCCAACCTTGAAGATCTATATGAAGCAAATGTTCCAGTGTATAGGTTTATTCAGCGACCTGGAGATCTGGTCTGGATAAATGCTGGCACTGTTCATTGGGTTCAAGCTATTGGCTGGTGCAACAATATTGCTTGGAATGTTGGTCCACTTACAGCCTGTCAGTATAAGTTAGCAGTGGAACGTTATGAATGGAACAAGTTGCAAAATGTAAAGTCAATAGTACCCATGGTTCATCTTTCCTGGAATATGGCACGAAATATCAAGGTTTCAGATCCAAAGCTTTTTGAAATGATTAAGTATTGTCTTCTGAGAACGCTGAAGCAATGTCAGACATTGAGGGAAGCTCTAATTGCTGCAGGAAAAGAGATCATATGGCACGGGCGGACAAAAGAAGAACCAGCTCATTATTGTAGTATTTGTGAGGTGGAGGTTTTTGATCTGCTTTTTGTCACTAATGAGAGTAATTCTCGAAAAACCTACATAGTACATTGCCAAGATTGTGCACGAAAAACAAGTGGGAATCTGGAAAATTTTGTGGTGCTAGAACAGTACAAAATGGAGGATCTGATGCAAGTCTATGACCAATTTACATTAGCTCCTCCATTACCATCCGCCTCATCTTGATATTGTTCCATGGACATTAAACATGAGACCTTTTCTGCTATTCAGAAAGTAACCCAGTTCTGCACCACTGCTATTTGTAGCTATCTCGTAAGGCTGCTGGCTGAAAACTGTGTCTATGCAACCTTCCAAGTGTGGAGTGTCAACCAACTGGACGGGAGAGTACTGCTCCTATGCCAGGACTCTCGTAAAGCTAATTAGCTGAACTTCAGAGAAAAAAAAAAGAATAATAATTACCACGTTTTGTATATATCTGACAAAACTGGCAACATCATAAAGACTACTGACTTGAAGACAACCTCTTTTATATTTCTCGATTTCTGGGCTAATGAATTTGTTTTCACCTATCTTTTCCCTTTCAGAATTTTATTCGGGGGGGAAAATAACTAGCCTAGCTGGTCATTTCTTTGTAAGGTAGTTAGCAATATTTAGTCTTTCTTTGGTCACCTTTTTTTTTTTAATGTGAAAAGTTAAGTAAGAAACTTTTTTTACTGCTTTTATGAATTTCTGTCTTGTTTTGAAACTATGATCGTTATAATTTTGGTTCCCAAATAAAACATTTAAAAAAAATAATTAACAGCAACGTCACAAAGATAATGGATTGCACATAGACTAAGAAATAAACTTCAGAATTGTGATTTTTTTTGTTTCTAATCTTGATGTAAATTTACACTATTTATAAATACATATTTATTGCCTGAAAATATTTGTGAATGGAATGCTGTTATTTTTTCCAGATTTACCTGCCATTGAAATTTTAAGGAGTTCTGTAATTTCAAACACTACTCCTATTACATTTTCTATGTGTAAATAAAACTGCTTAGCCTTGTACAGAAACTTTTATTAAAATTGTTTAATGTTTAAAGAGTTTTCTATTGTTTGAGTTTTAAAAAGAATTTATGTACAGTGCCCAATTTTTGTTCACTTTTCAAATCTGATTATATATATTTTATATATACTTATGTCTGTATATATAATATATATAGAAATCTAGATATATGTATAAAGATTTAGAATTTGAATTTTTCTTGTTTTAAGTTTCACATCTATGGTAGATTTTTGAGGTGTCTACTGTAAAGTATTGCTCACAAAAAGTATGATTATTTTTAAAGAAATATATATGGTATGTATCTTCAAGACCTAAAATGTCAGACTGGTTTATTGTTAAATTGCAACTACTGCAATTACAGACAAAAAAAATCTGCCAAATGTAGTATAATAGAAAACATAGTGATTGAACTTAAAACTTTAAAGGGAGTTTTAATACAGGCTTTTCAAATCCTA
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Sequence Source |
Ensembl |
Keyword |
KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0223--Dioxygenase KW-0408--Iron KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0802--TPR repeat KW-0862--Zinc --
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Interpro |
IPR003347--JmjC_dom IPR029517--KDM6A IPR013026--TPR-contain_dom IPR011990--TPR-like_helical_dom IPR019734--TPR_repeat
|
PROSITE |
PS51184--JMJC PS50005--TPR PS50293--TPR_REGION
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Pfam |
PF02373--JmjC PF13181--TPR_8
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Gene Ontology |
GO:0035097--C:histone methyltransferase complex GO:0044666--C:MLL3/4 complex GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0031490--F:chromatin DNA binding GO:0051213--F:dioxygenase activity GO:0071558--F:histone demethylase activity (H3-K27 specific) GO:0042802--F:identical protein binding GO:0046872--F:metal ion binding GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0060070--P:canonical Wnt signaling pathway GO:0072358--P:cardiovascular system development GO:0048568--P:embryonic organ development GO:0007507--P:heart development GO:0003007--P:heart morphogenesis GO:0071557--P:histone H3-K27 demethylation GO:0001701--P:in utero embryonic development GO:0048333--P:mesodermal cell differentiation GO:0035264--P:multicellular organism growth GO:0001843--P:neural tube closure GO:0021915--P:neural tube development GO:0048570--P:notochord morphogenesis GO:0010628--P:positive regulation of gene expression GO:0010468--P:regulation of gene expression GO:0003016--P:respiratory system process GO:0032525--P:somite rostral/caudal axis specification
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Orthology |
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Created Date |
25-Jun-2016 |