WERAM Information

Tag Content
WERAM ID WERAM-Mum-0122
Ensembl Protein ID ENSMUSP00000034085.7
Uniprot Accession O88665; BRD7_MOUSE; Q3UQ56; Q3UU06; Q9CT78
Genbank Protein ID NP_036177.1
Protein Name Bromodomain-containing protein 7
Genbank Nucleotide ID NM_012047.2
Gene Name BRD7;Bp75
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031660.13 ENSMUST00000034085.7 ENSMUSP00000034085.7
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 26878912
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 3.30e-18 67 150 218
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR.
Domain Profile
  Ac_Reader Bromodomain
             BROMO.txt   3 hevsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72 
                           ++ s +F+ pv     +p Y  iik+Pmd+st+ke+++++ Y+s+ee+ + ++l+++Na+ yn++++ ++
  ENSMUSP00000034085.7 150 KDPSAFFSFPVTD-FIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYY 218
                           5667888******.8**************************************************98876 PP
Protein Sequence
(Fasta)		MGKKHKKHKS DRHFYEEYVE KPLKLVLKVG GSEVTELSTG SSGHDSSLFE DRSDHDKHKD 60
RKRKKRKKGE KQAPGEEKGR KRRRVKEDKK KRDRDRAENE VDRDLQCHVP IRLDLPPEKP 120
LTSSLAKQEE VEQTPLQEAL NQLMRQLQRK DPSAFFSFPV TDFIAPGYSM IIKHPMDFST 180
MKEKIKNNDY QSIEELKDNF KLMCTNAMIY NKPETIYYKA AKKLLHSGMK ILSQERIQSL 240
KQSIDFMSDL QKTRKQKERT DACQSGEDSG CWQREREDSG DAETQAFRSP AKDNKRKDKD 300
VLEDKWRSSN SEREHEQIER VVQESGGKLT RRLANSQCEF ERRKPDGTTT LGLLHPVDPI 360
VGEPGYCPVR LGMTTGRLQS GVNTLQGFKE DKRNRVTPVL YLNYGPYSSY APHYDSTFAN 420
ISKDDSDLIY STYGEDSDLP NNFSISEFLA TCQDYPYVMA DSLLDVLTKG GHSRSLQDLD 480
MSSPEDEGQT RALDTAKEAE ITQIEPTGRL ESSSQDRLTA LQAVTTFGAP AEVFDSEEAE 540
VFQRKLDETT RLLRELQEAQ NERLSTRPPP NMICLLGPSY REMYLAEQVT NNLKELTQQV 600
TPGDVVSIHG VRKAMGISVP SPIVGNSFVD LTGECEEPKE TSTAECGPDA S 651
Nucleotide Sequence
(Fasta)		GCTGGTTTGC CGGCCTCTCG CCCTCTCGCC ACTGGTGTCG CGCTTCGGTC GCGTCCCGCG 60
CGTGGTTTTT TTTTTTTCTC GTGAGGGACC TCGCGCCGCC GGGCGCGTGC CGTCCCCCTG 120
CCTCGCGGCG CGGGCTCTCG CGGGCCCCGC TCCCGCCCTC CGCTCGCCTG GCCCGGACCG 180
GAAGCGGCGC CGCACGGCCT GGGCCTGGCG CGGGGGGCGG GCTCTGGGGC CCGGTCGGAC 240
ATGGGCAAGA AGCACAAGAA GCACAAGTCG GACCGCCACT TCTACGAGGA GTACGTGGAG 300
AAGCCCCTGA AGCTGGTCCT CAAAGTCGGG GGGAGCGAGG TCACCGAGCT CTCCACGGGC 360
AGCTCCGGGC ACGACTCCAG CCTCTTCGAA GACAGAAGCG ACCATGACAA ACACAAGGAC 420
AGAAAACGGA AAAAGAGGAA GAAAGGCGAG AAGCAGGCTC CGGGGGAAGA GAAGGGGAGA 480
AAACGGAGAA GAGTCAAGGA GGATAAAAAG AAGCGGGATC GAGACCGTGC AGAGAATGAG 540
GTGGACAGAG ATCTCCAGTG TCATGTCCCT ATAAGATTAG ACTTACCTCC TGAGAAGCCT 600
CTTACAAGCT CGTTAGCCAA ACAAGAAGAA GTAGAACAGA CACCCCTTCA GGAAGCTTTG 660
AATCAGCTCA TGAGACAATT GCAAAGAAAA GACCCAAGTG CTTTCTTTTC ATTTCCTGTG 720
ACGGATTTTA TTGCGCCTGG CTACTCCATG ATTATTAAAC ACCCAATGGA TTTTAGTACC 780
ATGAAAGAAA AGATCAAGAA TAACGACTAC CAGTCCATAG AAGAACTAAA GGATAACTTC 840
AAGCTAATGT GTACTAATGC AATGATTTAC AATAAGCCAG AGACCATTTA TTATAAAGCT 900
GCAAAGAAGC TGTTGCACTC AGGGATGAAA ATTCTCAGTC AGGAGAGAAT TCAGAGCCTG 960
AAGCAGAGTA TAGACTTCAT GTCAGACTTG CAGAAAACTC GGAAGCAGAA AGAACGAACA 1020
GATGCCTGTC AGAGTGGGGA GGACAGCGGC TGCTGGCAGC GCGAGAGGGA AGACTCTGGA 1080
GATGCTGAAA CACAGGCCTT CAGAAGCCCC GCTAAGGACA ATAAAAGGAA AGACAAAGAT 1140
GTGCTTGAAG ACAAATGGAG AAGCAGCAAC TCAGAAAGGG AGCATGAGCA GATTGAGCGC 1200
GTTGTCCAGG AGTCAGGAGG CAAGCTAACA CGGCGGCTGG CAAACAGTCA GTGTGAATTT 1260
GAAAGAAGAA AACCAGATGG GACAACAACA CTGGGGCTTC TCCATCCTGT GGATCCCATT 1320
GTGGGAGAGC CAGGCTACTG CCCTGTGAGA TTGGGGATGA CAACTGGAAG ACTGCAGTCT 1380
GGAGTGAACA CTCTGCAGGG GTTCAAAGAG GATAAAAGGA ACAGAGTAAC CCCAGTATTA 1440
TACTTGAATT ATGGACCCTA CAGTTCTTAT GCCCCACATT ATGACTCTAC ATTTGCCAAT 1500
ATTAGCAAAG ATGATTCTGA TTTAATCTAC TCAACATATG GGGAAGACTC TGACCTTCCA 1560
AACAATTTCA GCATCTCTGA GTTTTTGGCC ACATGCCAAG ATTACCCGTA TGTTATGGCA 1620
GATAGTTTAC TGGATGTTCT AACAAAAGGA GGACATTCCA GGAGCCTGCA GGACTTGGAC 1680
ATGTCATCTC CTGAAGATGA AGGCCAGACC AGAGCATTGG ACACAGCAAA AGAAGCAGAG 1740
ATTACACAAA TAGAGCCAAC AGGGCGTTTG GAGTCCAGCA GTCAGGACAG GCTCACAGCA 1800
CTGCAAGCTG TAACAACCTT TGGTGCTCCA GCTGAAGTCT TTGACTCCGA AGAGGCTGAG 1860
GTGTTCCAGA GGAAGCTTGA TGAGACGACA AGATTGCTCA GGGAGCTCCA GGAGGCACAG 1920
AATGAGCGAC TGAGCACTAG GCCTCCTCCC AATATGATCT GTCTCCTGGG TCCTTCTTAC 1980
AGAGAAATGT ACCTTGCTGA ACAAGTGACC AATAACCTCA AAGAACTCAC ACAGCAAGTG 2040
ACTCCAGGTG ATGTTGTAAG CATACACGGA GTGCGAAAAG CAATGGGGAT TTCTGTTCCT 2100
TCCCCCATCG TGGGAAACAG CTTCGTAGAT TTGACAGGAG AGTGTGAAGA ACCTAAGGAG 2160
ACCAGCACTG CTGAGTGTGG GCCTGACGCG AGCTGAACTA GCCTGGTATT TGATTCTATT 2220
ATGTACATAG TTTTTCATTC TGAACTTGGA GGTGCTTTTC AGAAGATATT AACTATTTGT 2280
AAATTGTGTT TTAATTAAGC TTTGGGACAG TTCCTTTTAA TGTTCCAAAG ATTGGCCTTG 2340
TATTAGGAAA TAAAGCTGAA CCTGGGACTG TGAGGCTCGC TGGTGTGTCA GCTGAATTAC 2400
CCTTTGCCTT GCTCGGCCTT GGTTCTGAGG ATGGACACCT AGGACACACA CCAGCCTTTC 2460
TCATGGTCAT CTTTCAAAGG AGCAGTCCTC AAATTAATTC CCCAAGTTTT CATATTTACC 2520
ACTCTTACTA GAACAATTAT AAGCAGCTAG TTATAAGCTC TGCCCTACCA GAGCTCATCT 2580
GAGTGACATT CAGAAAGTAG CCTTATGAGA TGGCCTTTCA GACTGCCACT AATGATGGTC 2640
TGACTTTTTA TTATTATTTT TATTATTATA TTGTTGAATG TGTATTATGT ACATACATAC 2700
ATACATGCAT GTAGCCCCTC CCCCTTTTGG GGTTTTTTTG TTTGGTTTAG TTTTGTTTTT 2760
TTGTTGTTTT TTTGAGATAG GGTTTCTCTG TGTAGCCCTG ACTGTCCTGA AATTAGCTCT 2820
GTAGACCAGG CTGTCTAAGA GGTCCGCCTG CCTCTGCATC CTGAATCCTA GGATTAAAGG 2880
TGTGCACCAC CTAGCTTAGA ACAACTTTTA GGAAAAGACT TTCTGCTTCC ATTGTAGATT 2940
CCATGGATTG AACTCAGGAC ATCAGACTTC TCAGAAAATG ATTTTTTATT CACTAAACTA 3000
TCTCAGTGGC TGAGGGCCCA ACTTTTTAAT CATAGTTCTG TCCACTGAGA CTTTCTAGCC 3060
TAACACCGTG AAAGTAAACA CACTCGAGAT AATGTTAAAG TTTCCCACTA TGGCTTCCTT 3120
CTCTGTACCT AATGGGAATG GTGTCCTCCT TCATGGTTAT TAGCTGCTGG GTCTGCTAGG 3180
AGGATGGTGG TGATGAAACG TGTCTAGTGT GTTTTCTTTT CCTTCTTTCT GTTTTTCCCA 3240
GTTACTTTGG AGCAATTGCA AATGGATGAA CCAAGTAAGA TGAGCCAAGT CACCCTTAGA 3300
CACATCAGAG TCTAGAGTTA GTGGAGAGCT TGCTCCTGCT CAGTTTTCCA AAGGCCACCT 3360
GTGTTTCATT TGTGCCCCCA AATCATTTCC CTGTTCTGAA ATACACAGGT CAAGTGACTG 3420
AGCACATTAG GTAGGAGACC ATCGGATATG TACCCTTATA TCACACTCAG TCACTGGACT 3480
GAGATAAATA ATAGTTTTTC CAAATATAAC CTCTTTAAGA GGCAAGCTGG GTATGGTAGG 3540
TTGCATTTAT AATCCCAGTA TTTGAGTGGC TGAGAGAGGA GGATTGCCAT GAATTTGAGT 3600
CCAGCTGGGC TATGAGACCA TGCCT 3626
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0103--Bromodomain
KW-0131--Cell cycle
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0879--Wnt signaling pathway
--
Interpro

IPR001487--Bromodomain
IPR021900--DUF3512
PROSITE

PS50014--BROMODOMAIN_2
Pfam

PF00439--Bromodomain
PF12024--DUF3512
Gene Ontology

GO:0090544--C:BAF-type complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0007049--P:cell cycle
GO:0008285--P:negative regulation of cell proliferation
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0035066--P:positive regulation of histone acetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0093 ENSRNOP00000068771.1 Rattus norvegicus 96 0.0 1186
WERAM-Chs-0058 ENSCSAP00000001667.1 Chlorocebus sabaeus 88 0.0 1101
WERAM-Hos-0182 ENSP00000378180.3 Homo sapiens 88 0.0 1100
WERAM-Cap-0167 ENSCPOP00000013943.2 Cavia porcellus 88 0.0 1094
WERAM-Mam-0024 ENSMMUP00000004172.2 Macaca mulatta 88 0.0 1093
WERAM-Paa-0198 ENSPANP00000012675.1 Papio anubis 88 0.0 1092
WERAM-Gog-0163 ENSGGOP00000014466.2 Gorilla gorilla 88 0.0 1092
WERAM-Poa-0067 ENSPPYP00000008289.2 Pongo abelii 88 0.0 1088
WERAM-Pat-0064 ENSPTRP00000013832.5 Pan troglodytes 88 0.0 1088
WERAM-Ict-0178 ENSSTOP00000022433.1 Ictidomys tridecemlineatus 90 0.0 1088
WERAM-Nol-0007 ENSNLEP00000001015.1 Nomascus leucogenys 88 0.0 1084
WERAM-Dan-0085 ENSDNOP00000008309.3 Dasypus novemcinctus 88 0.0 1082
WERAM-Fec-0100 ENSFCAP00000008411.3 Felis catus 88 0.0 1078
WERAM-Otg-0114 ENSOGAP00000010110.2 Otolemur garnettii 87 0.0 1076
WERAM-Orc-0026 ENSOCUP00000002696.3 Oryctolagus cuniculus 88 0.0 1075
WERAM-Caf-0111 ENSCAFP00000014506.3 Canis familiaris 87 0.0 1073
WERAM-Mup-0032 ENSMPUP00000003131.1 Mustela putorius furo 88 0.0 1066
WERAM-Tas-0035 ENSTSYP00000003514.1 Tarsius syrichta 87 0.0 1060
WERAM-Aim-0077 ENSAMEP00000007071.1 Ailuropoda melanoleuca 88 0.0 1053
WERAM-Bot-0186 ENSBTAP00000028747.5 Bos taurus 86 0.0 1046
WERAM-Eqc-0094 ENSECAP00000011216.1 Equus caballus 88 0.0 1045
WERAM-Chh-0076 ENSCHOP00000008281.1 Choloepus hoffmanni 86 0.0 1042
WERAM-Loa-0164 ENSLAFP00000014964.4 Loxodonta africana 85 0.0 1037
WERAM-Sus-0148 ENSSSCP00000019491.1 Sus scrofa 85 0.0 1035
WERAM-Ova-0179 ENSOARP00000018514.1 Ovis aries 86 0.0 1033
WERAM-Myl-0147 ENSMLUP00000012097.2 Myotis lucifugus 84 0.0 958
WERAM-Mod-0108 ENSMODP00000016344.2 Monodelphis domestica 76 0.0 932
WERAM-Gaga-0040 ENSGALP00000005996.4 Gallus gallus 74 0.0 905
WERAM-Fia-0002 ENSFALP00000000089.1 Ficedula albicollis 74 0.0 898
WERAM-Tag-0113 ENSTGUP00000008752.1 Taeniopygia guttata 74 0.0 885
WERAM-Ora-0015 ENSOANP00000002119.3 Ornithorhynchus anatinus 78 0.0 878
WERAM-Anp-0114 ENSAPLP00000013228.1 Anas platyrhynchos 75 0.0 878
WERAM-Meg-0049 ENSMGAP00000004675.2 Meleagris gallopavo 73 0.0 877
WERAM-Tut-0150 ENSTTRP00000012693.1 Tursiops truncatus 74 0.0 863
WERAM-Vip-0021 ENSVPAP00000002042.1 Vicugna pacos 75 0.0 863
WERAM-Pes-0091 ENSPSIP00000011295.1 Pelodiscus sinensis 76 0.0 859
WERAM-Ect-0107 ENSETEP00000012035.1 Echinops telfairi 76 0.0 856
WERAM-Tub-0101 ENSTBEP00000011843.1 Tupaia belangeri 73 0.0 822
WERAM-Anc-0153 ENSACAP00000014066.3 Anolis carolinensis 71 0.0 786
WERAM-Sah-0115 ENSSHAP00000012312.1 Sarcophilus harrisii 66 0.0 778
WERAM-Ptv-0034 ENSPVAP00000003954.1 Pteropus vampyrus 85 0.0 761
WERAM-Soa-0036 ENSSARP00000003496.1 Sorex araneus 83 0.0 757
WERAM-Leo-0070 ENSLOCP00000008916.1 Lepisosteus oculatus 57 0.0 640
WERAM-Xet-0116 ENSXETP00000039969.3 Xenopus tropicalis 57 5e-177 618
WERAM-Lac-0037 ENSLACP00000005934.1 Latimeria chalumnae 55 1e-171 600
WERAM-Dar-0022 ENSDARP00000112550.1 Danio rerio 52 8e-167 584
WERAM-Asm-0207 ENSAMXP00000019404.1 Astyanax mexicanus 55 4e-163 572
WERAM-Orn-0026 ENSONIP00000003564.1 Oreochromis niloticus 53 3e-161 566
WERAM-Pof-0185 ENSPFOP00000015672.2 Poecilia formosa 53 4e-159 559
WERAM-Orla-0149 ENSORLP00000017459.1 Oryzias latipes 51 4e-158 555
WERAM-Xim-0204 ENSXMAP00000016381.1 Xiphophorus maculatus 55 1e-156 550
WERAM-Gaa-0178 ENSGACP00000022076.1 Gasterosteus aculeatus 54 2e-155 546
WERAM-Prc-0106 ENSPCAP00000009591.1 Procavia capensis 85 2e-153 540
WERAM-Caj-0013 ENSCJAP00000003330.2 Callithrix jacchus 63 1e-152 537
WERAM-Tar-0099 ENSTRUP00000020220.1 Takifugu rubripes 49 3e-150 529
WERAM-Gam-0069 ENSGMOP00000006538.1 Gadus morhua 50 2e-132 470
WERAM-Pem-0045 ENSPMAP00000005437.1 Petromyzon marinus 46 5e-122 436
WERAM-Ere-0101 ENSEEUP00000010459.1 Erinaceus europaeus 70 1e-99 361
WERAM-Cis-0073 ENSCSAVP00000015900.1 Ciona savignyi 33 9e-74 275
WERAM-Cii-0025 ENSCINP00000009862.3 Ciona intestinalis 32 4e-72 270
WERAM-Drm-0043 FBpp0079111 Drosophila melanogaster 33 2e-62 237
WERAM-Dio-0031 ENSDORP00000003260.1 Dipodomys ordii 34 8e-58 222
WERAM-Ten-0214 ENSTNIP00000021580.1 Tetraodon nigroviridis 32 1e-55 215
WERAM-Cae-0034 C01H6.7a.1 Caenorhabditis elegans 28 9e-42 169
WERAM-Mae-0041 ENSMEUP00000003755.1 Macropus eugenii 63 9e-39 159
WERAM-Ocp-0079 ENSOPRP00000006857.2 Ochotona princeps 66 3e-22 104
WERAM-Tra-0090 Traes_2DS_3F067BAD4.1 Triticum aestivum 38 3e-18 91.3
WERAM-Brd-0013 BRADI1G26420.1 Brachypodium distachyon 37 4e-18 90.9
WERAM-Sei-0099 Si028722m Setaria italica 35 4e-18 90.5
WERAM-Aet-0035 EMT27625 Aegilops tauschii 38 4e-18 90.5
WERAM-Tru-0069 TRIUR3_26466-P1 Triticum urartu 38 5e-18 90.5
WERAM-Met-0062 AES70383 Medicago truncatula 35 6e-18 90.1
WERAM-Usm-0035 UM05887P0 Ustilago maydis 41 6e-18 90.1
WERAM-Spr-0041 CBQ70925 Sporisorium reilianum 41 1e-17 89.4
WERAM-Mua-0140 GSMUA_Achr9P11570_001 Musa acuminata 38 1e-17 89.4
WERAM-Glm-0234 GLYMA18G10891.1 Glycine max 35 1e-17 89.0
WERAM-Zem-0032 GRMZM2G044044_P01 Zea mays 41 1e-17 89.0
WERAM-Orbr-0086 OB07G21800.1 Oryza brachyantha 37 2e-17 88.2
WERAM-Ori-0086 BGIOSGA025787-PA Oryza indica 38 5e-17 87.0
WERAM-Orni-0075 ONIVA07G14220.1 Oryza nivara 38 6e-17 87.0
WERAM-Orm-0072 OMERI07G12350.1 Oryza meridionalis 38 6e-17 87.0
WERAM-Org-0077 ORGLA07G0130400.1 Oryza glaberrima 38 6e-17 87.0
WERAM-Orb-0077 OBART07G15930.1 Oryza barthii 38 6e-17 87.0
WERAM-Orp-0074 OPUNC07G14740.1 Oryza punctata 40 8e-17 86.7
WERAM-Orgl-0074 OGLUM07G15680.1 Oryza glumaepatula 40 1e-16 86.3
Created Date 25-Jun-2016