WERAM Information


Tag Content
WERAM ID WERAM-Ova-0179
Ensembl Protein ID ENSOARP00000018514.1
Gene Name BRD7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOARG00000017248.1 ENSOART00000018776.1 ENSOARP00000018514.1
Status Unreviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.90e-18 66.5 152 220
Organism Ovis aries
Domain Profile
  Ac_Reader Bromodomain

             BROMO.txt   3 hevsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72 
++ s +F+ pv +p Y iik+Pmd+st+ke+++++ Y+s+ee+ + ++l+++Na+ yn++++ ++
ENSOARP00000018514.1 152 KDPSAFFSFPVTD-FIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYY 220
5667888******.8**************************************************98876 PP

Protein Sequence
(Fasta)
GKRERREESE RKLFRFVLEY VEKPLKLVLK VGGNEVTELS TGSSGHDSSL FEDKNDHDKH 60
KERKRKKRKK GEKQIPGEEK GRKRRRVKED KRKRDRDHVD IEAEKDLQCQ APVRLDLPPE 120
KPLASSLAKQ EEVEQTPLQE ALNQLMRQLQ RKDPSAFFSF PVTDFIAPGY SMIIKHPMDF 180
STMKEKIKNN DYQSIEELKD NFKLMCTNAM IYNKPETIYY KAAKKLLHSG MKILSQERIQ 240
SLKQSIDFMA DLQKSRKQRD GTDTSQSGED SGSWPRERDD AGDAEAQGFK SPNKENKKKD 300
KDVLEDKFKS SNVEREQEQI DRIVKESGGK LTRRLVNSQC EFERRKPDGT TTLGLLHPVD 360
PVVGEPGYCP VRLGMTTGRL QSGVNTLQGF KEDKRNKVTP AVLYLSYGPY SSYAPHYDST 420
FANISKDDSD LIYSTYGEDP DLPSDFSIHE FLATCQDYPY VMADSLLDVL TKGGHSRTLQ 480
ESETSSPEDE GQTRILDTAK EMEQVTEVEL TGPLDSNHQD KFTALKAVTN FGAPVEVFDS 540
EEAEVFQRKL DETTKLLREL QEAQNERLST RPPPNMICLL GPSYREMHLA EQVTNNLKEL 600
AQQVTPGDIV STYGVRKAMG ISVPSPVIGN NLVDLTADFE EPKKTDVTEC EPDGI 655
Nucleotide Sequence
(Fasta)
GGAAAGCGGG AGAGAAGGGA GGAGTCAGAA AGGAAACTCT TTCGTTTCGT TTTAGAGTAT 60
GTAGAGAAGC CCCTGAAGCT AGTCCTCAAA GTGGGAGGAA ACGAAGTTAC CGAGCTCTCC 120
ACGGGCAGCT CTGGGCACGA CTCCAGCCTC TTTGAAGACA AAAACGATCA TGACAAACAC 180
AAAGAGAGAA AGCGGAAAAA GAGAAAGAAA GGAGAGAAGC AGATTCCAGG GGAAGAAAAG 240
GGGAGAAAAC GGAGACGTGT AAAGGAGGAT AAAAGAAAGC GAGATCGTGA CCATGTGGAT 300
ATTGAGGCAG AAAAAGACCT ACAGTGTCAG GCCCCTGTAC GATTAGACTT GCCTCCTGAG 360
AAGCCTCTTG CAAGCTCTTT AGCCAAACAA GAAGAAGTAG AACAGACACC TCTTCAAGAA 420
GCTTTGAATC AACTGATGAG ACAACTGCAG AGAAAAGACC CAAGTGCTTT CTTTTCATTT 480
CCTGTGACTG ATTTTATTGC CCCCGGCTAC TCCATGATCA TTAAACACCC AATGGATTTT 540
AGTACCATGA AAGAAAAGAT CAAGAACAAT GATTACCAGT CCATAGAAGA ACTGAAGGAT 600
AACTTCAAAC TAATGTGTAC TAACGCTATG ATTTACAACA AACCAGAGAC GATTTATTAT 660
AAAGCTGCGA AAAAGCTGTT GCACTCAGGG ATGAAAATTC TTAGCCAGGA GAGAATTCAG 720
AGCCTGAAGC AGAGCATAGA CTTCATGGCA GACTTACAGA AAAGTCGGAA GCAGAGAGAC 780
GGGACAGACA CCTCACAGAG TGGGGAGGAC AGCGGCTCCT GGCCAAGAGA GAGGGACGAT 840
GCTGGAGACG CTGAGGCACA GGGCTTCAAG AGCCCCAATA AGGAAAATAA AAAGAAAGAC 900
AAAGATGTGC TTGAAGATAA ATTTAAAAGC AGTAATGTAG AAAGAGAGCA GGAGCAGATT 960
GACCGTATCG TTAAGGAATC TGGAGGAAAG CTGACCAGGA GGCTTGTTAA TAGTCAGTGT 1020
GAATTTGAAA GGAGAAAACC AGATGGAACA ACAACATTGG GACTTCTCCA TCCTGTGGAT 1080
CCTGTTGTAG GAGAACCAGG CTATTGTCCT GTGAGACTGG GGATGACAAC TGGAAGACTA 1140
CAGTCTGGAG TGAATACTTT GCAGGGGTTC AAAGAGGATA AAAGGAACAA AGTAACTCCA 1200
GCAGTGTTAT ACTTGAGTTA TGGACCTTAC AGTTCTTACG CACCACATTA TGACTCCACG 1260
TTTGCAAATA TCAGCAAGGA CGATTCTGAT TTAATCTATT CAACCTATGG GGAGGACCCT 1320
GATCTCCCCA GTGATTTCAG CATCCATGAG TTTTTGGCCA CATGCCAAGA TTATCCATAT 1380
GTTATGGCAG ATAGTTTACT GGATGTTTTA ACAAAAGGAG GACATTCTAG AACCCTGCAG 1440
GAGTCAGAGA CGTCATCTCC TGAAGATGAA GGCCAGACTA GGATACTTGA CACAGCAAAA 1500
GAAATGGAGC AGGTTACAGA AGTTGAACTA ACAGGGCCTT TGGACTCCAA TCATCAAGAC 1560
AAGTTTACAG CGCTGAAAGC AGTCACAAAC TTTGGAGCTC CAGTTGAAGT GTTTGACTCC 1620
GAAGAAGCTG AAGTGTTCCA GAGGAAACTT GATGAGACCA CCAAACTGCT CAGAGAGCTC 1680
CAGGAAGCCC AGAATGAGCG TCTGAGCACC AGACCCCCTC CCAACATGAT CTGTCTCTTG 1740
GGTCCATCGT ACAGAGAAAT GCATCTCGCT GAACAAGTGA CCAATAACCT TAAAGAACTT 1800
GCACAGCAAG TAACTCCGGG TGATATTGTA AGCACATATG GAGTCCGAAA AGCAATGGGG 1860
ATTTCCGTCC CCTCCCCGGT CATTGGAAAC AACCTTGTGG ATTTAACAGC AGATTTTGAA 1920
GAACCTAAAA AGACTGATGT TACTGAGTGT GAACCTGATG GGATTTGAAT CTATCTGGTA 1980
TTTGATTATA TATTATGTAT ATATTTTTTT CATTAACTTG GAAATGCTTT TCAGAAGATA 2040
TTAAATATTT GTAAATTGTG TTTTTAATTA AACTTTGGAA CAGTTGATTT TAATGTTCCA 2100
GAGGTTGAAC TTCTGTTAGG TAATAAAGCT AAACCTGGAC TATGAGCTGT ATTGTACATA 2160
TCACCTGAGT TACCCCTTCA CCTTTTCCTG GGGCCGAATC TGAGGATGGA GTATTAGAGA 2220
AGAGCTTGGA GAATAGAACA GCCTTTTTCC TGACCATCCA TTAAAAAGTT GCCCAAATCA 2280
TTGAAATCCC TCATTTTCCC ATATTTGCCT TTCTTCTCAT TAAGGAAATT ATAACCAAAT 2340
GGTTCCTGAC TTAGCAGATT TCACTTCGAG GATTTATTCA AAAAGGGGCC TTGTGAGGAA 2400
GGAATGATTT GGACCTGTTG GAATACTGAG CAGAAAGTGG ATGGGAGTGG ACCTAGGCAG 2460
AGTTCTTGCA GAGGAGTGAT AGTGCTGCTT CCTTATGTTT CACAGGCAGG ACCATGACTG 2520
AGAAACCCTT CTTTAAAATT ACCATCCAGT GAGATTCCCA TTGTTATGCC ATGAAAACAA 2580
ATTCAACTTT AGAATTTACT AGCATGTCCC CCATATATGT ATTGAGGACG ATGTCCTTAT 2640
GTGGAAGGAG CAGGGCTTCC CACCACGAAA GCAAAACGAA ATAAAAATAT GTTAGGAGTT 2700
TCATAGCACT AACTTGTCTG GTGTTCCTTT TTGGTTTATT TTTGCCATTT GTAGAGGGGT 2760
TTTCCCAGTA TAATAAAAGG ACAAGCCAAA TAGGATACAA ACTAAATTGT CCATGAATAT 2820
GAAAAGGAAA TCACCAAGCT TAAAGGAAAG TTGATGTTTC TATTTACTGT TTTTCAACAG 2880
GTCACCTAAG ATTCTGCCAT GCCCCCGAAA CTGATACTCA TCTACTTCTA TCTGAAAGGC 2940
AAAGGTTAAG TTCCTGAGCA GTTTAATTAT TTAAGTAGGA AATGATACGT GGTCCTTCCT 3000
CTTCTGTGAC CAGGCACTAG ACTGTGACCT AATTCAGGAA CAAATCAGGT TTCAGACCCT 3060
ACTCAGACTG TATGGAGTCC TTCTGTAAAA CATCCAGGCT GGAAGCTATT TTATTATTTT 3120
CTTGACTTTG AAAACTAACA TTTAACAAGT AGGGTGAAGG AAAACTGAAT CTCTTAAGAG 3180
AGTTAAGATG ACCTAATCTT TCAAAAACAT ACTTGAAAAC ATATGCCAGA AGAATTAAAG 3240
AATCCATTCA AATATGTATT TATCAATATT TATCAAGTCT TTTTAGAGTT TGTCTCTCAA 3300
ATATAATTCA GGTAGCAACC AGCTCTTAAA ACTTTCAATC TATTTAGCTA AGTAGTTCCC 3360
AAAGACCAAG AAAACATTTA AATTCAAAAC ACTCCAGAAC AGGTTTTCCA GATTGCTGCT 3420
TTATCTATGA AAAGCTAAAC AAAAGAGAAA CACTGGTACT TTATAAAAAT GAAATATAAC 3480
ATTTTGAAAC AAATGTTACA GATCTATAAA TATTCAGTGT GTCGAATAAC CCCTAGTCGT 3540
TTCACCTACT TTCTCAAAGC CTATTTTTAT ACATATACAC AATGTATACA GTGGTTAATG 3600
ATCTTTTCTG TTTAGGAAAT TTTCTTAAGG AAATCAGAAA ACTTCACTAG CATCAGTGAG 3660
GCCACCGTAG TAGAGATATG AAGCATGTCC CTGACCCACA GAGAAGGTCA GTGTTAGGAA 3720
AAATACTTGT CTTGTCAAAG CAAAATGACA CCTGTGAACA AATGACTTGG TAATTGGAAA 3780
ATGAATTTAT AACAAGTAAC TAAGTGATTT TTATGGTCAG TTATACACTA TGATCTGAAT 3840
GTCAGAAATT CAGAACTTAA TATTACTCTT ATCTGAGCAC AGTGAAAAAA AAATACATAA 3900
ATGGTAACCA ATTATTTTTT AAACTCCCAA TTGGGATTTC TTTGCTGGAG GCAAACAGTA 3960
ATTTGTATGT TGCAGGAGTA GAAGCATGTC CACCTCAGAG AGGCCCAGCA TACTGATGTG 4020
TGTCTACACT GGATCAGTGA CAGAACCTTC GTGATTTCCC AGGAAAGCCC AGTCACTCCT 4080
GATTTTAAGG GTATAGATTT CAGCGTAGTA CTTAGATGAA GAACTGGTAT GTGAAAAAGG 4140
CAATCTAAGT AAGGTTTATT TCCCTTACCA GCGTTTTCAC CGTGAAACTC CTTTAGGACA 4200
GCAAGTTCTT GTGATTTATT CCCACCTGTT CTAGTGATGC ATCAGAGCTG CCACTAGCCC 4260
ACCCAACCCC AGGACTCAGC ACTGGCCAAC AGCAGGTTCG GCTCCAGTCC CCTCCCTGCC 4320
GTGGCTCACT CCACCGCCCC CGTCCCAGGC AAACTCGGCT GCTTAGTCAC CTGTCTGCAA 4380
GGTCGTGTCA TCTTTTAAAG CCTCACGTTT GCAAGACTTT ATAATTTCAG GGGAGTTCAT 4440
GGATGGCTTG TGGCTAGAAT TCCTGCTATA TAGTCAAGTT CAGCTGTATT AGAAACCCTG 4500
GTGATACTCT GGTTATGACG CAGTGAAGGC AGTTTGGAAA AGGGAATGGG CAGTTTGGTC 4560
TTTCCTCATG TTAAAACACA GATTGACTTC TTTCGATTCT TTTGGAGCTG AAGTGCTGTA 4620
AGACACCACA CCTCAAAAAC CTGGCTTTTT CACTTGCCTG GCTTCAGTCA GCTCAGAACA 4680
TCCAAGCATT TGTTTGTGAG AGGCCTGGCT TCCAAGATCC GGGAACCTCT GCACATGCTG 4740
ATGCTGAGTA GGTCCTCTTC AGAGCTAGCT GTGAGGACTG AAGGGGAGAA CTGCAGCCTG 4800
TCAGCTTCTC TCACACAGAG GCCACTCCTT TCCAGTATAA AGCTAAGACA GGCTGCAAGG 4860
TTGCCAGGGG CGCTCGGAAA TGCATGAGGA GTCAAGGAAG GGCTGAGAGC GTACACCTTC 4920
TTTTCTAAGG CTTTTCACTT ATTAAACCTA ATCTCAATTC TGGCTTCAAA GTTGTCTGAT 4980
TCAAGCCAAG GCTCTGCCAC TTGCTGCCTT CCTGTGGCCA CGCTCCTCAG AGCTCCATCC 5040
CACAGCTGAG ATGACCCCGT GAGCTCACAC AGGACAGTGG TCCCACTTGC GTGTCCATGG 5100
TTCCCAAGGA AGAGGCTACA CTGGAGGGAA GAGAATTTAT CCAGCATCTC AGAAGTCATT 5160
TAGAGGGTGA CACCTCAATT AATAATGAAT CCATTTTTAA ACAGACACAT GCCAAAGAGG 5220
ATAAGAAGTA AGTGTCCACT GTGGGGCTTT CTCCCTATTG TTTGAACCCA TTTGTAGATG 5280
TAAAACAATC TTTCAACTCC ATTTACCAGA ATGCCTATAT GAGAAGTGTG CGCTCTTGTA 5340
GCTGGTGTGC TGGGGAGAAA GGAGCTCCCA CCCATCCTGG ACGAGAAAAG ACACGTTCCA 5400
CGTGTGCAG
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Bot-0186 ENSBTAP00000028747.5 Bos taurus 98 0.0 1131
WERAM-Caf-0111 ENSCAFP00000014506.3 Canis familiaris 93 0.0 1090
WERAM-Fec-0100 ENSFCAP00000008411.3 Felis catus 92 0.0 1070
WERAM-Nol-0007 ENSNLEP00000001015.1 Nomascus leucogenys 92 0.0 1061
WERAM-Gog-0163 ENSGGOP00000014466.2 Gorilla gorilla 92 0.0 1061
WERAM-Aim-0077 ENSAMEP00000007071.1 Ailuropoda melanoleuca 92 0.0 1060
WERAM-Paa-0198 ENSPANP00000012675.1 Papio anubis 91 0.0 1058
WERAM-Hos-0182 ENSP00000378180.3 Homo sapiens 92 0.0 1056
WERAM-Pat-0064 ENSPTRP00000013832.5 Pan troglodytes 91 0.0 1056
WERAM-Chs-0058 ENSCSAP00000001667.1 Chlorocebus sabaeus 91 0.0 1055
WERAM-Orc-0026 ENSOCUP00000002696.3 Oryctolagus cuniculus 91 0.0 1054
WERAM-Poa-0067 ENSPPYP00000008289.2 Pongo abelii 92 0.0 1052
WERAM-Mup-0032 ENSMPUP00000003131.1 Mustela putorius furo 91 0.0 1050
WERAM-Mam-0024 ENSMMUP00000004172.2 Macaca mulatta 91 0.0 1049
WERAM-Dan-0085 ENSDNOP00000008309.3 Dasypus novemcinctus 91 0.0 1046
WERAM-Ict-0178 ENSSTOP00000022433.1 Ictidomys tridecemlineatus 90 0.0 1045
WERAM-Tas-0035 ENSTSYP00000003514.1 Tarsius syrichta 91 0.0 1045
WERAM-Sus-0148 ENSSSCP00000019491.1 Sus scrofa 92 0.0 1045
WERAM-Otg-0114 ENSOGAP00000010110.2 Otolemur garnettii 89 0.0 1036
WERAM-Eqc-0094 ENSECAP00000011216.1 Equus caballus 89 0.0 1032
WERAM-Cap-0167 ENSCPOP00000013943.2 Cavia porcellus 90 0.0 1032
WERAM-Chh-0076 ENSCHOP00000008281.1 Choloepus hoffmanni 89 0.0 1026
WERAM-Mum-0122 ENSMUSP00000034085.7 Mus musculus 86 0.0 1009
WERAM-Loa-0164 ENSLAFP00000014964.4 Loxodonta africana 88 0.0 1006
WERAM-Ran-0093 ENSRNOP00000068771.1 Rattus norvegicus 86 0.0 1000
WERAM-Myl-0147 ENSMLUP00000012097.2 Myotis lucifugus 88 0.0 969
WERAM-Mod-0108 ENSMODP00000016344.2 Monodelphis domestica 78 0.0 918
WERAM-Gaga-0040 ENSGALP00000005996.4 Gallus gallus 77 0.0 872
WERAM-Vip-0021 ENSVPAP00000002042.1 Vicugna pacos 81 0.0 868
WERAM-Fia-0002 ENSFALP00000000089.1 Ficedula albicollis 77 0.0 867
WERAM-Tag-0113 ENSTGUP00000008752.1 Taeniopygia guttata 77 0.0 865
WERAM-Anp-0114 ENSAPLP00000013228.1 Anas platyrhynchos 75 0.0 859
WERAM-Meg-0049 ENSMGAP00000004675.2 Meleagris gallopavo 76 0.0 855
WERAM-Ora-0015 ENSOANP00000002119.3 Ornithorhynchus anatinus 81 0.0 850
WERAM-Pes-0091 ENSPSIP00000011295.1 Pelodiscus sinensis 78 0.0 834
WERAM-Ect-0107 ENSETEP00000012035.1 Echinops telfairi 78 0.0 832
WERAM-Tub-0101 ENSTBEP00000011843.1 Tupaia belangeri 75 0.0 818
WERAM-Ptv-0034 ENSPVAP00000003954.1 Pteropus vampyrus 89 0.0 759
WERAM-Anc-0153 ENSACAP00000014066.3 Anolis carolinensis 71 0.0 744
WERAM-Sah-0115 ENSSHAP00000012312.1 Sarcophilus harrisii 68 0.0 736
WERAM-Soa-0036 ENSSARP00000003496.1 Sorex araneus 85 0.0 731
WERAM-Leo-0070 ENSLOCP00000008916.1 Lepisosteus oculatus 57 7e-168 588
WERAM-Xet-0116 ENSXETP00000039969.3 Xenopus tropicalis 56 1e-167 587
WERAM-Tut-0150 ENSTTRP00000012693.1 Tursiops truncatus 83 2e-165 580
WERAM-Lac-0037 ENSLACP00000005934.1 Latimeria chalumnae 53 7e-163 571
WERAM-Asm-0207 ENSAMXP00000019404.1 Astyanax mexicanus 55 1e-157 553
WERAM-Dar-0022 ENSDARP00000112550.1 Danio rerio 53 4e-153 539
WERAM-Xim-0204 ENSXMAP00000016381.1 Xiphophorus maculatus 53 2e-151 533
WERAM-Orn-0026 ENSONIP00000003564.1 Oreochromis niloticus 54 2e-151 533
WERAM-Gaa-0178 ENSGACP00000022076.1 Gasterosteus aculeatus 52 1e-150 531
WERAM-Pof-0185 ENSPFOP00000015672.2 Poecilia formosa 52 4e-148 522
WERAM-Orla-0149 ENSORLP00000017459.1 Oryzias latipes 51 2e-146 516
WERAM-Prc-0106 ENSPCAP00000009591.1 Procavia capensis 90 7e-144 508
WERAM-Tar-0099 ENSTRUP00000020220.1 Takifugu rubripes 48 1e-142 504
WERAM-Gam-0069 ENSGMOP00000006538.1 Gadus morhua 49 4e-126 449
WERAM-Pem-0045 ENSPMAP00000005437.1 Petromyzon marinus 47 6e-118 422
WERAM-Ere-0101 ENSEEUP00000010459.1 Erinaceus europaeus 72 2e-101 367
WERAM-Caj-0013 ENSCJAP00000003330.2 Callithrix jacchus 64 2e-81 301
WERAM-Cis-0073 ENSCSAVP00000015900.1 Ciona savignyi 35 2e-73 274
WERAM-Drm-0043 FBpp0079111 Drosophila melanogaster 32 1e-59 228
WERAM-Ten-0214 ENSTNIP00000021580.1 Tetraodon nigroviridis 34 2e-55 214
WERAM-Dio-0031 ENSDORP00000003260.1 Dipodomys ordii 33 2e-54 211
WERAM-Mae-0041 ENSMEUP00000003755.1 Macropus eugenii 63 2e-38 158
WERAM-Cae-0034 C01H6.7a.1 Caenorhabditis elegans 26 2e-37 155
WERAM-Cii-0025 ENSCINP00000009862.3 Ciona intestinalis 34 2e-36 151
WERAM-Ocp-0079 ENSOPRP00000006857.2 Ochotona princeps 66 5e-22 103
WERAM-Usm-0035 UM05887P0 Ustilago maydis 41 6e-18 90.1
WERAM-Tra-0090 Traes_2DS_3F067BAD4.1 Triticum aestivum 39 7e-18 90.1
WERAM-Aet-0035 EMT27625 Aegilops tauschii 39 9e-18 89.7
WERAM-Tru-0069 TRIUR3_26466-P1 Triticum urartu 40 1e-17 89.4
WERAM-Spr-0041 CBQ70925 Sporisorium reilianum 41 1e-17 89.0
WERAM-Zem-0032 GRMZM2G044044_P01 Zea mays 40 2e-17 88.6
WERAM-Mua-0140 GSMUA_Achr9P11570_001 Musa acuminata 38 2e-17 88.6
WERAM-Brd-0013 BRADI1G26420.1 Brachypodium distachyon 40 5e-17 87.0
WERAM-Met-0062 AES70383 Medicago truncatula 35 7e-17 86.7
WERAM-Orp-0074 OPUNC07G14740.1 Oryza punctata 40 9e-17 86.3
WERAM-Orbr-0086 OB07G21800.1 Oryza brachyantha 40 9e-17 86.3
WERAM-Orni-0075 ONIVA07G14220.1 Oryza nivara 40 1e-16 86.3
WERAM-Ori-0086 BGIOSGA025787-PA Oryza indica 39 1e-16 86.3
WERAM-Org-0077 ORGLA07G0130400.1 Oryza glaberrima 40 1e-16 86.3
WERAM-Orb-0077 OBART07G15930.1 Oryza barthii 40 1e-16 85.9
WERAM-Orm-0072 OMERI07G12350.1 Oryza meridionalis 40 1e-16 85.9
WERAM-Sei-0099 Si028722m Setaria italica 40 1e-16 85.9
WERAM-Orgl-0074 OGLUM07G15680.1 Oryza glumaepatula 40 1e-16 85.9
WERAM-Glm-0096 GLYMA08G43053.1 Glycine max 39 2e-16 85.1
Created Date 25-Jun-2016